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Professor Michael Schrader

Professor Michael Schrader

Professor of Cell Biology & Cytopathology

 5850

 Geoffrey Pope 224

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Michael Schrader in the lab

Michael Schrader in the lab

Overview

I am a molecular cell biologist interested in the biogenesis and dynamics of cellular compartments (organelles) in mammalian cells. My research focuses on the molecular machinery and signalling pathways, which mediate and regulate the formation, dynamics, abundance and cooperation of peroxisomes. Our goal is to understand the relation of organelle dynamics to organelle functionality and its impact on developmental and physiological processes. My teaching includes molecular cell biology and biomedical aspects. I am a member of the Cell Biology research group.

Qualifications

1996 PhD Cell Biology, University of Heidelberg, Germany
1991 Diploma in Biology, University of Bielefeld, Germany

Career

2017-present Professor of Cell Biology & Cytopathology, Biosciences, University of Exeter, UK
2012-2017 Associate Professor of Cell Biology, Biosciences, University of Exeter, UK

2007-2011 Head of research group at the Centre for Cell Biology & Dept. of Biology, University of Aveiro, Portugal
2002 Habilitation, Venia Legendi in Cell Biology, University of Marburg, Germany
2001-2006 Hochschulassistent (=Assistant Professor), Privatdozent (PD) and Group leader at the Dept. of Cell Biology and Cell Pathology, University of Marburg, Germany
1999-2000 Postdoctoral Research Fellow with H. F. Kern, University of Marburg, Germany
1997-1998 Postdoctoral Research Fellow with T. A. Schroer, Johns Hopkins University, Baltimore, MD, USA
1992-1996 PhD in Cell Biology (Laboratory of H. D. Fahimi), University of Heidelberg, Germany
1986-1991 Diploma in Biology, University of Bielefeld, Germany

Links

Research group links

Peroxisomes (green) in immunofluorescence

Peroxisomes (green) in immunofluorescence

Ultrastructure of peroxisomes (black) (DAB cytochemistry)

Ultrastructure of peroxisomes (black) (DAB cytochemistry)

Peroxisome (red, green) interactions and dynamics

Peroxisome (red, green) interactions and dynamics

PerFuMe

Peroxisomes: Key to Cell Performance and Health. www.itn-perfume.eu

PerICo

Peroxisome Interaction and Communication www.itn-perico.eu

Research

Research interests

During my research career my interests have been focused on the molecular mechanisms associated with organelle dynamics and biogenesis in mammalian cells and their relation to inter-organellar communication and cell physiology.

Our model organelle, among others, is the peroxisome. Peroxisomes contribute to several disease-relevant metabolic pathways in mammals (e.g., hydrogen peroxide metabolism, generation and scavenging of reactive oxygen species, break-down of fatty acids by beta-oxidation, and synthesis of ether phospholipids, which are important constituents of myelin sheaths) and have been associated with developmental processes, oxidative stress, ageing and neurodegeneration. In mammalian cells peroxisomes can easily be visualized by peroxisome-targeted fluorescent fusion proteins. Peroxisomes can be enriched and isolated from soft tissues and cells, and are biochemically accessible. Their high plasticity, the pharmacological (environmental) stimulation of their proliferation, and the defined morphological alterations during proliferation make them ideal model organelles with an interesting biology (for overview see Islinger, M., Grille, S., Fahimi, H. D., and M. Schrader: The peroxisome - an update on mysteries. Histochem Cell Biol. 137, 547–574, 2012).

The investigation of peroxisome morphology and dynamics has become an exciting new field in cell biology and biomedical sciences because of its relation to organelle functionality and its impact on developmental and physiological processes.

Research projects

Current research addresses the following fundamental biological questions by combining cell and molecular biology, biochemistry, microscopy, bioinformatics, modelling and cell physiology:

1. How do peroxisomes form, multiply and distribute, and how does this contribute to cell physiology and disease?

Unraveling the peroxisomal growth and division machinery: We have identified the first components of the peroxisomal division machinery in mammalian cells and presented evidence that peroxisomal growth and division is a multistep process involving peroxisome membrane deformation, elongation, constriction and final division. The functional characterization, interplay and regulation of the molecular components represent a major challenge. New disorders based on defects in the molecular machinery have been discovered.

2. How is the proliferation of peroxisomes regulated?

Regulation of peroxisome dynamics and abundance: There is particular interest in understanding how peroxisome dynamics and proliferation are regulated and how these processes might contribute to pathological conditions.

3. How do peroxisomes and other subcellular organelles co-operate to maintain cellular functions?

The peroxisome-mitochondria connection: We provided first evidence that peroxisomes and mitochondria share components of their division machinery indicating that both organelles exhibit a much closer interrelationship than previously appreciated. Thus, peroxisomal alterations in metabolism, biogenesis, dynamics and proliferation can potentially influence mitochondrial functions, and vice versa. This is of cell biological and clinical importance.

The peroxisome-ER connection: We discovered the first molecular mechanism for establishing peroxisome-ER (endoplasmic reticulum) interactions in mammalian cells and reported a new function for the acyl-CoA binding proteins ACBD5 and ACBD4 in peroxisome-ER tethering. Peroxisome-ER associations impact on a diverse number of physiological processes, including lipid metabolism, phospholipid exchange, metabolite transport, peroxisome biogenesis, positioning and movement.

4. Furthermore, we are interested in the biogenesis of zymogen granules. These are sorting and secretion organelles of acinar cells in the exocrine pancreas, which contain our digestive enzymes. Their malfunction can result in pancreatitis.

Grants/Funding (last 5 years)

Participation in EU-funded Marie Curie Initial Training Network PERICO 2018-2022, “Peroxisome Interaction and Communicationwww.itn-perico.eu

Participation in EU-funded Marie Curie Initial Training Network PERFUME 2013-2016, “Peroxisomes: Key to Cell Performance and Healthwww.itn-perfume.eu

DFG, J. Manchot Foundation, FCT, CRUP-DAAD, CRUP-Treaty of Windsor, BBSRC

Research grants

  • 2018 BBSRC Project Grant
    Biological Sciences
  • 2018 EU Marie Curie Training Grant
    PERICO
  • 2017 BBSRC ALERT 17
    Equipment Grant
  • 2016 BBSRC
    Biological Sciences
  • 2015 Wellcome Trust
    ISSF2
  • 2012 BBSRC
    Biological Sciences
  • 2012 EU Marie Curie Training Grant
    PERFUME
  • 2012 Wellcome Trust
    ISSF

Links


Publications

Key publications | Publications by category | Publications by year

Key publications


Ferdinandusse, S SF, Falkenberg, K KF, Koster, J JK, Mooyer PM, Jones, R RJ, van Roermund, C C, Pizzino, a AP, Schrader M, Wanders, R RW, Vanderver, a AV, et al (In Press). ACBD5 deficiency causes a defect in peroxisomal very long-chain fatty acid metabolism. J Med Genet Full text.
Costello J, Castro I, Camoes F, Schrader TA, McNeall D, Yang J, Giannopoulou EA, Gomes S, Pogenberg V, Bonekamp N, et al (In Press). Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells. Journal of Cell Science Full text.
Schrader M, Costello J, Godinho L, Azadi A, Islinger M (In Press). Proliferation and fission of peroxisomes - an update.  Full text.
Islinger M, Voelkl A, Fahimi HD, Schrader M (In Press). The peroxisome: an update on mysteries 2.0. Histochemistry and Cell Biology Full text.
Costello J, Schrader M (In Press). Unloosing the Gordian knot of peroxisome formation. Current Opinion in Cell Biology Full text.
Castro I, Richards DM, Metz J, Costello JL, Passmore JB, Schrader TA, Gouveia A, Ribeiro D, Schrader M (2018). A role for MIRO1 in motility and membrane dynamics of peroxisomes. Traffic Full text.

Publications by category


Books

Schrader M (eds)(2018). Proteomics of Peroxisomes - Identifying Novel Functions and Regulatory Networks 978-981-13-2232-7. Dordrecht, Springer Science + Business Media.
Schrader M, Islinger M (eds)(2017). MOLECULAR MECHANISMS AND PHYSIOLOGICAL SIGNIFICANCE OF ORGANELLE INTERACTIONS AND COOPERATION., Lausanne: Frontiers Media. Full text.

Journal articles

Costello JL, Castro, I, Hacker C, Schrader T, Metz J, Zeuschner D, Azadi A, Godinho L, Costina V, Findeisen P, et al (In Press). ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. Journal of Cell Biology Full text.
Ferdinandusse, S SF, Falkenberg, K KF, Koster, J JK, Mooyer PM, Jones, R RJ, van Roermund, C C, Pizzino, a AP, Schrader M, Wanders, R RW, Vanderver, a AV, et al (In Press). ACBD5 deficiency causes a defect in peroxisomal very long-chain fatty acid metabolism. J Med Genet Full text.
Lin C, Schuster M, Guimaraes SC, Ashwin P, Schrader M, Metz J, Hacker C, Gurr SJ, Steinberg G (In Press). Active diffusion and microtubule-based transport oppose myosin forces to position organelles in cells. Nat Commun, 7 Abstract.  Author URL.  Full text.
Barel O, Malicdan MC, Ben-Zeev B, Kandel J, Pri-Chen H, Stephen J, Castro I, Metz J, Atawa O, Moshkovitz S, et al (In Press). Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathy. Brain Full text.
Schrader TA, Islinger M, Schrader M (In Press). Detection and immunolabelling of peroxisomal proteins. Methods in Molecular Biology Full text.
Godinho L, Schrader M (In Press). Determination of Peroxisomal pH in Living Mammalian Cells Using pHRed. Methods in Molecular Biology Full text.
Castro I, Schrader M (In Press). Miro1 – the Missing Link to Peroxisome Motility. Communicative and Integrative Biology Full text.
Costello J, Castro I, Schrader TA, Islinger M, Schrader M (In Press). Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations. Cell Cycle Full text.
Magalhães, AC, Ferreira, AR, Gomes, S, Vieira, M, Gouveia, A, Valença, I, Islinger, M, Nascimento, R, Schrader M, Kagan, JC, et al (In Press). Peroxisomes are platforms for cytomegalovirus’ evasion from the cellular immune response. Scientific Reports Full text.
Costello J, Castro I, Camoes F, Schrader TA, McNeall D, Yang J, Giannopoulou EA, Gomes S, Pogenberg V, Bonekamp N, et al (In Press). Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells. Journal of Cell Science Full text.
Schrader M, Costello J, Godinho L, Azadi A, Islinger M (In Press). Proliferation and fission of peroxisomes - an update.  Full text.
Aroso M, Agricola B, Hacker C, Schrader M (In Press). Proteoglycans support proper granule formation in pancreatic acinar cells.  Full text.
Schrader M, Godinho L, Costello J, Islinger M (In Press). The different facets of organelle interplay - an overview of organelle interactions.  Full text.
Schrader M, Pellegrini L (In Press). The making of a mammalian peroxisome, version 2.0:. Cell Death and Differentiation Full text.
Islinger M, Voelkl A, Fahimi HD, Schrader M (In Press). The peroxisome: an update on mysteries 2.0. Histochemistry and Cell Biology Full text.
Passmore JB, Pinho S, Gomez-Lazaro M, Schrader M (In Press). The respiratory chain inhibitor rotenone affects peroxisomal dynamics via its microtubule-destabilizing activity. Histochemistry and Cell Biology Full text.
Costello J, Schrader M (In Press). Unloosing the Gordian knot of peroxisome formation. Current Opinion in Cell Biology Full text.
Schrader TA, Schrader M (In Press). siRNA-mediated Silencing of Peroxisomal Genes in Mammalian Cells. Methods in Molecular Biology Full text.
Castro I, Richards DM, Metz J, Costello JL, Passmore JB, Schrader TA, Gouveia A, Ribeiro D, Schrader M (2018). A role for MIRO1 in motility and membrane dynamics of peroxisomes. Traffic Full text.
Barel O, Malicdan MCV, Ben-Zeev B, Kandel J, Pri-Chen H, Stephen J, Castro IG, Metz J, Atawa O, Moshkovitz S, et al (2018). Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathy (vol 140, pg 568, 2017). BRAIN, 141 Author URL.  Full text.
Costello JL, Castro IG, Hacker C, Schrader TA, Metz J, Zeuschner D, Azadi AS, Godinho LF, Costina V, Findeisen P, et al (2017). ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. JOURNAL OF CELL BIOLOGY, 216(2), 331-342. Author URL.  Full text.
Metz J, Castro I, Schrader M (2017). Peroxisome Motility Measurement and Quantification Assay. Bio-protocol, 7, issue 17 Full text.
Aroso M, Agricola B, Hacker C, Schrader M (2016). Addendum to the paper: Proteoglycans support proper granule formation in pancreatic AR42J cells. Histochem Cell Biol, 146(1). Author URL.  Full text.
Schrader M, Islinger M (2016). Editorial: Molecular Mechanisms and Physiological Significance of Organelle Interactions and Cooperation. Front Cell Dev Biol, 4 Author URL.  Full text.
Silva AM, Varela-Moreira A, Pereira Gomes C, Molinos M, Leite M, Almeida M, Ribeiro D, Schrader M, Figueiredo C, Barbosa M, et al (2015). Integrated Analysis of Biological Samples by Imaging Flow Cytometry. Microsc Microanal, 21 Suppl 5, 95-96. Author URL.
Camões F, Islinger M, Guimarães SC, Kilaru S, Schuster M, Godinho LF, Steinberg G, Schrader M (2015). New insights into the peroxisomal protein inventory: Acyl-CoA oxidases and -dehydrogenases are an ancient feature of peroxisomes. Biochim Biophys Acta, 1853(1), 111-125. Abstract.  Author URL.  Full text.
Schrader M, Costello J, Godinho LF, Islinger M (2015). Peroxisome-mitochondria interplay and disease. Journal of Inherited Metabolic Disease, 38(4), 681-702. Abstract.
Schrader M, Costello J, Godinho LF, Islinger M (2015). Peroxisome-mitochondria interplay and disease. J Inherit Metab Dis, 38(4), 681-702. Abstract.  Author URL.  Full text.
Guimaraes SC, Schuster M, Bielska E, Dagdas G, Kilaru S, Meadows BRA, Schrader M, Steinberg G (2015). Peroxisomes, lipid droplets, and endoplasmic reticulum "hitchhike" on motile early endosomes. J Cell Biol, 211(5), 945-954. Abstract.  Author URL.  Full text.
Aroso M, Agricola B, Hacker C, Schrader M (2015). Proteoglycans support proper granule formation in pancreatic acinar cells. Histochemistry and Cell Biology, 144(4), 331-346. Abstract.
Williams C, Opalinski L, Landgraf C, Costello J, Schrader M, Krikken AM, Knoops K, Kram AM, Volkmer R, van der Klei IJ, et al (2015). The membrane remodeling protein Pex11p activates the GTPase Dnm1p during peroxisomal fission. Proc Natl Acad Sci U S A, 112(20), 6377-6382. Abstract.  Author URL.  Full text.
Huber N, Guimaraes S, Schrader M, Suter U, Niemann A (2013). Charcot-Marie-Tooth disease-associated mutants of GDAP1 dissociate its roles in peroxisomal and mitochondrial fission. EMBO Reports, 14(6), 545-552. Abstract.  Full text.
Bonekamp NA, Islinger M, Lázaro MG, Schrader M (2013). Cytochemical detection of peroxisomes and mitochondria. Methods Mol Biol, 931, 467-482. Abstract.  Author URL.
Castro I, Gouveia A, Ribeiro D, Schrader M (2013). Miro1 regulates microtubule-dependent motility of peroxisomes in mammalian cells. MOLECULAR BIOLOGY OF THE CELL, 24 Author URL.
Schrader M, Grille S, Fahimi HD, Islinger M (2013). Peroxisome interactions and cross-talk with other subcellular compartments in animal cells. Subcell Biochem, 69, 1-22. Abstract.  Author URL.
Bonekamp NA, Grille S, Cardoso MJ, Almeida M, Aroso M, Gomes S, Magalhaes AC, Ribeiro D, Islinger M, Schrader M, et al (2013). Self-interaction of human Pex11pβ during peroxisomal growth and division. PLoS One, 8(1). Abstract.  Author URL.  Full text.
Islinger M, Gomes S, Bonekamp N, Magalhaes AC, Camoes F, Castro I, Almeida M, Schrader M (2013). Targeting of tail-anchored proteins to peroxisomes requires Pex19 and a highly positively charged tail. MOLECULAR BIOLOGY OF THE CELL, 24 Author URL.
Bonekamp NA, Islinger M, Lázaro MG, Schrader M (2012). Cytochemical detection of peroxisomes and mitochondria. Methods in Molecular Biology, 931, 467-482. Abstract.
Schrader M, Bonekamp NA, Islinger M (2012). Fission and proliferation of peroxisomes. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1822(9), 1343-1357. Abstract.
Rinn C, Aroso M, Prüssing J, Islinger M, Schrader M (2012). Modulating zymogen granule formation in pancreatic AR42J cells. Exp Cell Res, 318(15), 1855-1866. Abstract.  Author URL.
Ribeiro D, Castro I, Dariush Fahimi H, Schrader M (2012). Peroxisome morphology in pathology. Histology and Histopathology, 27(6), 661-676. Abstract.
Schrader M, Almeida M, Grille S (2012). Postfixation detergent treatment liberates the membrane modelling protein Pex11β from peroxisomal membranes. Histochem Cell Biol, 138(3), 541-547. Abstract.  Author URL.
Islinger M, Grille S, Fahimi HD, Schrader M (2012). The peroxisome: an update on mysteries. Histochem Cell Biol, 137(5), 547-574. Abstract.  Author URL.
Bonekamp NA, Sampaio P, de Abreu FV, Lüers GH, Schrader M (2012). Transient Complex Interactions of Mammalian Peroxisomes Without Exchange of Matrix or Membrane Marker Proteins. Traffic, 13(7), 960-978. Abstract.
Bonekamp NA, Sampaio P, de Abreu FV, Lüers GH, Schrader M (2012). Transient complex interactions of mammalian peroxisomes without exchange of matrix or membrane marker proteins. Traffic, 13(7), 960-978. Abstract.  Author URL.
Bonekamp NA, Schrader M (2012). Transient complex peroxisomal interactions: a new facet of peroxisome dynamics in mammalian cells. Communicative and Integrative Biology, 5(6), 534-537. Abstract.  Full text.
Islinger M, Schrader M (2011). Peroxisomes. Curr Biol, 21(19), R800-R801. Author URL.
Delille HK, Dodt G, Schrader M (2011). Pex11pβ-mediated maturation of peroxisomes. Commun Integr Biol, 4(1), 51-54. Abstract.  Author URL.
Borta H, Aroso M, Rinn C, Gomez-Lazaro M, Vitorino R, Zeuschner D, Grabenbauer M, Amado F, Schrader M (2010). Analysis of low abundance membrane-associated proteins from rat pancreatic zymogen granules. J Proteome Res, 9(10), 4927-4939. Abstract.  Author URL.
Islinger M, Cardoso MJR, Schrader M (2010). Be different--the diversity of peroxisomes in the animal kingdom. Biochim Biophys Acta, 1803(8), 881-897. Abstract.  Author URL.
Bonekamp NA, Vormund K, Jacob R, Schrader M (2010). Dynamin-like protein 1 at the Golgi complex: a novel component of the sorting/targeting machinery en route to the plasma membrane. Exp Cell Res, 316(20), 3454-3467. Abstract.  Author URL.
Delille HK, Agricola B, Guimaraes SC, Borta H, Lüers GH, Fransen M, Schrader M (2010). Pex11pbeta-mediated growth and division of mammalian peroxisomes follows a maturation pathway. J Cell Sci, 123(Pt 16), 2750-2762. Abstract.  Author URL.
Gómez-Lázaro M, Rinn C, Aroso M, Amado F, Schrader M (2010). Proteomic analysis of zymogen granules. Expert Rev Proteomics, 7(5), 735-747. Abstract.  Author URL.
Fardilha M, Schrader M, da Cruz E Silva OAB, da Cruz E Silva EF (2010). Understanding fatty acid metabolism through an active learning approach. Biochem Mol Biol Educ, 38(2), 65-69. Abstract.  Author URL.
Schrader M (2009). Anniversaries, peroxisomes and reactive oxygen species. Histochemistry and Cell Biology, 131(4), 435-436.
Delille HK, Alves R, Schrader M (2009). Biogenesis of peroxisomes and mitochondria: linked by division. Histochem Cell Biol, 131(4), 441-446. Abstract.  Author URL.
Delille HK, Schrader M (2009). Hypertubulation of peroxisomes by multiple stimuli. EUROPEAN JOURNAL OF CELL BIOLOGY, 88, 68-68. Author URL.
Camões F, Bonekamp NA, Delille HK, Schrader M (2009). Organelle dynamics and dysfunction: a closer link between peroxisomes and mitochondria. J Inherit Metab Dis, 32(2), 163-180. Abstract.  Author URL.
Bonekamp NA, Völkl A, Fahimi HD, Schrader M (2009). Reactive oxygen species and peroxisomes: struggling for balance. Biofactors, 35(4), 346-355. Abstract.  Author URL.
Gomez-Lazaro M, Bonekamp NA, Galindo MF, Jordán J, Schrader M (2008). 6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells. Free Radical Biology and Medicine, 44(11), 1960-1969. Abstract.
Faust F, Gomez-Lazaro M, Borta H, Agricola B, Schrader M (2008). Rab8 is involved in zymogen granule formation in pancreatic acinar AR42J cells. Traffic, 9(6), 964-979. Abstract.  Author URL.
Delille HK, Schrader M (2008). Targeting of hFis1 to peroxisomes is mediated by Pex19p. J Biol Chem, 283(45), 31107-31115. Abstract.  Author URL.
Schrader M, Fahimi HD (2008). The peroxisome: still a mysterious organelle. Histochem Cell Biol, 129(4), 421-440. Abstract.  Author URL.  Full text.
Schrader M, Yoon Y (2007). Mitochondria and peroxisomes: are the 'big brother' and the 'little sister' closer than assumed?. Bioessays, 29(11), 1105-1114. Abstract.  Author URL.
Schrader M, Fahimi HD (2006). Growth and division of peroxisomes. Int Rev Cytol, 255, 237-290. Abstract.  Author URL.
Delille HK, Bonekamp NA, Schrader M (2006). Peroxisomes and disease - an overview. Int J Biomed Sci, 2(4), 308-314. Abstract.  Author URL.  Full text.
Schrader M, Fahimi HD (2006). Peroxisomes and oxidative stress. Biochim Biophys Acta, 1763(12), 1755-1766. Abstract.  Author URL.
Schrader M (2006). Shared components of mitochondrial and peroxisomal division. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1763(5-6), 531-541. Author URL.
Schrader M (2006). Shared components of mitochondrial and peroxisomal division. Biochim Biophys Acta, 1763(5-6), 531-541. Abstract.  Author URL.
Bach J-P, Borta H, Ackermann W, Faust F, Borchers O, Schrader M (2006). The secretory granule protein syncollin localizes to HL-60 cells and neutrophils. J Histochem Cytochem, 54(8), 877-888. Abstract.  Author URL.
Koch A, Yoon Y, Bonekamp NA, McNiven MA, Schrader M (2005). A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell, 16(11), 5077-5086. Abstract.  Author URL.
Schrader M, Gould SJ (2005). Assay and functional analysis of dynamin-like protein 1 in peroxisome division. Methods Enzymol, 404, 586-597. Abstract.  Author URL.
Boll A, Schrader M (2005). Elongation of peroxisomes as an indicator for efficient dynamin-like protein 1 knock down in mammalian cells. J Histochem Cytochem, 53(8), 1037-1040. Abstract.  Author URL.
Schrader M, Fahimi HD (2004). Mammalian peroxisomes and reactive oxygen species. Histochem Cell Biol, 122(4), 383-393. Abstract.  Author URL.
Schrader M (2004). Membrane targeting in secretion. Subcell Biochem, 37, 391-421. Abstract.  Author URL.
Koch A, Schneider G, Lüers GH, Schrader M (2004). Peroxisome elongation and constriction but not fission can occur independently of dynamin-like protein 1. J Cell Sci, 117(Pt 17), 3995-4006. Abstract.  Author URL.
Kovacs WJ, Schrader M, Walter I, Stangl H (2004). The hypolipidemic compound cetaben induces changes in Golgi morphology and vesicle movement. Histochemistry and Cell Biology, 122(2), 95-109. Abstract.
Koch A, Thiemann M, Grabenbauer M, Yoon Y, McNiven MA, Schrader M (2003). Dynamin-like protein 1 is involved in peroxisomal fission. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(10), 8597-8605. Author URL.
Schrader M, Thiemann M, Fahimi HD (2003). Peroxisomal motility and interaction with microtubules. Microsc Res Tech, 61(2), 171-178. Abstract.  Author URL.
Kalus I, Hodel A, Koch A, Kleene R, Edwardson JM, Schrader M (2002). Interaction of syncollin with GP-2, the major membrane protein of pancreatic zymogen granules, and association with lipid microdomains. Biochem J, 362(Pt 2), 433-442. Abstract.  Author URL.
Hodel A, an SJ, Hansen NJ, Lawrence J, Wäsle B, Schrader M, Edwardson JM (2001). Cholesterol-dependent interaction of syncollin with the membrane of the pancreatic zymogen granule. Biochem J, 356(Pt 3), 843-850. Abstract.  Author URL.
Schmidt K, Schrader M, Kern HF, Kleene R (2001). Regulated apical secretion of zymogens in rat pancreas. Involvement of the glycosylphosphatidylinositol-anchored glycoprotein GP-2, the lectin ZG16p, and cholesterol-glycosphingolipid-enriched microdomains. J Biol Chem, 276(17), 14315-14323. Abstract.  Author URL.
Schrader M (2001). Tubulo-reticular clusters of peroxisomes in living COS-7 cells: dynamic behavior and association with lipid droplets. J Histochem Cytochem, 49(11), 1421-1429. Abstract.  Author URL.
Schrader M, King SJ, Stroh TA, Schroer TA (2000). Evidence for peroxisomal reticuli in COS-7 cells: Association with lipid droplets. MOLECULAR BIOLOGY OF THE CELL, 11, 425A-425A. Author URL.
Hillebrand M, Schmidt K, Kern HF, Kleene R, Schrader M (2000). Inhibitors of glycosylation, GPI-anchor- and cholesterol biosynthesis interfere with granule formation and regulated secretion in the acinar cells of the exocrine rat pancreas. MOLECULAR BIOLOGY OF THE CELL, 11, 499A-499A. Author URL.
Thiemann M, Schrader M, Völkl A, Baumgart E, Fahimi HD (2000). Interaction of peroxisomes with microtubules. In vitro studies using a novel peroxisome-microtubule binding assay. Eur J Biochem, 267(20), 6264-6275. Abstract.  Author URL.
Schrader M, King SJ, Stroh TA, Schroer TA (2000). Real time imaging reveals a peroxisomal reticulum in living cells. J Cell Sci, 113 ( Pt 20), 3663-3671. Abstract.  Author URL.
Kleene R, Classen B, Zdzieblo J, Schrader M (2000). SH3 binding sites of ZG29p mediate an interaction with amylase and are involved in condensation-sorting in the exocrine rat pancreas. Biochemistry, 39(32), 9893-9900. Abstract.  Author URL.
Schrader M, Wodopia R, Fahimi HD (1999). Induction of tubular peroxisomes by UV irradiation and reactive oxygen species in HepG2 cells. J Histochem Cytochem, 47(9), 1141-1148. Abstract.  Author URL.
Valetti C, Wetzel DM, Schrader M, Hasbani MJ, Gill SR, Kreis TE, Schroer TA (1999). Role of dynactin in endocytic traffic: Effects of dynamitin overexpression and colocalization with CLIP-170. Molecular Biology of the Cell, 10(12), 4107-4120. Abstract.
Schrader M, Krieglstein K, Fahimi HD (1998). Tubular peroxisomes in HepG2 cells: selective induction by growth factors and arachidonic acid. Eur J Cell Biol, 75(2), 87-96. Abstract.  Author URL.
Kinscherf R, Kamencic H, Deigner HP, Pill J, Schmiedt W, Schrader M, Metz J (1997). Effect of alterations of blood cholesterol levels on macrophages in the myocardium of New Zealand White rabbits. J Leukoc Biol, 62(6), 719-725. Abstract.  Author URL.
Kinscherf R, Deigner HP, Usinger C, Pill J, Wagner M, Kamencic H, Hou D, Chen M, Schmiedt W, Schrader M, et al (1997). Induction of mitochondrial manganese superoxide dismutase in macrophages by oxidized LDL: its relevance in atherosclerosis of humans and heritable hyperlipidemic rabbits. FASEB J, 11(14), 1317-1328. Abstract.  Author URL.
Schrader M, Burkhardt JK, Baumgart E, Lüers G, Spring H, Völkl A, Fahimi HD (1996). Interaction of microtubules with peroxisomes. Tubular and spherical peroxisomes in HepG2 cells and their alterations induced by microtubule-active drugs. Eur J Cell Biol, 69(1), 24-35. Abstract.  Author URL.
Schrader M, Burkhardt JK, Baumgart E, Lüers G, Völkl A, Fahimi HD (1996). The importance of microtubules in determination of shape and intracellular distribution of peroxisomes. Ann N Y Acad Sci, 804, 669-671. Author URL.
Schrader M, Fahimi HD (1996). Tubular peroxisomes in HepG2 cells. The role of nutritional factors in their formation. MOLECULAR BIOLOGY OF THE CELL, 7, 2879-2879. Author URL.
Schrader M, Baumgart E, Fahimi HD (1995). Effects of fixation on the preservation of peroxisomal structures for immunofluorescence studies using HepG2 cells as a model system. Histochem J, 27(8), 615-619. Abstract.  Author URL.
Schrader M, Temm-Grove CJ, Lessard JL, Jockusch BM (1994). Chicken antibodies to rabbit muscle actin with a restricted repertoire of F-actin recognition. Eur J Cell Biol, 63(2), 326-335. Abstract.  Author URL.
Schrader M, Baumgart E, Völkl A, Fahimi HD (1994). Heterogeneity of peroxisomes in human hepatoblastoma cell line HepG2. Evidence of distinct subpopulations. Eur J Cell Biol, 64(2), 281-294. Abstract.  Author URL.

Chapters

Guimarães S, Kilaru S, Schrader M, Schuster M (In Press). Labeling of Peroxisomes for Live Cell Imaging in the Filamentous Fungus Ustilago maydis. In  (Ed) , Humana Press (Springer Imprint). Full text.
Costello J, Passmore J, Islinger M, Schrader M (2018). Multi-localized proteins: the peroxisome-mitochondria connection. In del Rio L, Schrader M (Eds.) Proteomics of Peroxisomes. Identifying Novel Functions and Regulatory Networks, Springer. Full text.
Schrader M, Castro I, Fahimi HD, Islinger M (2014). Peroxisome morphology in pathologies. In  (Ed) Molecular Machines Involved in Peroxisome Biogenesis and Maintenance, 125-151.  Abstract.

Conferences

Magalhaes AC, Gomes S, Ferreira AR, Oes FC, Nascimento R, Schrader M, Ribeiro D (2014). A role for peroxisomes on the cellular antiviral response to Cytomegalovirus infection.  Author URL.
Gouveia AMS, Gomes S, Guimaraes S, Lazaro MG, Sampaio P, Schrader M, Ribeiro D (2014). Functional specificity of the tail-anchored proteins Mff and Fis1 on peroxisomal and mitochondrial dynamics.  Author URL.
Camoes F, Islinger M, Costello J, Gomes S, Bonekamp N, Almeida M, Castro I, Ribeiro D, Schrader M (2014). Targeting of tail-anchored proteins to peroxisomes and mitochondria in mammalian cells.  Author URL.
Vormund K, Bonekamp NA, Jacob R, Schrader M (2008). A novel function of dynamin-like protein 1 at the Golgi complex.  Author URL.
Faust F, Borta H, Schrader M (2006). The small GTPase Rab8 is involved in zymogen granule formation in acinar cells of the exocrine pancreas.  Author URL.
Schmidt K, Agricola B, Kleene R, Schrader M (2002). Submembranous proteoglycans are required for granule formation and regulated secretion in the acinar cells of the exocrine pancreas.  Author URL.
Fahimi HD, Grabenbauer M, Schrader M, Stier H, Baumgart E (1998). Biogenesis and maturation of peroxisomes in mammalian cells.  Author URL.

Publications by year


In Press

Costello JL, Castro, I, Hacker C, Schrader T, Metz J, Zeuschner D, Azadi A, Godinho L, Costina V, Findeisen P, et al (In Press). ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. Journal of Cell Biology Full text.
Ferdinandusse, S SF, Falkenberg, K KF, Koster, J JK, Mooyer PM, Jones, R RJ, van Roermund, C C, Pizzino, a AP, Schrader M, Wanders, R RW, Vanderver, a AV, et al (In Press). ACBD5 deficiency causes a defect in peroxisomal very long-chain fatty acid metabolism. J Med Genet Full text.
Lin C, Schuster M, Guimaraes SC, Ashwin P, Schrader M, Metz J, Hacker C, Gurr SJ, Steinberg G (In Press). Active diffusion and microtubule-based transport oppose myosin forces to position organelles in cells. Nat Commun, 7 Abstract.  Author URL.  Full text.
Barel O, Malicdan MC, Ben-Zeev B, Kandel J, Pri-Chen H, Stephen J, Castro I, Metz J, Atawa O, Moshkovitz S, et al (In Press). Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathy. Brain Full text.
Schrader TA, Islinger M, Schrader M (In Press). Detection and immunolabelling of peroxisomal proteins. Methods in Molecular Biology Full text.
Godinho L, Schrader M (In Press). Determination of Peroxisomal pH in Living Mammalian Cells Using pHRed. Methods in Molecular Biology Full text.
Guimarães S, Kilaru S, Schrader M, Schuster M (In Press). Labeling of Peroxisomes for Live Cell Imaging in the Filamentous Fungus Ustilago maydis. In  (Ed) , Humana Press (Springer Imprint). Full text.
Castro I, Schrader M (In Press). Miro1 – the Missing Link to Peroxisome Motility. Communicative and Integrative Biology Full text.
Costello J, Castro I, Schrader TA, Islinger M, Schrader M (In Press). Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations. Cell Cycle Full text.
Magalhães, AC, Ferreira, AR, Gomes, S, Vieira, M, Gouveia, A, Valença, I, Islinger, M, Nascimento, R, Schrader M, Kagan, JC, et al (In Press). Peroxisomes are platforms for cytomegalovirus’ evasion from the cellular immune response. Scientific Reports Full text.
Costello J, Castro I, Camoes F, Schrader TA, McNeall D, Yang J, Giannopoulou EA, Gomes S, Pogenberg V, Bonekamp N, et al (In Press). Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells. Journal of Cell Science Full text.
Schrader M, Costello J, Godinho L, Azadi A, Islinger M (In Press). Proliferation and fission of peroxisomes - an update.  Full text.
Aroso M, Agricola B, Hacker C, Schrader M (In Press). Proteoglycans support proper granule formation in pancreatic acinar cells.  Full text.
Schrader M, Godinho L, Costello J, Islinger M (In Press). The different facets of organelle interplay - an overview of organelle interactions.  Full text.
Schrader M, Pellegrini L (In Press). The making of a mammalian peroxisome, version 2.0:. Cell Death and Differentiation Full text.
Islinger M, Voelkl A, Fahimi HD, Schrader M (In Press). The peroxisome: an update on mysteries 2.0. Histochemistry and Cell Biology Full text.
Passmore JB, Pinho S, Gomez-Lazaro M, Schrader M (In Press). The respiratory chain inhibitor rotenone affects peroxisomal dynamics via its microtubule-destabilizing activity. Histochemistry and Cell Biology Full text.
Costello J, Schrader M (In Press). Unloosing the Gordian knot of peroxisome formation. Current Opinion in Cell Biology Full text.
Schrader TA, Schrader M (In Press). siRNA-mediated Silencing of Peroxisomal Genes in Mammalian Cells. Methods in Molecular Biology Full text.

2018

Castro I, Richards DM, Metz J, Costello JL, Passmore JB, Schrader TA, Gouveia A, Ribeiro D, Schrader M (2018). A role for MIRO1 in motility and membrane dynamics of peroxisomes. Traffic Full text.
Barel O, Malicdan MCV, Ben-Zeev B, Kandel J, Pri-Chen H, Stephen J, Castro IG, Metz J, Atawa O, Moshkovitz S, et al (2018). Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathy (vol 140, pg 568, 2017). BRAIN, 141 Author URL.  Full text.
Costello J, Passmore J, Islinger M, Schrader M (2018). Multi-localized proteins: the peroxisome-mitochondria connection. In del Rio L, Schrader M (Eds.) Proteomics of Peroxisomes. Identifying Novel Functions and Regulatory Networks, Springer. Full text.
Schrader M (eds)(2018). Proteomics of Peroxisomes - Identifying Novel Functions and Regulatory Networks 978-981-13-2232-7. Dordrecht, Springer Science + Business Media.

2017

Costello JL, Castro IG, Hacker C, Schrader TA, Metz J, Zeuschner D, Azadi AS, Godinho LF, Costina V, Findeisen P, et al (2017). ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. JOURNAL OF CELL BIOLOGY, 216(2), 331-342. Author URL.  Full text.
Schrader M, Islinger M (eds)(2017). MOLECULAR MECHANISMS AND PHYSIOLOGICAL SIGNIFICANCE OF ORGANELLE INTERACTIONS AND COOPERATION., Lausanne: Frontiers Media. Full text.
Metz J, Castro I, Schrader M (2017). Peroxisome Motility Measurement and Quantification Assay. Bio-protocol, 7, issue 17 Full text.

2016

Aroso M, Agricola B, Hacker C, Schrader M (2016). Addendum to the paper: Proteoglycans support proper granule formation in pancreatic AR42J cells. Histochem Cell Biol, 146(1). Author URL.  Full text.
Schrader M, Islinger M (2016). Editorial: Molecular Mechanisms and Physiological Significance of Organelle Interactions and Cooperation. Front Cell Dev Biol, 4 Author URL.  Full text.

2015

Silva AM, Varela-Moreira A, Pereira Gomes C, Molinos M, Leite M, Almeida M, Ribeiro D, Schrader M, Figueiredo C, Barbosa M, et al (2015). Integrated Analysis of Biological Samples by Imaging Flow Cytometry. Microsc Microanal, 21 Suppl 5, 95-96. Author URL.
Camões F, Islinger M, Guimarães SC, Kilaru S, Schuster M, Godinho LF, Steinberg G, Schrader M (2015). New insights into the peroxisomal protein inventory: Acyl-CoA oxidases and -dehydrogenases are an ancient feature of peroxisomes. Biochim Biophys Acta, 1853(1), 111-125. Abstract.  Author URL.  Full text.
Schrader M, Costello J, Godinho LF, Islinger M (2015). Peroxisome-mitochondria interplay and disease. Journal of Inherited Metabolic Disease, 38(4), 681-702. Abstract.
Schrader M, Costello J, Godinho LF, Islinger M (2015). Peroxisome-mitochondria interplay and disease. J Inherit Metab Dis, 38(4), 681-702. Abstract.  Author URL.  Full text.
Guimaraes SC, Schuster M, Bielska E, Dagdas G, Kilaru S, Meadows BRA, Schrader M, Steinberg G (2015). Peroxisomes, lipid droplets, and endoplasmic reticulum "hitchhike" on motile early endosomes. J Cell Biol, 211(5), 945-954. Abstract.  Author URL.  Full text.
Aroso M, Agricola B, Hacker C, Schrader M (2015). Proteoglycans support proper granule formation in pancreatic acinar cells. Histochemistry and Cell Biology, 144(4), 331-346. Abstract.
Williams C, Opalinski L, Landgraf C, Costello J, Schrader M, Krikken AM, Knoops K, Kram AM, Volkmer R, van der Klei IJ, et al (2015). The membrane remodeling protein Pex11p activates the GTPase Dnm1p during peroxisomal fission. Proc Natl Acad Sci U S A, 112(20), 6377-6382. Abstract.  Author URL.  Full text.

2014

Magalhaes AC, Gomes S, Ferreira AR, Oes FC, Nascimento R, Schrader M, Ribeiro D (2014). A role for peroxisomes on the cellular antiviral response to Cytomegalovirus infection.  Author URL.
Gouveia AMS, Gomes S, Guimaraes S, Lazaro MG, Sampaio P, Schrader M, Ribeiro D (2014). Functional specificity of the tail-anchored proteins Mff and Fis1 on peroxisomal and mitochondrial dynamics.  Author URL.
Schrader M, Castro I, Fahimi HD, Islinger M (2014). Peroxisome morphology in pathologies. In  (Ed) Molecular Machines Involved in Peroxisome Biogenesis and Maintenance, 125-151.  Abstract.
Camoes F, Islinger M, Costello J, Gomes S, Bonekamp N, Almeida M, Castro I, Ribeiro D, Schrader M (2014). Targeting of tail-anchored proteins to peroxisomes and mitochondria in mammalian cells.  Author URL.

2013

Huber N, Guimaraes S, Schrader M, Suter U, Niemann A (2013). Charcot-Marie-Tooth disease-associated mutants of GDAP1 dissociate its roles in peroxisomal and mitochondrial fission. EMBO Reports, 14(6), 545-552. Abstract.  Full text.
Bonekamp NA, Islinger M, Lázaro MG, Schrader M (2013). Cytochemical detection of peroxisomes and mitochondria. Methods Mol Biol, 931, 467-482. Abstract.  Author URL.
Castro I, Gouveia A, Ribeiro D, Schrader M (2013). Miro1 regulates microtubule-dependent motility of peroxisomes in mammalian cells. MOLECULAR BIOLOGY OF THE CELL, 24 Author URL.
Schrader M, Grille S, Fahimi HD, Islinger M (2013). Peroxisome interactions and cross-talk with other subcellular compartments in animal cells. Subcell Biochem, 69, 1-22. Abstract.  Author URL.
Bonekamp NA, Grille S, Cardoso MJ, Almeida M, Aroso M, Gomes S, Magalhaes AC, Ribeiro D, Islinger M, Schrader M, et al (2013). Self-interaction of human Pex11pβ during peroxisomal growth and division. PLoS One, 8(1). Abstract.  Author URL.  Full text.
Islinger M, Gomes S, Bonekamp N, Magalhaes AC, Camoes F, Castro I, Almeida M, Schrader M (2013). Targeting of tail-anchored proteins to peroxisomes requires Pex19 and a highly positively charged tail. MOLECULAR BIOLOGY OF THE CELL, 24 Author URL.

2012

Bonekamp NA, Islinger M, Lázaro MG, Schrader M (2012). Cytochemical detection of peroxisomes and mitochondria. Methods in Molecular Biology, 931, 467-482. Abstract.
Schrader M, Bonekamp NA, Islinger M (2012). Fission and proliferation of peroxisomes. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1822(9), 1343-1357. Abstract.
Rinn C, Aroso M, Prüssing J, Islinger M, Schrader M (2012). Modulating zymogen granule formation in pancreatic AR42J cells. Exp Cell Res, 318(15), 1855-1866. Abstract.  Author URL.
Ribeiro D, Castro I, Dariush Fahimi H, Schrader M (2012). Peroxisome morphology in pathology. Histology and Histopathology, 27(6), 661-676. Abstract.
Schrader M, Almeida M, Grille S (2012). Postfixation detergent treatment liberates the membrane modelling protein Pex11β from peroxisomal membranes. Histochem Cell Biol, 138(3), 541-547. Abstract.  Author URL.
Islinger M, Grille S, Fahimi HD, Schrader M (2012). The peroxisome: an update on mysteries. Histochem Cell Biol, 137(5), 547-574. Abstract.  Author URL.
Bonekamp NA, Sampaio P, de Abreu FV, Lüers GH, Schrader M (2012). Transient Complex Interactions of Mammalian Peroxisomes Without Exchange of Matrix or Membrane Marker Proteins. Traffic, 13(7), 960-978. Abstract.
Bonekamp NA, Sampaio P, de Abreu FV, Lüers GH, Schrader M (2012). Transient complex interactions of mammalian peroxisomes without exchange of matrix or membrane marker proteins. Traffic, 13(7), 960-978. Abstract.  Author URL.
Bonekamp NA, Schrader M (2012). Transient complex peroxisomal interactions: a new facet of peroxisome dynamics in mammalian cells. Communicative and Integrative Biology, 5(6), 534-537. Abstract.  Full text.

2011

Islinger M, Schrader M (2011). Peroxisomes. Curr Biol, 21(19), R800-R801. Author URL.
Delille HK, Dodt G, Schrader M (2011). Pex11pβ-mediated maturation of peroxisomes. Commun Integr Biol, 4(1), 51-54. Abstract.  Author URL.

2010

Borta H, Aroso M, Rinn C, Gomez-Lazaro M, Vitorino R, Zeuschner D, Grabenbauer M, Amado F, Schrader M (2010). Analysis of low abundance membrane-associated proteins from rat pancreatic zymogen granules. J Proteome Res, 9(10), 4927-4939. Abstract.  Author URL.
Islinger M, Cardoso MJR, Schrader M (2010). Be different--the diversity of peroxisomes in the animal kingdom. Biochim Biophys Acta, 1803(8), 881-897. Abstract.  Author URL.
Bonekamp NA, Vormund K, Jacob R, Schrader M (2010). Dynamin-like protein 1 at the Golgi complex: a novel component of the sorting/targeting machinery en route to the plasma membrane. Exp Cell Res, 316(20), 3454-3467. Abstract.  Author URL.
Delille HK, Agricola B, Guimaraes SC, Borta H, Lüers GH, Fransen M, Schrader M (2010). Pex11pbeta-mediated growth and division of mammalian peroxisomes follows a maturation pathway. J Cell Sci, 123(Pt 16), 2750-2762. Abstract.  Author URL.
Gómez-Lázaro M, Rinn C, Aroso M, Amado F, Schrader M (2010). Proteomic analysis of zymogen granules. Expert Rev Proteomics, 7(5), 735-747. Abstract.  Author URL.
Fardilha M, Schrader M, da Cruz E Silva OAB, da Cruz E Silva EF (2010). Understanding fatty acid metabolism through an active learning approach. Biochem Mol Biol Educ, 38(2), 65-69. Abstract.  Author URL.

2009

Schrader M (2009). Anniversaries, peroxisomes and reactive oxygen species. Histochemistry and Cell Biology, 131(4), 435-436.
Delille HK, Alves R, Schrader M (2009). Biogenesis of peroxisomes and mitochondria: linked by division. Histochem Cell Biol, 131(4), 441-446. Abstract.  Author URL.
Delille HK, Schrader M (2009). Hypertubulation of peroxisomes by multiple stimuli. EUROPEAN JOURNAL OF CELL BIOLOGY, 88, 68-68. Author URL.
Camões F, Bonekamp NA, Delille HK, Schrader M (2009). Organelle dynamics and dysfunction: a closer link between peroxisomes and mitochondria. J Inherit Metab Dis, 32(2), 163-180. Abstract.  Author URL.
Bonekamp NA, Völkl A, Fahimi HD, Schrader M (2009). Reactive oxygen species and peroxisomes: struggling for balance. Biofactors, 35(4), 346-355. Abstract.  Author URL.

2008

Gomez-Lazaro M, Bonekamp NA, Galindo MF, Jordán J, Schrader M (2008). 6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells. Free Radical Biology and Medicine, 44(11), 1960-1969. Abstract.
Vormund K, Bonekamp NA, Jacob R, Schrader M (2008). A novel function of dynamin-like protein 1 at the Golgi complex.  Author URL.
Faust F, Gomez-Lazaro M, Borta H, Agricola B, Schrader M (2008). Rab8 is involved in zymogen granule formation in pancreatic acinar AR42J cells. Traffic, 9(6), 964-979. Abstract.  Author URL.
Delille HK, Schrader M (2008). Targeting of hFis1 to peroxisomes is mediated by Pex19p. J Biol Chem, 283(45), 31107-31115. Abstract.  Author URL.
Schrader M, Fahimi HD (2008). The peroxisome: still a mysterious organelle. Histochem Cell Biol, 129(4), 421-440. Abstract.  Author URL.  Full text.

2007

Schrader M, Yoon Y (2007). Mitochondria and peroxisomes: are the 'big brother' and the 'little sister' closer than assumed?. Bioessays, 29(11), 1105-1114. Abstract.  Author URL.

2006

Schrader M, Fahimi HD (2006). Growth and division of peroxisomes. Int Rev Cytol, 255, 237-290. Abstract.  Author URL.
Delille HK, Bonekamp NA, Schrader M (2006). Peroxisomes and disease - an overview. Int J Biomed Sci, 2(4), 308-314. Abstract.  Author URL.  Full text.
Schrader M, Fahimi HD (2006). Peroxisomes and oxidative stress. Biochim Biophys Acta, 1763(12), 1755-1766. Abstract.  Author URL.
Schrader M (2006). Shared components of mitochondrial and peroxisomal division. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1763(5-6), 531-541. Author URL.
Schrader M (2006). Shared components of mitochondrial and peroxisomal division. Biochim Biophys Acta, 1763(5-6), 531-541. Abstract.  Author URL.
Bach J-P, Borta H, Ackermann W, Faust F, Borchers O, Schrader M (2006). The secretory granule protein syncollin localizes to HL-60 cells and neutrophils. J Histochem Cytochem, 54(8), 877-888. Abstract.  Author URL.
Faust F, Borta H, Schrader M (2006). The small GTPase Rab8 is involved in zymogen granule formation in acinar cells of the exocrine pancreas.  Author URL.

2005

Koch A, Yoon Y, Bonekamp NA, McNiven MA, Schrader M (2005). A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell, 16(11), 5077-5086. Abstract.  Author URL.
Schrader M, Gould SJ (2005). Assay and functional analysis of dynamin-like protein 1 in peroxisome division. Methods Enzymol, 404, 586-597. Abstract.  Author URL.
Boll A, Schrader M (2005). Elongation of peroxisomes as an indicator for efficient dynamin-like protein 1 knock down in mammalian cells. J Histochem Cytochem, 53(8), 1037-1040. Abstract.  Author URL.

2004

Schrader M, Fahimi HD (2004). Mammalian peroxisomes and reactive oxygen species. Histochem Cell Biol, 122(4), 383-393. Abstract.  Author URL.
Schrader M (2004). Membrane targeting in secretion. Subcell Biochem, 37, 391-421. Abstract.  Author URL.
Koch A, Schneider G, Lüers GH, Schrader M (2004). Peroxisome elongation and constriction but not fission can occur independently of dynamin-like protein 1. J Cell Sci, 117(Pt 17), 3995-4006. Abstract.  Author URL.
Kovacs WJ, Schrader M, Walter I, Stangl H (2004). The hypolipidemic compound cetaben induces changes in Golgi morphology and vesicle movement. Histochemistry and Cell Biology, 122(2), 95-109. Abstract.

2003

Koch A, Thiemann M, Grabenbauer M, Yoon Y, McNiven MA, Schrader M (2003). Dynamin-like protein 1 is involved in peroxisomal fission. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(10), 8597-8605. Author URL.
Schrader M, Thiemann M, Fahimi HD (2003). Peroxisomal motility and interaction with microtubules. Microsc Res Tech, 61(2), 171-178. Abstract.  Author URL.

2002

Kalus I, Hodel A, Koch A, Kleene R, Edwardson JM, Schrader M (2002). Interaction of syncollin with GP-2, the major membrane protein of pancreatic zymogen granules, and association with lipid microdomains. Biochem J, 362(Pt 2), 433-442. Abstract.  Author URL.
Schmidt K, Agricola B, Kleene R, Schrader M (2002). Submembranous proteoglycans are required for granule formation and regulated secretion in the acinar cells of the exocrine pancreas.  Author URL.

2001

Hodel A, an SJ, Hansen NJ, Lawrence J, Wäsle B, Schrader M, Edwardson JM (2001). Cholesterol-dependent interaction of syncollin with the membrane of the pancreatic zymogen granule. Biochem J, 356(Pt 3), 843-850. Abstract.  Author URL.
Schmidt K, Schrader M, Kern HF, Kleene R (2001). Regulated apical secretion of zymogens in rat pancreas. Involvement of the glycosylphosphatidylinositol-anchored glycoprotein GP-2, the lectin ZG16p, and cholesterol-glycosphingolipid-enriched microdomains. J Biol Chem, 276(17), 14315-14323. Abstract.  Author URL.
Schrader M (2001). Tubulo-reticular clusters of peroxisomes in living COS-7 cells: dynamic behavior and association with lipid droplets. J Histochem Cytochem, 49(11), 1421-1429. Abstract.  Author URL.

2000

Schrader M, King SJ, Stroh TA, Schroer TA (2000). Evidence for peroxisomal reticuli in COS-7 cells: Association with lipid droplets. MOLECULAR BIOLOGY OF THE CELL, 11, 425A-425A. Author URL.
Hillebrand M, Schmidt K, Kern HF, Kleene R, Schrader M (2000). Inhibitors of glycosylation, GPI-anchor- and cholesterol biosynthesis interfere with granule formation and regulated secretion in the acinar cells of the exocrine rat pancreas. MOLECULAR BIOLOGY OF THE CELL, 11, 499A-499A. Author URL.
Thiemann M, Schrader M, Völkl A, Baumgart E, Fahimi HD (2000). Interaction of peroxisomes with microtubules. In vitro studies using a novel peroxisome-microtubule binding assay. Eur J Biochem, 267(20), 6264-6275. Abstract.  Author URL.
Schrader M, King SJ, Stroh TA, Schroer TA (2000). Real time imaging reveals a peroxisomal reticulum in living cells. J Cell Sci, 113 ( Pt 20), 3663-3671. Abstract.  Author URL.
Kleene R, Classen B, Zdzieblo J, Schrader M (2000). SH3 binding sites of ZG29p mediate an interaction with amylase and are involved in condensation-sorting in the exocrine rat pancreas. Biochemistry, 39(32), 9893-9900. Abstract.  Author URL.

1999

Schrader M, Wodopia R, Fahimi HD (1999). Induction of tubular peroxisomes by UV irradiation and reactive oxygen species in HepG2 cells. J Histochem Cytochem, 47(9), 1141-1148. Abstract.  Author URL.
Valetti C, Wetzel DM, Schrader M, Hasbani MJ, Gill SR, Kreis TE, Schroer TA (1999). Role of dynactin in endocytic traffic: Effects of dynamitin overexpression and colocalization with CLIP-170. Molecular Biology of the Cell, 10(12), 4107-4120. Abstract.

1998

Fahimi HD, Grabenbauer M, Schrader M, Stier H, Baumgart E (1998). Biogenesis and maturation of peroxisomes in mammalian cells.  Author URL.
Schrader M, Krieglstein K, Fahimi HD (1998). Tubular peroxisomes in HepG2 cells: selective induction by growth factors and arachidonic acid. Eur J Cell Biol, 75(2), 87-96. Abstract.  Author URL.

1997

Kinscherf R, Kamencic H, Deigner HP, Pill J, Schmiedt W, Schrader M, Metz J (1997). Effect of alterations of blood cholesterol levels on macrophages in the myocardium of New Zealand White rabbits. J Leukoc Biol, 62(6), 719-725. Abstract.  Author URL.
Kinscherf R, Deigner HP, Usinger C, Pill J, Wagner M, Kamencic H, Hou D, Chen M, Schmiedt W, Schrader M, et al (1997). Induction of mitochondrial manganese superoxide dismutase in macrophages by oxidized LDL: its relevance in atherosclerosis of humans and heritable hyperlipidemic rabbits. FASEB J, 11(14), 1317-1328. Abstract.  Author URL.

1996

Schrader M, Burkhardt JK, Baumgart E, Lüers G, Spring H, Völkl A, Fahimi HD (1996). Interaction of microtubules with peroxisomes. Tubular and spherical peroxisomes in HepG2 cells and their alterations induced by microtubule-active drugs. Eur J Cell Biol, 69(1), 24-35. Abstract.  Author URL.
Schrader M, Burkhardt JK, Baumgart E, Lüers G, Völkl A, Fahimi HD (1996). The importance of microtubules in determination of shape and intracellular distribution of peroxisomes. Ann N Y Acad Sci, 804, 669-671. Author URL.
Schrader M, Fahimi HD (1996). Tubular peroxisomes in HepG2 cells. The role of nutritional factors in their formation. MOLECULAR BIOLOGY OF THE CELL, 7, 2879-2879. Author URL.

1995

Schrader M, Baumgart E, Fahimi HD (1995). Effects of fixation on the preservation of peroxisomal structures for immunofluorescence studies using HepG2 cells as a model system. Histochem J, 27(8), 615-619. Abstract.  Author URL.

1994

Schrader M, Temm-Grove CJ, Lessard JL, Jockusch BM (1994). Chicken antibodies to rabbit muscle actin with a restricted repertoire of F-actin recognition. Eur J Cell Biol, 63(2), 326-335. Abstract.  Author URL.
Schrader M, Baumgart E, Völkl A, Fahimi HD (1994). Heterogeneity of peroxisomes in human hepatoblastoma cell line HepG2. Evidence of distinct subpopulations. Eur J Cell Biol, 64(2), 281-294. Abstract.  Author URL.

Michael_Schrader Details from cache as at 2018-12-10 07:09:48

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External Engagment and Impact

Committee/panel activities

Academic Lead, Cell Biology, Biosciences, University of Exeter

Member of the MRC/Wellcome Trust Strategy Group

H2020 Marie Curie ITN PERICO –member of the Management Consortium

FP7 Marie Curie ITN PERFUME –member of the Management Consortium

Member of the Research & Impact Committee, Biosciences, University of Exeter

Member of the GM Safety Committee, Biosciences, University of Exeter

FP7 COST Action BM1203 “EU-ROS”– substitute member Management Committee

Vice-Director/Coordinator, Centre for Cell Biology, Aveiro, Portugal (2008-11)

 


Editorial responsibilities

Reviewer for Current Biology, EMBO Journal, Journal of Cell Science, Molecular Biology of the Cell, Traffic, New England Journal of Medicine, PNAS, Nature Communications ......

Editor–in-Chief Greater Europe, Histochemistry and Cell Biology (2016 - ) Springer Nature

Guest Associate Editor for Frontiers in Cell and Developmental Biology, Organisation & Hosting of a Frontiers Research Topic on “Molecular mechanisms and physiological significance of organelle interactions and cooperation” Lausanne: Frontiers Media. ISBN 978-2-88945-104-3. DOI 10.3389/978-2-88945-104-3 (E-Book) (COVER ART) (2014-2016)

Editor for a book on “Peroxisomes”, Methods in Molecular Biology, Humana Press. Springer Science + Business Media. ISBN 978-1-4939-6935-7. DOI 10.1007/978-1-4939-6937-1 (COVER ART) (2015-2016).

Co-editor for a book on "Proteomics of peroxisomes", Subcellular Biochemistry Series, Springer Science + Business Media (2017-2018)

 


Invited lectures

2008-2018 Given invited seminars at 6 UK Universities and 35 Universities outside the UK

Selected

2018  6th Open European Peroxisome Meeting, Groningen, The Netherlands

2018 2nd EMBO Workshop on Membrane Contact Sites, Arosa, Switzerland (invited speaker)

2018 SSIEM Annual Symposium, Athens, Greece (Plenary Lecture)

2018 Mini symposium “New Horizons in Peroxisome Biology”, Weizmann Institute of Science, Rehovot, Israel

2018 Hong Kong (School visits, open evening)

2018 Zellweger UK Family Meeting & Conference, Okehampton, UK

2017 Academic Medical Center, Amsterdam, The Netherlands

2017 Zellweger UK Family Meeting, London, UK

2016 Annual Meeting of the ASCB, San Francisco, USA (Minisymposium on Organelle Contact Sites and Biogenesis)

2016 5th Open European Peroxisome Meeting, Vienna, Austria 

2016 Institute Pasteur, Paris, France

2016 Zellweger UK Family Meeting, Birmingham, UK

2016 PERFUME Conference, Hamburg, Germany

2016 EU ROS symposium, Lisbon, Portugal

2016 Annual symposium of the APS (Arbeitsgemeinschaft für Stoffwechselstörungen in der Pädiatrie), Fulda, Germany (Plenary Lecture)

2016 Minerva-Gentner Peroxisystem symposium, Weizmann Institute of Science, Rehovot, Israel  (Plenary Lecture)

2016 Spalding Gentlemen’s Society, Spalding, UK

2015 Inst. for Biochemistry, University of Tübingen, Germany

2015 Academic Medical Center, Amsterdam, The Netherlands

2014 Organisation of the EU FP7 Marie Curie ITN PERFUME Workshop “Peroxisomes in Health and Disease”, Exeter, UK

2014 Joint International Symposium SFB 593 & GRK 1216 “Mechanisms of cellular compartmentalization”, Philipps-University Marburg, Germany (Plenary Lecture)

2014 SSIEM Annual Symposium, Innsbruck, Austria (Plenary Lecture)

2014 University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), Groningen, The Netherlands

2014 Medical University of Vienna, Centre for Anatomy and Cell Biology, Vienna, Austria

2013 PERFUME Marie Curie ITN, Kick-off-conference, Groningen, The Netherlands (Plenary Lecture)

2013 GABBA Annual Symposium "Science Heartbeat", Porto, Portugal (Plenary Lecture)

2013 Glaxo Smith Kline, Stevenage, UK

2013 Faculty of Biological Sciences, University of Leeds, UK

2012 10th National NCL Conference, Hamburg, Germany

2012 GABBA course Cell Division, IBMC, Porto, Portugal, “Organelle partitioning during cell division”

2011 EMBO Meeting, Vienna, Austria

2011 CIIMAR/IPATIMUP, University of Porto, Portugal

2010 SFB 593 "Mechanisms of cellular compartmentalization", University of Marburg, Germany

2009 SINAL – 3rd National Meeting on Signal Transduction, Aveiro, Portugal

2009 EMBO Meeting, Amsterdam, The Netherlands, Recent advances in peroxisome biology

2009 Dept. of Cell Biology, ETH Zürich, Switzerland

2009 Department of Zoology & Center for Neuroscience and Cell Biology, University of Coimbra, Portugal

2009 Inst. for Biochemistry (Cellular Biochemistry), University of Tübingen, Germany

2008 SSIEM Annual Symposium, Lisbon, Portugal (Plenary Lecture)

2008 50th Anniversary Symposium of the Society for Histochemistry, Interlaken, Switzerland (co-chair and co-organizer of a session on peroxisomes in honour of Prof. H. D. Fahimi on the occasion of his 75th anniversary)

2008 Dept. of Medical Sciences (Neuropharmacology), University of Castilla-La-Mancha, Albacete, Spain

2007 102nd Annual Meeting of the German Society for Anatomy, Giessen, Germany

2006 46th Annual Meeting of the ASCB, San Diego, USA (co-chair and co-organizer of a Minisymposium on Organelle Inheritance and Maintenance)


Media Coverage

Press Release “Future European science leaders to work on cutting-edge peroxisome research”, Research News, University of Exeter, 04 October 2018, http://www.exeter.ac.uk/news/research/title_685534_en.html

Schrader, M: Peroxisomes take centre stage. SciTech Europa Quarterly 28, 144-145, 2018. http://edition.pagesuite-professional.co.uk/html5/reader/production/default.aspx?pubname=&edid=79ea7db3-29e5-46d8-b329-91045b3ff3b4

Schrader, M., H. R. Waterham, K. Hughes, C. Burton, N. Anderson-Hunt: Battling Zellweger Spectrum Disorders. SciTech Europa Quarterly 28, 142-143, 2018. http://edition.pagesuite-professional.co.uk/html5/reader/production/default.aspx?pubname=&edid=79ea7db3-29e5-46d8-b329-91045b3ff3b4

Schrader, M: Peroxisomes on the rise. Scientia 148, 2018. https://doi.org/10.26320/SCIENTIA148

Press Release “Pulling power reveals new insights into membrane dynamics in human cells“, Research News, University of Exeter, 25 January 2018, http://www.exeter.ac.uk/research/newsandevents/news/title_635625_en.html

N. Hunt, Zellweger UK Charity (23.11.2017, BIO3086 Patient-centred session) http://www.zellweger.org.uk/index.php/news-2/lr-151655/

https://www.facebook.com/zellwegeruk/posts/1130082373792943

Costello, J., D. McNeall, M. Islinger, and M. Schrader: Cloudy with a chance of biology. Laboratory News (Features) Dec 6, 2017, https://www.labnews.co.uk/uncategorized/cloudy-chance-biology-06-12-2017/

Press Release “Weather forecasting technology used to predict where proteins anchor within human cells“, Featured News, University of Exeter, 30 March 2017, http://www.exeter.ac.uk/news/research/title_576535_en.html

Press Release “Breakthrough by Exeter cell biologists - We all need contacts – how organelles hug in cells“, Featured News, University of Exeter, 20 January 2017, http://www.exeter.ac.uk/news/featurednews/title_565173_en.html

Press Release “How to organise a cell: novel insight from a fungus“, Research News, Biosciences, University of Exeter, 2 June 2016, http://biosciences.exeter.ac.uk/news/research/title_515132_en.html

“Granule formation in pancreatic acinar cell”, Atlas of Science, 10 December 2015, http://atlasofscience.org/proteoglycans-support-granule/

Press Release “Scientists discover an additional function for the peroxisome protein Pex11p”, Research News, Biosciences, University of Exeter, 14 May 2015, http://biosciences.exeter.ac.uk/news/featurednews/title_451624_en.html

Press Release “Prestigious European training network comes to Biosciences”, Research News, Biosciences, University of Exeter, 1 December 2014, http://biosciences.exeter.ac.uk/news/featurednews/title_424671_en.html

Press Release “New model gives scientists insight into cells’ fat-metabolisers”, Research News, Biosciences, University of Exeter, 29 October 2014, http://biosciences.exeter.ac.uk/news/research/title_419085_en.html

“Understanding new disorders with defects in organelle dynamics” I. Castro, J. Costello, T. A. Schrader, A. Sadeghi, L. Godinho, M. Schrader. Medical and Health Showcase, June 27, 2014, Exeter, UK (Best Poster Award). http://medicine.exeter.ac.uk/events/healthshowcase/

Press Release “Future European Science Leaders to Work on Cutting-edge Peroxisome Research”, Research News, Biosciences, University of Exeter, 9 April 2013, http://biosciences.exeter.ac.uk/news/research/title_278980_en.html

Press Release “Study of the machinery of cells reveals clues to neurological disorder”, Research News, University of Exeter, 16 May 2013, http://www.exeter.ac.uk/news/featurednews/title_290807_en.html
 

Press Release “Kissing organelles – new dynamic behaviour of peroxisomes. research@ua 2011, Research Highlights, University of Aveiro, Portugal

College textbook “CELL AND MOLECULAR BIOLOGY”, 6e, by Gerald Karp (photographic material) (2010)

Newspaper article "Matrix and membrane hold the key to disease of the pancreas", Oberhessische Presse, Marburg, 2004

Video "Free Radicals", Spektrum Verlag, 1996 (photographic material)


Workshops/Conferences organised

2016 Cell Biology Theme Event, Exeter, UK

2014 EU FP7 Marie Curie ITN PERFUME Workshop “Peroxisomes in Health and Disease”, Exeter, UK

2008 Session on peroxisomes in honour of Prof. H. D. Fahimi on the occasion of his 75th anniversary at the 50th Anniversary Symposium of the Society for Histochemistry, Interlaken, Switzerland

2006 Minisymposium on “Organelle Inheritance and Maintenance” at the 46th Annual Meeting of the American Society for Cell Biology (ASCB), San Diego, CA, USA

Teaching

  • BIO2088 Advanced Cell Biology
  • BIO2098 Microbiology and Cells II
  • BIO3084 The Cytoskeleton in Human Disease (Module Coordinator)
  • BIO3086 Cell Biology of Disease (Module Coordinator)
  • BIO1313 Academic Tutorials yr1
  • BIO2071 Academic Tutorials yr2
  • BIOM540 Biotechnology and Enterprise MSc
  • BIOM509 Professional Skills MSc
  • BIO3063 Biosciences Dissertations (L3)
  • BIO3064 Biosciences Independent Research project (L3)
  • EH4 Expanding Horizons BSc (Hons) Medical Sciences, UoE Medical School
  • Erasmus Programme
  • Marie Curie Initial Training Network PERFUME
  • Marie Curie Initial Training Network PERICO

Modules

2018/19


Supervision / Group

Postdoctoral researchers

  • Joe Costello
  • Maki Kamoshita
  • Tina Schrader (Research Technician)

Postgraduate researchers

  • Suzan Kors
  • Josiah Passmore

Research Technicians

  • Tina Schrader

Alumni

  • Afsoon S. Azadi (PhD student)
  • Alexa Bishop (MbyRes)
  • Ines Castro (PhD student)

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