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Dr Jackie Lighten

Dr Jackie Lighten

BBSRC Research Fellow

 

I am an evolutionary biologist investigating links between genomic/epigenomic and phenotypic variation, which infer adaptation. In particular, I am interested in host-parasite interactions, and evolution of the immune system, as well as adaptation as a result of human impact on species. My central research project focusses on applying evolutionary genomic approaches to the management of farmed animals, specifically with the aim to reduce infectious disease in aquaculture. I also have on-going projects that focus on the interplay between immune-genomic variation, parasite infections, and phenotypic variation in natural populations.

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The Carp Health Project

Qualifications

2015 - Ph.D Evolutionary genetics (Dalhousie University)

2007 - M.Sc Evolutionary Biology (Imperial College London and the British Natural History Museum)

2002- B.Sc (Hons) Zoology (University of Southampton)

Career

2018-2021 BBSRC Research Fellow, University of Exeter

2014-2017 Senior Research Associate, University of East Anglia

Research

Research interests

  • Molecular ecology
  • Population genetics
  • Host-parasite interactions
  • Genomics of farming
  • Carp ecology

Research projects

The Carp Health Project
I am applying cutting-edge genomic approaches to understand infectious disease resistance in one of the world’s most important farmed fish, Common Carp (Cyprinus carpio). The objective of this research is to identify the global level differences in DNA between individual carp that are either resistant or susceptible to the deadly Koi Herpesvirus (KHV). Understanding resistance at the DNA level may offer part of the solution to the problems facing aquaculture, enabling farmers to create diverse brood-stocks with resistance to local pathogens, thus promoting food security. The analysis tools developed during this project will be applied to other emerging infectious diseases of carp.

Grants/Funding:

2017 BBSRC Research Fellowship
Applying genomics to establish mechanisms of disease resistance against a virus impacting on a globally farmed fish, the Common Carp (Cyprinus carpio):

2016 Separate funding from; Crowdfunding, Fisheries Society of the British Isles, Norwich Research Park Science Links Seed Corn funding, Nash Bait and Tackle
“CARPIOMICS: Development of genomic tools to improve the health, disease resistance and conservation of Europe and Asia’s most widely farmed fresh water fish, the Common Carp (Cyprinus carpio)”

2015 British Ecological Society Large Research Grant
“Towards a fuller understanding of host-parasite co-evolution”

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Horne JB, Mcbride MC, Lighten J, Bradbury IR, Bentzen P (In Press). Annotated mitochondrial genome assemblies for two sand lances (genus: Ammodytes) from the northwest Atlantic. Mitochondrial DNA a DNA Mapp Seq Anal, 27(6), 4607-4608. Abstract.  Author URL.
Lighten J, Papadopulos AST, Mohammed RS, Ward BJ, G Paterson I, Baillie L, Bradbury IR, Hendry AP, Bentzen P, van Oosterhout C, et al (In Press). Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen. Nat Commun, 8(1). Abstract.  Author URL.
Santonastaso T, Lighten J, van Oosterhout C, Jones KL, Foufopoulos J, Anthony NM (In Press). The effects of historical fragmentation on major histocompatibility complex class II β and microsatellite variation in the Aegean island reptile, Podarcis erhardii. Ecol Evol, 7(13), 4568-4581. Abstract.  Author URL.
Lighten J, van Oosterhout C (2017). Biocontrol of common carp in Australia poses risks to biosecurity. Nat Ecol Evol, 1(3). Author URL.
Lighten J, Incarnato D, Ward BJ, van Oosterhout C, Bradbury I, Hanson M, Bentzen P (2016). Adaptive phenotypic response to climate enabled by epigenetics in a K-strategy species, the fish Leucoraja ocellata (Rajidae). R Soc Open Sci, 3(10). Abstract.  Author URL.
Lighten J, van Oosterhout C, Bentzen P (2014). Critical review of NGS analyses for de novo genotyping multigene families. Mol Ecol, 23(16), 3957-3972. Abstract.  Author URL.
Papadopulos AST, Kaye M, Devaux C, Hipperson H, Lighten J, Dunning LT, Hutton I, Baker WJ, Butlin RK, Savolainen V, et al (2014). Evaluation of genetic isolation within an island flora reveals unusually widespread local adaptation and supports sympatric speciation. Philos Trans R Soc Lond B Biol Sci, 369(1648). Abstract.  Author URL.
Bradbury IR, Bowman S, Borza T, Snelgrove PVR, Hutchings JA, Berg PR, Rodríguez-Ezpeleta N, Lighten J, Ruzzante DE, Taggart C, et al (2014). Long distance linkage disequilibrium and limited hybridization suggest cryptic speciation in atlantic cod. PLoS One, 9(9). Abstract.  Author URL.
Lighten J, van Oosterhout C, Paterson IG, McMullan M, Bentzen P (2014). Ultra-deep Illumina sequencing accurately identifies MHC class IIb alleles and provides evidence for copy number variation in the guppy (Poecilia reticulata). Mol Ecol Resour, 14(4), 753-767. Abstract.  Author URL.

Publications by year


In Press

Horne JB, Mcbride MC, Lighten J, Bradbury IR, Bentzen P (In Press). Annotated mitochondrial genome assemblies for two sand lances (genus: Ammodytes) from the northwest Atlantic. Mitochondrial DNA a DNA Mapp Seq Anal, 27(6), 4607-4608. Abstract.  Author URL.
Lighten J, Papadopulos AST, Mohammed RS, Ward BJ, G Paterson I, Baillie L, Bradbury IR, Hendry AP, Bentzen P, van Oosterhout C, et al (In Press). Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen. Nat Commun, 8(1). Abstract.  Author URL.
Santonastaso T, Lighten J, van Oosterhout C, Jones KL, Foufopoulos J, Anthony NM (In Press). The effects of historical fragmentation on major histocompatibility complex class II β and microsatellite variation in the Aegean island reptile, Podarcis erhardii. Ecol Evol, 7(13), 4568-4581. Abstract.  Author URL.

2017

Lighten J, van Oosterhout C (2017). Biocontrol of common carp in Australia poses risks to biosecurity. Nat Ecol Evol, 1(3). Author URL.

2016

Lighten J, Incarnato D, Ward BJ, van Oosterhout C, Bradbury I, Hanson M, Bentzen P (2016). Adaptive phenotypic response to climate enabled by epigenetics in a K-strategy species, the fish Leucoraja ocellata (Rajidae). R Soc Open Sci, 3(10). Abstract.  Author URL.

2014

Lighten J, van Oosterhout C, Bentzen P (2014). Critical review of NGS analyses for de novo genotyping multigene families. Mol Ecol, 23(16), 3957-3972. Abstract.  Author URL.
Papadopulos AST, Kaye M, Devaux C, Hipperson H, Lighten J, Dunning LT, Hutton I, Baker WJ, Butlin RK, Savolainen V, et al (2014). Evaluation of genetic isolation within an island flora reveals unusually widespread local adaptation and supports sympatric speciation. Philos Trans R Soc Lond B Biol Sci, 369(1648). Abstract.  Author URL.
Bradbury IR, Bowman S, Borza T, Snelgrove PVR, Hutchings JA, Berg PR, Rodríguez-Ezpeleta N, Lighten J, Ruzzante DE, Taggart C, et al (2014). Long distance linkage disequilibrium and limited hybridization suggest cryptic speciation in atlantic cod. PLoS One, 9(9). Abstract.  Author URL.
Lighten J, van Oosterhout C, Paterson IG, McMullan M, Bentzen P (2014). Ultra-deep Illumina sequencing accurately identifies MHC class IIb alleles and provides evidence for copy number variation in the guppy (Poecilia reticulata). Mol Ecol Resour, 14(4), 753-767. Abstract.  Author URL.

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