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Dr Olga Nev

Dr Olga Nev

Postdoctoral Research Fellow

 Geoffrey Pope 322

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

I obtained two “specialist” diplomas with honours (comparable to MMath) at Nizhniy Novgorod State University: the first in 2006, in Applied Mathematics and Computer Science, and the second in 2008, in Business studies. In 2012, I obtained an MSc with honours in Mathematical Methods of Economic Analysis at St. Petersburg School of Economics.

I subsequently worked as a Research Assistant on the project Asymptotic properties of stochastic dynamical systems at St. Petersburg State University from 2011 to 2014, and I co-authored four papers during that period.

In 2017 I obtained a PhD degree in Mathematical Biology at the University of Warwick working on a project whose objective was to characterise how bacterial cells respond to changing environmental conditions by adjusting the expression levels of the transport systems and enzymes supporting various metabolic pathways, and I co-authored five papers during that period.

During my PhD study I was funded by the EU under FP7 Marie Curie Actions, and trained within an international cohort of early stage researchers under the multi-disciplinary theme Predictive modelling of bacterial cell division. Although originally trained as a mathematician, I have gained extensive interdisciplinary experience and now I have an excellent working knowledge of microbial physiology and the underlying biochemistry.

During the second year of my PhD study I was seconded for two months to TU Delft where I was able to collaborate with experimental scientists and established important contacts with other researchers in industry and academia. I took part in Delft's "zero growth" project aimed at maximising the yield of desirable products whilst minimising biomass formation. I carried out retentostat experiments and also extended my knowledge of microbiology and became familiar with the research culture in an experimental lab. I have contributed to the development of low-yield bioreactor regimes via data analysis and model development. This is an on-going collaboration.

At the University of Warwick, I supported undergraduate teaching in the Mathematics Institute. In addition, I have teaching experience from my time in Russia, where I led workshops in Advanced Mathematics for two years.

From 2018 I have been working as a Postdoctoral Research Fellow on the interdisciplinary project titled "The Evolution of Competition and Cooperation: how polymorphisms in microbial populations optimise virulence and mediate drug resistance" in the group of Professor Ivana Gudelj.

This project aims to address the following challenge: how the shift in the composition from susceptible to resistant species caused by antibiotics is mediated by resource utilisation strategies? We consider laboratory communities of devastating human fungal pathogens that kill more people than tuberculosis, malaria or breast cancer, focusing on Candida species. We aim to quantify how microbial community composition is determined by the metabolism, genetics and physiology of individual players, establishing principles by which microbial composition affects antimicrobial resistance.

Qualifications

2015 - 2017: PhD in Mathematical Biology, University of Warwick

2010 - 2012: MSc in Mathematical Methods of Economic Analysis, Saint-Petersburg branch of High School of Economics

2004 - 2008: BSc in Enterprise Economics and Management, Nizhniy Novgorod State University

2001 - 2006: BSc in Applied Mathematics and Informatics, Nizhniy Novgorod State University

Research

Research interests

Mathematical modelling of microbial metabolism, physiology, ecology and evolution.

My immediate career focus is on postdoctoral research in Applied Mathematics and further development as an interdisciplinary scientist, bringing non-trivial mathematical insights and techniques to the other disciplines.

Research projects

From 2018 I have been working as a Postdoctoral Research Fellow on the interdisciplinary project titled "The Evolution of Competition and Cooperation: how polymorphisms in microbial populations optimise virulence and mediate drug resistance" in the group of Professor Ivana Gudelj.

This project aims to address the following challenge: how the shift in the composition from susceptible to resistant species caused by antibiotics is mediated by resource utilisation strategies? We consider laboratory communities of devastating human fungal pathogens that kill more people than tuberculosis, malaria or breast cancer, focusing on Candida species. We aim to quantify how microbial community composition is determined by the metabolism, genetics and physiology of individual players, establishing principles by which microbial composition affects antimicrobial resistance.

Grants/Funding

2015 – 2017: FP7 Marie Curie Actions funded PhD student

2018 – current: ERC funded Postdoctoral Research Fellow

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Nev OA, van den Berg HA (2018). Holling Type I versus Holling Type II functional responses in Gram-negative bacteria. Transactions of Mathematics and its Applications, 2, 1-19. Full text.
Nev OA, van den Berg HA (2018). Microbial metabolism and growth under conditions of starvation modelled as the sliding mode of a differential inclusion. Dynamical Systems, 33(1), 93-112. Abstract.  Full text.
Nev OA, van den Berg HA (2017). Erratum to: Variable-Internal-Stores models of microbial growth and metabolism with dynamic allocation of cellular resources (Journal of Mathematical Biology, (2017), 74, 1-2, (409-445), 10.1007/s00285-016-1030-4). Journal of Mathematical Biology, 74(1-2). Abstract.  Full text.
Nev OA, van Den Berg HA (2017). Mathematical models of microbial growth and metabolism: a whole-organism perspective. Science Progress, 100(4), 343-362. Abstract.  Full text.
Nev OA, Nev OA, van den Berg HA (2017). Optimal management of nutrient reserves in microorganisms under time-varying environmental conditions. Journal of Theoretical Biology, 429, 124-141. Abstract.  Full text.
Nev OA, van den Berg HA (2017). Variable-Internal-Stores models of microbial growth and metabolism with dynamic allocation of cellular resources. Journal of Mathematical Biology, 74(1-2), 409-445. Abstract.  Full text.
Krivulin NK, Nev OA (2014). Calculation of the asymptotic characteristics of a stochastic synchronized dynamic system. Vestnik St. Petersburg University: Mathematics, 47(4), 145-153. Abstract.

Publications by year


2018

Nev OA, van den Berg HA (2018). Holling Type I versus Holling Type II functional responses in Gram-negative bacteria. Transactions of Mathematics and its Applications, 2, 1-19. Full text.
Nev OA, van den Berg HA (2018). Microbial metabolism and growth under conditions of starvation modelled as the sliding mode of a differential inclusion. Dynamical Systems, 33(1), 93-112. Abstract.  Full text.

2017

Nev OA, van den Berg HA (2017). Erratum to: Variable-Internal-Stores models of microbial growth and metabolism with dynamic allocation of cellular resources (Journal of Mathematical Biology, (2017), 74, 1-2, (409-445), 10.1007/s00285-016-1030-4). Journal of Mathematical Biology, 74(1-2). Abstract.  Full text.
Nev OA, van Den Berg HA (2017). Mathematical models of microbial growth and metabolism: a whole-organism perspective. Science Progress, 100(4), 343-362. Abstract.  Full text.
Nev OA, Nev OA, van den Berg HA (2017). Optimal management of nutrient reserves in microorganisms under time-varying environmental conditions. Journal of Theoretical Biology, 429, 124-141. Abstract.  Full text.
Nev OA, van den Berg HA (2017). Variable-Internal-Stores models of microbial growth and metabolism with dynamic allocation of cellular resources. Journal of Mathematical Biology, 74(1-2), 409-445. Abstract.  Full text.

2014

Krivulin NK, Nev OA (2014). Calculation of the asymptotic characteristics of a stochastic synchronized dynamic system. Vestnik St. Petersburg University: Mathematics, 47(4), 145-153. Abstract.

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Teaching

2007 - 2008: Nizhniy Novgorod State University, faculty of Economics, department of Information Technologies

Leading workshops and lab classes for students (Advanced MathematicsMethods of Optimization) 

2012 - 2013: Saint-Petersburg University of Economics, faculty of Information Systems in Economics and Management, department of Advanced Mathematics

Leading workshops for students (Advanced Mathematics)

2015 – 2017: University of Warwick, Mathematics Institute

Undergraduate teaching support

2018: Postgraduate Award in Teaching and Learning in Higher Education, University of Warwick

Supervision / Group

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