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Harry White

Wellcome Trust Career Re-Entry Fellow

 3795

 Biocatalysis Centre BC 2.1

 

Biocatalysis Centre, University of Exeter, The Henry Wellcome Building for Biocatalysis, Stocker Road, Exeter, EX4 4QD , UK

I am a molecular biologist with an interest in antibodies. Working with colleagues at Exeter and collaborators at the LMB in Cambridge, I am developing novel approaches for using high-throughput DNA sequencing to analyse antibody responses.

Qualifications

MA Industrial Design, Central Saint Martins School of Art and Design, ‘Communicating Science with Design’
PhD, University of London, Molecular Biology of Leukaemia
BA, Cambridge University, Genetics

Research

Research interests

B-lymphocytes.

Research projects

Grants/Funding:

  • 2013 Wellcome Trust
  • 2001 Wellcome Trust

Research networks

  • Paul Dear, LMB Cambridge

Research grants

  • 2012 Wellcome Trust
    Molecular Biology of Antibody responses

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Meng Q-H, White HN (In Press). CD21int CD23+ follicular B cells express antigen-specific secretory IgM mRNA as primary and memory responses. Immunology, 151(2), 211-218. Abstract.  Author URL.  Full text.
White HN (In Press). Restriction-PCR fingerprinting of the immunoglobulin VH repertoire: direct detection of an immune response and global analysis of B cell clonality. Eur J Immunol, 28(10), 3268-3279. Abstract.  Author URL.
White HN, Meng Q-H (2012). Diversification of specificity after maturation of the antibody response to the HIV gp41 epitope ELDKWA. PLoS One, 7(2). Abstract.  Author URL.
White HN, Meng Q-H (2012). Recruitment of a distinct but related set of VH sequences into the murine CD21hi/CD23- marginal zone B cell repertoire to that seen in the class-switched antibody response. J Immunol, 188(1), 287-293. Abstract.  Author URL.
Gaspar HB, Parsley KL, Howe S, King D, Gilmour KC, Sinclair J, Brouns G, Schmidt M, Von Kalle C, Barington T, et al (2004). Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector. Lancet, 364(9452), 2181-2187. Abstract.  Author URL.
D'Sa S, Peggs K, Pizzey A, Verfuerth S, Thuraisundaram D, Watts M, White H, Hale G, Waldmann H, Goldstone A, et al (2003). T- and B-cell immune reconstitution and clinical outcome in patients with multiple myeloma receiving T-cell-depleted, reduced-intensity allogeneic stem cell transplantation with an alemtuzumab-containing conditioning regimen followed by escalated donor lymphocyte infusions. Br J Haematol, 123(2), 309-322. Abstract.  Author URL.
Wedderburn LR, Jeffery R, White H, Patel A, Varsani H, Linch D, Murray K, Woo P (2001). Autologous stem cell transplantation for paediatric-onset polyarteritis nodosa: changes in autoimmune phenotype in the context of reduced diversity of the T- and B-cell repertoires, and evidence for reversion from the CD45RO(+) to RA(+) phenotype. Rheumatology (Oxford), 40(11), 1299-1307. Abstract.  Author URL.
White H, Gray D (2000). Analysis of immunoglobulin (Ig) isotype diversity and IgM/D memory in the response to phenyl-oxazolone. J Exp Med, 191(12), 2209-2220. Abstract.  Author URL.
Baxendale HE, Davis Z, White HN, Spellerberg MB, Stevenson FK, Goldblatt D (2000). Immunogenetic analysis of the immune response to pneumococcal polysaccharide. Eur J Immunol, 30(4), 1214-1223. Abstract.  Author URL.
White H, Thrasher A, Veys P, Kinnon C, Gaspar HB (2000). Intrinsic defects of B cell function in X-linked severe combined immunodeficiency. Eur J Immunol, 30(3), 732-737. Abstract.  Author URL.

Publications by year


In Press

Meng Q-H, White HN (In Press). CD21int CD23+ follicular B cells express antigen-specific secretory IgM mRNA as primary and memory responses. Immunology, 151(2), 211-218. Abstract.  Author URL.  Full text.
White HN (In Press). Restriction-PCR fingerprinting of the immunoglobulin VH repertoire: direct detection of an immune response and global analysis of B cell clonality. Eur J Immunol, 28(10), 3268-3279. Abstract.  Author URL.

2012

White HN, Meng Q-H (2012). Diversification of specificity after maturation of the antibody response to the HIV gp41 epitope ELDKWA. PLoS One, 7(2). Abstract.  Author URL.
White HN, Meng Q-H (2012). Recruitment of a distinct but related set of VH sequences into the murine CD21hi/CD23- marginal zone B cell repertoire to that seen in the class-switched antibody response. J Immunol, 188(1), 287-293. Abstract.  Author URL.

2004

Gaspar HB, Parsley KL, Howe S, King D, Gilmour KC, Sinclair J, Brouns G, Schmidt M, Von Kalle C, Barington T, et al (2004). Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector. Lancet, 364(9452), 2181-2187. Abstract.  Author URL.

2003

D'Sa S, Peggs K, Pizzey A, Verfuerth S, Thuraisundaram D, Watts M, White H, Hale G, Waldmann H, Goldstone A, et al (2003). T- and B-cell immune reconstitution and clinical outcome in patients with multiple myeloma receiving T-cell-depleted, reduced-intensity allogeneic stem cell transplantation with an alemtuzumab-containing conditioning regimen followed by escalated donor lymphocyte infusions. Br J Haematol, 123(2), 309-322. Abstract.  Author URL.

2001

Wedderburn LR, Jeffery R, White H, Patel A, Varsani H, Linch D, Murray K, Woo P (2001). Autologous stem cell transplantation for paediatric-onset polyarteritis nodosa: changes in autoimmune phenotype in the context of reduced diversity of the T- and B-cell repertoires, and evidence for reversion from the CD45RO(+) to RA(+) phenotype. Rheumatology (Oxford), 40(11), 1299-1307. Abstract.  Author URL.

2000

White H, Gray D (2000). Analysis of immunoglobulin (Ig) isotype diversity and IgM/D memory in the response to phenyl-oxazolone. J Exp Med, 191(12), 2209-2220. Abstract.  Author URL.
Baxendale HE, Davis Z, White HN, Spellerberg MB, Stevenson FK, Goldblatt D (2000). Immunogenetic analysis of the immune response to pneumococcal polysaccharide. Eur J Immunol, 30(4), 1214-1223. Abstract.  Author URL.
White H, Thrasher A, Veys P, Kinnon C, Gaspar HB (2000). Intrinsic defects of B cell function in X-linked severe combined immunodeficiency. Eur J Immunol, 30(3), 732-737. Abstract.  Author URL.

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