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Professor Adilia Warris

Professor (Clinical) (Deputy Centre Director MRC CMM)

 Geoffrey Pope 318

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

I am a professor in paediatric infectious diseases with a specific interest in medical mycology. I am co-director of the MRC Centre for Medical Mycology at the University of Exeter and a consultant in paediatric infectious diseases in Great Ormond Street Hospital, London.

My research profile has a strong translational focus and specific areas of interest include the host-fungus interaction in specific patient groups with an emphasis on Aspergillus species; the unique interaction of A. nidulans and the CGD host, Aspergillus infections in people with cystic fibrosis, the development of new management strategies for invasive fungal disease in children, the epidemiology of invasive fungal infections in children, and the pharmacology of antifungals in paediatrics. I chair the European Paediatric Mycology Network (EPMyN) through which post-graduate courses in Paediatric Mycology are coordinated as well as multi-center European studies to obtain a better insight in the fungal and clinical epidemiology of fungal infections in neonates and children. Current studies are focussing on the fungal and clinical epidemiology of invasive fungal diseases in neonates and children (EPMyN-EUROCANDY study) and paediatric antifungal stewardship (PASOAP study).

 

 

Qualifications

1994                MD, University of Groningen, the Netherlands

2004                PhD Medical Science, Radboud University Nijmegen, the Netherlands

2014                Fellow of the Royal College of Paediatrics and Child Health

2018                Fellow of the Academy of the European Council Medical Mycology

Career

2003                Paediatrician

2005-2012       Consultant Paediatric Infectious Diseases & Immunology, Radboud University Nijmegen, the Netherlands

2009                Visiting Research Fellow, National Institutes of Health, Bethesda, MD, US

2012-2013       Associate Professor Paediatric Infectious Diseases & Immunology, Radboud University Nijmegen, the Netherlands

2013                Clinical Reader Medical Mycology, University of Aberdeen, UK

2013-2019      Honorary Consultant Paediatric Infectious Diseases, Royal Aberdeen Children’s Hospital, UK

2015-2019      Personal Chair, University of Aberdeen, UK

2019               Consultant Paediatric Infectious Diseases, Great Ormond Street Hospital, London

Research

Research interests

My research is aimed at unravelling unique host-fungus interactions based on clinical observations.

Patients with chronic granulomatous disease (CGD), suffering from an inborn error in the function of white blood cells, have an extremely high-risk to develop invasive aspergillosis and often these infections are fatal. Invasive aspergillosis in patients with CGD is caused by 2 different Aspergillus species, Aspergillus fumigatus and Aspergillus nidulans, with the latter having a unique predilection for this specific patient group. Our studies are focussed on the molecular interaction between immune cells from CGD patients and those fungi, with the ultimate goal to find new targets to improve treatment. In addition we are researching how A. fumigatus can persist and adapt in the lungs of patients with CGD, leading to recurrent infections and the fungus becoming resistant to antifungal therapy.

Comparable studies are done with immune cells from people with cystic fibrosis (CF). Half of the people with CF will be infected with A. fumigatus in their lungs leading to exacerbation of lung disease. The pathophysiology of Aspergillus infections in people with CF is not well understood and next to the presence of the thick sticky mucus entrapping the fungal spores in the lungs of people with CF, their immune cells respond abnormally to the presence of A. fumigatus. By studying the interaction between CF immune cells and A. fumigatus we aim to increase our insight in this specific host-fungus interactions and to find new treatment modalities to preserve lung function.

Publications

Key publications | Publications by category | Publications by year

Publications by category


Books

Tenbrink T, Stell J, Galton A, Wood Z (2013). Preface.

Journal articles

Nooitgedagt JE, Warris A, Liem KDD, van t Hek L, Henriet SS (In Press). Kinkhoest bij jonge zuigelingen: een gevaarlijke ziekte met aspecifieke verschijnselen. Nederlands tijdschrift voor geneeskunde, 157 Abstract.
Warris A, Bercusson A, Armstrong-James D (2019). Aspergillus colonization and antifungal immunity in cystic fibrosis patients. Med Mycol, 57(Supplement_2), S118-S126. Abstract.  Author URL.
Akase IE, Olowoyo O, Oladele RO, Obiako RO, Warris A, Akanmu SA (2019). Cryptococcal meningitis after ART: Need for proper baseline evaluation in the era of 'Test & Treat'. Med Mycol Case Rep, 24, 58-60. Abstract.  Author URL.
Warris A, Lehrnbecher T, Roilides E, Castagnola E, Brüggemann RJM, Groll AH (2019). ESCMID-ECMM guideline: diagnosis and management of invasive aspergillosis in neonates and children. Clin Microbiol Infect, 25(9), 1096-1113. Abstract.  Author URL.
Warris A (2019). Immunopathology of Aspergillus Infections in Children with Chronic Granulomatous Disease and Cystic Fibrosis. Pediatr Infect Dis J, 38(5), e96-e98. Author URL.
Lempers VJ, Meuwese E, Mavinkurve-Groothuis AM, Henriet S, van der Sluis IM, Hanff LM, Warris A, Koch BCP, Brüggemann RJ (2019). Impact of dose adaptations following voriconazole therapeutic drug monitoring in pediatric patients. Med Mycol, 57(8), 937-943. Abstract.  Author URL.
Brown AJP, Gow NAR, Warris A, Brown GD (2019). Memory in Fungal Pathogens Promotes Immune Evasion, Colonisation, and Infection. Trends in Microbiology, 27(3), 219-230. Abstract.
Warris A, Ballou ER (2019). Oxidative responses and fungal infection biology. Seminars in Cell and Developmental Biology, 89, 34-46. Abstract.
Ballard E, Zoll J, Melchers WJG, Brown AJP, Warris A, Verweij PE (2019). Raw genome sequence data for 13 isogenic Aspergillus fumigatus strains isolated over a 2 year period from a patient with chronic granulomatous disease. Data Brief, 25 Abstract.  Author URL.
Ballard E, Weber J, Melchers WJG, Tammireddy S, Whitfield PD, Brakhage AA, Brown AJP, Verweij PE, Warris A (2019). Recreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanism. Fungal Genet Biol, 130, 98-106. Abstract.  Author URL.
Brunel SF, Willment JA, Brown GD, Devereux G, Warris A (2018). Aspergillus-induced superoxide production by cystic fibrosis phagocytes is associated with disease severity. ERS Monograph, 4(2). Abstract.
Warris A (2018). Candida auris, what do paediatricians need to know?. Archives of Disease in Childhood, 103(9), 891-894. Abstract.
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, et al (2018). Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline. Clinical Microbiology and Infection, 24, e1-e38. Abstract.
Bercusson A, Colley T, Shah A, Warris A, Armstrong-James D (2018). Ibrutinib blocks Btk-dependent NF-ĸB and NFAT responses in human macrophages during Aspergillus fumigatus phagocytosis. Blood, 132(18), 1985-1988.
Ballard E, Melchers WJG, Zoll J, Brown AJP, Verweij PE, Warris A (2018). In-host microevolution of Aspergillus fumigatus: a phenotypic and genotypic analysis. Fungal Genetics and Biology, 113, 1-13. Abstract.
Van Dijck P, Sjollema J, Cammue BP, Lagrou K, Berman J, d'Enfert C, Andes DR, Arendrup MC, Brakhage AA, Calderone R, et al (2018). Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms. Microb Cell, 5(7), 300-326. Abstract.  Author URL.
An SQ, Warris A, Turner S (2018). Microbiome characteristics of induced sputum compared to bronchial fluid and upper airway samples. Pediatric Pulmonology, 53(7), 921-928. Abstract.
Warris A (2018). Special issue: Host–fungus interactions. Journal of Fungi, 4(1).
Gow NAR, Amin T, McArdle K, Brown AJP, Brown GD, Warris A, the WTSA-MMFI Consortium (2018). Strategic Research Funding: a Success Story for Medical Mycology. Trends in Microbiology, 26(10), 811-813. Abstract.
Seyedmousavi S, van der Lee HA, Verweij PE, Warris A (2017). Absent in vitro interaction between chloroquine and antifungals against Aspergillus fumigatus. Clinical Microbiology and Infection, 23(9), 679-681.
Pana ZD, Roilides E, Warris A, Groll AH, Zaoutis T (2017). Epidemiology of Invasive Fungal Disease in Children. Journal of the Pediatric Infectious Diseases Society, 6(1), S3-S11. Abstract.
Bastiaans DET, Immohr LI, Zeinstra GG, Strik-Albers R, Pein-Hackelbusch M, van der Flier M, de Haan AFJ, Boelens JJ, Lankester AC, Burger DM, et al (2017). In vivo and in vitro palatability testing of a new paediatric formulation of valaciclovir. British Journal of Clinical Pharmacology, 83(12), 2789-2797. Abstract.
Brunel SF, Bain JM, King J, Heung LJ, Kasahara S, Hohl TM, Warris A (2017). Live imaging of antifungal activity by human primary neutrophils and monocytes in response to A. fumigatus. Journal of Visualized Experiments, 2017(122). Abstract.
Naselli A, Bishop H, Walker S, Warris A (2017). Neutropenic acute acalculous cholecystitis (AAC) in a 12-year-old boy with T-acute lymphoblastic leukemia successfully managed with conservative treatment. Pediatric Hematology and Oncology, 34(1), 24-28. Abstract.
Warris A, Lehrnbecher T (2017). Progress in the Diagnosis of Invasive Fungal Disease in Children. Current Fungal Infection Reports, 11(2), 35-44. Abstract.
King J, Pana ZD, Lehrnbecher T, Steinbach WJ, Warris A (2017). Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children. Journal of the Pediatric Infectious Diseases Society, 6(1), S12-S21. Abstract.
Calley JL, Warris A (2017). Recognition and diagnosis of invasive fungal infections in neonates. Journal of Infection, 74, S108-S113. Abstract.
Bastiaans DET, Bartels-Wilmer CM, Colbers APH, Heijens CAW, Velthoven-Graafland K, Smeets OSNM, Vink N, Harbers VEM, Warris A, Burger DM, et al (2016). A new paediatric formulation of valaciclovir: Development and bioequivalence assessment. Archives of Disease in Childhood, 101(10), 971-972.
King J, Henriet SSV, Warris A (2016). Aspergillosis in chronic granulomatous disease. Journal of Fungi, 2(2). Abstract.
King J, Brunel SF, Warris A (2016). Aspergillus infections in cystic fibrosis. Journal of Infection, 72, S50-S55. Abstract.
Tak R, Semmekrot B, Warris A, Yntema JB, Stelma F, Neeleman C (2016). Bacterial Tracheitis and Septic Shock. Pediatric Infectious Disease Journal, 35(2), 226-227.
Henriet SSV, Van De Sande WWJ, Lee MJ, Simonetti E, Momany M, Verweij PE, Rijs AJMM, Ferwerda G, Sheppard DC, De Jonge MI, et al (2016). Decreased Cell Wall Galactosaminogalactan in Aspergillus nidulans Mediates Dysregulated Inflammation in the Chronic Granulomatous Disease Host. Journal of Interferon and Cytokine Research, 36(8), 488-498. Abstract.
Toubiana J, Okada S, Hiller J, Oleastro M, Lagos Gomez M, Aldave Becerra JC, Ouachee-Chardin M, Fouyssac F, Girisha KM, Etzioni A, et al (2016). Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype. BLOOD, 127(25), 3154-3164. Author URL.
Warris A (2016). Prophylactic antibiotics should be used in children with repaired oesophageal atresia and tracheo-oesophageal fistula: the case against. Paediatric Respiratory Reviews, 18, 62-63.
Bart IY, Mourits M, van Gent R, van Leuken MH, Hilbink M, Warris A, Wever PC, de Vries E (2016). Sputum Induction in Children is Feasible and Useful in a Bustling General Hospital Practice. Glob Pediatr Health, 3 Abstract.  Author URL.
Warris A (2016). The European Paediatric Mycology Network (EPMyN): Towards a Better Understanding and Management of Fungal Infections in Children. Current Fungal Infection Reports, 10(1), 7-9. Abstract.
Agrawal S, Barnes R, Brüggemann RJ, Rautemaa-Richardson R, Warris A (2016). The role of the multidisciplinary team in antifungal stewardship. Journal of Antimicrobial Chemotherapy, 71, ii37-ii42. Abstract.
Bhatt JM, Bush A, van Gerven M, Nissenkorn A, Renke M, Yarlett L, Taylor M, Tonia T, Warris A, Zielen S, et al (2015). Ataxia telangiectasia: why should the ERS care?. Eur Respir J, 46(6), 1557-1560. Author URL.
Warris A (2015). Azole-resistant aspergillosis. Journal of Infection, 71(S1), S121-S125. Abstract.
Cohen S, Van Bilsen WPH, Smit C, Fraaij PLA, Warris A, Kuijpers TW, Geelen SPM, Wolfs TFW, Scherpbier HJ, Van Rossum AMC, et al (2015). Country of birth does not influence long-term clinical, virologic, and immunological outcome of HIV-infected children living in the Netherlands: a cohort study comparing children born in the Netherlands with children born in Sub-Saharan Africa. Journal of Acquired Immune Deficiency Syndromes, 68(2), 178-185. Abstract.
Zoll J, Rahamat-Langendoen J, Ahout I, Jonge MID, Jans J, Huijnen MA, Ferwerda G, Warris A, Melchers WJG (2015). Direct multiplexed whole genome sequencing of respiratory tract samples reveals full viral genomic information. Journal of Clinical Virology, 66, 6-11. Abstract.
Bhatt JM, Bush A, van Gerven M, Nissenkorn A, Renke M, Yarlett L, Taylor M, Tonia T, Warris A, Zielen S, et al (2015). ERS statement on the multidisciplinary respiratory management of ataxia telangiectasia. Eur Respir Rev, 24(138), 565-581. Abstract.  Author URL.
Muilwijk EW, Lempers VJC, Burger DM, Warris A, Pickkers P, Aarnoutse RE, Brüggemann RJM (2015). Impact of special patient populations on the pharmacokinetics of echinocandins. Expert Review of Anti-Infective Therapy, 13(6), 799-815. Abstract.
Verweij PE, Ananda-Rajah M, Andes D, Arendrup MC, Brüggemann RJ, Chowdhary A, Cornely OA, Denning DW, Groll AH, Izumikawa K, et al (2015). International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus. Drug Resistance Updates, 21-22, 30-40. Abstract.
Brand HK, Ahout IML, De Ridder D, Van Diepen A, Li Y, Zaalberg M, Andeweg A, Roeleveld N, De Groot R, Warris A, et al (2015). Olfactomedin 4 serves as a marker for disease severity in pediatric respiratory syncytial virus (RSV) infection. PLoS ONE, 10(7). Abstract.
van der Linden JWM, Arendrup MC, Warris A, Lagrou K, Pelloux H, Hauser PM, Chryssanthou E, Mellado E, Kidd SE, Tortorano AM, et al (2015). Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus. Emerging Infectious Diseases, 21(6), 1041-1044. Abstract.
Lestner JM, Versporten A, Doerholt K, Warris A, Roilides E, Sharland M, Bielicki J, Goossens H (2015). Systemic antifungal prescribing in neonates and children: Outcomes from the antibiotic resistance and prescribing in european children (arpec) study. Antimicrobial Agents and Chemotherapy, 59(2), 782-789. Abstract.
Westra D, Kurvers RAJ, Van den Heuvel LP, Würzner R, Hoppenreijs EPAH, Van der Flier M, Van de Kar NCAJ, Warris A (2014). Compound heterozygous mutations in the C6 gene of a child with recurrent infections. Molecular Immunology, 58(2), 201-205. Abstract.
Murray JE, Bicknell LS, Yigit G, Duker AL, van Kogelenberg M, Haghayegh S, Wieczorek D, Kayserili H, Albert MH, Wise CA, et al (2014). Extreme Growth Failure is a Common Presentation of Ligase IV Deficiency. Human Mutation, 35(1), 76-85. Abstract.
Groll AH, Castagnola E, Cesaro S, Dalle JH, Engelhard D, Hope W, Roilides E, Styczynski J, Warris A, Lehrnbecher T, et al (2014). Fourth European Conference on Infections in Leukaemia (ECIL-4): Guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantation. The Lancet Oncology, 15(8). Abstract.
Warris A, Henriet SSV (2014). Invasive fungal infections in the child with chronic granulomatous disease. Current Fungal Infection Reports, 8(1), 37-44. Abstract.
de Boer M, van Leeuwen K, Geissler J, Weemaes CM, van den Berg TK, Kuijpers TW, Warris A, Roos D (2014). Primary Immunodeficiency Caused by an Exonized Retroposed Gene Copy Inserted in the CYBB Gene. Human Mutation, 35(4), 486-496. Abstract.
Broenen E, Mavinkurve-Groothuis A, Kamphuis-Van Ulzen K, Brüggemann R, Verweij P, Warris A (2014). Screening of the central nervous system in children with invasive pulmonary aspergillosis. Medical Mycology Case Reports, 4(1), 8-11. Abstract.
Kurvers RAJ, Westra D, van Heijst AF, Walk TLM, Warris A, van de Kar NCAJ (2014). Severe infantile Bordetella pertussis pneumonia in monozygotic twins with a congenital C3 deficiency. European Journal of Pediatrics, 173(12), 1591-1594. Abstract.
Warris A (2014). The biology of pulmonary aspergillus infections. Journal of Infection, 69(S1), S36-S41. Abstract.
Driessen GJ, Ijspeert H, Weemaes CMR, Haraldsson A, Trip M, Warris A, Van Der Flier M, Wulffraat N, Verhagen MMM, Taylor MA, et al (2013). Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity. Journal of Allergy and Clinical Immunology, 131(5). Abstract.
Verhagen LM, Luesink M, Warris A, De Groot R, Hermans PWM (2013). Bacterial respiratory pathogens in children with inherited immune and airway disorders: Nasopharyngeal carriage and disease risk. Pediatric Infectious Disease Journal, 32(4), 399-404. Abstract.
Schatorjé EJH, van der Steeg H, Stelma F, Hebeda K, Warris A (2013). Borrelia-lymfocytoom. Nederlands tijdschrift voor geneeskunde, 157 Abstract.
Brand HK, Ferwerda G, Preijers F, de Groot R, Neeleman C, Staal FJT, Warris A, Hermans PWM (2013). CD4+ T-cell counts and interleukin-8 and CCL-5 plasma concentrations discriminate disease severity in children with RSV infection. Pediatr Res, 73(2), 187-193. Abstract.  Author URL.
Henriet SSV, Jans J, Simonetti E, Kwon-Chung KJ, Rijs AJMM, Hermans PWM, Holland SM, De Jonge MI, Warris A (2013). Chloroquine modulates the fungal immune response in phagocytic cells from patients with chronic granulomatous disease. Journal of Infectious Diseases, 207(12), 1932-1939. Abstract.
Ijspeert H, Warris A, van der Flier M, Reisli I, Keles S, Chishimba S, van Dongen JJM, van Gent DC, Van der Burg M (2013). Clinical Spectrum of LIG4 Deficiency is Broadened with Severe Dysmaturity, Primordial Dwarfism, and Neurological Abnormalities. Human Mutation, 34(12), 1611-1614. Abstract.
Driessen GJ, Dalm VASH, van Hagen PM, Anne Grashoff H, Hartwig NG, van Rossum AMC, Warris A, de Vries E, Barendregt BH, Pico I, et al (2013). Common variable immunodeficiency and idiopathic primary hypogammaglobulinemia: Two different conditions within the same disease spectrum. Haematologica, 98(10), 1617-1623. Abstract.
De Mol M, De Jongste JC, Van Westreenen M, Merkus PJFM, De Vries AHC, Hop WCJ, Warris A, Janssens HM (2013). Diagnosis of invasive pulmonary aspergillosis in children with bronchoalveolar lavage galactomannan. Pediatric Pulmonology, 48(8), 789-796. Abstract.
Kinabo GD, van der Ven A, Msuya LJ, Shayo AM, Schimana W, Ndaro A, van Asten HAGH, Dolmans WMV, Warris A, Hermans PWM, et al (2013). Dynamics of nasopharyngeal bacterial colonisation in HIV-exposed young infants in Tanzania. Tropical Medicine and International Health, 18(3), 286-295. Abstract.
Opstelten W, Ruijs WL, Warris A, van Binnendijk RS, Wolfs TFW, Hahné SJM (2013). Er heerst weer mazelen. Nederlands tijdschrift voor geneeskunde, 157 Abstract.
Jans J, Brüggemann RJM, Christdmann V, Verweij PE, Warris A (2013). Favorable outcome of neonatal cerebrospinal fluid shunt-associated Candida meningitis with caspofungin. Antimicrobial Agents and Chemotherapy, 57(5), 2391-2393. Abstract.
Henriet S, Verweij PE, Holland SM, Warris A (2013). Invasive fungal infections in patients with chronic granulomatous disease. Advances in Experimental Medicine and Biology, 764, 27-55. Abstract.
Cohen S, Smit C, Van Rossum AMC, Fraaij PLA, Wolfs TFW, Geelen SPM, Schölvinck EH, Warris A, Scherpbier HJ, Pajkrt D, et al (2013). Long-term response to combination antiretroviral therapy in HIV-infected children in the Netherlands registered from 1996 to 2012. AIDS, 27(16), 2567-2575. Abstract.
Stol K, Verhaegh SJC, Graamans K, Engel JAM, Sturm PDJ, Melchers WJG, Meis JF, Warris A, Hays JP, Hermans PWM, et al (2013). Microbial profiling does not differentiate between childhood recurrent acute otitis media and chronic otitis media with effusion. International Journal of Pediatric Otorhinolaryngology, 77(4), 488-493. Abstract.
Kinabo GD, Sprengers M, Msuya LJ, Shayo AM, van Asten H, Dolmans WMV, van der Ven AJAM, Warris A (2013). Prevalence of lipodystrophy in HIV-infected children in Tanzania on highly active antiretroviral therapy. Pediatr Infect Dis J, 32(1), 39-44. Abstract.  Author URL.
Geelen J, Pfundt R, Meijer J, Verheijen FW, van Kuilenburg ABP, Warris A, Marcelis C (2013). Severe phenotype of severe combined immunodeficiency caused by adenosine deaminase deficiency in a patient with a homozygous mutation due to uniparental disomy. J Allergy Clin Immunol, 132(1), 222-223. Author URL.
Verweij PE, Warris A (2013). Update on antifungal resistance in children: Epidemiology and recommendations. Pediatric Infectious Disease Journal, 32(5), 556-557.
Verhagen LM, López D, Hermans PWM, Warris A, de Groot R, García JF, de Waard JH, Aarnoutse RE (2012). Pharmacokinetics of anti-tuberculosis drugs in Venezuelan children younger than 16 years of age: supportive evidence for the implementation of revised WHO dosing recommendations. Trop Med Int Health, 17(12), 1449-1456. Abstract.  Author URL.
Steinbach WJ, Roilides E, Berman D, Hoffman JA, Groll AH, Bin-Hussain I, Palazzi DL, Castagnola E, Halasa N, Velegraki A, et al (2012). Results from a prospective, international, epidemiologic study of invasive candidiasis in children and neonates. Pediatr Infect Dis J, 31(12), 1252-1257. Abstract.  Author URL.
Driessen GJ, van Zelm MC, van Hagen PM, Hartwig NG, Trip M, Warris A, de Vries E, Barendregt BH, Pico I, Hop W, et al (2011). B-cell replication history and somatic hypermutation status identify distinct pathophysiologic backgrounds in common variable immunodeficiency. Blood, 118(26), 6814-6823. Abstract.  Author URL.
Henriet SSV, Hermans PWM, Verweij PE, Simonetti E, Holland SM, Sugui JA, Kwon-Chung KJ, Warris A (2011). Human leukocytes kill Aspergillus nidulans by reactive oxygen species-independent mechanisms. Infect Immun, 79(2), 767-773. Abstract.  Author URL.

Conferences

Kelly A, Weiss M (2009). Preface.

Publications by year


In Press

Nooitgedagt JE, Warris A, Liem KDD, van t Hek L, Henriet SS (In Press). Kinkhoest bij jonge zuigelingen: een gevaarlijke ziekte met aspecifieke verschijnselen. Nederlands tijdschrift voor geneeskunde, 157 Abstract.

2019

Warris A, Bercusson A, Armstrong-James D (2019). Aspergillus colonization and antifungal immunity in cystic fibrosis patients. Med Mycol, 57(Supplement_2), S118-S126. Abstract.  Author URL.
Akase IE, Olowoyo O, Oladele RO, Obiako RO, Warris A, Akanmu SA (2019). Cryptococcal meningitis after ART: Need for proper baseline evaluation in the era of 'Test & Treat'. Med Mycol Case Rep, 24, 58-60. Abstract.  Author URL.
Warris A, Lehrnbecher T, Roilides E, Castagnola E, Brüggemann RJM, Groll AH (2019). ESCMID-ECMM guideline: diagnosis and management of invasive aspergillosis in neonates and children. Clin Microbiol Infect, 25(9), 1096-1113. Abstract.  Author URL.
Warris A (2019). Immunopathology of Aspergillus Infections in Children with Chronic Granulomatous Disease and Cystic Fibrosis. Pediatr Infect Dis J, 38(5), e96-e98. Author URL.
Lempers VJ, Meuwese E, Mavinkurve-Groothuis AM, Henriet S, van der Sluis IM, Hanff LM, Warris A, Koch BCP, Brüggemann RJ (2019). Impact of dose adaptations following voriconazole therapeutic drug monitoring in pediatric patients. Med Mycol, 57(8), 937-943. Abstract.  Author URL.
Brown AJP, Gow NAR, Warris A, Brown GD (2019). Memory in Fungal Pathogens Promotes Immune Evasion, Colonisation, and Infection. Trends in Microbiology, 27(3), 219-230. Abstract.
Warris A, Ballou ER (2019). Oxidative responses and fungal infection biology. Seminars in Cell and Developmental Biology, 89, 34-46. Abstract.
Ballard E, Zoll J, Melchers WJG, Brown AJP, Warris A, Verweij PE (2019). Raw genome sequence data for 13 isogenic Aspergillus fumigatus strains isolated over a 2 year period from a patient with chronic granulomatous disease. Data Brief, 25 Abstract.  Author URL.
Ballard E, Weber J, Melchers WJG, Tammireddy S, Whitfield PD, Brakhage AA, Brown AJP, Verweij PE, Warris A (2019). Recreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanism. Fungal Genet Biol, 130, 98-106. Abstract.  Author URL.

2018

Brunel SF, Willment JA, Brown GD, Devereux G, Warris A (2018). Aspergillus-induced superoxide production by cystic fibrosis phagocytes is associated with disease severity. ERS Monograph, 4(2). Abstract.
Warris A (2018). Candida auris, what do paediatricians need to know?. Archives of Disease in Childhood, 103(9), 891-894. Abstract.
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, et al (2018). Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline. Clinical Microbiology and Infection, 24, e1-e38. Abstract.
Bercusson A, Colley T, Shah A, Warris A, Armstrong-James D (2018). Ibrutinib blocks Btk-dependent NF-ĸB and NFAT responses in human macrophages during Aspergillus fumigatus phagocytosis. Blood, 132(18), 1985-1988.
Ballard E, Melchers WJG, Zoll J, Brown AJP, Verweij PE, Warris A (2018). In-host microevolution of Aspergillus fumigatus: a phenotypic and genotypic analysis. Fungal Genetics and Biology, 113, 1-13. Abstract.
Van Dijck P, Sjollema J, Cammue BP, Lagrou K, Berman J, d'Enfert C, Andes DR, Arendrup MC, Brakhage AA, Calderone R, et al (2018). Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms. Microb Cell, 5(7), 300-326. Abstract.  Author URL.
An SQ, Warris A, Turner S (2018). Microbiome characteristics of induced sputum compared to bronchial fluid and upper airway samples. Pediatric Pulmonology, 53(7), 921-928. Abstract.
Warris A (2018). Special issue: Host–fungus interactions. Journal of Fungi, 4(1).
Gow NAR, Amin T, McArdle K, Brown AJP, Brown GD, Warris A, the WTSA-MMFI Consortium (2018). Strategic Research Funding: a Success Story for Medical Mycology. Trends in Microbiology, 26(10), 811-813. Abstract.

2017

Seyedmousavi S, van der Lee HA, Verweij PE, Warris A (2017). Absent in vitro interaction between chloroquine and antifungals against Aspergillus fumigatus. Clinical Microbiology and Infection, 23(9), 679-681.
Pana ZD, Roilides E, Warris A, Groll AH, Zaoutis T (2017). Epidemiology of Invasive Fungal Disease in Children. Journal of the Pediatric Infectious Diseases Society, 6(1), S3-S11. Abstract.
Bastiaans DET, Immohr LI, Zeinstra GG, Strik-Albers R, Pein-Hackelbusch M, van der Flier M, de Haan AFJ, Boelens JJ, Lankester AC, Burger DM, et al (2017). In vivo and in vitro palatability testing of a new paediatric formulation of valaciclovir. British Journal of Clinical Pharmacology, 83(12), 2789-2797. Abstract.
Brunel SF, Bain JM, King J, Heung LJ, Kasahara S, Hohl TM, Warris A (2017). Live imaging of antifungal activity by human primary neutrophils and monocytes in response to A. fumigatus. Journal of Visualized Experiments, 2017(122). Abstract.
Naselli A, Bishop H, Walker S, Warris A (2017). Neutropenic acute acalculous cholecystitis (AAC) in a 12-year-old boy with T-acute lymphoblastic leukemia successfully managed with conservative treatment. Pediatric Hematology and Oncology, 34(1), 24-28. Abstract.
Warris A, Lehrnbecher T (2017). Progress in the Diagnosis of Invasive Fungal Disease in Children. Current Fungal Infection Reports, 11(2), 35-44. Abstract.
King J, Pana ZD, Lehrnbecher T, Steinbach WJ, Warris A (2017). Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children. Journal of the Pediatric Infectious Diseases Society, 6(1), S12-S21. Abstract.
Calley JL, Warris A (2017). Recognition and diagnosis of invasive fungal infections in neonates. Journal of Infection, 74, S108-S113. Abstract.

2016

Bastiaans DET, Bartels-Wilmer CM, Colbers APH, Heijens CAW, Velthoven-Graafland K, Smeets OSNM, Vink N, Harbers VEM, Warris A, Burger DM, et al (2016). A new paediatric formulation of valaciclovir: Development and bioequivalence assessment. Archives of Disease in Childhood, 101(10), 971-972.
King J, Henriet SSV, Warris A (2016). Aspergillosis in chronic granulomatous disease. Journal of Fungi, 2(2). Abstract.
King J, Brunel SF, Warris A (2016). Aspergillus infections in cystic fibrosis. Journal of Infection, 72, S50-S55. Abstract.
Tak R, Semmekrot B, Warris A, Yntema JB, Stelma F, Neeleman C (2016). Bacterial Tracheitis and Septic Shock. Pediatric Infectious Disease Journal, 35(2), 226-227.
Henriet SSV, Van De Sande WWJ, Lee MJ, Simonetti E, Momany M, Verweij PE, Rijs AJMM, Ferwerda G, Sheppard DC, De Jonge MI, et al (2016). Decreased Cell Wall Galactosaminogalactan in Aspergillus nidulans Mediates Dysregulated Inflammation in the Chronic Granulomatous Disease Host. Journal of Interferon and Cytokine Research, 36(8), 488-498. Abstract.
Toubiana J, Okada S, Hiller J, Oleastro M, Lagos Gomez M, Aldave Becerra JC, Ouachee-Chardin M, Fouyssac F, Girisha KM, Etzioni A, et al (2016). Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype. BLOOD, 127(25), 3154-3164. Author URL.
Warris A (2016). Prophylactic antibiotics should be used in children with repaired oesophageal atresia and tracheo-oesophageal fistula: the case against. Paediatric Respiratory Reviews, 18, 62-63.
Bart IY, Mourits M, van Gent R, van Leuken MH, Hilbink M, Warris A, Wever PC, de Vries E (2016). Sputum Induction in Children is Feasible and Useful in a Bustling General Hospital Practice. Glob Pediatr Health, 3 Abstract.  Author URL.
Warris A (2016). The European Paediatric Mycology Network (EPMyN): Towards a Better Understanding and Management of Fungal Infections in Children. Current Fungal Infection Reports, 10(1), 7-9. Abstract.
Agrawal S, Barnes R, Brüggemann RJ, Rautemaa-Richardson R, Warris A (2016). The role of the multidisciplinary team in antifungal stewardship. Journal of Antimicrobial Chemotherapy, 71, ii37-ii42. Abstract.

2015

Bhatt JM, Bush A, van Gerven M, Nissenkorn A, Renke M, Yarlett L, Taylor M, Tonia T, Warris A, Zielen S, et al (2015). Ataxia telangiectasia: why should the ERS care?. Eur Respir J, 46(6), 1557-1560. Author URL.
Warris A (2015). Azole-resistant aspergillosis. Journal of Infection, 71(S1), S121-S125. Abstract.
Cohen S, Van Bilsen WPH, Smit C, Fraaij PLA, Warris A, Kuijpers TW, Geelen SPM, Wolfs TFW, Scherpbier HJ, Van Rossum AMC, et al (2015). Country of birth does not influence long-term clinical, virologic, and immunological outcome of HIV-infected children living in the Netherlands: a cohort study comparing children born in the Netherlands with children born in Sub-Saharan Africa. Journal of Acquired Immune Deficiency Syndromes, 68(2), 178-185. Abstract.
Zoll J, Rahamat-Langendoen J, Ahout I, Jonge MID, Jans J, Huijnen MA, Ferwerda G, Warris A, Melchers WJG (2015). Direct multiplexed whole genome sequencing of respiratory tract samples reveals full viral genomic information. Journal of Clinical Virology, 66, 6-11. Abstract.
Bhatt JM, Bush A, van Gerven M, Nissenkorn A, Renke M, Yarlett L, Taylor M, Tonia T, Warris A, Zielen S, et al (2015). ERS statement on the multidisciplinary respiratory management of ataxia telangiectasia. Eur Respir Rev, 24(138), 565-581. Abstract.  Author URL.
Muilwijk EW, Lempers VJC, Burger DM, Warris A, Pickkers P, Aarnoutse RE, Brüggemann RJM (2015). Impact of special patient populations on the pharmacokinetics of echinocandins. Expert Review of Anti-Infective Therapy, 13(6), 799-815. Abstract.
Verweij PE, Ananda-Rajah M, Andes D, Arendrup MC, Brüggemann RJ, Chowdhary A, Cornely OA, Denning DW, Groll AH, Izumikawa K, et al (2015). International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus. Drug Resistance Updates, 21-22, 30-40. Abstract.
Brand HK, Ahout IML, De Ridder D, Van Diepen A, Li Y, Zaalberg M, Andeweg A, Roeleveld N, De Groot R, Warris A, et al (2015). Olfactomedin 4 serves as a marker for disease severity in pediatric respiratory syncytial virus (RSV) infection. PLoS ONE, 10(7). Abstract.
van der Linden JWM, Arendrup MC, Warris A, Lagrou K, Pelloux H, Hauser PM, Chryssanthou E, Mellado E, Kidd SE, Tortorano AM, et al (2015). Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus. Emerging Infectious Diseases, 21(6), 1041-1044. Abstract.
Lestner JM, Versporten A, Doerholt K, Warris A, Roilides E, Sharland M, Bielicki J, Goossens H (2015). Systemic antifungal prescribing in neonates and children: Outcomes from the antibiotic resistance and prescribing in european children (arpec) study. Antimicrobial Agents and Chemotherapy, 59(2), 782-789. Abstract.

2014

Westra D, Kurvers RAJ, Van den Heuvel LP, Würzner R, Hoppenreijs EPAH, Van der Flier M, Van de Kar NCAJ, Warris A (2014). Compound heterozygous mutations in the C6 gene of a child with recurrent infections. Molecular Immunology, 58(2), 201-205. Abstract.
Murray JE, Bicknell LS, Yigit G, Duker AL, van Kogelenberg M, Haghayegh S, Wieczorek D, Kayserili H, Albert MH, Wise CA, et al (2014). Extreme Growth Failure is a Common Presentation of Ligase IV Deficiency. Human Mutation, 35(1), 76-85. Abstract.
Groll AH, Castagnola E, Cesaro S, Dalle JH, Engelhard D, Hope W, Roilides E, Styczynski J, Warris A, Lehrnbecher T, et al (2014). Fourth European Conference on Infections in Leukaemia (ECIL-4): Guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantation. The Lancet Oncology, 15(8). Abstract.
Warris A, Henriet SSV (2014). Invasive fungal infections in the child with chronic granulomatous disease. Current Fungal Infection Reports, 8(1), 37-44. Abstract.
de Boer M, van Leeuwen K, Geissler J, Weemaes CM, van den Berg TK, Kuijpers TW, Warris A, Roos D (2014). Primary Immunodeficiency Caused by an Exonized Retroposed Gene Copy Inserted in the CYBB Gene. Human Mutation, 35(4), 486-496. Abstract.
Broenen E, Mavinkurve-Groothuis A, Kamphuis-Van Ulzen K, Brüggemann R, Verweij P, Warris A (2014). Screening of the central nervous system in children with invasive pulmonary aspergillosis. Medical Mycology Case Reports, 4(1), 8-11. Abstract.
Kurvers RAJ, Westra D, van Heijst AF, Walk TLM, Warris A, van de Kar NCAJ (2014). Severe infantile Bordetella pertussis pneumonia in monozygotic twins with a congenital C3 deficiency. European Journal of Pediatrics, 173(12), 1591-1594. Abstract.
Warris A (2014). The biology of pulmonary aspergillus infections. Journal of Infection, 69(S1), S36-S41. Abstract.

2013

Driessen GJ, Ijspeert H, Weemaes CMR, Haraldsson A, Trip M, Warris A, Van Der Flier M, Wulffraat N, Verhagen MMM, Taylor MA, et al (2013). Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity. Journal of Allergy and Clinical Immunology, 131(5). Abstract.
Verhagen LM, Luesink M, Warris A, De Groot R, Hermans PWM (2013). Bacterial respiratory pathogens in children with inherited immune and airway disorders: Nasopharyngeal carriage and disease risk. Pediatric Infectious Disease Journal, 32(4), 399-404. Abstract.
Schatorjé EJH, van der Steeg H, Stelma F, Hebeda K, Warris A (2013). Borrelia-lymfocytoom. Nederlands tijdschrift voor geneeskunde, 157 Abstract.
Brand HK, Ferwerda G, Preijers F, de Groot R, Neeleman C, Staal FJT, Warris A, Hermans PWM (2013). CD4+ T-cell counts and interleukin-8 and CCL-5 plasma concentrations discriminate disease severity in children with RSV infection. Pediatr Res, 73(2), 187-193. Abstract.  Author URL.
Henriet SSV, Jans J, Simonetti E, Kwon-Chung KJ, Rijs AJMM, Hermans PWM, Holland SM, De Jonge MI, Warris A (2013). Chloroquine modulates the fungal immune response in phagocytic cells from patients with chronic granulomatous disease. Journal of Infectious Diseases, 207(12), 1932-1939. Abstract.
Ijspeert H, Warris A, van der Flier M, Reisli I, Keles S, Chishimba S, van Dongen JJM, van Gent DC, Van der Burg M (2013). Clinical Spectrum of LIG4 Deficiency is Broadened with Severe Dysmaturity, Primordial Dwarfism, and Neurological Abnormalities. Human Mutation, 34(12), 1611-1614. Abstract.
Driessen GJ, Dalm VASH, van Hagen PM, Anne Grashoff H, Hartwig NG, van Rossum AMC, Warris A, de Vries E, Barendregt BH, Pico I, et al (2013). Common variable immunodeficiency and idiopathic primary hypogammaglobulinemia: Two different conditions within the same disease spectrum. Haematologica, 98(10), 1617-1623. Abstract.
De Mol M, De Jongste JC, Van Westreenen M, Merkus PJFM, De Vries AHC, Hop WCJ, Warris A, Janssens HM (2013). Diagnosis of invasive pulmonary aspergillosis in children with bronchoalveolar lavage galactomannan. Pediatric Pulmonology, 48(8), 789-796. Abstract.
Kinabo GD, van der Ven A, Msuya LJ, Shayo AM, Schimana W, Ndaro A, van Asten HAGH, Dolmans WMV, Warris A, Hermans PWM, et al (2013). Dynamics of nasopharyngeal bacterial colonisation in HIV-exposed young infants in Tanzania. Tropical Medicine and International Health, 18(3), 286-295. Abstract.
Opstelten W, Ruijs WL, Warris A, van Binnendijk RS, Wolfs TFW, Hahné SJM (2013). Er heerst weer mazelen. Nederlands tijdschrift voor geneeskunde, 157 Abstract.
Jans J, Brüggemann RJM, Christdmann V, Verweij PE, Warris A (2013). Favorable outcome of neonatal cerebrospinal fluid shunt-associated Candida meningitis with caspofungin. Antimicrobial Agents and Chemotherapy, 57(5), 2391-2393. Abstract.
Henriet S, Verweij PE, Holland SM, Warris A (2013). Invasive fungal infections in patients with chronic granulomatous disease. Advances in Experimental Medicine and Biology, 764, 27-55. Abstract.
Cohen S, Smit C, Van Rossum AMC, Fraaij PLA, Wolfs TFW, Geelen SPM, Schölvinck EH, Warris A, Scherpbier HJ, Pajkrt D, et al (2013). Long-term response to combination antiretroviral therapy in HIV-infected children in the Netherlands registered from 1996 to 2012. AIDS, 27(16), 2567-2575. Abstract.
Stol K, Verhaegh SJC, Graamans K, Engel JAM, Sturm PDJ, Melchers WJG, Meis JF, Warris A, Hays JP, Hermans PWM, et al (2013). Microbial profiling does not differentiate between childhood recurrent acute otitis media and chronic otitis media with effusion. International Journal of Pediatric Otorhinolaryngology, 77(4), 488-493. Abstract.
Tenbrink T, Stell J, Galton A, Wood Z (2013). Preface.
Kinabo GD, Sprengers M, Msuya LJ, Shayo AM, van Asten H, Dolmans WMV, van der Ven AJAM, Warris A (2013). Prevalence of lipodystrophy in HIV-infected children in Tanzania on highly active antiretroviral therapy. Pediatr Infect Dis J, 32(1), 39-44. Abstract.  Author URL.
Geelen J, Pfundt R, Meijer J, Verheijen FW, van Kuilenburg ABP, Warris A, Marcelis C (2013). Severe phenotype of severe combined immunodeficiency caused by adenosine deaminase deficiency in a patient with a homozygous mutation due to uniparental disomy. J Allergy Clin Immunol, 132(1), 222-223. Author URL.
Verweij PE, Warris A (2013). Update on antifungal resistance in children: Epidemiology and recommendations. Pediatric Infectious Disease Journal, 32(5), 556-557.

2012

Verhagen LM, López D, Hermans PWM, Warris A, de Groot R, García JF, de Waard JH, Aarnoutse RE (2012). Pharmacokinetics of anti-tuberculosis drugs in Venezuelan children younger than 16 years of age: supportive evidence for the implementation of revised WHO dosing recommendations. Trop Med Int Health, 17(12), 1449-1456. Abstract.  Author URL.
Steinbach WJ, Roilides E, Berman D, Hoffman JA, Groll AH, Bin-Hussain I, Palazzi DL, Castagnola E, Halasa N, Velegraki A, et al (2012). Results from a prospective, international, epidemiologic study of invasive candidiasis in children and neonates. Pediatr Infect Dis J, 31(12), 1252-1257. Abstract.  Author URL.

2011

Driessen GJ, van Zelm MC, van Hagen PM, Hartwig NG, Trip M, Warris A, de Vries E, Barendregt BH, Pico I, Hop W, et al (2011). B-cell replication history and somatic hypermutation status identify distinct pathophysiologic backgrounds in common variable immunodeficiency. Blood, 118(26), 6814-6823. Abstract.  Author URL.
Henriet SSV, Hermans PWM, Verweij PE, Simonetti E, Holland SM, Sugui JA, Kwon-Chung KJ, Warris A (2011). Human leukocytes kill Aspergillus nidulans by reactive oxygen species-independent mechanisms. Infect Immun, 79(2), 767-773. Abstract.  Author URL.

2009

Kelly A, Weiss M (2009). Preface.

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