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Dr Aaron Jeffries

Dr Aaron Jeffries

Research Fellow

 01392 408221

 

Aaron Jeffries is a Research Fellow working at the University of Exeter Medical School and Exeter Sequencing Service. Aaron obtained an Honours degree in Genetics from Cardiff University and completed his PhD in King’s College London in 2004. Aaron’s PhD involved mapping and sequencing of t(6;11) translocation associated with schizophrenia like psychosis in a three generation pedigree, leading to the identification of a potential candidate gene explaining the psychosis and the winning publication for the Lilly Molecular Psychiatry award 2003. He also undertook the largest genotype/phenotype study of ring chromosome 22 to date. Aaron joined a developmental neurobiology group at King’s College London in 2005. While his initial work was around signalling pathways, he moved into studying allele specific heterogeneity observed in clonal cells, known as Random Monoallelic Expression. Working with clonal stem cells, and later epigenetic reprogramming techniques, he has furthered this work using stem cells as model systems. Aaron joined the Complex Disease Epigenetics group in January 2014 to further his research in single cell heterogeneity and its relation to disease. Through this he has performed single cell research using a variety of platforms and further psychiatric genetic/transcriptomic and epigenetic research. In April 2017, Aaron joined the Exeter Sequencing Service to oversee the PacBio sequencer.

Research

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Jeffries AR, Uwanogho DA, Cocks G, Perfect LW, Dempster E, Mill J, Price J (In Press). Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming. RNA, 22(10), 1620-1630. Abstract.  Author URL.  Full text.
Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K (2015). A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders. Biotechniques, 59(4), 241-246. Abstract.  Author URL.  Full text.
Wong CCY, Meaburn EL, Ronald A, Price TS, Jeffries AR, Schalkwyk LC, Plomin R, Mill J (2014). Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Mol Psychiatry, 19(4), 495-503. Abstract.  Author URL.  Full text.

Publications by year


In Press

Jeffries AR, Uwanogho DA, Cocks G, Perfect LW, Dempster E, Mill J, Price J (In Press). Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming. RNA, 22(10), 1620-1630. Abstract.  Author URL.  Full text.

2015

Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K (2015). A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders. Biotechniques, 59(4), 241-246. Abstract.  Author URL.  Full text.

2014

Wong CCY, Meaburn EL, Ronald A, Price TS, Jeffries AR, Schalkwyk LC, Plomin R, Mill J (2014). Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Mol Psychiatry, 19(4), 495-503. Abstract.  Author URL.  Full text.

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