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 Charlie Jeynes

Charlie Jeynes

Wellcome Trust Research Fellow

 7473

 01392 727473

 Living Systems Institute Level 2, Room S02.01

 

Living Systems Institute, University of Exeter, Stocker Road, Exeter, EX4 4QD

Please see my personal website.

Dr Charlie Jeynes is a Wellcome Trust Fellow working at the Centre for Biomedical Modelling and Analysis, University of Exeter, U.K. This centre is an Institutional Strategic Support Fund, with the aim of developing computational analysis and mathematical modelling within the life sciences.   

After studying for a degree in Biochemistry and Genetics at the University of Wales, Cardiff, he moved to the University of Surrey where he was awarded a PhD functionalising carbon nanotubes with DNA.

He then worked as a Post-Doc for the CONFORM consortium, a collaboration between a number of institutions including the Universities of Oxford/Surrey/Manchester and the Cockcroft Institute, investigating next generation particle accelerators largely for cancer treatment.

Following this, he worked as the biological liaison officer for the Surrey Ion Beam Centre, facilitating beam access for various institutions, as well as pursuing his own research interests into nanoparticle enhanced radiation therapies.

He then moved to the University of Reading where he completed his Higher Education associate fellow training (AFHFA).

Currently, he is at the University of Exeter as a Wellcome Trust Fellow at the Centre for Biomedical Modelling and Analysis, working with a range of academics including Prof Christian Soeller and Prof John Terry.

Broad research specialisms:

  • X-ray fluorescence microscopy
  • Single Molecule Imaging
  • Image Processing
  • Toxicology
  • Nanotechnology

Qualifications

2015 Associate Fellow Higher Education Academy
2003-2007 Ph.D, Bio-nanotechnology, University of Surrey
1999-2003 B.Sc, Genetics, University of Cardiff (year in industry Merck KgA)

Research

Research interests

The broad theme of my work is to investigate nanoparticles for human health. This includes studying the toxic effect of nanoparticles from air pollution; using nanoparticles to develop new tools to probe biological processes on a single molecule level; as well as developing novel drugs based on nanoparticle designs.

Key to my research is using analytical imaging methods to quantify nanoparticles in human cells and tissue.

I use a range of imaging techniques including electron microscopy, chemical imaging (Infra-Red/Raman), X-ray fluorescence microscopy (see IBC, Diamond Synchrotron) optical super resolution microscopy and fluorescent imaging.

I am also involved in a range of “seed corn” projects with academics at the University of Exeter supported through the Centre for Biomedical Modelling and Analysis. These projects involve utilising my analytical imaging skills for novel applications.

Research projects

Please see my project website.

Grants/funding

  • 2017 March: STFC funded workshop (£6K)
  • 2017 Feb: EPSRC funded beam access time Surrey Ion Beam Centre (£9.5K)
  • 2016 Sept: Royal Society Partnership grant with Chumleigh Secondary School (Devon) (£3K) 

  • 2016 March: Royal Society International exchange grant (£3K). A visit to the CIBA group (National University of Singapore) to use their accelerator. 

  • 2016 Feb: Diamond Synchrotron (Oxford) beamtime access grant (in kind £10K) 

  • 2015 Nov: Royal Society of Chemistry Event, November 2015, Tavistock 
College, Devon (£0.7K) 

  • 2015 June: Wellcome trust “seedcorn” consumables for my fellowship (£10K) 


Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Palombo F, Tamagnini F, Jeynes J, Mattana S, Swift I, Nallala J, Hancock J, Brown J, Randall A, Stone N, et al (2018). Detection of Aβ plaque-associated astrogliosis in Alzheimer’s disease brain by spectroscopic imaging and immunohistochemistry. Analyst, 143, 850-857. Full text.
Jeynes JCG, Geraki K, Jeynes C, Zhaohong M, Bettiol AA, Latorre E, Harries LW, Soeller C (2017). Nanoscale Properties of Human Telomeres Measured with a Dual Purpose X-ray Fluorescence and Super Resolution Microscopy Gold Nanoparticle Probe. ACS Nano, 11(12), 12632-12640. Abstract.  Author URL.  Full text.
Latorre E, Birar VC, Sheerin AN, Jeynes JCC, Hooper A, Dawe HR, Melzer D, Cox LS, Faragher RGA, Ostler EL, et al (2017). Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence. BMC Cell Biol, 18(1). Abstract.  Author URL.  Full text.
Georgantzoglou A, Merchant MJ, Jeynes JCG, Mayhead N, Punia N, Butler RE, Jena R (2016). Applications of high-throughput clonogenic survival assays in high-LET particle microbeams. Frontiers in Oncology, 5(JAN). Abstract.
Jeynes JCG, Jeynes C, Palitsin V, Townley HE (2016). Direct quantification of rare earth doped titania nanoparticles in individual human cells. NANOTECHNOLOGY, 27(28). Author URL.
Georgantzoglou A, Merchant MJ, Jeynes JCG, Wera A-C, Kirkby KJ, Kirkby NF, Jena R (2015). Automatic cell detection in bright-field microscopy for microbeam irradiation studies. PHYSICS IN MEDICINE AND BIOLOGY, 60(16), 6289-6303. Author URL.
Barazzuol L, Jeynes JCG, Merchant MJ, Wera A-C, Barry MA, Kirkby KJ, Suzuki M (2015). Radiosensitization of glioblastoma cells using a histone deacetylase inhibitor (SAHA) comparing carbon ions with X-rays. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 91(1), 90-98. Author URL.
Mohamad AS, Jeynes JCG, Hughes MP (2014). Dielectrophoretic Response of DNA Shows Different Conduction Mechanisms for Poly(dG)-Poly(dC) and Poly(dA)-Poly(dT) in Solution. IEEE TRANSACTIONS ON NANOBIOSCIENCE, 13(1), 51-54. Author URL.
Wera A-C, Barazzuol L, Jeynes JCG, Merchant MJ, Suzuki M, Kirkby KJ (2014). Influence of the nucleus area distribution on the survival fraction after charged particles broad beam irradiation. PHYSICS IN MEDICINE AND BIOLOGY, 59(15), 4197-4211. Author URL.
Jeynes JCG, Merchant MJ, Spindler A, Wera A-C, Kirkby KJ (2014). Investigation of gold nanoparticle radiosensitization mechanisms using a free radical scavenger and protons of different energies. PHYSICS IN MEDICINE AND BIOLOGY, 59(21), 6431-6443. Author URL.
Jeynes JCG, Merchant MJ, Barazzuol L, Barry M, Guest D, Palitsin VV, Grime GW, Tullis IDC, Barber PR, Vojnovic B, et al (2013). "Broadbeam" irradiation of mammalian cells using a vertical microbeam facility. RADIATION AND ENVIRONMENTAL BIOPHYSICS, 52(4), 513-521. Author URL.
Barazzuol L, Jena R, Burnet NG, Meira LB, Jeynes JCG, Kirkby KJ, Kirkby NF (2013). Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma. RADIATION ONCOLOGY, 8 Author URL.
Jeynes JCG, Jeynes C, Merchant MJ, Kirkby KJ (2013). Measuring and modelling cell-to-cell variation in uptake of gold nanoparticles. ANALYST, 138(23), 7070-7074. Author URL.
Merchant MJ, Jeynes JCG, Grime GW, Palitsin V, Tullis IDW, Barber PR, Vojnovic B, Webb RP, Kirkby KJ (2012). A Focused Scanning Vertical Beam for Charged Particle Irradiation of Living Cells with Single Counted Particles. RADIATION RESEARCH, 178(3), 182-190. Author URL.
Doria D, Kakolee KF, Kar S, Litt SK, Fiorini F, Ahmed H, Green S, Jeynes JCG, Kavanagh J, Kirby D, et al (2012). Biological effectiveness on live cells of laser driven protons at dose rates exceeding 10(9) Gy/s. AIP ADVANCES, 2(1). Author URL.
Barazzuol L, Jena R, Burnet NG, Jeynes JCG, Merchant MJ, Kirkby KJ, Kirkby NF (2012). In Vitro Evaluation of Combined Temozolomide and Radiotherapy Using X Rays and High-Linear Energy Transfer Radiation for Glioblastoma. RADIATION RESEARCH, 177(5), 651-662. Author URL.
Fiorini F, Kirby D, Borghesi M, Doria D, Jeynes JCG, Kakolee KF, Kar S, Kaur S, Kirby KJ, Merchant MJ, et al (2011). Dosimetry and spectral analysis of a radiobiological experiment using laser-driven proton beams. PHYSICS IN MEDICINE AND BIOLOGY, 56(21), 6969-6982. Author URL.
Jeynes JCG, Webb M, Kirkby KJ, Kirkby NF, Bradley DA (2009). Proceedings of the First International Conference on Biomedical Applications of High Energy Ion Beams Preface. APPLIED RADIATION AND ISOTOPES, 67(3), 369-370. Author URL.
Jeynes JCG, Mendoza E, Chow DCS, Watts PCR, McFadden J, Silva SRP (2006). Generation of chemically unmodified pure single-walled carbon nanotubes by solubilizing with RNA and treatment with ribonuclease A. ADVANCED MATERIALS, 18(12), 1598-+. Author URL.
Newcombe J, Jeynes JC, Mendoza E, Hinds J, Marsden GL, Stabler RA, Marti M, McFadden JJ (2005). Phenotypic and transcriptional characterization of the meningococcal PhoPQ system, a magnesium-sensing two-component regulatory system that controls genes involved in remodeling the meningococcal cell surface. J Bacteriol, 187(14), 4967-4975. Abstract.  Author URL.

Conferences

Kar S, Doria D, Kakolee KF, Prasad R, Litt S, Ahmed H, Nersisyan G, Lewis C, Zepf M, Borghesi M, et al (2013). First Results on Cell Irradiation with laser-driven protons on the TARANIS system.  Author URL.
Prakrajang K, Jeynes JCG, Merchant MJ, Kirkby K, Kirkby N, Thopan P, Yu LD (2013). MeV single-ion beam irradiation of mammalian cells using the Surrey vertical nanobeam, compared with broad proton beam and X-ray irradiations.  Author URL.
Hanton F, Doria D, Kakolee KF, Kar S, Litt SK, Fiorini F, Ahmed H, Green S, Jeynes JCG, Kavanagh J, et al (2013). Radiobiology at ultra-high dose rates employing laser-driven ions.  Author URL.
Doria D, Kakolee KF, Kar S, Litt SK, Fiorini F, Ahmed H, Green S, Jeynes JCG, Kavanagh J, Kirby D, et al (2012). Biological Cell Irradiation at Ultrahigh Dose Rate Employing Laser Driven Protons.  Author URL.
Jeynes JCG, Bailey MJ, Coley H, Kirkby KJ, Jeynes C (2010). Microbeam PIXE analysis of platinum resistant and sensitive ovarian cancer cells.  Author URL.
Jeynes JCG, Jeynes C, Kirkby KJ, Ruemmeli A, Silva SRP (2008). RBS/EBS/PIXE measurement of single-walled carbon nanotube modification by nitric acid purification treatment.  Author URL.
Jeynes JCG, Mendoza E, Chow D, McFadden J, Silva SRP (2005). DNA/RNA purified single walled carbon nanotubes on self-assembled networks.  Abstract.

Publications by year


2018

Palombo F, Tamagnini F, Jeynes J, Mattana S, Swift I, Nallala J, Hancock J, Brown J, Randall A, Stone N, et al (2018). Detection of Aβ plaque-associated astrogliosis in Alzheimer’s disease brain by spectroscopic imaging and immunohistochemistry. Analyst, 143, 850-857. Full text.

2017

Jeynes JCG, Geraki K, Jeynes C, Zhaohong M, Bettiol AA, Latorre E, Harries LW, Soeller C (2017). Nanoscale Properties of Human Telomeres Measured with a Dual Purpose X-ray Fluorescence and Super Resolution Microscopy Gold Nanoparticle Probe. ACS Nano, 11(12), 12632-12640. Abstract.  Author URL.  Full text.
Latorre E, Birar VC, Sheerin AN, Jeynes JCC, Hooper A, Dawe HR, Melzer D, Cox LS, Faragher RGA, Ostler EL, et al (2017). Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence. BMC Cell Biol, 18(1). Abstract.  Author URL.  Full text.

2016

Georgantzoglou A, Merchant MJ, Jeynes JCG, Mayhead N, Punia N, Butler RE, Jena R (2016). Applications of high-throughput clonogenic survival assays in high-LET particle microbeams. Frontiers in Oncology, 5(JAN). Abstract.
Jeynes JCG, Jeynes C, Palitsin V, Townley HE (2016). Direct quantification of rare earth doped titania nanoparticles in individual human cells. NANOTECHNOLOGY, 27(28). Author URL.

2015

Georgantzoglou A, Merchant MJ, Jeynes JCG, Wera A-C, Kirkby KJ, Kirkby NF, Jena R (2015). Automatic cell detection in bright-field microscopy for microbeam irradiation studies. PHYSICS IN MEDICINE AND BIOLOGY, 60(16), 6289-6303. Author URL.
Barazzuol L, Jeynes JCG, Merchant MJ, Wera A-C, Barry MA, Kirkby KJ, Suzuki M (2015). Radiosensitization of glioblastoma cells using a histone deacetylase inhibitor (SAHA) comparing carbon ions with X-rays. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 91(1), 90-98. Author URL.

2014

Mohamad AS, Jeynes JCG, Hughes MP (2014). Dielectrophoretic Response of DNA Shows Different Conduction Mechanisms for Poly(dG)-Poly(dC) and Poly(dA)-Poly(dT) in Solution. IEEE TRANSACTIONS ON NANOBIOSCIENCE, 13(1), 51-54. Author URL.
Wera A-C, Barazzuol L, Jeynes JCG, Merchant MJ, Suzuki M, Kirkby KJ (2014). Influence of the nucleus area distribution on the survival fraction after charged particles broad beam irradiation. PHYSICS IN MEDICINE AND BIOLOGY, 59(15), 4197-4211. Author URL.
Jeynes JCG, Merchant MJ, Spindler A, Wera A-C, Kirkby KJ (2014). Investigation of gold nanoparticle radiosensitization mechanisms using a free radical scavenger and protons of different energies. PHYSICS IN MEDICINE AND BIOLOGY, 59(21), 6431-6443. Author URL.

2013

Jeynes JCG, Merchant MJ, Barazzuol L, Barry M, Guest D, Palitsin VV, Grime GW, Tullis IDC, Barber PR, Vojnovic B, et al (2013). "Broadbeam" irradiation of mammalian cells using a vertical microbeam facility. RADIATION AND ENVIRONMENTAL BIOPHYSICS, 52(4), 513-521. Author URL.
Barazzuol L, Jena R, Burnet NG, Meira LB, Jeynes JCG, Kirkby KJ, Kirkby NF (2013). Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma. RADIATION ONCOLOGY, 8 Author URL.
Kar S, Doria D, Kakolee KF, Prasad R, Litt S, Ahmed H, Nersisyan G, Lewis C, Zepf M, Borghesi M, et al (2013). First Results on Cell Irradiation with laser-driven protons on the TARANIS system.  Author URL.
Prakrajang K, Jeynes JCG, Merchant MJ, Kirkby K, Kirkby N, Thopan P, Yu LD (2013). MeV single-ion beam irradiation of mammalian cells using the Surrey vertical nanobeam, compared with broad proton beam and X-ray irradiations.  Author URL.
Jeynes JCG, Jeynes C, Merchant MJ, Kirkby KJ (2013). Measuring and modelling cell-to-cell variation in uptake of gold nanoparticles. ANALYST, 138(23), 7070-7074. Author URL.
Hanton F, Doria D, Kakolee KF, Kar S, Litt SK, Fiorini F, Ahmed H, Green S, Jeynes JCG, Kavanagh J, et al (2013). Radiobiology at ultra-high dose rates employing laser-driven ions.  Author URL.

2012

Merchant MJ, Jeynes JCG, Grime GW, Palitsin V, Tullis IDW, Barber PR, Vojnovic B, Webb RP, Kirkby KJ (2012). A Focused Scanning Vertical Beam for Charged Particle Irradiation of Living Cells with Single Counted Particles. RADIATION RESEARCH, 178(3), 182-190. Author URL.
Doria D, Kakolee KF, Kar S, Litt SK, Fiorini F, Ahmed H, Green S, Jeynes JCG, Kavanagh J, Kirby D, et al (2012). Biological Cell Irradiation at Ultrahigh Dose Rate Employing Laser Driven Protons.  Author URL.
Doria D, Kakolee KF, Kar S, Litt SK, Fiorini F, Ahmed H, Green S, Jeynes JCG, Kavanagh J, Kirby D, et al (2012). Biological effectiveness on live cells of laser driven protons at dose rates exceeding 10(9) Gy/s. AIP ADVANCES, 2(1). Author URL.
Barazzuol L, Jena R, Burnet NG, Jeynes JCG, Merchant MJ, Kirkby KJ, Kirkby NF (2012). In Vitro Evaluation of Combined Temozolomide and Radiotherapy Using X Rays and High-Linear Energy Transfer Radiation for Glioblastoma. RADIATION RESEARCH, 177(5), 651-662. Author URL.

2011

Fiorini F, Kirby D, Borghesi M, Doria D, Jeynes JCG, Kakolee KF, Kar S, Kaur S, Kirby KJ, Merchant MJ, et al (2011). Dosimetry and spectral analysis of a radiobiological experiment using laser-driven proton beams. PHYSICS IN MEDICINE AND BIOLOGY, 56(21), 6969-6982. Author URL.

2010

Jeynes JCG, Bailey MJ, Coley H, Kirkby KJ, Jeynes C (2010). Microbeam PIXE analysis of platinum resistant and sensitive ovarian cancer cells.  Author URL.

2009

Jeynes JCG, Webb M, Kirkby KJ, Kirkby NF, Bradley DA (2009). Proceedings of the First International Conference on Biomedical Applications of High Energy Ion Beams Preface. APPLIED RADIATION AND ISOTOPES, 67(3), 369-370. Author URL.

2008

Jeynes JCG, Jeynes C, Kirkby KJ, Ruemmeli A, Silva SRP (2008). RBS/EBS/PIXE measurement of single-walled carbon nanotube modification by nitric acid purification treatment.  Author URL.

2006

Jeynes JCG, Mendoza E, Chow DCS, Watts PCR, McFadden J, Silva SRP (2006). Generation of chemically unmodified pure single-walled carbon nanotubes by solubilizing with RNA and treatment with ribonuclease A. ADVANCED MATERIALS, 18(12), 1598-+. Author URL.

2005

Jeynes JCG, Mendoza E, Chow D, McFadden J, Silva SRP (2005). DNA/RNA purified single walled carbon nanotubes on self-assembled networks.  Abstract.
Newcombe J, Jeynes JC, Mendoza E, Hinds J, Marsden GL, Stabler RA, Marti M, McFadden JJ (2005). Phenotypic and transcriptional characterization of the meningococcal PhoPQ system, a magnesium-sensing two-component regulatory system that controls genes involved in remodeling the meningococcal cell surface. J Bacteriol, 187(14), 4967-4975. Abstract.  Author URL.

Charlie_Jeynes Details from cache as at 2018-10-15 17:42:57

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Editorial responsibilities

Reviewer for a number of journals including Nanotechnology, Chemosphere and PLOS one. 



Invited lectures

2016 (Sept) “Measuring telomere lengths in images to inform ageing models” BioDynamics, Exeter, UK

2016 (July) “Getting more from QFISH: correlative super resolution microscopy and X-ray spectroscopy”, 16th international conference of biochemistry and molecular biology, Vancouver, Canada

2014 (Sep) “PIXE analysis of gold nanoparticles in human cells”, BioPIXE, Slovenia 


I am currently supervising with course lead James Wakefield, and Christian Soeller, a number of 3rd year undergraduate projects on the Natural Sciences degree.

PhD Students (PG researchers):

I am currently involved in a Doctoral Training Centre associated with CBMA  and co-supervising a number of PhD students.

Postgraduate researchers

  • I am currently involved in a Doctoral Training Centre associated with CBMA and co-supervising and helping a number of Ph.D students.

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