Dr Aaron Butt
Geoffrey Pope Lab 401
Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK
2013-15: Filling the target void: Identification of novel antibacterial therapeutics
- Constructing deletion or conditional mutants in genes predicted to be essential in either growth or virulence
- Determine the phenotype of these mutants in appropriate assays
- Collaborate with biochemists to solve the protein structure of novel targets and to design inhibitors as therapeutics.
2009-13: Identification and characterisation of Toxin-antitoxin systems in Burkholderia pseudomallei
The aim of this project was to identify novel Toxin-antitoxin systems in B pseudomallei, the causative agent of melioidosis and elucidate their biological role in persister cell formation and chronic persistent disease.
- Defence Science and Technology Laboratory (DSTL)