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Dr Alexandra Brand

Dr Alexandra Brand

Associate Professor

 Geoffrey Pope 319

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

Career

2017 - 22   Wellcome Senior Research Fellowship

2018 - 19   Institute of Medical Sciences, Researcher Development Lead, University of Aberdeen

2014 - 21   BBSRC Commitee E - panel member

2016 - 21   Royal Society Newton International Fellowship - panel member

2013          Elected Fellow of the Royal Society of Biology

2015 - 18   Co-Lead, Microbiology Research Programme, University of Aberdeen

2010          British Mycological Society Berkeley Award for Early-Career Scientists

2010 - 14   Medical Research Council New Investigator

2009 - 17   Royal Society University Research Fellow

2006 - 09   Researcher Co-Investigator, BBSRC, with Prof Neil Gow

2004          PhD in Microbiology, University of Aberdeen

2000          BSc Biochemistry 1st Class, University of Aberdeen

1995         Access Course, University of Aberdeen

Research

Research interests

Systemic fungal infections kill more than 1 million people a year. Almost half of these deaths are caused by two fungi that produce invasive hyphal filaments.

These filaments penetrate deep within human tissue causing cell damage, inflammation and fatal levels of sepsis. A key virulence trait of these filaments is their ability to steer as they grow and respond to physical features they encounter in the environment.

Although fungi are relatively simple organisms, we do not yet understand how this information is sensed or how the direction of growth is altered. We have developed an imaging system that enables us to monitor hyphal growth and track the movement of intracellular fluorescent proteins at the same time. By deleting candidate genes, we can compare the mutant strains with normal cells to find out which proteins are important for hyphal steering.

Mutants that cannot steer normally are not able to penetrate human tissue so drugs that uncouple the steering mechanism in fungal cells might be effective at halting deep-seated tissue invasion by these fungal pathogens.

Publications

Key publications | Publications by category | Publications by year

Publications by category


Books

Brand A, Gow NAR (2012). Tropic orientation responses of pathogenic fungi. Abstract.

Journal articles

Martin-Yken H, Bedekovic T, Brand AC, Richard ML, Znaidi S, Enfert CD, Dague E (In Press). A conserved fungal hub protein involved in adhesion and drug resistance in the human pathogen Candida albicans. The Cell Surface, 4, 10-19. Abstract.
Chen Y-L, Brand A, Morrison EL, Silao FGS, Bigol UG, Malbas FF, Nett JE, Andes DR, Solis NV, Filler SG, et al (In Press). Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis. Eukaryotic Cell, 10, 803-819. Abstract.
Thomson DD, Wehmeier S, Byfield FJ, Janmey PA, Caballero-Lima D, Crossley A, Brand AC (In Press). Contact-induced apical asymmetry drives the thigmotropic responses of Candida albicans hyphae. Cellular Microbiology, 17, 342-354. Abstract.
Thomson DD, Berman J, Brand AC (In Press). High frame-rate resolution of cell division during Candida albicans filamentation. Fungal Genetics and Biology, 88, 54-58. Abstract.
Munro CA, Bates S, Buurman ET, Hughes HB, MacCallum DM, Bertram G, Atrih A, Ferguson MA, Bain JM, Brand AC, et al (In Press). Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence. The Journal of Biological Chemistry, 280, 1051-1060. Abstract.
Gonia S, Norton J, Watanaskui L, Pulver R, Morrison E, Brand A, Gale CA (In Press). Rax2 is important for directional establishment of growth sites, but not for reorientation of growth axes, during Candida albicans hyphal morphogenesis. Fungal Genetics and Biology, 56, 116-124. Abstract.
Chavez-Dozal AA, Bernardo SM, Rane HS, Herrera G, Kulkarny V, Wagener J, Cunningham I, Brand AC, Gow NAR, Lee SA, et al (In Press). Retraction for Chavez-Dozal et al. the Candida albicans Exocyst Subunit Sec6 Contributes to Cell Wall Integrity and is a Determinant of Hyphal Branching. Eukaryotic Cell, 14, i-i.
du Pré S, Beckmann N, Almeida MC, Sibley GEM, Law D, Brand AC, Birch M, Read ND, Oliver JD (In Press). The effect of the novel antifungal drug F901318 (Olorofim) on the growth and viability of Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy, 62, 1-11. Abstract.
Riquelme M, Aime MC, Branco S, Brand A, Brown A, Glass NL, Kahmann R, Momany M, Rokas A, Trail F, et al (In Press). The power of discussion: Support for women at the fungal Gordon Research Conference. Fungal Genetics and Biology, 121, 65-67. Abstract.
Almeida MC, Brand A, Heitman J, Gow NAR (In Press). Thigmo responses: the fungal sense of touch. Microbiology spectrum, 5 Abstract.
Chavez-Dozal AA, Bernardo SM, Rane HS, Herrera G, Kulkarny V, Wagener J, Cunningham I, Brand AC, Gow NAR, Leea SA, et al (2015). The Candida albicans exocyst subunit Sec6 contributes to cell wall integrity and is a determinant of hyphal branching. Eukaryotic Cell, 14(7), 684-697. Abstract.
Brand AC, Morrison E, Milne S, Gonia S, Gale CA, Gow NAR (2014). Cdc42 GTPase dynamics control directional growth responses. Proceedings of the National Academy of Sciences of the United States of America, 111(2), 811-816. Abstract.
Ene IV, Adya AK, Wehmeier S, Brand AC, Maccallum DM, Gow NAR, Brown AJP (2012). Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen. Cellular Microbiology, 14(9), 1319-1335. Abstract.
Brand A (2012). Hyphal growth in human fungal pathogens and its role in virulence. International Journal of Microbiology, 2012 Abstract.
Yang M, Brand A, Srikantha T, Daniels KJ, Soll DR, Gow NAR (2011). Fig1 facilitates calcium influx and localizes to membranes destined to undergo fusion during mating in Candida albicans. Eukaryotic Cell, 10(3), 435-444. Abstract.
Mora-Montes HM, Bates S, Netea MG, Castillo L, Brand A, Buurman ET, Díaz-Jiménez DF, Jan Kullberg B, Brown AJP, Odds FC, et al (2010). A multifunctional mannosyltransferase family in Candida albicans determines cell wall mannan structure and host-fungus interactions. J Biol Chem, 285(16), 12087-12095. Abstract.  Author URL.
Brand A, Lee K, Veses V, Gow NAR (2009). Calcium homeostasis is required for contact-dependent helical and sinusoidal tip growth in Candida albicans hyphae. Molecular Microbiology, 71(5), 1155-1164. Abstract.
Brand A, Gow NA (2009). Mechanisms of hypha orientation of fungi. Current Opinion in Microbiology, 12(4), 350-357. Abstract.
Brand A, Vacharaksa A, Bendel C, Norton J, Haynes P, Henry-Stanley M, Wells C, Ross K, Gow NAR, Gale CA, et al (2008). An internal polarity landmark is important for externally induced hyphal behaviors in Candida albicans. Eukaryotic Cell, 7(4), 712-720. Abstract.
Brand A, Barnes JD, Mackenzie KS, Odds FC, Gow NAR (2008). Cell wall glycans and soluble factors determine the interactions between the hyphae of Candida albicans and Pseudomonas aeruginosa. FEMS Microbiology Letters, 287(1), 48-55. Abstract.
Brand A, Shanks S, Duncan VMS, Yang M, Mackenzie K, Gow NAR (2007). Hyphal Orientation of Candida albicans is Regulated by a Calcium-Dependent Mechanism. Current Biology, 17(4), 347-352. Abstract.
Brand A, MacCallum DM, Brown AJP, Gow NAR, Odds FC (2004). Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus. Eukaryotic Cell, 3(4), 900-909. Abstract.

Publications by year


In Press

Martin-Yken H, Bedekovic T, Brand AC, Richard ML, Znaidi S, Enfert CD, Dague E (In Press). A conserved fungal hub protein involved in adhesion and drug resistance in the human pathogen Candida albicans. The Cell Surface, 4, 10-19. Abstract.
Chen Y-L, Brand A, Morrison EL, Silao FGS, Bigol UG, Malbas FF, Nett JE, Andes DR, Solis NV, Filler SG, et al (In Press). Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis. Eukaryotic Cell, 10, 803-819. Abstract.
Thomson DD, Wehmeier S, Byfield FJ, Janmey PA, Caballero-Lima D, Crossley A, Brand AC (In Press). Contact-induced apical asymmetry drives the thigmotropic responses of Candida albicans hyphae. Cellular Microbiology, 17, 342-354. Abstract.
Thomson DD, Berman J, Brand AC (In Press). High frame-rate resolution of cell division during Candida albicans filamentation. Fungal Genetics and Biology, 88, 54-58. Abstract.
Munro CA, Bates S, Buurman ET, Hughes HB, MacCallum DM, Bertram G, Atrih A, Ferguson MA, Bain JM, Brand AC, et al (In Press). Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence. The Journal of Biological Chemistry, 280, 1051-1060. Abstract.
Gonia S, Norton J, Watanaskui L, Pulver R, Morrison E, Brand A, Gale CA (In Press). Rax2 is important for directional establishment of growth sites, but not for reorientation of growth axes, during Candida albicans hyphal morphogenesis. Fungal Genetics and Biology, 56, 116-124. Abstract.
Chavez-Dozal AA, Bernardo SM, Rane HS, Herrera G, Kulkarny V, Wagener J, Cunningham I, Brand AC, Gow NAR, Lee SA, et al (In Press). Retraction for Chavez-Dozal et al. the Candida albicans Exocyst Subunit Sec6 Contributes to Cell Wall Integrity and is a Determinant of Hyphal Branching. Eukaryotic Cell, 14, i-i.
du Pré S, Beckmann N, Almeida MC, Sibley GEM, Law D, Brand AC, Birch M, Read ND, Oliver JD (In Press). The effect of the novel antifungal drug F901318 (Olorofim) on the growth and viability of Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy, 62, 1-11. Abstract.
Riquelme M, Aime MC, Branco S, Brand A, Brown A, Glass NL, Kahmann R, Momany M, Rokas A, Trail F, et al (In Press). The power of discussion: Support for women at the fungal Gordon Research Conference. Fungal Genetics and Biology, 121, 65-67. Abstract.
Almeida MC, Brand A, Heitman J, Gow NAR (In Press). Thigmo responses: the fungal sense of touch. Microbiology spectrum, 5 Abstract.

2015

Chavez-Dozal AA, Bernardo SM, Rane HS, Herrera G, Kulkarny V, Wagener J, Cunningham I, Brand AC, Gow NAR, Leea SA, et al (2015). The Candida albicans exocyst subunit Sec6 contributes to cell wall integrity and is a determinant of hyphal branching. Eukaryotic Cell, 14(7), 684-697. Abstract.

2014

Brand AC, Morrison E, Milne S, Gonia S, Gale CA, Gow NAR (2014). Cdc42 GTPase dynamics control directional growth responses. Proceedings of the National Academy of Sciences of the United States of America, 111(2), 811-816. Abstract.

2012

Ene IV, Adya AK, Wehmeier S, Brand AC, Maccallum DM, Gow NAR, Brown AJP (2012). Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen. Cellular Microbiology, 14(9), 1319-1335. Abstract.
Brand A (2012). Hyphal growth in human fungal pathogens and its role in virulence. International Journal of Microbiology, 2012 Abstract.
Brand A, Gow NAR (2012). Tropic orientation responses of pathogenic fungi. Abstract.

2011

Yang M, Brand A, Srikantha T, Daniels KJ, Soll DR, Gow NAR (2011). Fig1 facilitates calcium influx and localizes to membranes destined to undergo fusion during mating in Candida albicans. Eukaryotic Cell, 10(3), 435-444. Abstract.
Brand A (2011). Host Fungus Interactions Vol 1 & 2.

2010

Mora-Montes HM, Bates S, Netea MG, Castillo L, Brand A, Buurman ET, Díaz-Jiménez DF, Jan Kullberg B, Brown AJP, Odds FC, et al (2010). A multifunctional mannosyltransferase family in Candida albicans determines cell wall mannan structure and host-fungus interactions. J Biol Chem, 285(16), 12087-12095. Abstract.  Author URL.

2009

Brand A, Lee K, Veses V, Gow NAR (2009). Calcium homeostasis is required for contact-dependent helical and sinusoidal tip growth in Candida albicans hyphae. Molecular Microbiology, 71(5), 1155-1164. Abstract.
Brand A, Gow NA (2009). Mechanisms of hypha orientation of fungi. Current Opinion in Microbiology, 12(4), 350-357. Abstract.

2008

Brand A, Vacharaksa A, Bendel C, Norton J, Haynes P, Henry-Stanley M, Wells C, Ross K, Gow NAR, Gale CA, et al (2008). An internal polarity landmark is important for externally induced hyphal behaviors in Candida albicans. Eukaryotic Cell, 7(4), 712-720. Abstract.
Brand A, Barnes JD, Mackenzie KS, Odds FC, Gow NAR (2008). Cell wall glycans and soluble factors determine the interactions between the hyphae of Candida albicans and Pseudomonas aeruginosa. FEMS Microbiology Letters, 287(1), 48-55. Abstract.

2007

Brand A, Shanks S, Duncan VMS, Yang M, Mackenzie K, Gow NAR (2007). Hyphal Orientation of Candida albicans is Regulated by a Calcium-Dependent Mechanism. Current Biology, 17(4), 347-352. Abstract.

2004

Brand A, MacCallum DM, Brown AJP, Gow NAR, Odds FC (2004). Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus. Eukaryotic Cell, 3(4), 900-909. Abstract.

Alexandra_Brand Details from cache as at 2019-11-19 12:31:17

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External Engagement and Impact

BBSRC Committee E Member

Royal Society Newton International Fellowship Panel

Royal Society Research Grant Board: Biological Sciences

Teaching

Supervision / Group

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