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Dr Aaron Butt

Dr Aaron Butt

Research Fellow

 Not Known

 Geoffrey Pope Lab 401

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Qualifications

PhD Biological Sciences (Exeter)

Research

Research projects

2013-15: Filling the target void: Identification of novel antibacterial therapeutics

Work includes:

  • Constructing deletion or conditional mutants in genes predicted to be essential in either growth or virulence
  • Determine the phenotype of these mutants in appropriate assays
  • Collaborate with biochemists to solve the protein structure of novel targets and to design inhibitors as therapeutics.

PhD project:

2009-13: Identification and characterisation of Toxin-antitoxin systems in Burkholderia pseudomallei

The aim of this project was to identify novel Toxin-antitoxin systems in B pseudomallei, the causative agent of melioidosis and elucidate their biological role in persister cell formation and chronic persistent disease.

Grants/Funding:

  • Defence Science and Technology Laboratory (DSTL)

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Butt A, Higman VA, Williams C, Crump MP, Hemsley CM, Harmer N, Titball RW (2014). The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation. Biochem J, 459(2), 333-344. Abstract.  Author URL.  Full text.
Butt A, Müller C, Harmer N, Titball RW (2013). Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiol Lett, 338(1), 86-94. Abstract.  Author URL.  Full text.
Butt A, Muller C, Harmer N, Titball RW (2013). Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiology Letters, 338(1), 86-94.

Publications by year


2014

Butt A, Higman VA, Williams C, Crump MP, Hemsley CM, Harmer N, Titball RW (2014). The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation. Biochem J, 459(2), 333-344. Abstract.  Author URL.  Full text.

2013

Butt A, Müller C, Harmer N, Titball RW (2013). Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiol Lett, 338(1), 86-94. Abstract.  Author URL.  Full text.
Butt A, Muller C, Harmer N, Titball RW (2013). Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiology Letters, 338(1), 86-94.

Aaron_Butt Details from cache as at 2018-10-20 05:52:52

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