The entrance to the active site of the citric acid cycle enzyme succinyl-CoA synthetase

The entrance to the active site of the citric acid cycle enzyme succinyl-CoA synthetase

Peroxisomes (green) and mitochondria (red) in a mammalian cell. The nucleus (blue) contains the cellular DNA.

Dr Michael Schrader was part of a study that has shed new light on a protein which is linked to a common neurological disorder called Charcot-Marie-Tooth disease. The team has discovered that a protein previously identified on mitochondria - the energy factories of the cell - is also found on the fat-metabolising organelles peroxisomes, suggesting a closer link between the two organelles.

Cellular & Chemical Biology

Research in the Cellular & Chemical Biology theme aims to explain how the properties of living cells emerge from the functions and interactions of their constituent molecules. Our research spans many areas from molecular structure through to cells and their interactions. Using a broad range of methods, including microscopy, biochemistry, molecular genetics, x-ray crystallography and mathematical modelling we investigate key cellular processes including the cell-cycle, cell and organelle motility, and metabolism.

Our research provides fundamental knowledge, which helps to understand the molecular basis of diseases and the virulence of animal and plant pathogens. We have specific strengths in live-cell imaging, metallobiology, biological rythmicity and organelle dynamics, function and evolution. Furthermore, research in this theme has led to the discovery of new enzymes for biotechnology and new strategies for molecular diagnostics.

We have strong links with the Evolution and Microbes & Disease themes.

Research funding

Substantial research income is present in the group from:

  • Dstl
  • EU
  • Glaxo Smith Kline
  • Gwent Group
  • iNET
  • MRC
  • NERC
  • Royal Society
  • Statoil
  • Syngenta
  • Unilever