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Professor Ken Haynes

Professor Ken Haynes

 

Overview

We are greatly saddened by the loss of our friend and colleague Professor Ken Haynes who was a great fungal biologist with a keen eye for the Grand Vision, a loyal, supportive and hilarious friend to many in the fungal community, an inspiring mentor to innumerable junior scientists, and a loyal supporter of Fulham Football Club.

Ken was diagnosed with leukaemia. He underwent a bone marrow transplant in late 2016, but his immune system never fully recovered and he suffered a series of infections, finally succumbing on 19th March 2018. 

Ken might have left, but he leaves behind a fantastic legacy of great science, fantastic people and a wonderful medical mycology community. He was a great mentor, an incredibly loyal friend, and fantastic colleague.

http://www.bsmm.org/2018/07/19/obituary-ken-haynes/

For any outstanding strain requests or queries please contact Jane Usher at j.usher@exeter.ac.uk

Research group links

Research

Publications

Key publications | Publications by category | Publications by year

Key publications


Cairns TC, Sidhu YS, Chaudhari YK, Talbot NJ, Studholme DJ, Haynes K (2015). Construction and high-throughput phenotypic screening ofZymoseptoria tritici over-expression strains. Fungal Genet Biol, 79, 110-117. Abstract.  Author URL.
Schwarzmüller T, Ma B, Hiller E, Istel F, Tscherner M, Brunke S, Ames L, Firon A, Green B, Cabral V, et al (2014). Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes. PLoS Pathog, 10(6). Abstract.  Author URL.
Maharjan R, Nilsson S, Sung J, Haynes K, Beardmore RE, Hurst LD, Ferenci T, Gudelj I (2013). The form of a trade-off determines the response to competition. Ecology Letters, 16(10), 1267-1276. Abstract.
Armstrong-James DPH, Turnbull SA, Teo I, Stark J, Rogers NJ, Rogers TRF, Bignell E, Haynes K (2009). Impaired interferon-gamma responses, increased interleukin-17 expression, and a tumor necrosis factor-alpha transcriptional program in invasive aspergillosis. J Infect Dis, 200(8), 1341-1351. Abstract.  Author URL.
Taylor PR, Tsoni SV, Willment JA, Dennehy KM, Rosas M, Findon H, Haynes K, Steele C, Botto M, Gordon S, et al (2007). Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol, 8(1), 31-38. Abstract.  Author URL.
Kamran M, Calcagno A-M, Findon H, Bignell E, Jones MD, Warn P, Hopkins P, Denning DW, Butler G, Rogers T, et al (2004). Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence. Eukaryot Cell, 3(2), 546-552. Abstract.  Author URL.

Publications by category


Journal articles

Rodrigues CF, Vilas Boas D, Haynes K, Henriques M (2018). The MNN2 Gene Knockout Modulates the Antifungal Resistance of Biofilms of Candida glabrata. Biomolecules, 8(4). Abstract.  Author URL.
Cairns TC, Studholme DJ, Talbot NJ, Haynes K (2016). New and Improved Techniques for the Study of Pathogenic Fungi. Trends in Microbiology, 24(1), 35-50. Abstract.
Sidhu YS, Chaudhari YK, Usher J, Cairns TC, Csukai M, Haynes K (2015). A suite of Gateway® compatible ternary expression vectors for functional analysis in Zymoseptoria tritici. Fungal Genet Biol, 79, 180-185. Abstract.  Author URL.
Ho H-L, Haynes K (2015). Candida glabrata: new tools and technologies-expanding the toolkit. FEMS Yeast Res, 15(6). Abstract.  Author URL.
Marchegiani E, Sidhu Y, Haynes K, Lebrun M-H (2015). Conditional gene expression and promoter replacement in Zymoseptoria tritici using fungal nitrate reductase promoters. Fungal Genet Biol, 79, 174-179. Abstract.  Author URL.
Cairns TC, Sidhu YS, Chaudhari YK, Talbot NJ, Studholme DJ, Haynes K (2015). Construction and high-throughput phenotypic screening ofZymoseptoria tritici over-expression strains. Fungal Genet Biol, 79, 110-117. Abstract.  Author URL.
Sidhu YS, Cairns TC, Chaudhari YK, Usher J, Talbot NJ, Studholme DJ, Csukai M, Haynes K (2015). Exploitation of sulfonylurea resistance marker and non-homologous end joining mutants for functional analysis in Zymoseptoria tritici. Fungal Genet Biol, 79, 102-109. Abstract.  Author URL.
Komalapriya C, Kaloriti D, Tillmann AT, Yin Z, Herrero-de-Dios C, Jacobsen MD, Belmonte RC, Cameron G, Haynes K, Grebogi C, et al (2015). Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans. PLoS One, 10(9). Abstract.  Author URL.
Usher J, Thomas G, Haynes K (2015). Utilising established SDL-screening methods as a tool for the functional genomic characterisation of model and non-model organisms. FEMS Yeast Res, 15(8). Abstract.  Author URL.
Usher J, Thomas G, Haynes K (2015). Utilising established SDL-screening methods as a tool for the functional genomic characterisation of modeland non-model organisms. FEMS Yeast Research, 15(8). Abstract.
Barnes RA, Gow NAR, Denning DW, May RC, Haynes K (2014). Antifungal resistance: More research needed. The Lancet, 384(9952).
Holland LM, Schröder MS, Turner SA, Taff H, Andes D, Grózer Z, Gácser A, Ames L, Haynes K, Higgins DG, et al (2014). Comparative phenotypic analysis of the major fungal pathogens Candida parapsilosis and Candida albicans. PLoS Pathog, 10(9). Abstract.  Author URL.
Kasper L, Seider K, Gerwien F, Allert S, Brunke S, Schwarzmüller T, Ames L, Zubiria-Barrera C, Mansour MK, Becken U, et al (2014). Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages. PLoS One, 9(5). Abstract.  Author URL.  Full text.
Kaloriti D, Jacobsen M, Yin Z, Patterson M, Tillmann A, Smith DA, Cook E, you T, Grimm MJ, Bohovych I, et al (2014). Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes. MBio, 5(4), e01334-e01314. Abstract.  Author URL.
Schwarzmüller T, Ma B, Hiller E, Istel F, Tscherner M, Brunke S, Ames L, Firon A, Green B, Cabral V, et al (2014). Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes. PLoS Pathog, 10(6). Abstract.  Author URL.
Ke R, Ingram PJ, Haynes K (2013). An integrative model of ion regulation in yeast. PLoS Comput Biol, 9(1). Abstract.  Author URL.
West L, Lowman DW, Mora-Montes HM, Grubb S, Murdoch C, Thornhill MH, Gow NAR, Williams D, Haynes K (2013). Differential virulence of Candida glabrata glycosylation mutants. J Biol Chem, 288(30), 22006-22018. Abstract.  Author URL.  Full text.
Ke R, Haynes K, Stark J (2013). Modelling the activation of alkaline pH response transcription factor PacC in Aspergillus nidulans: involvement of a negative feedback loop. J Theor Biol, 326, 11-20. Abstract.  Author URL.
Maharjan R, Nilsson S, Sung J, Haynes K, Beardmore RE, Hurst LD, Ferenci T, Gudelj I (2013). The form of a trade-off determines the response to competition. Ecology Letters, 16(10), 1267-1276. Abstract.
You T, Ingram P, Jacobsen MD, Cook E, McDonagh A, Thorne T, Lenardon MD, de Moura APS, Romano MC, Thiel M, et al (2012). A systems biology analysis of long and short-term memories of osmotic stress adaptation in fungi. BMC Res Notes, 5 Abstract.  Author URL.
Kaloriti D, Tillmann A, Cook E, Jacobsen M, you T, Lenardon M, Ames L, Barahona M, Chandrasekaran K, Coghill G, et al (2012). Combinatorial stresses kill pathogenic Candida species. Med Mycol, 50(7), 699-709. Abstract.  Author URL.
Kaloriti D, Tillmann A, Jacobsen M, Yin Z, Patterson M, Radmaneshfar E, you T, Chandrasekaran K, Pang W, Coghill G, et al (2012). Impact of combinatorial stresses upon Candida albicans. MYCOSES, 55, 15-15. Author URL.
Haynes K (2011). Emerging fungal pathogens. Microbiology Today, 38(1), 26-29.
Lowman DW, West LJ, Bearden DW, Wempe MF, Power TD, Ensley HE, Haynes K, Williams DL, Kruppa MD (2011). New insights into the structure of (1→3,1→6)-β-D-glucan side chains in the Candida glabrata cell wall. PLoS One, 6(11). Abstract.  Author URL.
Thorne TW, Ho H-L, Huvet M, Haynes K, Stumpf MPH (2011). Prediction of putative protein interactions through evolutionary analysis of osmotic stress response in the model yeast Saccharomyces cerevisae. Fungal Genet Biol, 48(5), 504-511. Abstract.  Author URL.
Murray DB, Haynes K, Tomita M (2011). Redox regulation in respiring Saccharomyces cerevisiae. Biochimica et Biophysica Acta - General Subjects, 1810(10), 945-958. Abstract.
Stead DA, Walker J, Holcombe L, Gibbs SRS, Yin Z, Selway L, Butler G, Brown AJP, Haynes K (2010). Impact of the transcriptional regulator, Ace2, on the Candida glabrata secretome. Proteomics, 10(2), 212-223. Abstract.  Author URL.
Armstrong-James DPH, Turnbull SA, Teo I, Stark J, Rogers NJ, Rogers TRF, Bignell E, Haynes K (2009). Impaired interferon-gamma responses, increased interleukin-17 expression, and a tumor necrosis factor-alpha transcriptional program in invasive aspergillosis. J Infect Dis, 200(8), 1341-1351. Abstract.  Author URL.
Brown AJP, Haynes K, Quinn J (2009). Nitrosative and oxidative stress responses in fungal pathogenicity. Curr Opin Microbiol, 12(4), 384-391. Abstract.  Author URL.
Sasse C, Bignell EM, Hasenberg M, Haynes K, Gunzer M, Braus GH, Krappmann S (2008). Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis. Fungal Genet Biol, 45(5), 693-704. Abstract.  Author URL.
Findon H, Haynes K (2008). Chapter 7 Ace2 and fungal virulence. British Mycological Society Symposia Series, 27(C), 97-107. Abstract.
McDonagh A, Fedorova ND, Crabtree J, Yu Y, Kim S, Chen D, Loss O, Cairns T, Goldman G, Armstrong-James D, et al (2008). Sub-telomere directed gene expression during initiation of invasive aspergillosis. PLoS Pathog, 4(9). Abstract.  Author URL.  Full text.
Lilic D, Haynes K (2007). Candida. , 361-382. Abstract.
Taylor PR, Tsoni SV, Willment JA, Dennehy KM, Rosas M, Findon H, Haynes K, Steele C, Botto M, Gordon S, et al (2007). Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol, 8(1), 31-38. Abstract.  Author URL.
Schrettl M, Bignell E, Kragl C, Sabiha Y, Loss O, Eisendle M, Wallner A, Arst HN, Haynes K, Haas H, et al (2007). Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. PLoS Pathog, 3(9), 1195-1207. Abstract.  Author URL.
Eckert SE, Heinz WJ, Zakikhany K, Thewes S, Haynes K, Hube B, Mühlschlegel FA (2007). PGA4, a GAS homologue from Candida albicans, is up-regulated early in infection processes. Fungal Genet Biol, 44(5), 368-377. Abstract.  Author URL.
MacCallum DM, Findon H, Kenny CC, Butler G, Haynes K, Odds FC (2006). Different consequences of ACE2 and SWI5 gene disruptions for virulence of pathogenic and nonpathogenic yeasts. Infect Immun, 74(9), 5244-5248. Abstract.  Author URL.
Calcagno A-M, Bignell E, Rogers TR, Jones MD, Mühlschlegel FA, Haynes K (2005). Candida glabrata Ste11 is involved in adaptation to hypertonic stress, maintenance of wild-type levels of filamentation and plays a role in virulence. Med Mycol, 43(4), 355-364. Abstract.  Author URL.
Klengel T, Liang W-J, Chaloupka J, Ruoff C, Schröppel K, Naglik JR, Eckert SE, Mogensen EG, Haynes K, Tuite MF, et al (2005). Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence. Curr Biol, 15(22), 2021-2026. Abstract.  Author URL.
Sheth CC, Johnson E, Baker ME, Haynes K, Mühlschlegel FA (2005). Phenotypic identification of Candida albicans by growth on chocolate agar. Med Mycol, 43(8), 735-738. Abstract.  Author URL.
Stead D, Findon H, Yin Z, Walker J, Selway L, Cash P, Dujon BA, Hennequin C, Brown AJP, Haynes K, et al (2005). Proteomic changes associated with inactivation of the Candida glabrata ACE2 virulence-moderating gene. Proteomics, 5(7), 1838-1848. Abstract.  Author URL.
Bignell E, Negrete-Urtasun S, Calcagno AM, Haynes K, Arst HN, Rogers T (2005). The Aspergillus pH-responsive transcription factor PacC regulates virulence. Mol Microbiol, 55(4), 1072-1084. Abstract.  Author URL.
Bignell E, Negrete-Urtasun S, Calcagno AM, Arst HN, Rogers T, Haynes K (2005). Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice. Infect Immun, 73(8), 5204-5207. Abstract.  Author URL.
Calcagno A-M, Bignell E, Rogers TR, Canedo M, Mühlschlegel FA, Haynes K (2004). Candida glabrata Ste20 is involved in maintaining cell wall integrity and adaptation to hypertonic stress, and is required for wild-type levels of virulence. Yeast, 21(7), 557-568. Abstract.  Author URL.
Haynes K (2004). Host-microbe interactions: Fungi. Current Opinion in Microbiology, 7(4), 321-323.
Kamran M, Calcagno A-M, Findon H, Bignell E, Jones MD, Warn P, Hopkins P, Denning DW, Butler G, Rogers T, et al (2004). Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence. Eukaryot Cell, 3(2), 546-552. Abstract.  Author URL.
Schrettl M, Bignell E, Kragl C, Joechl C, Rogers T, Arst HN, Haynes K, Haas H (2004). Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence. J Exp Med, 200(9), 1213-1219. Abstract.  Author URL.
Krappmann S, Bignell EM, Reichard U, Rogers T, Haynes K, Braus GH (2004). The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen. Mol Microbiol, 52(3), 785-799. Abstract.  Author URL.
Calcagno A-M, Bignell E, Warn P, Jones MD, Denning DW, Mühlschlegel FA, Rogers TR, Haynes K (2003). Candida glabrata STE12 is required for wild-type levels of virulence and nitrogen starvation induced filamentation. Mol Microbiol, 50(4), 1309-1318. Abstract.  Author URL.
Weig M, Haynes K, Rogers TR, Kurzai O, Frosch M, Mühlschlegel FA (2001). A GAS-like gene family in the pathogenic fungus Candida glabrata. Microbiology, 147(Pt 8), 2007-2019. Abstract.  Author URL.
Haynes K (2001). Virulence in Candida species. Trends Microbiol, 9(12), 591-596. Abstract.  Author URL.
Csank C, Haynes K (2000). Candida glabrata displays pseudohyphal growth. FEMS Microbiol Lett, 189(1), 115-120. Abstract.  Author URL.
El Barkani A, Haynes K, Mösch H, Frosch M, Mühlschlegel FA (2000). Candida glabrata shuttle vectors suitable for translational fusions to lacZ and use of beta-galactosidase as a reporter of gene expression. Gene, 246(1-2), 151-155. Abstract.  Author URL.
Barnes RA, Rogers TR, Pittet D, Burnie J, Haynes KA (1999). Nosocomial fungal infection: diagnosis and typing. J Hosp Infect, 43 Suppl, S215-S218. Author URL.
Gilfillan GD, Sullivan DJ, Haynes K, Parkinson T, Coleman DC, Gow NA (1998). Candida dubliniensis: phylogeny and putative virulence factors. Microbiology, 144 ( Pt 4), 829-838. Abstract.  Author URL.
Coleman DC, Rinaldi MG, Haynes KA, Rex JH, Summerbell RC, Anaissie EJ, Li A, Sullivan DJ (1998). Importance of Candida species other than Candida albicans as opportunistic pathogens. Journal of Medical and Veterinary Mycology, 3, 156-165. Abstract.
Coleman DC, Rinaldi MG, Haynes KA, Rex JH, Summerbell RC, Anaissie EJ, Li A, Sullivan DJ (1998). Importance of Candida species other than Candida albicans as opportunistic pathogens. Med Mycol, 36 Suppl 1, 156-165. Abstract.  Author URL.
Coleman D, Sullivan D, Harrington B, Haynes K, Henman M, Shanley D, Bennett D, Moran G, McCreary C, O'Neill L, et al (1997). Molecular and phenotypic analysis of Candida dubliniensis: a recently identified species linked with oral candidosis in HIV-infected and AIDS patients. Oral Dis, 3 Suppl 1, S96-101. Abstract.  Author URL.
Sullivan D, Haynes K, Bille J, Boerlin P, Rodero L, Lloyd S, Henman M, Coleman D (1997). Widespread geographic distribution of oral Candida dubliniensis strains in human immunodeficiency virus-infected individuals. J Clin Microbiol, 35(4), 960-964. Abstract.  Author URL.
Haynes KA, Rogers TR (1996). Clinical perspectives and diagnosis of invasive aspergillosis. Revista Iberoamericana de Micologia, 13(SUPPL. 1). Abstract.
Sullivan D, Haynes K, Moran G, Shanley D, Coleman D (1996). Persistence, replacement, and microevolution of Cryptococcus neoformans strains in recurrent meningitis in AIDS patients. J Clin Microbiol, 34(7), 1739-1744. Abstract.  Author URL.
Haynes KA, Tuinstra P, Hughes TA, Wijnands LM, Rogers TR, Allen AK (1996). Purification and characterization of a 93 kDa Aspergillus fumigatus antigen with diagnostic potential. Medical Mycology, 34(6), 421-426. Abstract.
Haynes KA, Tuinstra P, Hughes TA, Wijnands LM, Rogers TR, Allen AK (1996). Purification and characterization of a 93 kDa Aspergillus fumigatus antigen with diagnostic potential. J Med Vet Mycol, 34(6), 421-426. Abstract.  Author URL.
Haynes KA, Westerneng TJ (1996). Rapid identification of Candida albicans, C. glabrata, C. parapsilosis and C. krusei by species-specific PCR of large subunit ribosomal DNA. J Med Microbiol, 44(5), 390-396. Abstract.  Author URL.
Sullivan DJ, Westerneng TJ, Haynes KA, Bennett DE, Coleman DC (1995). Candida dubliniensis sp. nov.: phenotypic and molecular characterization of a novel species associated with oral candidosis in HIV-infected individuals. Microbiology, 141 ( Pt 7), 1507-1521. Abstract.  Author URL.
Haynes KA, Sullivan DJ, Coleman DC, Clarke JC, Emilianus R, Atkinson C, Cann KJ (1995). Involvement of multiple Cryptococcus neoformans strains in a single episode of cryptococcosis and reinfection with novel strains in recurrent infection demonstrated by random amplification of polymorphic DNA and DNA fingerprinting. J Clin Microbiol, 33(1), 99-102. Abstract.  Author URL.
Haynes KA, Westerneng TJ, Fell JW, Moens W (1995). Rapid detection and identification of pathogenic fungi by polymerase chain reaction amplification of large subunit ribosomal DNA. Medical Mycology, 33(5), 319-325. Abstract.
Haynes KA, Westerneng TJ, Fell JW, Moens W (1995). Rapid detection and identification of pathogenic fungi by polymerase chain reaction amplification of large subunit ribosomal DNA. J Med Vet Mycol, 33(5), 319-325. Abstract.  Author URL.
HAYNES K, WESTERNENG T (1995). SIMULTANEOUS EXTRACTION OF HIGH-QUALITY DNA AND RNA FROM MICROSPORUM-CANIS. MICROBIOLOGY-UK, 141, 247-248. Author URL.
Haynes K, Rogers TR (1994). Retrospective evaluation of a latex agglutination test for diagnosis of invasive aspergillosis in immunocompromised patients. Eur J Clin Microbiol Infect Dis, 13(8), 670-674. Abstract.  Author URL.
Haynes KA, Rogers TR, Latge JP, Barnes RA (1992). Antigen detection in invasive aspergillosis. Clin Microbiol Rev, 5(2). Author URL.
Hyatt DS, Young YM, Haynes KA, Taylor JM, McCarthy DM, Rogers TR (1992). Rhinocerebral mucormycosis following bone marrow transplantation. J Infect, 24(1), 67-71. Abstract.  Author URL.
Latgé JP, Moutaouakil M, Debeaupuis JP, Bouchara JP, Haynes K, Prévost MC (1991). The 18-kilodalton antigen secreted by Aspergillus fumigatus. Infect Immun, 59(8), 2586-2594. Abstract.  Author URL.
Haynes KA, Latge JP, Rogers TR (1990). Detection of Aspergillus antigens associated with invasive infection. J Clin Microbiol, 28(9), 2040-2044. Abstract.  Author URL.
Rogers TR, Haynes KA, Barnes RA (1990). Value of antigen detection in predicting invasive pulmonary aspergillosis. Lancet, 336(8725), 1210-1213. Abstract.  Author URL.

Conferences

Ho H-L, Chaudhari Y, O'Neill P, Haynes K (2015). Gain-of-function overexpression screens to identify genes important for C. glabrata stress adaptation.  Author URL.
Ames L, Cromie G, Jeffery E, Dudley A, Haynes K (2015). Investigating novel factors underlying oxidative stress resistance in the pathogenic yeast Candida glabrata.  Author URL.

Publications by year


2018

Rodrigues CF, Vilas Boas D, Haynes K, Henriques M (2018). The MNN2 Gene Knockout Modulates the Antifungal Resistance of Biofilms of Candida glabrata. Biomolecules, 8(4). Abstract.  Author URL.

2016

Cairns TC, Studholme DJ, Talbot NJ, Haynes K (2016). New and Improved Techniques for the Study of Pathogenic Fungi. Trends in Microbiology, 24(1), 35-50. Abstract.

2015

Sidhu YS, Chaudhari YK, Usher J, Cairns TC, Csukai M, Haynes K (2015). A suite of Gateway® compatible ternary expression vectors for functional analysis in Zymoseptoria tritici. Fungal Genet Biol, 79, 180-185. Abstract.  Author URL.
Ho H-L, Haynes K (2015). Candida glabrata: new tools and technologies-expanding the toolkit. FEMS Yeast Res, 15(6). Abstract.  Author URL.
Marchegiani E, Sidhu Y, Haynes K, Lebrun M-H (2015). Conditional gene expression and promoter replacement in Zymoseptoria tritici using fungal nitrate reductase promoters. Fungal Genet Biol, 79, 174-179. Abstract.  Author URL.
Cairns TC, Sidhu YS, Chaudhari YK, Talbot NJ, Studholme DJ, Haynes K (2015). Construction and high-throughput phenotypic screening ofZymoseptoria tritici over-expression strains. Fungal Genet Biol, 79, 110-117. Abstract.  Author URL.
Sidhu YS, Cairns TC, Chaudhari YK, Usher J, Talbot NJ, Studholme DJ, Csukai M, Haynes K (2015). Exploitation of sulfonylurea resistance marker and non-homologous end joining mutants for functional analysis in Zymoseptoria tritici. Fungal Genet Biol, 79, 102-109. Abstract.  Author URL.
Ho H-L, Chaudhari Y, O'Neill P, Haynes K (2015). Gain-of-function overexpression screens to identify genes important for C. glabrata stress adaptation.  Author URL.
Komalapriya C, Kaloriti D, Tillmann AT, Yin Z, Herrero-de-Dios C, Jacobsen MD, Belmonte RC, Cameron G, Haynes K, Grebogi C, et al (2015). Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans. PLoS One, 10(9). Abstract.  Author URL.
Ames L, Cromie G, Jeffery E, Dudley A, Haynes K (2015). Investigating novel factors underlying oxidative stress resistance in the pathogenic yeast Candida glabrata.  Author URL.
Usher J, Thomas G, Haynes K (2015). Utilising established SDL-screening methods as a tool for the functional genomic characterisation of model and non-model organisms. FEMS Yeast Res, 15(8). Abstract.  Author URL.
Usher J, Thomas G, Haynes K (2015). Utilising established SDL-screening methods as a tool for the functional genomic characterisation of modeland non-model organisms. FEMS Yeast Research, 15(8). Abstract.

2014

Barnes RA, Gow NAR, Denning DW, May RC, Haynes K (2014). Antifungal resistance: More research needed. The Lancet, 384(9952).
Holland LM, Schröder MS, Turner SA, Taff H, Andes D, Grózer Z, Gácser A, Ames L, Haynes K, Higgins DG, et al (2014). Comparative phenotypic analysis of the major fungal pathogens Candida parapsilosis and Candida albicans. PLoS Pathog, 10(9). Abstract.  Author URL.
Kasper L, Seider K, Gerwien F, Allert S, Brunke S, Schwarzmüller T, Ames L, Zubiria-Barrera C, Mansour MK, Becken U, et al (2014). Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages. PLoS One, 9(5). Abstract.  Author URL.  Full text.
Kaloriti D, Jacobsen M, Yin Z, Patterson M, Tillmann A, Smith DA, Cook E, you T, Grimm MJ, Bohovych I, et al (2014). Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes. MBio, 5(4), e01334-e01314. Abstract.  Author URL.
Schwarzmüller T, Ma B, Hiller E, Istel F, Tscherner M, Brunke S, Ames L, Firon A, Green B, Cabral V, et al (2014). Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes. PLoS Pathog, 10(6). Abstract.  Author URL.

2013

Ke R, Ingram PJ, Haynes K (2013). An integrative model of ion regulation in yeast. PLoS Comput Biol, 9(1). Abstract.  Author URL.
West L, Lowman DW, Mora-Montes HM, Grubb S, Murdoch C, Thornhill MH, Gow NAR, Williams D, Haynes K (2013). Differential virulence of Candida glabrata glycosylation mutants. J Biol Chem, 288(30), 22006-22018. Abstract.  Author URL.  Full text.
Ke R, Haynes K, Stark J (2013). Modelling the activation of alkaline pH response transcription factor PacC in Aspergillus nidulans: involvement of a negative feedback loop. J Theor Biol, 326, 11-20. Abstract.  Author URL.
Maharjan R, Nilsson S, Sung J, Haynes K, Beardmore RE, Hurst LD, Ferenci T, Gudelj I (2013). The form of a trade-off determines the response to competition. Ecology Letters, 16(10), 1267-1276. Abstract.

2012

You T, Ingram P, Jacobsen MD, Cook E, McDonagh A, Thorne T, Lenardon MD, de Moura APS, Romano MC, Thiel M, et al (2012). A systems biology analysis of long and short-term memories of osmotic stress adaptation in fungi. BMC Res Notes, 5 Abstract.  Author URL.
Kaloriti D, Tillmann A, Cook E, Jacobsen M, you T, Lenardon M, Ames L, Barahona M, Chandrasekaran K, Coghill G, et al (2012). Combinatorial stresses kill pathogenic Candida species. Med Mycol, 50(7), 699-709. Abstract.  Author URL.
Kaloriti D, Tillmann A, Jacobsen M, Yin Z, Patterson M, Radmaneshfar E, you T, Chandrasekaran K, Pang W, Coghill G, et al (2012). Impact of combinatorial stresses upon Candida albicans. MYCOSES, 55, 15-15. Author URL.

2011

Haynes K (2011). Emerging fungal pathogens. Microbiology Today, 38(1), 26-29.
Lowman DW, West LJ, Bearden DW, Wempe MF, Power TD, Ensley HE, Haynes K, Williams DL, Kruppa MD (2011). New insights into the structure of (1→3,1→6)-β-D-glucan side chains in the Candida glabrata cell wall. PLoS One, 6(11). Abstract.  Author URL.
Thorne TW, Ho H-L, Huvet M, Haynes K, Stumpf MPH (2011). Prediction of putative protein interactions through evolutionary analysis of osmotic stress response in the model yeast Saccharomyces cerevisae. Fungal Genet Biol, 48(5), 504-511. Abstract.  Author URL.
Murray DB, Haynes K, Tomita M (2011). Redox regulation in respiring Saccharomyces cerevisiae. Biochimica et Biophysica Acta - General Subjects, 1810(10), 945-958. Abstract.

2010

Stead DA, Walker J, Holcombe L, Gibbs SRS, Yin Z, Selway L, Butler G, Brown AJP, Haynes K (2010). Impact of the transcriptional regulator, Ace2, on the Candida glabrata secretome. Proteomics, 10(2), 212-223. Abstract.  Author URL.

2009

Armstrong-James DPH, Turnbull SA, Teo I, Stark J, Rogers NJ, Rogers TRF, Bignell E, Haynes K (2009). Impaired interferon-gamma responses, increased interleukin-17 expression, and a tumor necrosis factor-alpha transcriptional program in invasive aspergillosis. J Infect Dis, 200(8), 1341-1351. Abstract.  Author URL.
Brown AJP, Haynes K, Quinn J (2009). Nitrosative and oxidative stress responses in fungal pathogenicity. Curr Opin Microbiol, 12(4), 384-391. Abstract.  Author URL.

2008

Sasse C, Bignell EM, Hasenberg M, Haynes K, Gunzer M, Braus GH, Krappmann S (2008). Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis. Fungal Genet Biol, 45(5), 693-704. Abstract.  Author URL.
Findon H, Haynes K (2008). Chapter 7 Ace2 and fungal virulence. British Mycological Society Symposia Series, 27(C), 97-107. Abstract.
McDonagh A, Fedorova ND, Crabtree J, Yu Y, Kim S, Chen D, Loss O, Cairns T, Goldman G, Armstrong-James D, et al (2008). Sub-telomere directed gene expression during initiation of invasive aspergillosis. PLoS Pathog, 4(9). Abstract.  Author URL.  Full text.

2007

Lilic D, Haynes K (2007). Candida. , 361-382. Abstract.
Taylor PR, Tsoni SV, Willment JA, Dennehy KM, Rosas M, Findon H, Haynes K, Steele C, Botto M, Gordon S, et al (2007). Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol, 8(1), 31-38. Abstract.  Author URL.
Schrettl M, Bignell E, Kragl C, Sabiha Y, Loss O, Eisendle M, Wallner A, Arst HN, Haynes K, Haas H, et al (2007). Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. PLoS Pathog, 3(9), 1195-1207. Abstract.  Author URL.
Eckert SE, Heinz WJ, Zakikhany K, Thewes S, Haynes K, Hube B, Mühlschlegel FA (2007). PGA4, a GAS homologue from Candida albicans, is up-regulated early in infection processes. Fungal Genet Biol, 44(5), 368-377. Abstract.  Author URL.

2006

MacCallum DM, Findon H, Kenny CC, Butler G, Haynes K, Odds FC (2006). Different consequences of ACE2 and SWI5 gene disruptions for virulence of pathogenic and nonpathogenic yeasts. Infect Immun, 74(9), 5244-5248. Abstract.  Author URL.

2005

Calcagno A-M, Bignell E, Rogers TR, Jones MD, Mühlschlegel FA, Haynes K (2005). Candida glabrata Ste11 is involved in adaptation to hypertonic stress, maintenance of wild-type levels of filamentation and plays a role in virulence. Med Mycol, 43(4), 355-364. Abstract.  Author URL.
Klengel T, Liang W-J, Chaloupka J, Ruoff C, Schröppel K, Naglik JR, Eckert SE, Mogensen EG, Haynes K, Tuite MF, et al (2005). Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence. Curr Biol, 15(22), 2021-2026. Abstract.  Author URL.
Sheth CC, Johnson E, Baker ME, Haynes K, Mühlschlegel FA (2005). Phenotypic identification of Candida albicans by growth on chocolate agar. Med Mycol, 43(8), 735-738. Abstract.  Author URL.
Stead D, Findon H, Yin Z, Walker J, Selway L, Cash P, Dujon BA, Hennequin C, Brown AJP, Haynes K, et al (2005). Proteomic changes associated with inactivation of the Candida glabrata ACE2 virulence-moderating gene. Proteomics, 5(7), 1838-1848. Abstract.  Author URL.
Bignell E, Negrete-Urtasun S, Calcagno AM, Haynes K, Arst HN, Rogers T (2005). The Aspergillus pH-responsive transcription factor PacC regulates virulence. Mol Microbiol, 55(4), 1072-1084. Abstract.  Author URL.
Bignell E, Negrete-Urtasun S, Calcagno AM, Arst HN, Rogers T, Haynes K (2005). Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice. Infect Immun, 73(8), 5204-5207. Abstract.  Author URL.

2004

Calcagno A-M, Bignell E, Rogers TR, Canedo M, Mühlschlegel FA, Haynes K (2004). Candida glabrata Ste20 is involved in maintaining cell wall integrity and adaptation to hypertonic stress, and is required for wild-type levels of virulence. Yeast, 21(7), 557-568. Abstract.  Author URL.
Haynes K (2004). Host-microbe interactions: Fungi. Current Opinion in Microbiology, 7(4), 321-323.
Kamran M, Calcagno A-M, Findon H, Bignell E, Jones MD, Warn P, Hopkins P, Denning DW, Butler G, Rogers T, et al (2004). Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence. Eukaryot Cell, 3(2), 546-552. Abstract.  Author URL.
Schrettl M, Bignell E, Kragl C, Joechl C, Rogers T, Arst HN, Haynes K, Haas H (2004). Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence. J Exp Med, 200(9), 1213-1219. Abstract.  Author URL.
Krappmann S, Bignell EM, Reichard U, Rogers T, Haynes K, Braus GH (2004). The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen. Mol Microbiol, 52(3), 785-799. Abstract.  Author URL.

2003

Calcagno A-M, Bignell E, Warn P, Jones MD, Denning DW, Mühlschlegel FA, Rogers TR, Haynes K (2003). Candida glabrata STE12 is required for wild-type levels of virulence and nitrogen starvation induced filamentation. Mol Microbiol, 50(4), 1309-1318. Abstract.  Author URL.

2001

Weig M, Haynes K, Rogers TR, Kurzai O, Frosch M, Mühlschlegel FA (2001). A GAS-like gene family in the pathogenic fungus Candida glabrata. Microbiology, 147(Pt 8), 2007-2019. Abstract.  Author URL.
Haynes K (2001). Virulence in Candida species. Trends Microbiol, 9(12), 591-596. Abstract.  Author URL.

2000

Csank C, Haynes K (2000). Candida glabrata displays pseudohyphal growth. FEMS Microbiol Lett, 189(1), 115-120. Abstract.  Author URL.
El Barkani A, Haynes K, Mösch H, Frosch M, Mühlschlegel FA (2000). Candida glabrata shuttle vectors suitable for translational fusions to lacZ and use of beta-galactosidase as a reporter of gene expression. Gene, 246(1-2), 151-155. Abstract.  Author URL.

1999

Barnes RA, Rogers TR, Pittet D, Burnie J, Haynes KA (1999). Nosocomial fungal infection: diagnosis and typing. J Hosp Infect, 43 Suppl, S215-S218. Author URL.

1998

Gilfillan GD, Sullivan DJ, Haynes K, Parkinson T, Coleman DC, Gow NA (1998). Candida dubliniensis: phylogeny and putative virulence factors. Microbiology, 144 ( Pt 4), 829-838. Abstract.  Author URL.
Coleman DC, Rinaldi MG, Haynes KA, Rex JH, Summerbell RC, Anaissie EJ, Li A, Sullivan DJ (1998). Importance of Candida species other than Candida albicans as opportunistic pathogens. Journal of Medical and Veterinary Mycology, 3, 156-165. Abstract.
Coleman DC, Rinaldi MG, Haynes KA, Rex JH, Summerbell RC, Anaissie EJ, Li A, Sullivan DJ (1998). Importance of Candida species other than Candida albicans as opportunistic pathogens. Med Mycol, 36 Suppl 1, 156-165. Abstract.  Author URL.

1997

Coleman D, Sullivan D, Harrington B, Haynes K, Henman M, Shanley D, Bennett D, Moran G, McCreary C, O'Neill L, et al (1997). Molecular and phenotypic analysis of Candida dubliniensis: a recently identified species linked with oral candidosis in HIV-infected and AIDS patients. Oral Dis, 3 Suppl 1, S96-101. Abstract.  Author URL.
Sullivan D, Haynes K, Bille J, Boerlin P, Rodero L, Lloyd S, Henman M, Coleman D (1997). Widespread geographic distribution of oral Candida dubliniensis strains in human immunodeficiency virus-infected individuals. J Clin Microbiol, 35(4), 960-964. Abstract.  Author URL.

1996

Haynes KA, Rogers TR (1996). Clinical perspectives and diagnosis of invasive aspergillosis. Revista Iberoamericana de Micologia, 13(SUPPL. 1). Abstract.
Sullivan D, Haynes K, Moran G, Shanley D, Coleman D (1996). Persistence, replacement, and microevolution of Cryptococcus neoformans strains in recurrent meningitis in AIDS patients. J Clin Microbiol, 34(7), 1739-1744. Abstract.  Author URL.
Haynes KA, Tuinstra P, Hughes TA, Wijnands LM, Rogers TR, Allen AK (1996). Purification and characterization of a 93 kDa Aspergillus fumigatus antigen with diagnostic potential. Medical Mycology, 34(6), 421-426. Abstract.
Haynes KA, Tuinstra P, Hughes TA, Wijnands LM, Rogers TR, Allen AK (1996). Purification and characterization of a 93 kDa Aspergillus fumigatus antigen with diagnostic potential. J Med Vet Mycol, 34(6), 421-426. Abstract.  Author URL.
Haynes KA, Westerneng TJ (1996). Rapid identification of Candida albicans, C. glabrata, C. parapsilosis and C. krusei by species-specific PCR of large subunit ribosomal DNA. J Med Microbiol, 44(5), 390-396. Abstract.  Author URL.

1995

Sullivan DJ, Westerneng TJ, Haynes KA, Bennett DE, Coleman DC (1995). Candida dubliniensis sp. nov.: phenotypic and molecular characterization of a novel species associated with oral candidosis in HIV-infected individuals. Microbiology, 141 ( Pt 7), 1507-1521. Abstract.  Author URL.
Haynes KA, Sullivan DJ, Coleman DC, Clarke JC, Emilianus R, Atkinson C, Cann KJ (1995). Involvement of multiple Cryptococcus neoformans strains in a single episode of cryptococcosis and reinfection with novel strains in recurrent infection demonstrated by random amplification of polymorphic DNA and DNA fingerprinting. J Clin Microbiol, 33(1), 99-102. Abstract.  Author URL.
Haynes KA, Westerneng TJ, Fell JW, Moens W (1995). Rapid detection and identification of pathogenic fungi by polymerase chain reaction amplification of large subunit ribosomal DNA. Medical Mycology, 33(5), 319-325. Abstract.
Haynes KA, Westerneng TJ, Fell JW, Moens W (1995). Rapid detection and identification of pathogenic fungi by polymerase chain reaction amplification of large subunit ribosomal DNA. J Med Vet Mycol, 33(5), 319-325. Abstract.  Author URL.
HAYNES K, WESTERNENG T (1995). SIMULTANEOUS EXTRACTION OF HIGH-QUALITY DNA AND RNA FROM MICROSPORUM-CANIS. MICROBIOLOGY-UK, 141, 247-248. Author URL.

1994

Haynes K, Rogers TR (1994). Retrospective evaluation of a latex agglutination test for diagnosis of invasive aspergillosis in immunocompromised patients. Eur J Clin Microbiol Infect Dis, 13(8), 670-674. Abstract.  Author URL.

1992

Haynes KA, Rogers TR, Latge JP, Barnes RA (1992). Antigen detection in invasive aspergillosis. Clin Microbiol Rev, 5(2). Author URL.
Hyatt DS, Young YM, Haynes KA, Taylor JM, McCarthy DM, Rogers TR (1992). Rhinocerebral mucormycosis following bone marrow transplantation. J Infect, 24(1), 67-71. Abstract.  Author URL.

1991

Latgé JP, Moutaouakil M, Debeaupuis JP, Bouchara JP, Haynes K, Prévost MC (1991). The 18-kilodalton antigen secreted by Aspergillus fumigatus. Infect Immun, 59(8), 2586-2594. Abstract.  Author URL.

1990

Haynes KA, Latge JP, Rogers TR (1990). Detection of Aspergillus antigens associated with invasive infection. J Clin Microbiol, 28(9), 2040-2044. Abstract.  Author URL.
Rogers TR, Haynes KA, Barnes RA (1990). Value of antigen detection in predicting invasive pulmonary aspergillosis. Lancet, 336(8725), 1210-1213. Abstract.  Author URL.

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