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Professor Mark Macnair

Professor Mark Macnair

Dean of Undergraduate Studies and Professor of Evolutionary Genetics

 3791

 Hatherly C5

 

Hatherly Building, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK

Professor Mark Macnair

Professor Mark Macnair

Overview

I am an Evolutionary Geneticist interested in the genetics of adaptation. For many years I have studied the genetics of metal tolerance in plants as a model system, in which the selective force is easy to identify and dissect. More recently I have worked on metal hyperaccumulation by plants, a fascinating phenomenon in which plants accumulate per-cent quantities of toxic metals such as nickel or zinc. I have also worked on plant speciation, particularly the evolution of edaphic endemics. I am a member of the Evolutionary Genetics research theme. My teaching has involved evolution, genetics and quantitative methods.

Qualifications

MA (Cantab)
PhD (Liverpool)

Career

2004-present Dean of Undergraduate Studies, University of Exeter
2003-2004: Dean of Faculty, Academic Partnerships, University of Exeter
1997-present Professor of Evolutionary Genetics, School of Biosciences, University of Exeter School of Biological Sciences, University of Exeter
1993-1997 Reader in Evolutionary Genetics, School of Biological Sciences, University of Exeter School of Biological Sciences, University of Exeter
1991-1996 Head of School, School of Biological Sciences, University of Exeter School of Biological Sciences, University of Exeter
1990-1993 Senior Lecturer, School of Biological Sciences, University of Exeter School of Biological Sciences, University of Exeter
1978-1990 Lecturer, School of Biological Sciences, University of Exeter School of Biological Sciences, University of Exeter
1977-1978 Temporary Lecturer, Department of Genetics, University of Liverpool
1976-1977 NERC Research Fellow, University of Liverpool

Professor Mark Macnair with a member of his research group

Professor Mark Macnair with a member of his research group

Research

Research interests

My primary research interest is into the genetics and evolution of adaptation. My model system has been metal tolerance, where some plant species have evolved the ability to grow on heavily contaminated soils. The evolutionary selective force is clear and the adaptation easy to study and dissect. Recently I have also become interested in the phenomenon of hyperaccumulation. Most plants, when exposed to metals, restrict the metal to their roots; in hyperaccumulators, the plants translocate large quantities of metal to their shoots, which can achieve concentrations of more than 5%. This poses fascinating problems - how can the plants accumulate vast quantities of toxic material? Why do they do it?

We currently have two projects, one investigating the how, and one the why. Funded by the NERC Environmental Genomics initiative, we are investigating the differences in expression between Arabidopsis halleri (a zinc hyperaccumulator) and its sister species A. petraea. We have crossed the species, and obtained a segregating F3. We are also comparing gene expression of the extreme F3 families. Any genes which are genuinely involved in accumulation should be seen in both the parents and the F3s. In the other project, also funded by NERC, we are testing the hypothesis that hyperaccumulation of zinc has evolved as a by-product of the plants searching for another metal (the so called inadvertent uptake hypothesis).

Research networks

A French group investigating the isotopic fractionation of Zinc by hyperaccumulator plants, with Anne-Marie Aucour of the Universite Claude-Bernard Lyon

Research grants

  • 2004 Royal Society
    Research visit by Prof Yan Chongling.
  • 2003 NERC
    Molecular bases of zinc tolerance and hyperaccumulation in Arabidopsis halleri.
  • 2003 NERC
    Evolution of hyperaccumulation in Arabidopsis halleri

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Logoteta B, Xu XY, Macnair MR, McGrath SP, Zhao FJ (2009). Arsenite efflux is not enhanced in the arsenate-tolerant phenotype of Holcus lanatus. New Phytol, 183(2), 340-348. Abstract.  Author URL.
Smithson A, Juillet N, Macnair MR, Gigord LDB (2008). Do rewardless orchids show a positive relationship between phenotypic diversity and reproductive success? (vol 88, pg 434, 2007). ECOLOGY, 89(6). Author URL.
Macnair MR, Dowdle J, Filatov V, Ford-Lloyd B (2007). A quantitative trait loci analysis of zinc hyperaccumulation in Arabidopsis halleri. New Phytologist, 174(3), 580-590.
Juillet, N. Macnair, M.R. Gigord, L.D.B. (2007). Do rewardless orchids show a positive relationship between phenotypic diversity and reproductive success?. Ecology, 88, 434-442.
MacNair, M.R. (2007). Life history variation in Thlaspi caerulescens. New Phytologist, 173, 6-8.
Yan, C. Macnair, M.R. Hu, J. (2007). Vertical distribution of acid-volatile sulfide and simultaneously extracted metals in mangrove sediments from the Jiulong River Estuary, Fujian, China. Environmental Science and Pollution Research, 14, 345-349.
Macnair MR, Dowdle J, Ford-Lloyd B, Smirnoff N (2006). Comparison of gene expression in segregating families identifies genes and genomic regions involved in a novel adaptation, zinc hyperaccumulation. Molecular Ecology, 15(10), 3045-3059.
Chongling, Y. Macnair, M.R. Jun, H. (2006). Distribution and speciation of some metals in mangrove sediments from Jiulong River estuary, People's Republic of China. Bulletin of Environmental Contamination and Toxicology, 76, 815-822.
Macnair, M.R. (2006). Within and between population variation for zinc and nickel accumulation in two species of Thlaspi (Brassicaceae). New Phytologist, 169, 505-514.
Taylor SI, Macnair MR (2006). Within and between population variation for zinc and nickel accumulation in two species of Thlaspi (Brassicaceae). New Phytol, 169(3), 505-513. Abstract.  Author URL.
Macnair, M.R. Meharg, A.A. Shore, R.F. (2005). The distribution of arsenic in the body tissues of wood mice and bank voles. Archives of Environmental Contamination and Toxicology, 49, 569-576.
Cresswell, J.E. Macnair, M.R. (2005). The potential for adaptive evolution of pollen grain size in Mimulus guttatus. New Phytologist, 167, 289-296.
Gigord LDB, Macnair MR, Smithson A (2004). Negative frequency-dependent selection maintains a dramatic flower color polymorphism in the rewardless orchid Dactylorhiza sambucina (L.) Soo (vol 98, pg 6253, 2001). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(20), 7839-7839. Author URL.
Macnair, M.R. Bachmann, K. (2004). QTL Mapping for a Trade-off between Leaf and Bud Production in a Recombinant Inbred Population of Microseris douglasii and M. bigelovii (Asteraceae, Lactuceae): a Potential Preadaptation for the Colonization of Serpentine Soils. Plant Biology, 6, 440-446.
Huitson, S. (2003). Does zinc protect the zinc hyperaccumulator Arabidopsis halleri from herbivory by snails?. New Phytologist, 159(2), 453-459.
Macnair, M.R. (2003). The hyperaccumulation of heavy metals by plants. Advances in Botanical Research, 40, 64-105.
Macnair MR (2003). The hyperaccumulation of metals by plants. ADVANCES IN BOTANICAL RESEARCH, VOL 40, 40, 63-105. Author URL.
Toro, I. Schnepf, D. Macnair, M.R. (2002). Copper tolerance in populations of Mimulus luteus var. variegatus exposed and non exposed to copper pollution. Geochemistry : Exploration, Environment, Analysis, 2, 151-156.
McConway, K.J. Hughes, Z. (2002). Ecological and genetic correlates of long-term population trends in the park grass experiment. American Naturalist, 160, 409-420.
Macnair, M.R. Stritesky, M. Smithson, A. (2002). The potential for floral mimicry in rewardless orchids: an experimental study. Proceedings of the Royal Society B, 269, 1389-1395.
Macnair MR (2002). Within and between population genetic variation for zinc accumulation in Arabdopsis halleri. New Phytologist, 155(1), 59-66.
Macnair, M.R. (2001). Multiple metal tolerance to nickel in Mimulus guttatus Fischer ex DC. South African Journal of Science. South African Journal of Science, 97, 539-544.
Macnair MR, Gigord LDB, Smithson A (2001). Negative frequency-dependent selection maintains a dramatic flower colour polymorphism in the rewardless orchid Dactylorhiza sambucina(L.) Soo. Proceedings of the National Academy of Sciences, 98(11), 6253-6255. Full text.
Bachmann, K. Smirnoff, N. Macnair, M.R. (2001). The role of drought tolerance in serpentine tolerance in the Mimulus guttatus Fischer ex DC. complex. South African Journal of Science, 97, 581-586.

Publications by year


2009

Logoteta B, Xu XY, Macnair MR, McGrath SP, Zhao FJ (2009). Arsenite efflux is not enhanced in the arsenate-tolerant phenotype of Holcus lanatus. New Phytol, 183(2), 340-348. Abstract.  Author URL.

2008

Smithson A, Juillet N, Macnair MR, Gigord LDB (2008). Do rewardless orchids show a positive relationship between phenotypic diversity and reproductive success? (vol 88, pg 434, 2007). ECOLOGY, 89(6). Author URL.

2007

Macnair MR, Dowdle J, Filatov V, Ford-Lloyd B (2007). A quantitative trait loci analysis of zinc hyperaccumulation in Arabidopsis halleri. New Phytologist, 174(3), 580-590.
Juillet, N. Macnair, M.R. Gigord, L.D.B. (2007). Do rewardless orchids show a positive relationship between phenotypic diversity and reproductive success?. Ecology, 88, 434-442.
MacNair, M.R. (2007). Life history variation in Thlaspi caerulescens. New Phytologist, 173, 6-8.
Yan, C. Macnair, M.R. Hu, J. (2007). Vertical distribution of acid-volatile sulfide and simultaneously extracted metals in mangrove sediments from the Jiulong River Estuary, Fujian, China. Environmental Science and Pollution Research, 14, 345-349.

2006

Macnair MR, Dowdle J, Ford-Lloyd B, Smirnoff N (2006). Comparison of gene expression in segregating families identifies genes and genomic regions involved in a novel adaptation, zinc hyperaccumulation. Molecular Ecology, 15(10), 3045-3059.
Chongling, Y. Macnair, M.R. Jun, H. (2006). Distribution and speciation of some metals in mangrove sediments from Jiulong River estuary, People's Republic of China. Bulletin of Environmental Contamination and Toxicology, 76, 815-822.
Macnair, M.R. (2006). Within and between population variation for zinc and nickel accumulation in two species of Thlaspi (Brassicaceae). New Phytologist, 169, 505-514.
Taylor SI, Macnair MR (2006). Within and between population variation for zinc and nickel accumulation in two species of Thlaspi (Brassicaceae). New Phytol, 169(3), 505-513. Abstract.  Author URL.

2005

Macnair, M.R. Meharg, A.A. Shore, R.F. (2005). The distribution of arsenic in the body tissues of wood mice and bank voles. Archives of Environmental Contamination and Toxicology, 49, 569-576.
Cresswell, J.E. Macnair, M.R. (2005). The potential for adaptive evolution of pollen grain size in Mimulus guttatus. New Phytologist, 167, 289-296.

2004

Gigord LDB, Macnair MR, Smithson A (2004). Negative frequency-dependent selection maintains a dramatic flower color polymorphism in the rewardless orchid Dactylorhiza sambucina (L.) Soo (vol 98, pg 6253, 2001). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(20), 7839-7839. Author URL.
Macnair, M.R. Bachmann, K. (2004). QTL Mapping for a Trade-off between Leaf and Bud Production in a Recombinant Inbred Population of Microseris douglasii and M. bigelovii (Asteraceae, Lactuceae): a Potential Preadaptation for the Colonization of Serpentine Soils. Plant Biology, 6, 440-446.

2003

Huitson, S. (2003). Does zinc protect the zinc hyperaccumulator Arabidopsis halleri from herbivory by snails?. New Phytologist, 159(2), 453-459.
Macnair, M.R. (2003). The hyperaccumulation of heavy metals by plants. Advances in Botanical Research, 40, 64-105.
Macnair MR (2003). The hyperaccumulation of metals by plants. ADVANCES IN BOTANICAL RESEARCH, VOL 40, 40, 63-105. Author URL.

2002

Toro, I. Schnepf, D. Macnair, M.R. (2002). Copper tolerance in populations of Mimulus luteus var. variegatus exposed and non exposed to copper pollution. Geochemistry : Exploration, Environment, Analysis, 2, 151-156.
McConway, K.J. Hughes, Z. (2002). Ecological and genetic correlates of long-term population trends in the park grass experiment. American Naturalist, 160, 409-420.
Macnair, M.R. Stritesky, M. Smithson, A. (2002). The potential for floral mimicry in rewardless orchids: an experimental study. Proceedings of the Royal Society B, 269, 1389-1395.
Macnair MR (2002). Within and between population genetic variation for zinc accumulation in Arabdopsis halleri. New Phytologist, 155(1), 59-66.

2001

Macnair, M.R. (2001). Multiple metal tolerance to nickel in Mimulus guttatus Fischer ex DC. South African Journal of Science. South African Journal of Science, 97, 539-544.
Macnair MR, Gigord LDB, Smithson A (2001). Negative frequency-dependent selection maintains a dramatic flower colour polymorphism in the rewardless orchid Dactylorhiza sambucina(L.) Soo. Proceedings of the National Academy of Sciences, 98(11), 6253-6255. Full text.
Bachmann, K. Smirnoff, N. Macnair, M.R. (2001). The role of drought tolerance in serpentine tolerance in the Mimulus guttatus Fischer ex DC. complex. South African Journal of Science, 97, 581-586.

mark_macnair Details from cache as at 2018-12-15 15:48:52

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External Engagment and Impact

Committee/panel activities

1999-03 Chair, NERC Sheffield Molecular Genetics Facility

2002-07 Member, Steering Group, NERC Environmental Genomics "


Invited lectures

2001 ESEB: invited contributor to symposium, Aarhus.

2002 American Botanical Society Congress: invited speaker.

2002 New Phytologist symposium, Philadelphia: invited speaker.

Professor Mark Macnair

Professor Mark Macnair

Teaching

I have primarily taught Genetics (particularly at level 1) and Evolution (level 2 and 3). I have also taught statistics and experimental design to levels 1, 2 and M.

Supervision / Group

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