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Dr Karen Moore

Dr Karen Moore

Experimental Officer - Exeter Sequencing Service

 6203

 Geoffrey Pope 313

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

I am a molecular biologist with a background in DNA replication and its integration with the cell cycle in plants and yeasts. I have worked on molecular and synthetic biology approaches in biofuels production where I focused on algal bacterial consortia. Currently, I work for Exeter Sequencing Service where I aim to develop next generation genetic approaches to enable improved understanding of genomic models.

Broad research specialisms

In the rapidly evolving field of genomics my aim is to assist scientists perform up to date quality experiments in a cost efficient manner. Three areas are important: first, optimization of routine NGS library preparation protocols including controls and using sequencing metrics to improve service delivery; second, to develop custom designed functional genomics assays for a wide range of aims and objectives and third, to provide training and consultancy to enable a successful genomics projects from start to end (including planning, sample management, experimental pipelines and bioinformatics analysis). Development of experimental pipelines and bioinformatics analysis is undertaken by Paul O’Neill.

Qualifications

2000    PhD Biological Sciences, University of Exeter, UK

1995    BSc hons Biological Sciences, University of Exeter, UK

Research

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Shaw S, Le Cocq K, Paszkiewicz K, Moore K, Winsbury R, Studholme D, Salmon D, Thornton CR, Grant MR (In Press). Transcriptional reprogramming of Trichoderma hamatum GD12 in soil during plant growth promotion and biological control of Sclerotinia sclerotiorum. Environmental Microbiology
Tennant RK, Sambles CM, Diffey GE, Moore KA, Love J (2017). Metagenomic Analysis of Silage. Journal of Visualized Experiments, 119, e54936-e54936. Full text.
Williams TA, Nakjang S, Campbell SE, Freeman MA, Eydal M, Moore K, Hirt RP, Embley TM, Williams BAP (2016). A recent whole-genome duplication divides populations of a globally-distributed microsporidian. Molecular Biology and Evolution Abstract.  Full text.
Laver TW, Caswell RC, Moore KA, Poschmann J, Johnson MB, Owens MM, Ellard S, Paszkiewicz KH, Weedon MN (2016). Pitfalls of haplotype phasing from amplicon-based long-read sequencing. Sci Rep, 6 Abstract.  Author URL.
Shaw S, Le Cocq K, Paszkiewicz K, Moore K, Winsbury R, Studholme D, Salmon D, Thornton CR, Grant MR (2016). Transcriptional reprogramming underpins enhanced plant growth promotion by the biocontrol fungus Trichoderma hamatum GD12 during antagonistic interactions with Sclerotinia sclerotiorum in soil. Molecular Plant Pathology, 17, 1425-1441. Abstract.  Full text.
Watson AK, Williams TA, Williams BAP, Moore KA, Hirt RP, Embley TM (2015). Transcriptomic profiling of host-parasite interactions in the microsporidian Trachipleistophora hominis. BMC Genomics Abstract.  Full text.
Bertolini C, van Aerle R, Lampis S, Moore KA, Paszkiewicz K, Butler CS, Vallini G, van der Giezen M (2014). Draft Genome Sequence of Stenotrophomonas maltophilia SeITE02, a Gammaproteobacterium Isolated from Selenite-Contaminated Mining Soil. Genome Announc, 2(3). Abstract.  Author URL.
Brabbs TR, He Z, Hogg K, Kamenski A, Li Y, Paszkiewicz KH, Moore KA, O'Toole P, Graham IA, Jones L, et al (2013). The stochastic silencing phenotype of Arabidopsis morc6 mutants reveals a role in efficient RNA -directed DNA methylation. Plant Journal, 75(5), 836-846. Abstract.
Brabbs TR, He Z, Hogg K, Kamenski A, Li Y, Paszkiewicz KH, Moore KA, O'Toole P, Graham IA, Jones L, et al (2013). The stochastic silencing phenotype of Arabidopsis morc6 mutants reveals a role in efficient RNA-directed DNA methylation. Plant Journal
Wood V, Gwilliam R, Rajandream MA, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, et al (2003). The genome sequence of Schizosaccharomyces pombe (vol 415, pg 871, 2002). NATURE, 421(6918), 94-94. Author URL.
Moore, K. Aves, S.J. (2001). Origins and complexes: the initiation of DNA replication. Journal of Experimental Botany, 52, 193-202.

Chapters

Moore, K. Aves, S.J. (2008). Mcm10 and DNA replication in fission yeast. In Bryant J, Francis D (Eds.) The Eukaryotic Cell Cycle, Taylor & Francis, 45-69.

Publications by year


In Press

Shaw S, Le Cocq K, Paszkiewicz K, Moore K, Winsbury R, Studholme D, Salmon D, Thornton CR, Grant MR (In Press). Transcriptional reprogramming of Trichoderma hamatum GD12 in soil during plant growth promotion and biological control of Sclerotinia sclerotiorum. Environmental Microbiology

2017

Tennant RK, Sambles CM, Diffey GE, Moore KA, Love J (2017). Metagenomic Analysis of Silage. Journal of Visualized Experiments, 119, e54936-e54936. Full text.

2016

Williams TA, Nakjang S, Campbell SE, Freeman MA, Eydal M, Moore K, Hirt RP, Embley TM, Williams BAP (2016). A recent whole-genome duplication divides populations of a globally-distributed microsporidian. Molecular Biology and Evolution Abstract.  Full text.
Laver TW, Caswell RC, Moore KA, Poschmann J, Johnson MB, Owens MM, Ellard S, Paszkiewicz KH, Weedon MN (2016). Pitfalls of haplotype phasing from amplicon-based long-read sequencing. Sci Rep, 6 Abstract.  Author URL.
Shaw S, Le Cocq K, Paszkiewicz K, Moore K, Winsbury R, Studholme D, Salmon D, Thornton CR, Grant MR (2016). Transcriptional reprogramming underpins enhanced plant growth promotion by the biocontrol fungus Trichoderma hamatum GD12 during antagonistic interactions with Sclerotinia sclerotiorum in soil. Molecular Plant Pathology, 17, 1425-1441. Abstract.  Full text.

2015

Watson AK, Williams TA, Williams BAP, Moore KA, Hirt RP, Embley TM (2015). Transcriptomic profiling of host-parasite interactions in the microsporidian Trachipleistophora hominis. BMC Genomics Abstract.  Full text.

2014

Bertolini C, van Aerle R, Lampis S, Moore KA, Paszkiewicz K, Butler CS, Vallini G, van der Giezen M (2014). Draft Genome Sequence of Stenotrophomonas maltophilia SeITE02, a Gammaproteobacterium Isolated from Selenite-Contaminated Mining Soil. Genome Announc, 2(3). Abstract.  Author URL.

2013

Brabbs TR, He Z, Hogg K, Kamenski A, Li Y, Paszkiewicz KH, Moore KA, O'Toole P, Graham IA, Jones L, et al (2013). The stochastic silencing phenotype of Arabidopsis morc6 mutants reveals a role in efficient RNA -directed DNA methylation. Plant Journal, 75(5), 836-846. Abstract.
Brabbs TR, He Z, Hogg K, Kamenski A, Li Y, Paszkiewicz KH, Moore KA, O'Toole P, Graham IA, Jones L, et al (2013). The stochastic silencing phenotype of Arabidopsis morc6 mutants reveals a role in efficient RNA-directed DNA methylation. Plant Journal

2008

Moore, K. Aves, S.J. (2008). Mcm10 and DNA replication in fission yeast. In Bryant J, Francis D (Eds.) The Eukaryotic Cell Cycle, Taylor & Francis, 45-69.

2003

Wood V, Gwilliam R, Rajandream MA, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, et al (2003). The genome sequence of Schizosaccharomyces pombe (vol 415, pg 871, 2002). NATURE, 421(6918), 94-94. Author URL.

2001

Moore, K. Aves, S.J. (2001). Origins and complexes: the initiation of DNA replication. Journal of Experimental Botany, 52, 193-202.

karen_moore Details from cache as at 2018-06-24 19:06:43

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Karen Moore

The Wellcome Trust awarded the University a £1.5million  Institutional Strategic Support Fund (ISSF) in 2012, which allowed me to join the Biomedical Informatics Hub as a molecular biology applications specialist whilst continuing to supervise the preparation and running of NGS projects for Exeter Sequencing Service. Therefore, a minimum of 10% of my time will always be available to support pilot projects and offer training courses to any technician, PhD students, PDRAs or academic within the University.

PhD Students (PG researchers) and Postdoctoral researchers:

The Wellcome Trust awarded the University a £1.5million  Institutional Strategic Support Fund (ISSF) in 2012, which allowed me to join the Biomedical Informatics Hub as a molecular biology applications specialist whilst continuing to supervise the preparation and running of NGS projects for Exeter Sequencing Service. Therefore, a minimum of 10% of my time will always be available to support pilot projects and offer training courses to any technician, PhD students, PDRAs or academic within the University.

Laboratory Science Apprentice

I supervise and train a laboratory science apprentice (level 3) who works 4 days a week in the ESS laboratory and attends Bicton Collage for 1 day a week. I liaise with the collage tutors to ensure a coordinated training scheme.

PoreCamp

I was involved in 42 participants from 13 countries generated over 5Tb of sequencing data during the University of Exeter Porecamp held at Penryn Campus in Cornwall during 15-19 August 2016. Groups generated data for over 36 projects for sequencing on Oxford Nanopore’s MinION platform. These including WGS bacterial sequencing, PCR amplicons and BAC sequencing to help close mammalian genomes.

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