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Dr Matthew Winter

Dr Matthew Winter

Senior Research Fellow

 6258

 01392 726258

 Hatherly D7

 

Hatherly Building, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK

Research interests: 

  • Pharmaceutical R&D applications of the zebrafish model. Current research activity focussed on drug-induced seizures and epilepsy; drug-induced kidney injury; and pancreatic beta cell regeneration. 
  • The effects of pharmaceuticals in the aquatic environment, particularly: sublethal markers of toxicity in fish; the use of preclincial data in ecotoxicology; and novel experimental approaches for environmental risk assessment.

Qualifications

2015: Post graduate Certificate in Academic Practice (Fellow of the Higher Education Academy)

1996–1999: Ph.D., Environmental Physiology (endocrinology). The University of Manchester

1992-1995: B.Sc. (Hons) Oceanography with Marine Biology. The University of Southampton

         

 

Career

June 2014 - present: Senior Research Fellow, Biosciences, University of Exeter 

2009-2014: Associate Principle Scientist, Safety, Health and Environment, AstraZeneca, Brixham Laboratory

2005-2009: Senior Scientist, Safety, Health and Environment, AstraZeneca, Brixham Laboratory 

2003-2005: Research Environmental Toxicologist, AstraZeneca, Brixham Laboratory

2000-2003: Post-Doctoral Research Associate, Toxicology, The University of Birmingham

1999-2000: Post-Doctoral Research Assistant, Endocrinology, The University of Manchester

Research

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Winter MJ, Windell D, Metz J, Matthews P, Pinion J, Brown JT, Hetheridge MJ, Ball JS, Owen SF, Redfern WS, et al (2017). 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain. Sci Rep, 7(1). Abstract.  Author URL.  Full text.
Huerta B, Margiotta-Casaluci L, Rodríguez-Mozaz S, Scholze M, Winter MJ, Barceló D, Sumpter JP (2016). Anti-anxiety drugs and fish behavior: Establishing the link between internal concentrations of oxazepam and behavioral effects. Environmental Toxicology and Chemistry, 35(11), 2782-2790.
Corcoran J, Winter MJ, Lange A, Cumming R, Owen SF, Tyler CR (2015). Effects of the lipid regulating drug clofibric acid on PPARα-regulated gene transcript levels in common carp (Cyprinus carpio) at pharmacological and environmental exposure levels. Aquat Toxicol, 161, 127-137. Abstract.  Author URL.
Parker T, Libourel P-A, Hetheridge MJ, Cumming RI, Sutcliffe TP, Goonesinghe AC, Ball JS, Owen SF, Chomis Y, Winter MJ, et al (2014). A multi-endpoint in vivo larval zebrafish (Danio rerio) model for the assessment of integrated cardiovascular function. J Pharmacol Toxicol Methods, 69(1), 30-38. Abstract.  Author URL.
Corcoran J, Lange A, Cumming RI, Owen SF, Ball JS, Tyler CR, Winter MJ (2014). Bioavailability of the imidazole antifungal agent clotrimazole and its effects on key biotransformation genes in the common carp (Cyprinus carpio). Aquat Toxicol, 152, 57-65. Abstract.  Author URL.
Margiotta-Casaluci L, Owen SF, Cumming RI, de Polo A, Winter MJ, Panter GH, Rand-Weaver M, Sumpter JP (2014). Quantitative Cross-Species Extrapolation between Humans and Fish: the Case of the Anti-Depressant Fluoxetine. PLoS ONE, 9(10), e110467-e110467.
Scholz S, Sela E, Blaha L, Braunbeck T, Galay-Burgos M, García-Franco M, Guinea J, Klüver N, Schirmer K, Tanneberger K, et al (2013). A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment. Regulatory Toxicology and Pharmacology, 67(3), 506-530.
Corcoran J, Lange A, Winter MJ, Tyler CR (2012). Effects of Pharmaceuticals on the Expression of Genes Involved in Detoxification in a Carp Primary Hepatocyte Model. Environmental Science and Technology, 46(11), 6306-6314. Abstract.
Bartram AE, Winter MJ, Huggett DB, McCormack P, Constantine LA, Hetheridge MJ, Hutchinson TH, Kinter LB, Ericson JF, Sumpter JP, et al (2012). In vivo and in vitro liver and gill EROD activity in rainbow trout (Oncorhynchus mykiss) exposed to the beta-blocker propranolol. Environ Toxicol, 27(10), 573-582. Abstract.  Author URL.
David RM, Jones HS, Panter GH, Winter MJ, Hutchinson TH, Kevin Chipman J (2012). Interference with xenobiotic metabolic activity by the commonly used vehicle solvents dimethylsulfoxide and methanol in zebrafish (Danio rerio) larvae but not Daphnia magna. Chemosphere, 88(8), 912-917.
Buck LM, Winter MJ, Redfern WS, Whitfield TT (2012). Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish. Hearing Research, 284(1-2), 67-81.
Buck L, Winter M, Redfern W, Whitfield T (2012). Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish. Journal of Pharmacological and Toxicological Methods, 66(2), 163-163.
David RM, Dakic V, Williams TD, Winter MJ, Chipman JK (2011). Transcriptional responses in neonate and adult Daphnia magna in relation to relative susceptibility to genotoxicants. Aquatic Toxicology, 104(3-4), 192-204.
Corcoran J, Winter MJ, Tyler CR (2010). Pharmaceuticals in the aquatic environment: a critical review of the evidence for health effects in fish. Crit Rev Toxicol, 40(4), 287-304. Abstract.  Author URL.
Winter MJ, Owen SF, Murray-Smith R, Panter GH, Hetheridge MJ, Kinter LB (2010). Using data from drug discovery and development to aid the aquatic environmental risk assessment of human pharmaceuticals: concepts, considerations, and challenges. Integr Environ Assess Manag, 6(1), 38-51. Abstract.  Author URL.
Easter A, Bell ME, Damewood JR, Redfern WS, Valentin J-P, Winter MJ, Fonck C, Bialecki RA (2009). Approaches to seizure risk assessment in preclinical drug discovery. Drug Discovery Today, 14(17-18), 876-884.
Hutchinson TH, Bögi C, Winter MJ, Owens JW (2009). Benefits of the maximum tolerated dose (MTD) and maximum tolerated concentration (MTC) concept in aquatic toxicology. Aquatic Toxicology, 91(3), 197-202.
Giltrow E, Eccles PD, Winter MJ, McCormack PJ, Rand-Weaver M, Hutchinson TH, Sumpter JP (2009). Chronic effects assessment and plasma concentrations of the β-blocker propranolol in fathead minnows (Pimephales promelas). Aquatic Toxicology, 95(3), 195-202.
Tyler CR, Filby AL, Bickley LK, Cumming RI, Gibson R, Labadie P, Katsu Y, Liney KE, Shears JA, Silva-Castro V, et al (2009). Environmental health impacts of equine estrogens derived from hormone replacement therapy. Environ Sci Technol, 43(10), 3897-3904. Abstract.  Author URL.
Bickley LK, Lange A, Winter MJ, Tyler CR (2009). Evaluation of a carp primary hepatocyte culture system for screening chemicals for oestrogenic activity. Aquat Toxicol, 94(3), 195-203. Abstract.  Author URL.
David RM, Winter MJ, Chipman JK (2009). INDUCTION OF DNA STRAND BREAKS BY GENOTOXICANTS IN THE ALGA CHLAMYDOMONAS REINHARDTII. Environmental Toxicology and Chemistry, 28(9), 1893-1893.
Winter MJ, Lillicrap AD, Caunter JE, Schaffner C, Alder AC, Ramil M, Ternes TA, Giltrow E, Sumpter JP, Hutchinson TH, et al (2008). Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas). Aquatic Toxicology, 86(3), 361-369.
Winter MJ, Redfern WS, Hayfield AJ, Owen SF, Valentin J-P, Hutchinson TH (2008). Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs. Journal of Pharmacological and Toxicological Methods, 57(3), 176-187.
Richards F, Alderton W, Kimber G, Liu Z, Strang I, Redfern W, Valentin J-P, Winter M, Hutchinson T (2008). Validation of the use of zebrafish larvae in visual safety assessment. Journal of Pharmacological and Toxicological Methods, 58(1), 50-58.
Redfern WS, Waldron G, Winter MJ, Butler P, Holbrook M, Wallis R, Valentin J-P (2008). Zebrafish assays as early safety pharmacology screens: Paradigm shift or red herring?. Journal of Pharmacological and Toxicological Methods, 58(2), 110-117.
OWEN S, GILTROW E, HUGGETT D, HUTCHINSON T, SAYE J, WINTER M, SUMPTER J (2007). Comparative physiology, pharmacology and toxicology of β-blockers: Mammals versus fish. Aquatic Toxicology, 82(3), 145-162.
McKenzie D, Garofalo E, Winter M, Ceradini S, Verweij F, Day N, Hayes R, van der Oost R, Butler P, Chipman J, et al (2007). Complex physiological traits as biomarkers of the sub-lethal toxicological effects of pollutant exposure in fishes. Philosophical Transactions of the Royal Society B: Biological Sciences, 362(1487), 2043-2059.
Bickley L, Lange A, Tyler C, Winter M (2007). Fish hepatocyte cultures as an alternative to in vivo tests for screening oestrogen receptor active chemicals. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 146(4), S72-S72. Author URL.
Winter MJ, Ellis LC, Hutchinson TH (2007). Formation of micronuclei in erythrocytes of the fathead minnow (Pimephales promelas) after acute treatment with mitomycin C or cyclophosphamide. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 629(2), 89-99.
Hutchinson T, Shillabeer N, Winter M, Pickford D (2006). Acute and chronic effects of carrier solvents in aquatic organisms: a critical review. Aquatic Toxicology, 76(1), 69-92.
Aniagu SO, Day N, Chipman JK, Taylor EW, Butler PJ, Winter MJ (2006). Does exhaustive exercise result in oxidative stress and associated DNA damage in the chub (Leuciscus cephalus)?. Environmental and Molecular Mutagenesis, 47(8), 616-623.
Winter MJ, Verweij F, Garofalo E, Ceradini S, McKenzie DJ, Williams MA, Taylor EW, Butler PJ, van der Oost R, Kevin Chipman J, et al (2005). Tissue levels and biomarkers of organic contaminants in feral and caged chub (Leuciscus cephalus) from rivers in the West Midlands, UK. Aquatic Toxicology, 73(4), 394-405.
Hayes RA, Regondi S, Winter MJ, Butler PJ, Agradi E, Taylor EW, Kevin Chipman J (2004). Cloning of a chub metallothionein cDNA and development of competitive RT-PCR of chub metallothionein mRNA as a potential biomarker of heavy metal exposure. Marine Environmental Research, 58(2-5), 665-669.
Winter MJ, Day N, Hayes RA, Taylor EW, Butler PJ, Chipman J (2004). DNA strand breaks and adducts determined in feral and caged chub (Leuciscus cephalus) exposed to rivers exhibiting variable water quality around Birmingham, UK. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 552(1-2), 163-175.
Kirk CJ, Bottomley L, Minican N, Carpenter H, Shaw S, Kohli N, Winter M, Taylor EW, Waring RH, Michelangeli F, et al (2003). Environmental endocrine disrupters dysregulate estrogen metabolism and Ca2+ homeostasis in fish and mammals via receptor-independent mechanisms. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 135(1), 1-8.
Wilkinson I (2002). High plasma concentrations of human urotensin II do not alter local or systemic hemodynamics in man. Cardiovascular Research, 53(2), 341-347.
Affolter JT, Newby DE, Wilkinson IB, Winter MJ, Balment RJ, Webb DJ (2002). No effect on central or peripheral blood pressure of systemic urotensin II infusion in humans. British Journal of Clinical Pharmacology, 54(6), 617-621.
Bond H, Winter MJ, Warne JM, McCrohan CR, Balment RJ (2002). Plasma concentrations of arginine vasotocin and urotensin II are reduced following transfer of the euryhaline flounder (Platichthys flesus) from seawater to fresh water. Gen Comp Endocrinol, 125, 113-120.
Winter MJ, Ashworth A, Bond H, Brierley MJ, McCrohan CR, Balment RJ (2000). The caudal neurosecretory system: control and function of a novel neuroendocrine system in fish. Biochemistry and Cell Biology, 78(3), 193-203.
Winter MJ, Hubbard PC, McCrohan CR, Balment RJ (1999). A homologous radioimmunoassay for the measurement of urotensin II in the euryhaline flounder, Platichthys flesus. General and comparative endocrinology, 114, 249-256.

Conferences

Corcoran J, Lange A, Tyler CR, Winter MJ (2010). Investigating drug-metabolising cytochrome P450 (cyp) isoforms in a fish hepatocyte model.  Author URL.

Publications by year


2017

Winter MJ, Windell D, Metz J, Matthews P, Pinion J, Brown JT, Hetheridge MJ, Ball JS, Owen SF, Redfern WS, et al (2017). 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain. Sci Rep, 7(1). Abstract.  Author URL.  Full text.

2016

Huerta B, Margiotta-Casaluci L, Rodríguez-Mozaz S, Scholze M, Winter MJ, Barceló D, Sumpter JP (2016). Anti-anxiety drugs and fish behavior: Establishing the link between internal concentrations of oxazepam and behavioral effects. Environmental Toxicology and Chemistry, 35(11), 2782-2790.

2015

Corcoran J, Winter MJ, Lange A, Cumming R, Owen SF, Tyler CR (2015). Effects of the lipid regulating drug clofibric acid on PPARα-regulated gene transcript levels in common carp (Cyprinus carpio) at pharmacological and environmental exposure levels. Aquat Toxicol, 161, 127-137. Abstract.  Author URL.

2014

Parker T, Libourel P-A, Hetheridge MJ, Cumming RI, Sutcliffe TP, Goonesinghe AC, Ball JS, Owen SF, Chomis Y, Winter MJ, et al (2014). A multi-endpoint in vivo larval zebrafish (Danio rerio) model for the assessment of integrated cardiovascular function. J Pharmacol Toxicol Methods, 69(1), 30-38. Abstract.  Author URL.
Corcoran J, Lange A, Cumming RI, Owen SF, Ball JS, Tyler CR, Winter MJ (2014). Bioavailability of the imidazole antifungal agent clotrimazole and its effects on key biotransformation genes in the common carp (Cyprinus carpio). Aquat Toxicol, 152, 57-65. Abstract.  Author URL.
Margiotta-Casaluci L, Owen SF, Cumming RI, de Polo A, Winter MJ, Panter GH, Rand-Weaver M, Sumpter JP (2014). Quantitative Cross-Species Extrapolation between Humans and Fish: the Case of the Anti-Depressant Fluoxetine. PLoS ONE, 9(10), e110467-e110467.

2013

Scholz S, Sela E, Blaha L, Braunbeck T, Galay-Burgos M, García-Franco M, Guinea J, Klüver N, Schirmer K, Tanneberger K, et al (2013). A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment. Regulatory Toxicology and Pharmacology, 67(3), 506-530.

2012

Corcoran J, Lange A, Winter MJ, Tyler CR (2012). Effects of Pharmaceuticals on the Expression of Genes Involved in Detoxification in a Carp Primary Hepatocyte Model. Environmental Science and Technology, 46(11), 6306-6314. Abstract.
Bartram AE, Winter MJ, Huggett DB, McCormack P, Constantine LA, Hetheridge MJ, Hutchinson TH, Kinter LB, Ericson JF, Sumpter JP, et al (2012). In vivo and in vitro liver and gill EROD activity in rainbow trout (Oncorhynchus mykiss) exposed to the beta-blocker propranolol. Environ Toxicol, 27(10), 573-582. Abstract.  Author URL.
David RM, Jones HS, Panter GH, Winter MJ, Hutchinson TH, Kevin Chipman J (2012). Interference with xenobiotic metabolic activity by the commonly used vehicle solvents dimethylsulfoxide and methanol in zebrafish (Danio rerio) larvae but not Daphnia magna. Chemosphere, 88(8), 912-917.
Buck LM, Winter MJ, Redfern WS, Whitfield TT (2012). Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish. Hearing Research, 284(1-2), 67-81.
Buck L, Winter M, Redfern W, Whitfield T (2012). Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish. Journal of Pharmacological and Toxicological Methods, 66(2), 163-163.

2011

David RM, Dakic V, Williams TD, Winter MJ, Chipman JK (2011). Transcriptional responses in neonate and adult Daphnia magna in relation to relative susceptibility to genotoxicants. Aquatic Toxicology, 104(3-4), 192-204.

2010

Corcoran J, Lange A, Tyler CR, Winter MJ (2010). Investigating drug-metabolising cytochrome P450 (cyp) isoforms in a fish hepatocyte model.  Author URL.
Corcoran J, Winter MJ, Tyler CR (2010). Pharmaceuticals in the aquatic environment: a critical review of the evidence for health effects in fish. Crit Rev Toxicol, 40(4), 287-304. Abstract.  Author URL.
Winter MJ, Owen SF, Murray-Smith R, Panter GH, Hetheridge MJ, Kinter LB (2010). Using data from drug discovery and development to aid the aquatic environmental risk assessment of human pharmaceuticals: concepts, considerations, and challenges. Integr Environ Assess Manag, 6(1), 38-51. Abstract.  Author URL.

2009

Easter A, Bell ME, Damewood JR, Redfern WS, Valentin J-P, Winter MJ, Fonck C, Bialecki RA (2009). Approaches to seizure risk assessment in preclinical drug discovery. Drug Discovery Today, 14(17-18), 876-884.
Hutchinson TH, Bögi C, Winter MJ, Owens JW (2009). Benefits of the maximum tolerated dose (MTD) and maximum tolerated concentration (MTC) concept in aquatic toxicology. Aquatic Toxicology, 91(3), 197-202.
Giltrow E, Eccles PD, Winter MJ, McCormack PJ, Rand-Weaver M, Hutchinson TH, Sumpter JP (2009). Chronic effects assessment and plasma concentrations of the β-blocker propranolol in fathead minnows (Pimephales promelas). Aquatic Toxicology, 95(3), 195-202.
Tyler CR, Filby AL, Bickley LK, Cumming RI, Gibson R, Labadie P, Katsu Y, Liney KE, Shears JA, Silva-Castro V, et al (2009). Environmental health impacts of equine estrogens derived from hormone replacement therapy. Environ Sci Technol, 43(10), 3897-3904. Abstract.  Author URL.
Bickley LK, Lange A, Winter MJ, Tyler CR (2009). Evaluation of a carp primary hepatocyte culture system for screening chemicals for oestrogenic activity. Aquat Toxicol, 94(3), 195-203. Abstract.  Author URL.
David RM, Winter MJ, Chipman JK (2009). INDUCTION OF DNA STRAND BREAKS BY GENOTOXICANTS IN THE ALGA CHLAMYDOMONAS REINHARDTII. Environmental Toxicology and Chemistry, 28(9), 1893-1893.

2008

Winter MJ, Lillicrap AD, Caunter JE, Schaffner C, Alder AC, Ramil M, Ternes TA, Giltrow E, Sumpter JP, Hutchinson TH, et al (2008). Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas). Aquatic Toxicology, 86(3), 361-369.
Winter MJ, Redfern WS, Hayfield AJ, Owen SF, Valentin J-P, Hutchinson TH (2008). Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs. Journal of Pharmacological and Toxicological Methods, 57(3), 176-187.
Richards F, Alderton W, Kimber G, Liu Z, Strang I, Redfern W, Valentin J-P, Winter M, Hutchinson T (2008). Validation of the use of zebrafish larvae in visual safety assessment. Journal of Pharmacological and Toxicological Methods, 58(1), 50-58.
Redfern WS, Waldron G, Winter MJ, Butler P, Holbrook M, Wallis R, Valentin J-P (2008). Zebrafish assays as early safety pharmacology screens: Paradigm shift or red herring?. Journal of Pharmacological and Toxicological Methods, 58(2), 110-117.

2007

OWEN S, GILTROW E, HUGGETT D, HUTCHINSON T, SAYE J, WINTER M, SUMPTER J (2007). Comparative physiology, pharmacology and toxicology of β-blockers: Mammals versus fish. Aquatic Toxicology, 82(3), 145-162.
McKenzie D, Garofalo E, Winter M, Ceradini S, Verweij F, Day N, Hayes R, van der Oost R, Butler P, Chipman J, et al (2007). Complex physiological traits as biomarkers of the sub-lethal toxicological effects of pollutant exposure in fishes. Philosophical Transactions of the Royal Society B: Biological Sciences, 362(1487), 2043-2059.
Bickley L, Lange A, Tyler C, Winter M (2007). Fish hepatocyte cultures as an alternative to in vivo tests for screening oestrogen receptor active chemicals. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 146(4), S72-S72. Author URL.
Winter MJ, Ellis LC, Hutchinson TH (2007). Formation of micronuclei in erythrocytes of the fathead minnow (Pimephales promelas) after acute treatment with mitomycin C or cyclophosphamide. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 629(2), 89-99.

2006

Hutchinson T, Shillabeer N, Winter M, Pickford D (2006). Acute and chronic effects of carrier solvents in aquatic organisms: a critical review. Aquatic Toxicology, 76(1), 69-92.
Aniagu SO, Day N, Chipman JK, Taylor EW, Butler PJ, Winter MJ (2006). Does exhaustive exercise result in oxidative stress and associated DNA damage in the chub (Leuciscus cephalus)?. Environmental and Molecular Mutagenesis, 47(8), 616-623.

2005

Winter MJ, Verweij F, Garofalo E, Ceradini S, McKenzie DJ, Williams MA, Taylor EW, Butler PJ, van der Oost R, Kevin Chipman J, et al (2005). Tissue levels and biomarkers of organic contaminants in feral and caged chub (Leuciscus cephalus) from rivers in the West Midlands, UK. Aquatic Toxicology, 73(4), 394-405.

2004

Hayes RA, Regondi S, Winter MJ, Butler PJ, Agradi E, Taylor EW, Kevin Chipman J (2004). Cloning of a chub metallothionein cDNA and development of competitive RT-PCR of chub metallothionein mRNA as a potential biomarker of heavy metal exposure. Marine Environmental Research, 58(2-5), 665-669.
Winter MJ, Day N, Hayes RA, Taylor EW, Butler PJ, Chipman J (2004). DNA strand breaks and adducts determined in feral and caged chub (Leuciscus cephalus) exposed to rivers exhibiting variable water quality around Birmingham, UK. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 552(1-2), 163-175.

2003

Kirk CJ, Bottomley L, Minican N, Carpenter H, Shaw S, Kohli N, Winter M, Taylor EW, Waring RH, Michelangeli F, et al (2003). Environmental endocrine disrupters dysregulate estrogen metabolism and Ca2+ homeostasis in fish and mammals via receptor-independent mechanisms. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 135(1), 1-8.

2002

Wilkinson I (2002). High plasma concentrations of human urotensin II do not alter local or systemic hemodynamics in man. Cardiovascular Research, 53(2), 341-347.
Affolter JT, Newby DE, Wilkinson IB, Winter MJ, Balment RJ, Webb DJ (2002). No effect on central or peripheral blood pressure of systemic urotensin II infusion in humans. British Journal of Clinical Pharmacology, 54(6), 617-621.
Bond H, Winter MJ, Warne JM, McCrohan CR, Balment RJ (2002). Plasma concentrations of arginine vasotocin and urotensin II are reduced following transfer of the euryhaline flounder (Platichthys flesus) from seawater to fresh water. Gen Comp Endocrinol, 125, 113-120.

2000

Winter MJ, Ashworth A, Bond H, Brierley MJ, McCrohan CR, Balment RJ (2000). The caudal neurosecretory system: control and function of a novel neuroendocrine system in fish. Biochemistry and Cell Biology, 78(3), 193-203.

1999

Winter MJ, Hubbard PC, McCrohan CR, Balment RJ (1999). A homologous radioimmunoassay for the measurement of urotensin II in the euryhaline flounder, Platichthys flesus. General and comparative endocrinology, 114, 249-256.

Matthew_Winter Details from cache as at 2018-08-17 12:13:59

Refresh publications

Postgraduate researchers

  • Sophie Gould PhD (Merck-collaboration) ~ Integrated health effects analysis of antidepressants inhibiting serotonin and/or norepinephrine reuptake using zebrafish models.
  • Charles Hamilton PhD (BBSRC-CASE with Astrazeneca) ~ Advancing mechanistic understanding of glucocorticoid effects in fish.
  • Joseph Pinion MRes ~ The effect of chemoconvulsant drug exposure on neural network activity in the larval zebrafish

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