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Dr Tetsuhiro Kudoh

Dr Tetsuhiro Kudoh

Senior Lecturer in Developmental Biology

 3473

 Geoffrey Pope 213

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Dr Tetsu Kudoh in the lab

Dr Tetsu Kudoh in the lab

Qualifications

1996 PhD Osaka University, Japan
1991 MSc Tokyo Institute of Technology, Japan
1989 BSc International Christian University, Japan

Career

2012-present Senior Lecturer in Developmental Biology, Biosciences, University of Exeter
2006-2012 Lecturer in Developmental Biology, Biosciences, University of Exeter
2001-2006 Senior Research Fellow, Anatomy and Developmental Biology, University College London
1996-2001 Postdoctoral Research Fellow, Molecular Genetics, NICHD, NIH, USA

Links

Dr Tetsu Kudoh in the aquarium

Dr Tetsu Kudoh in the aquarium

Research

Research interests

Our research group focuses on various aspects of embryogenesis - including gene functions in normal embryo development and environmental impacts on embryogenesis. We use a variety of embryo systems including zebrafish, mangrove killifish, trout, blind cavefish, pond snail and limpet.

Research projects

Current research projects in our group:
Zebrafish (Danio relio):
- Analyses of genes that regulate cell fate for brain and spinal cord in zebrafish embryos
- Mechanisms of yolk cell fusion (syncytium formation) in zebrafish embryos
- Developing transgenic zebrafish that detects chemical pollutants (e.g. estrogen, androgen, oxidative stressors)
- toxicological analysis of silver nano-particles using the zebrafish embryo

Mangrove killifish (Kryptolebias marmoratus):
- Developing the self fertilising mangrove killifish as a model for developmental biology
- Behavior studies on the mangrove killifish

Pond snail (Lymnaea stagnalis) and Limpet (Patella vulgate):
- Molecular mechanisms of shell formation

Bioinformatics:
- Generating transcriptomics database in embryos of mangrove killifish, blind cavefish, pond snail and limpet.

 

Research networks

Tetsu Kudoh’s Webpage

 

Key publications | Publications by category | Publications by year

Key publications


Lee OH, Takesono A, Tada M, Tyler CR, Kudoh T (2012). Biosensor zebrafish provide new insights into potential health effects of environmental estrogens. Environ Health Perspect, 120, 990-996. Full text.
Takesono A, Moger J, Farooq S, Cartwright E, Dawid IB, Wilson SW, Kudoh T (2012). Solute carrier family 3 member 2 (Slc3a2) controls yolk syncytial layer (YSL) formation by regulating microtubule networks in the zebrafish embryo. Proc Natl Acad Sci U S A, 109(9), 3371-3376. Abstract.  Author URL.
Mourabit S, Edenbrow M, Croft DP, Kudoh T (2011). Embryonic development of the self-fertilizing mangrove killifish Kryptolebias marmoratus. Dev Dyn, 240(7), 1694-1704. Abstract.  Author URL.
Finch E, Cruz C, Sloman KA, Kudoh T (2010). Heterochrony in the germ ring closure and tail bud formation in embryonic development of rainbow trout (Oncorhynchus mykiss). J Exp Zool B Mol Dev Evol, 314(3), 187-195. Abstract.  Author URL.
Cruz C, Maegawa S, Weinberg ES, Wilson SW, Dawid IB, Kudoh T (2010). Induction and patterning of trunk and tail neural ectoderm by a homeobox gene eve1 in the zebrafish embryo. Proc. Natl. Acad. Sci. U.S.A., 107, 3564-3569. Abstract.

Publications by category


Journal articles

Green JM, Metz J, Lee O, Trznadel M, Takesono A, Brown AR, Owen SF, Kudoh T, Tyler CR (In Press). High-Content and Semi-Automated Quantification of Responses to Estrogenic Chemicals Using a Novel Translucent Transgenic Zebrafish. Environ Sci Technol, 50(12), 6536-6545. Abstract.  Author URL.
Osborne OJ, Mukaigasa K, Nakajima H, Stolpe B, Romer I, Philips U, Lynch I, Mourabit S, Hirose S, Lead JR, et al (In Press). Sensory systems and ionocytes are targets for silver nanoparticle effects in fish. Nanotoxicology, 10(9), 1276-1286. Abstract.  Author URL.
Green JM, Lange A, Scott A, Trznadel M, Wai HA, Takesono A, Brown AR, Owen SF, Kudoh T, Tyler CR, et al (2018). Early life exposure to ethinylestradiol enhances subsequent responses to environmental estrogens measured in a novel transgenic zebrafish. Sci Rep, 8(1). Abstract.  Author URL.  Full text.
Moreman J, Takesono A, Trznadel M, Winter MJ, Perry A, Wood ME, Rogers NJ, Kudoh T, Tyler CR (2018). Estrogenic Mechanisms and Cardiac Responses Following Early Life Exposure to Bisphenol a (BPA) and its Metabolite 4-Methyl-2,4-bis( p-hydroxyphenyl)pent-1-ene (MBP) in Zebrafish. Environ Sci Technol, 52(11), 6656-6665. Abstract.  Author URL.
Moreman J, Lee O, Trznadel M, David A, Kudoh T, Tyler CR (2017). Acute Toxicity, Teratogenic, and Estrogenic Effects of Bisphenol a and its Alternative Replacements Bisphenol S, Bisphenol F, and Bisphenol AF in Zebrafish Embryo-Larvae. Environ Sci Technol, 51(21), 12796-12805. Abstract.  Author URL.
Mourabit S, Moles MW, Smith E, van Aerle R, Kudoh T (2014). Bmp suppression in mangrove killifish embryos causes a split in the body axis. PLoS One, 9(1). Abstract.  Author URL.  Full text.
Osborne OJ, Johnston BD, Moger J, Balousha M, Lead JR, Kudoh T, Tyler CR (2013). Effects of particle size and coating on nanoscale Ag and TiO₂ exposure in zebrafish (Danio rerio) embryos. Nanotoxicology, 7(8), 1315-1324. Abstract.  Author URL.
Shimizu K, Iijima M, Setiamarga DHE, Sarashina I, Kudoh T, Asami T, Gittenberger E, Endo K (2013). Left-right asymmetric expression of dpp in the mantle of gastropods correlates with asymmetric shell coiling. EvoDevo, 4(1). Abstract.  Full text.
Lee OH, Takesono A, Tada M, Tyler CR, Kudoh T (2012). Biosensor zebrafish provide new insights into potential health effects of environmental estrogens. Environ Health Perspect, 120, 990-996. Full text.
Lee O, Tyler CR, Kudoh T (2012). Development of a transient expression assay for detecting environmental oestrogens in zebrafish and medaka embryos. BMC Biotechnol, 12 Abstract.  Author URL.  Full text.
Mourabit S, Kudoh T (2012). Manipulation and imaging of Kryptolebias marmoratus embryos. Integr Comp Biol, 52(6), 761-768. Abstract.  Author URL.
Takesono A, Moger J, Farooq S, Cartwright E, Dawid IB, Wilson SW, Kudoh T (2012). Solute carrier family 3 member 2 (Slc3a2) controls yolk syncytial layer (YSL) formation by regulating microtubule networks in the zebrafish embryo. Proc Natl Acad Sci U S A, 109(9), 3371-3376. Abstract.  Author URL.
Dente L, Gestri G, Tsang M, Kudoh T, Wilson SW, Dawid IB, Andreazzoli M (2011). Cloning and developmental expression of zebrafish pdzrn3. Int. J. Dev. Biol., 55, 989-993.
Mourabit S, Edenbrow M, Croft DP, Kudoh T (2011). Embryonic development of the self-fertilizing mangrove killifish Kryptolebias marmoratus. Dev Dyn, 240(10). Abstract.
Mourabit S, Edenbrow M, Croft DP, Kudoh T (2011). Embryonic development of the self-fertilizing mangrove killifish Kryptolebias marmoratus. Dev Dyn, 240(7), 1694-1704. Abstract.  Author URL.
So J-H, Hong S-K, Kim H-T, Jung S-H, Lee M-S, Choi J-H, Bae Y-K, Kudoh T, Kim J-H, Kim C-H, et al (2010). Gicerin/Cd146 is involved in zebrafish cardiovascular development and tumor angiogenesis. Genes Cells, 15(11), 1099-1110. Abstract.  Author URL.
Finch E, Cruz C, Sloman KA, Kudoh T (2010). Heterochrony in the germ ring closure and tail bud formation in embryonic development of rainbow trout (Oncorhynchus mykiss). J Exp Zool B Mol Dev Evol, 314(3), 187-195. Abstract.  Author URL.
Cruz C, Maegawa S, Weinberg ES, Wilson SW, Dawid IB, Kudoh T (2010). Induction and patterning of trunk and tail neural ectoderm by a homeobox gene eve1 in the zebrafish embryo. Proc. Natl. Acad. Sci. U.S.A., 107, 3564-3569. Abstract.
Ghosh J, Wilson RW, Kudoh T (2009). Normal development of the tomato clownfish Amphiprion frenatus: live imaging and in situ hybridization analyses of mesodermal and neurectodermal development. J. Fish Biol., 75, 2287-2298. Abstract.
Kudoh T, Concha ML, Dawid IB, Houart C (2004). Combinatorial Fgf and Bmp signaling patterns the gastrula ectoderm into prospective neural and epidermis domains. Development, 131(15), 3581-3592.
Solomon KS, Kudoh T, Dawid IB, Fritz A (2003). Zebrafish foxi1 mediates otic placode formation and jaw development. Development, 130, 929-940.
Itoh M, Kudoh T, Dedekian M, Kim CH, Chitnis AB (2002). A role for iro1 and iro7 in the establishment of an anteroposterior compartment of the ectoderm adjacent to the midbrain-hindbrain boundary. Development, 2317-2327.
Kudoh T, Dawid IB, Wilson SW (2002). Distinct roles for Fgf, Wnt and retinoic acid in posteriorising the neural ectoderm. Development, 129(18), 4335-4346.
Tsang M, Friesel R, Kudoh T, Dawid IB (2002). Identification of Sef, a novel modulator of FGF signalling. Nat Cell Biol, 4(2), 165-169. Abstract.  Author URL.
Hong SK, Kim CH, Yoo KW, Kim HS, Kudoh T, Dawid IB, Huh TL (2002). Isolation and expression of a novel neuron-specific onecut homeobox gene in zebrafish. Mech Dev, 112, 199-202.
Kudoh T, Chen X, Hukriede NA, Tsang M (2001). A gene expression screen in zebrafish embryogenesis. Genome Research, 11(12), 1979-1987.
Kudoh T, Dawid IB (2001). Role of the iroquois3 homeobox gene in organizer formation. Proceedings of the National Academy of Sciences, 98(14), 7852-7857.
Kudoh T, Dawid IB (2001). Zebrafish mab21l2 is specifically expressed in the presumptive eye and tectum from early somitogenesis onwards. Mech Dev, 109(1), 95-98. Abstract.  Author URL.
Tsang M, Kim R, de Caestecker MP, Kudoh T, Roberts AB, Dawid IB (2000). Zebrafish nma is involved in TGFbeta family signaling. Genesis, 28(2), 47-57. Abstract.  Author URL.
Murata Y, Kudoh T, Sugiyama H, Toyoshima K, Akiyama T (1997). The Wilms tumor. suppressor gene WT1 induces G1 arrest and apoptosis in myeloblastic leukemia M1 cells. FEBS Lett., 409, 41-45.
Dobashi Y, Kudoh T, Ishidate T, Shoji M, Toyoshima K, Akiyama T (1997). The Wilms tumor protein is persistently associated with the nuclear matrix throughout the cell cycle. Mol. Cell. Biochem., 171, 121-126.
Kudoh T, Ishidate T, Nakamura T, Toyoshima K, Akiyama T (1996). Constitutive expression of the Wilms tumor suppressor gene WT1 in F9 embryonal carcinoma cells induces apoptotic cell death in response to retinoic acid. Oncogene, 13(7), 1431-1439. Abstract.
Yamagami T, Sugiyama H, Inoue K, Ogawa H, Tatekawa T, Hirata M, Kudoh T, Akiyama T, Murakami A, Maekawa T, et al (1996). Growth inhibition of human leukemic cells by WT1 (Wilms tumor gene) antisense oligodeoxynucleotides: implications for the involvement of WT1 in leukemogenesis. Blood, 87, 2878-2884.
Dobashi Y, Kudoh T, Toyoshima K, Akiyama T (1996). Persistent activation of CDK4 during neuronal differentiation of rat pheochromocytoma PC12 cells. Biochem. Biophys. Res. Commun., 221, 351-355.
Dobashi Y, Kudoh T, Matsumine A, Toyoshima K, Akiyama T (1995). Constitutive overexpression of CDK2 inhibits neuronal differentiation of rat pheochromocytoma PC12 cells. J. Biol. Chem., 23031-23037.
Kudoh T, Ishidate T, Moriyama M, Toyoshima K, Akiyama T (1995). G1 phase arrest induced by Wilms tumor protein WT1 is abrogated by cyclin/CDK complexes. Proc. Natl. Acad. Sci. USA., 92(10), 4517-4521. Abstract.

Conferences

Moreman J, Lee O, Kudoh T, Tyler CR (2012). Application of ERE-transgenic biosensor zebrafish to identify target tissues and effect mechanisms of the environmental estrogen, bisphenol A.  Author URL.
Tyler CR, Hamilton PB, Lange A, Filby AL, Soffkar M, Lee O, Takesono A, Kudoh T, Paull GC, Iguchi T, et al (2012). Health impacts of exposure to environmental oestrogens in fish.  Author URL.
Kudoh T (2012). The hermaphroditic mangrove killifish as a model for embryological studies.  Author URL.
Mourabit S, Kudoh T (2012). The mangrove killifish as a model for environmental embryology.  Author URL.

Publications by year


In Press

Green JM, Metz J, Lee O, Trznadel M, Takesono A, Brown AR, Owen SF, Kudoh T, Tyler CR (In Press). High-Content and Semi-Automated Quantification of Responses to Estrogenic Chemicals Using a Novel Translucent Transgenic Zebrafish. Environ Sci Technol, 50(12), 6536-6545. Abstract.  Author URL.
Osborne OJ, Mukaigasa K, Nakajima H, Stolpe B, Romer I, Philips U, Lynch I, Mourabit S, Hirose S, Lead JR, et al (In Press). Sensory systems and ionocytes are targets for silver nanoparticle effects in fish. Nanotoxicology, 10(9), 1276-1286. Abstract.  Author URL.

2018

Green JM, Lange A, Scott A, Trznadel M, Wai HA, Takesono A, Brown AR, Owen SF, Kudoh T, Tyler CR, et al (2018). Early life exposure to ethinylestradiol enhances subsequent responses to environmental estrogens measured in a novel transgenic zebrafish. Sci Rep, 8(1). Abstract.  Author URL.  Full text.
Moreman J, Takesono A, Trznadel M, Winter MJ, Perry A, Wood ME, Rogers NJ, Kudoh T, Tyler CR (2018). Estrogenic Mechanisms and Cardiac Responses Following Early Life Exposure to Bisphenol a (BPA) and its Metabolite 4-Methyl-2,4-bis( p-hydroxyphenyl)pent-1-ene (MBP) in Zebrafish. Environ Sci Technol, 52(11), 6656-6665. Abstract.  Author URL.

2017

Moreman J, Lee O, Trznadel M, David A, Kudoh T, Tyler CR (2017). Acute Toxicity, Teratogenic, and Estrogenic Effects of Bisphenol a and its Alternative Replacements Bisphenol S, Bisphenol F, and Bisphenol AF in Zebrafish Embryo-Larvae. Environ Sci Technol, 51(21), 12796-12805. Abstract.  Author URL.

2014

Mourabit S, Moles MW, Smith E, van Aerle R, Kudoh T (2014). Bmp suppression in mangrove killifish embryos causes a split in the body axis. PLoS One, 9(1). Abstract.  Author URL.  Full text.

2013

Osborne OJ, Johnston BD, Moger J, Balousha M, Lead JR, Kudoh T, Tyler CR (2013). Effects of particle size and coating on nanoscale Ag and TiO₂ exposure in zebrafish (Danio rerio) embryos. Nanotoxicology, 7(8), 1315-1324. Abstract.  Author URL.
Shimizu K, Iijima M, Setiamarga DHE, Sarashina I, Kudoh T, Asami T, Gittenberger E, Endo K (2013). Left-right asymmetric expression of dpp in the mantle of gastropods correlates with asymmetric shell coiling. EvoDevo, 4(1). Abstract.  Full text.

2012

Moreman J, Lee O, Kudoh T, Tyler CR (2012). Application of ERE-transgenic biosensor zebrafish to identify target tissues and effect mechanisms of the environmental estrogen, bisphenol A.  Author URL.
Lee OH, Takesono A, Tada M, Tyler CR, Kudoh T (2012). Biosensor zebrafish provide new insights into potential health effects of environmental estrogens. Environ Health Perspect, 120, 990-996. Full text.
Lee O, Tyler CR, Kudoh T (2012). Development of a transient expression assay for detecting environmental oestrogens in zebrafish and medaka embryos. BMC Biotechnol, 12 Abstract.  Author URL.  Full text.
Tyler CR, Hamilton PB, Lange A, Filby AL, Soffkar M, Lee O, Takesono A, Kudoh T, Paull GC, Iguchi T, et al (2012). Health impacts of exposure to environmental oestrogens in fish.  Author URL.
Mourabit S, Kudoh T (2012). Manipulation and imaging of Kryptolebias marmoratus embryos. Integr Comp Biol, 52(6), 761-768. Abstract.  Author URL.
Takesono A, Moger J, Farooq S, Cartwright E, Dawid IB, Wilson SW, Kudoh T (2012). Solute carrier family 3 member 2 (Slc3a2) controls yolk syncytial layer (YSL) formation by regulating microtubule networks in the zebrafish embryo. Proc Natl Acad Sci U S A, 109(9), 3371-3376. Abstract.  Author URL.
Kudoh T (2012). The hermaphroditic mangrove killifish as a model for embryological studies.  Author URL.
Mourabit S, Kudoh T (2012). The mangrove killifish as a model for environmental embryology.  Author URL.

2011

Dente L, Gestri G, Tsang M, Kudoh T, Wilson SW, Dawid IB, Andreazzoli M (2011). Cloning and developmental expression of zebrafish pdzrn3. Int. J. Dev. Biol., 55, 989-993.
Mourabit S, Edenbrow M, Croft DP, Kudoh T (2011). Embryonic development of the self-fertilizing mangrove killifish Kryptolebias marmoratus. Dev Dyn, 240(10). Abstract.
Mourabit S, Edenbrow M, Croft DP, Kudoh T (2011). Embryonic development of the self-fertilizing mangrove killifish Kryptolebias marmoratus. Dev Dyn, 240(7), 1694-1704. Abstract.  Author URL.

2010

So J-H, Hong S-K, Kim H-T, Jung S-H, Lee M-S, Choi J-H, Bae Y-K, Kudoh T, Kim J-H, Kim C-H, et al (2010). Gicerin/Cd146 is involved in zebrafish cardiovascular development and tumor angiogenesis. Genes Cells, 15(11), 1099-1110. Abstract.  Author URL.
Finch E, Cruz C, Sloman KA, Kudoh T (2010). Heterochrony in the germ ring closure and tail bud formation in embryonic development of rainbow trout (Oncorhynchus mykiss). J Exp Zool B Mol Dev Evol, 314(3), 187-195. Abstract.  Author URL.
Cruz C, Maegawa S, Weinberg ES, Wilson SW, Dawid IB, Kudoh T (2010). Induction and patterning of trunk and tail neural ectoderm by a homeobox gene eve1 in the zebrafish embryo. Proc. Natl. Acad. Sci. U.S.A., 107, 3564-3569. Abstract.

2009

Ghosh J, Wilson RW, Kudoh T (2009). Normal development of the tomato clownfish Amphiprion frenatus: live imaging and in situ hybridization analyses of mesodermal and neurectodermal development. J. Fish Biol., 75, 2287-2298. Abstract.

2004

Kudoh T, Concha ML, Dawid IB, Houart C (2004). Combinatorial Fgf and Bmp signaling patterns the gastrula ectoderm into prospective neural and epidermis domains. Development, 131(15), 3581-3592.

2003

Solomon KS, Kudoh T, Dawid IB, Fritz A (2003). Zebrafish foxi1 mediates otic placode formation and jaw development. Development, 130, 929-940.

2002

Itoh M, Kudoh T, Dedekian M, Kim CH, Chitnis AB (2002). A role for iro1 and iro7 in the establishment of an anteroposterior compartment of the ectoderm adjacent to the midbrain-hindbrain boundary. Development, 2317-2327.
Kudoh T, Dawid IB, Wilson SW (2002). Distinct roles for Fgf, Wnt and retinoic acid in posteriorising the neural ectoderm. Development, 129(18), 4335-4346.
Tsang M, Friesel R, Kudoh T, Dawid IB (2002). Identification of Sef, a novel modulator of FGF signalling. Nat Cell Biol, 4(2), 165-169. Abstract.  Author URL.
Hong SK, Kim CH, Yoo KW, Kim HS, Kudoh T, Dawid IB, Huh TL (2002). Isolation and expression of a novel neuron-specific onecut homeobox gene in zebrafish. Mech Dev, 112, 199-202.

2001

Kudoh T, Chen X, Hukriede NA, Tsang M (2001). A gene expression screen in zebrafish embryogenesis. Genome Research, 11(12), 1979-1987.
Kudoh T, Dawid IB (2001). Role of the iroquois3 homeobox gene in organizer formation. Proceedings of the National Academy of Sciences, 98(14), 7852-7857.
Kudoh T, Dawid IB (2001). Zebrafish mab21l2 is specifically expressed in the presumptive eye and tectum from early somitogenesis onwards. Mech Dev, 109(1), 95-98. Abstract.  Author URL.

2000

Tsang M, Kim R, de Caestecker MP, Kudoh T, Roberts AB, Dawid IB (2000). Zebrafish nma is involved in TGFbeta family signaling. Genesis, 28(2), 47-57. Abstract.  Author URL.

1997

Murata Y, Kudoh T, Sugiyama H, Toyoshima K, Akiyama T (1997). The Wilms tumor. suppressor gene WT1 induces G1 arrest and apoptosis in myeloblastic leukemia M1 cells. FEBS Lett., 409, 41-45.
Dobashi Y, Kudoh T, Ishidate T, Shoji M, Toyoshima K, Akiyama T (1997). The Wilms tumor protein is persistently associated with the nuclear matrix throughout the cell cycle. Mol. Cell. Biochem., 171, 121-126.

1996

Kudoh T, Ishidate T, Nakamura T, Toyoshima K, Akiyama T (1996). Constitutive expression of the Wilms tumor suppressor gene WT1 in F9 embryonal carcinoma cells induces apoptotic cell death in response to retinoic acid. Oncogene, 13(7), 1431-1439. Abstract.
Yamagami T, Sugiyama H, Inoue K, Ogawa H, Tatekawa T, Hirata M, Kudoh T, Akiyama T, Murakami A, Maekawa T, et al (1996). Growth inhibition of human leukemic cells by WT1 (Wilms tumor gene) antisense oligodeoxynucleotides: implications for the involvement of WT1 in leukemogenesis. Blood, 87, 2878-2884.
Dobashi Y, Kudoh T, Toyoshima K, Akiyama T (1996). Persistent activation of CDK4 during neuronal differentiation of rat pheochromocytoma PC12 cells. Biochem. Biophys. Res. Commun., 221, 351-355.

1995

Dobashi Y, Kudoh T, Matsumine A, Toyoshima K, Akiyama T (1995). Constitutive overexpression of CDK2 inhibits neuronal differentiation of rat pheochromocytoma PC12 cells. J. Biol. Chem., 23031-23037.
Kudoh T, Ishidate T, Moriyama M, Toyoshima K, Akiyama T (1995). G1 phase arrest induced by Wilms tumor protein WT1 is abrogated by cyclin/CDK complexes. Proc. Natl. Acad. Sci. USA., 92(10), 4517-4521. Abstract.

tetsu_kudoh Details from cache as at 2018-10-15 11:47:38

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I teach Developmental Biology. I am interested in embryology, evolution and genome biology. In my lectures, I include the latest findings in the research fields. I also aim to discuss with students about philosophical and ethical aspects of biological science that include topics for human cloning, birth control, gene therapy and genome analyses.

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