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Professor Ivana Gudelj

Professor Ivana Gudelj

Professor of Evolutionary Systems Biology

 Not Known

 Geoffrey Pope 319

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Qualifications

1998 – 2002 PhD in Applied Mathematics, University of Bath
1994 – 1998 BSc in Mathematical Sciences, University of Bath

Career

2015 – present Professor of Evolutionary Systems Biology, Biosciences, University of Exeter
2012 – 2015 Associate Professor of Evolutionary Systems Biology, Biosciences, University of Exeter
2011 – present NERC Advanced Fellow/ Associate Professor in Systems Biology, Biosciences, University of Exeter
2008 – 2010 NERC Advanced Fellow/ Lecturer in Applied Mathematics, Department of Mathematics, Imperial College London
2007 - 2008 NERC Advanced Fellow, Department of Mathematics, University of Bath
2006 – 2007 NERC EMS Fellow, Department of Mathematics, University of Bath
2004 – 2006 NERC EMS Fellow, NERC Centre for Population Biology, Imperial College London 
2001 – 2004 Postdoctoral Research Associate, Rothamsted Research

Links

Research

Research interests

Microbes are ubiquitous in nature and occupy virtually every environmental niche on earth. Contributing to this evolutionary success are diverse metabolic strategies as well as the ability to adapt to changing environments.

Microbes can be extremely beneficial. They play an important role in cycling vital elements such as carbon and nitrogen and can be used for biodegradation of soil and water pollutants.

However microbes can also have devastating impact on human heath. They are the biggest killer of hospital patients in intensive care units. Moreover microbes can also cause severe plant disease and are responsible for huge harvest losses each year.

Experimental evolution has provided an ideal setting for studying microbes in action – from the adaptation to novel environments, diversification, through to the evolution of drug resistance. Such experiments are conducted in controlled environments using culturable strains that are easily manipulated, raising the following important questions: How do we know whether a given experimental outcome is particular to the laboratory system? What can we learn from laboratory experiments about microorganisms in the wild?

My group utilizes theoretical and experimental approaches to answer fundamental questions in evolutionary biology. By developing novel modeling approaches that bring together cellular, molecular, genetic levels systems biology into a population level framework we strive to bridge the gap between laboratory experiments and the real world. We also closely collaborate with microbiologists and experimental evolutionary biologists from all over the world.

Research projects

  • The evolution of microbial cooperation
  • The coevolving interactions between bacteria and its viruses
  • Systems ecology of fungal pathogens

Research grants

  • 2011 BBSRC
    Transmission and coevolutionary dynamics drive the evolution of generalist and specialist viruses
  • 2009 NERC
    Mathematical models of bacteria-phage coevolution
  • 2009 BBSRC SABR Programme Grant
    Combinatorial responses of fungal pathogens to their human hosts: an integrative systems biology approach
  • 2008 NSF
    Mathematical models, microbes and evolutionary diversification
  • 2008 EPSRC
    Mathematical Models and Experimental Microbial Systems: Tools for Studying Evolution
  • 2007 EPSRC Interdisciplinary Workshop
    Mathematical Models and Experimental Microbial Systems: Tools for Studying Evolution
  • 2007 NERC Advanced Fellowship
    Mathematical models of experimental microbial evolution
  • 2004 NERC EMS Fellowship
    Mathematical models of evolution with trade-offs in host-parasite systems

Key publications | Publications by category | Publications by year

Key publications


Lindsay RJ, Kershaw MJ, Pawlowska BJ, Talbot NJ, Gudelj I (In Press). Harbouring public good mutants within a pathogen population can increase both fitness and virulence. Elife, 5 Abstract.  Author URL.  Full text.
Beardmore RE, Gudelj I, Lipson DA, Hurst LD (2011). Metabolic trade-offs and the maintenance of the fittest and the flattest. Nature, 472(7343), 342-346. Abstract.  Author URL.  Full text.
MaClean RC, Fuentes-Hernandez A, Greig D, Hurst LD, Gudelj I (2010). A mixture of "cheats" and "co-operators" can enable maximal group benefit. PLoS Biol, 8(9). Abstract.  Author URL.  Full text.
Gudelj I, Weitz JS, Ferenci T, Claire Horner-Devine M, Marx CJ, Meyer JR, Forde SE (2010). An integrative approach to understanding microbial diversity: from intracellular mechanisms to community structure. Ecol Lett, 13(9), 1073-1084. Abstract.  Author URL.
Forde SE, Beardmore RE, Gudelj I, Arkin SS, Thompson JN, Hurst LD (2008). Understanding the limits to generalizability of experimental evolutionary models. Nature, 455(7210), 220-223. Abstract.  Author URL.  Full text.
MacLean RC, Gudelj I (2006). Resource competition and social conflict in experimental populations of yeast. Nature, 441(7092), 498-501. Abstract.  Author URL.

Publications by category


Journal articles

Takano S, Pawlowska BJ, Gudelj I, Yomo T, Tsuru S (In Press). Density-Dependent Recycling Promotes the Long-Term Survival of Bacterial Populations during Periods of Starvation. MBio, 8(1). Abstract.  Author URL.
Lindsay RJ, Kershaw MJ, Pawlowska BJ, Talbot NJ, Gudelj I (In Press). Harbouring public good mutants within a pathogen population can increase both fitness and virulence. Elife, 5 Abstract.  Author URL.  Full text.
Lindsay RJ, Pawlowska BJ, Gudelj I (2018). When increasing population density can promote the evolution of metabolic cooperation. ISME J, 12(3), 849-859. Abstract.  Author URL.  Full text.
Reding-Roman C, Hewlett M, Duxbury S, Gori F, Gudelj I, Beardmore R (2017). The unconstrained evolution of fast and efficient antibiotic-resistant bacterial genomes. Nature Ecology & Evolution, 1(3), 0050-0050. Full text.
Rashkov P, Barrett IP, Beardmore RE, Bendtsen C, Gudelj I (2016). Kinase Inhibition Leads to Hormesis in a Dual Phosphorylation-Dephosphorylation Cycle. PLoS Comput Biol, 12(11). Abstract.  Author URL.  Full text.
Gudelj I, Kinnersley M, Rashkov P, Schmidt K, Rosenzweig F (2016). Stability of Cross-Feeding Polymorphisms in Microbial Communities. PLoS Computational Biology, 12(12). Abstract.  Full text.
Meyer JR, Gudelj I, Beardmore R (2015). Biophysical mechanisms that maintain biodiversity through trade-offs. Nat Commun, 6 Abstract.  Author URL.  Full text.
Fuentes-Hernandez A, Plucain J, Gori F, Pena-Miller R, Reding C, Jansen G, Schulenburg H, Gudelj I, Beardmore R (2015). Using a sequential regimen to eliminate bacteria at sublethal antibiotic dosages. PLoS Biol, 13(4). Abstract.  Author URL.  Full text.
Sieber M, Robb M, Forde SE, Gudelj I (2014). Dispersal network structure and infection mechanism shape diversity in a coevolutionary bacteria-phage system. ISME Journal, 8(3), 504-514. Abstract.
Sieber M, Gudelj I (2014). Do-or-die life cycles and diverse post-infection resistance mechanisms limit the evolution of parasite host ranges. Ecology Letters, 17(4), 491-498. Abstract.  Full text.
Peña-Miller R, Fuentes-Hernandez A, Reding C, Gudelj I, Beardmore R (2014). Testing the optimality properties of a dual antibiotic treatment in a two-locus, two-allele model. J R Soc Interface, 11(96). Abstract.  Author URL.
Maharjan R, Nilsson S, Sung J, Haynes K, Beardmore RE, Hurst LD, Ferenci T, Gudelj I (2013). The form of a trade-off determines the response to competition. Ecology Letters, 16(10), 1267-1276.
Maharjan R, Nilsson S, Sung J, Haynes K, Beardmore RE, Hurst LD, Ferenci T, Gudelj I (2013). The form of a trade-off determines the response to competition. Ecol Lett, 16(10), 1267-1276. Abstract.  Author URL.
Levert M, Zamfir O, Clermont O, Bouvet O, Lespinats S, Hipeaux MC, Branger C, Picard B, Saint-Ruf C, Norel F, et al (2011). Correction: Molecular and Evolutionary Bases of Within-Patient Genotypic and Phenotypic Diversity in Escherichia coli Extraintestinal Infections. PLoS Pathog, 7(6). Abstract.
Beardmore RE, Gudelj I, Lipson DA, Hurst LD (2011). Metabolic trade-offs and the maintenance of the fittest and the flattest. Nature, 472(7343), 342-346. Abstract.  Author URL.  Full text.
MaClean RC, Fuentes-Hernandez A, Greig D, Hurst LD, Gudelj I (2010). A mixture of "cheats" and "co-operators" can enable maximal group benefit. PLoS Biol, 8(9). Abstract.  Author URL.  Full text.
Gudelj I, Weitz JS, Ferenci T, Claire Horner-Devine M, Marx CJ, Meyer JR, Forde SE (2010). An integrative approach to understanding microbial diversity: from intracellular mechanisms to community structure. Ecol Lett, 13(9), 1073-1084. Abstract.  Author URL.
Estrela S, Gudelj I (2010). Evolution of cooperative cross-feeding could be less challenging than originally thought. PLoS One, 5(11). Abstract.  Author URL.  Full text.
Levert M, Zamfir O, Clermont O, Bouvet O, Lespinats S, Hipeaux MC, Branger C, Picard B, Saint-Ruf C, Norel F, et al (2010). Molecular and evolutionary bases of within-patient genotypic and phenotypic diversity in Escherichia coli extraintestinal infections. PLoS Pathog, 6(9). Abstract.  Author URL.  Full text.
Forde SE, Beardmore RE, Gudelj I, Arkin SS, Thompson JN, Hurst LD (2008). Understanding the limits to generalizability of experimental evolutionary models. Nature, 455(7210), 220-223. Abstract.  Author URL.  Full text.
Gudelj I, Beardmore RE, Arkin SS, MacLean RC (2007). Constraints on microbial metabolism drive evolutionary diversification in homogeneous environments. J Evol Biol, 20(5), 1882-1889. Abstract.  Author URL.
Gudelj I, Coman CD, Beardmore RE (2006). Classifying the role of trade-offs in the evolutionary diversity of pathogens. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 462(2065), 97-116. Abstract.
MacLean RC, Gudelj I (2006). Resource competition and social conflict in experimental populations of yeast. Nature, 441(7092), 498-501. Abstract.  Author URL.
Gudelj I, Fitt BDL, van den Bosch F (2004). Evolution of sibling fungal plant pathogens in relation to host specialization. Phytopathology, 94(7), 789-795. Abstract.  Author URL.
Gudelj I, White KAJ (2004). Spatial heterogeneity, social structure and disease dynamics of animal populations. Theor Popul Biol, 66(2), 139-149. Abstract.  Author URL.
Gudelj I, White KAJ, Britton NF (2004). The effects of spatial movement and group interactions on disease dynamics of social animals. Bull Math Biol, 66(1), 91-108. Abstract.  Author URL.
Gudelj I, van den Bosch F, Gilligan CA (2004). Transmission rates and adaptive evolution of pathogens in sympatric heterogeneous plant populations. Proc Biol Sci, 271(1553), 2187-2194. Abstract.  Author URL.
Beardmore I, Beardmore R (2003). The global structure of a spatial model of infectious disease. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 459(2034), 1427-1448. Abstract.
Beardmore I, White KA (2001). Spreading disease through social groupings in competition. J Theor Biol, 212(2), 253-269. Abstract.  Author URL.

Publications by year


In Press

Takano S, Pawlowska BJ, Gudelj I, Yomo T, Tsuru S (In Press). Density-Dependent Recycling Promotes the Long-Term Survival of Bacterial Populations during Periods of Starvation. MBio, 8(1). Abstract.  Author URL.
Lindsay RJ, Kershaw MJ, Pawlowska BJ, Talbot NJ, Gudelj I (In Press). Harbouring public good mutants within a pathogen population can increase both fitness and virulence. Elife, 5 Abstract.  Author URL.  Full text.

2018

Lindsay RJ, Pawlowska BJ, Gudelj I (2018). When increasing population density can promote the evolution of metabolic cooperation. ISME J, 12(3), 849-859. Abstract.  Author URL.  Full text.

2017

Reding-Roman C, Hewlett M, Duxbury S, Gori F, Gudelj I, Beardmore R (2017). The unconstrained evolution of fast and efficient antibiotic-resistant bacterial genomes. Nature Ecology & Evolution, 1(3), 0050-0050. Full text.

2016

Rashkov P, Barrett IP, Beardmore RE, Bendtsen C, Gudelj I (2016). Kinase Inhibition Leads to Hormesis in a Dual Phosphorylation-Dephosphorylation Cycle. PLoS Comput Biol, 12(11). Abstract.  Author URL.  Full text.
Gudelj I, Kinnersley M, Rashkov P, Schmidt K, Rosenzweig F (2016). Stability of Cross-Feeding Polymorphisms in Microbial Communities. PLoS Computational Biology, 12(12). Abstract.  Full text.

2015

Meyer JR, Gudelj I, Beardmore R (2015). Biophysical mechanisms that maintain biodiversity through trade-offs. Nat Commun, 6 Abstract.  Author URL.  Full text.
Fuentes-Hernandez A, Plucain J, Gori F, Pena-Miller R, Reding C, Jansen G, Schulenburg H, Gudelj I, Beardmore R (2015). Using a sequential regimen to eliminate bacteria at sublethal antibiotic dosages. PLoS Biol, 13(4). Abstract.  Author URL.  Full text.

2014

Sieber M, Robb M, Forde SE, Gudelj I (2014). Dispersal network structure and infection mechanism shape diversity in a coevolutionary bacteria-phage system. ISME Journal, 8(3), 504-514. Abstract.
Sieber M, Gudelj I (2014). Do-or-die life cycles and diverse post-infection resistance mechanisms limit the evolution of parasite host ranges. Ecology Letters, 17(4), 491-498. Abstract.  Full text.
Peña-Miller R, Fuentes-Hernandez A, Reding C, Gudelj I, Beardmore R (2014). Testing the optimality properties of a dual antibiotic treatment in a two-locus, two-allele model. J R Soc Interface, 11(96). Abstract.  Author URL.

2013

Maharjan R, Nilsson S, Sung J, Haynes K, Beardmore RE, Hurst LD, Ferenci T, Gudelj I (2013). The form of a trade-off determines the response to competition. Ecology Letters, 16(10), 1267-1276.
Maharjan R, Nilsson S, Sung J, Haynes K, Beardmore RE, Hurst LD, Ferenci T, Gudelj I (2013). The form of a trade-off determines the response to competition. Ecol Lett, 16(10), 1267-1276. Abstract.  Author URL.

2011

Levert M, Zamfir O, Clermont O, Bouvet O, Lespinats S, Hipeaux MC, Branger C, Picard B, Saint-Ruf C, Norel F, et al (2011). Correction: Molecular and Evolutionary Bases of Within-Patient Genotypic and Phenotypic Diversity in Escherichia coli Extraintestinal Infections. PLoS Pathog, 7(6). Abstract.
Beardmore RE, Gudelj I, Lipson DA, Hurst LD (2011). Metabolic trade-offs and the maintenance of the fittest and the flattest. Nature, 472(7343), 342-346. Abstract.  Author URL.  Full text.

2010

MaClean RC, Fuentes-Hernandez A, Greig D, Hurst LD, Gudelj I (2010). A mixture of "cheats" and "co-operators" can enable maximal group benefit. PLoS Biol, 8(9). Abstract.  Author URL.  Full text.
Gudelj I, Weitz JS, Ferenci T, Claire Horner-Devine M, Marx CJ, Meyer JR, Forde SE (2010). An integrative approach to understanding microbial diversity: from intracellular mechanisms to community structure. Ecol Lett, 13(9), 1073-1084. Abstract.  Author URL.
Estrela S, Gudelj I (2010). Evolution of cooperative cross-feeding could be less challenging than originally thought. PLoS One, 5(11). Abstract.  Author URL.  Full text.
Levert M, Zamfir O, Clermont O, Bouvet O, Lespinats S, Hipeaux MC, Branger C, Picard B, Saint-Ruf C, Norel F, et al (2010). Molecular and evolutionary bases of within-patient genotypic and phenotypic diversity in Escherichia coli extraintestinal infections. PLoS Pathog, 6(9). Abstract.  Author URL.  Full text.

2008

Forde SE, Beardmore RE, Gudelj I, Arkin SS, Thompson JN, Hurst LD (2008). Understanding the limits to generalizability of experimental evolutionary models. Nature, 455(7210), 220-223. Abstract.  Author URL.  Full text.

2007

Gudelj I, Beardmore RE, Arkin SS, MacLean RC (2007). Constraints on microbial metabolism drive evolutionary diversification in homogeneous environments. J Evol Biol, 20(5), 1882-1889. Abstract.  Author URL.

2006

Gudelj I, Coman CD, Beardmore RE (2006). Classifying the role of trade-offs in the evolutionary diversity of pathogens. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 462(2065), 97-116. Abstract.
MacLean RC, Gudelj I (2006). Resource competition and social conflict in experimental populations of yeast. Nature, 441(7092), 498-501. Abstract.  Author URL.

2004

Gudelj I, Fitt BDL, van den Bosch F (2004). Evolution of sibling fungal plant pathogens in relation to host specialization. Phytopathology, 94(7), 789-795. Abstract.  Author URL.
Gudelj I, White KAJ (2004). Spatial heterogeneity, social structure and disease dynamics of animal populations. Theor Popul Biol, 66(2), 139-149. Abstract.  Author URL.
Gudelj I, White KAJ, Britton NF (2004). The effects of spatial movement and group interactions on disease dynamics of social animals. Bull Math Biol, 66(1), 91-108. Abstract.  Author URL.
Gudelj I, van den Bosch F, Gilligan CA (2004). Transmission rates and adaptive evolution of pathogens in sympatric heterogeneous plant populations. Proc Biol Sci, 271(1553), 2187-2194. Abstract.  Author URL.

2003

Beardmore I, Beardmore R (2003). The global structure of a spatial model of infectious disease. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 459(2034), 1427-1448. Abstract.

2001

Beardmore I, White KA (2001). Spreading disease through social groupings in competition. J Theor Biol, 212(2), 253-269. Abstract.  Author URL.

Ivana_Gudelj Details from cache as at 2018-04-20 18:09:46

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Awards/Honorary fellowships

 NERC Advanced Fellow 2007-2012


Committee/panel activities

 NERC College Peer Review Member


Editorial responsibilities

 Editor of Plos ONE


Invited lectures

2008 - International workshop on Viral Dynamics and Evolution, Georgia Tech, USA

2008 - Conference of the European Society for Mathematical and Theoretical Biology, Edinburgh, UK

2008 - BIOMAPS seminar series, Rutgers University, USA

2008 - British Mathematics Colloquium, York, UK

2009 - Evolution, Ecology and Biodiversity colloquium, UBC, Vancouver, Canada

2009 - Ecology Seminar, University of Alberta, Edmonton, Canada

2009 - The American Society for Microbiology General Meeting, Philadelphia, USA

2009 - The Ecological Society of America General Meeting, Albuquerque, USA

2009 - Darwin Seminar Series, University of Bath, UK

2010 - International workshop, Modelling evolutionary and ecological processes in biogeochemical cycles, University of East Anglia, UK

2010 - Max Planck Institute for Evolutionary Biology, Ploen, Germany

2010 - UK-Brazil Frontiers of Science Symposium, Campinas, Brazil

2010 - Inaugural Colloquium, Systems and Synthetic Biology Program, Campus Univ. Autonoma de Madrid, Spain

2011 - International workshop on Biothermodynamics of Metabolic and Ecological Networks, Bonn, Germany 

2011 - International workshop, Mathematics of Microbes: Biological Details of the Evolving Cell, London, UK

2011 - Genetics, Evolution and Environment Seminar, UCL, London

2011 - Society for General Microbiology Meeting, Harrogate, UK

2012 - Genomes and Genetics Department, Institut Pasteur, Paris, France

2012- Gordon Research Conference on Cellular and Molecular Fungal Biology, New Hampshire, USA

2012 - Center for the Environment, Harvard University , US

2012 - 10th International Conference of Numerical analysis and applied mathematics, Kos, Greece 

2012 - Biosciences Science Colloquia, Birmingham University, UK

2013 - CoSyDy Meeting: Complexity in Biological Systems, Imperial College London, UK

2013 - International meeting, Quantitative Evolution Dynamics, University of Exeter, UK

2013 - FEBS Advanced Course: Molecular mechanisms of host-pathogen interactions and virulence in human fungal pathogens, La Colle-sur-Loup, France 

2013 - Evolution seminar, CNRS, Montpellier, France


Media Coverage

New Scientist: Too much food can be bad for biodiversity, September 2008

Science Daily: Selfishness can sometimes help the common good, 15th September 2012

BBC Radio Bristol and BBC Radio Wiltshire: Selfishness can sometimes help the common good, aured 15th September 2010


Workshops/Conferences organised

2009 - EPSRC International workshop: Evolution of Antibiotic Resistance, Imperial College London, UK

2009 - EPSRC International workshop: Evolution of Stress Responses, University of Aberdeen, UK

2010 - EPSRC International workshop: Models and Microbial Model Systems, University of Liverpool, UK

2011- EPSRC International workshop: Evolution of Microbial Cooperation, University of Bath, UK

Postdoctoral researchers

Postgraduate researchers

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