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Professor Alistair Brown

Professor Alistair Brown

Professor (E & R) (Deputy Centre Director MRC CMM)

 Geoffrey Pope 314a

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

Career

1979-1981    Research Scientist: Brewing Research Foundation, Surry, UK

1981-1983    Postdoc Fellow: MIT, Cambridge, MA, USA

1983-1989    Lecturer: University of Glasgow

1989-2019    Lecturer, Senior Lecturer, Reader, Professor: University of Aberdeen

2019-            Professor: MRC Centre for Medical Mycology, University of Exeter

 


2002             SGM Kathleen Barton-Wright Memorial Prize

2004             Fellow, Institute of Biology (now Royal Society of Biology)

2005             Fellow, Royal Society of Edinburgh

2008             Fellow, American Academy of Microbiology

2000-2003    Coordinator, Galar Fungail 1 Consortium

2008-2012    Coordinator, FINSysB Marie Curie Initial Training Network

2008-2014    Director, SABR Systems Biology Consortium (CRISP) 

2010-2015    European Research Council Advanced Grant Holder (STRIFE) 

2012-2019    Co-Director, Wellcome Trust Strategic Award in Medical Mycology & Fungal Immunology 

2016-            Co-Director, MRC Centre for Medical Mycology

Research

Research interests

My group studies the pathogenic yeast, Candida albicans. Candida normally lives in our gut, doing us no harm. However, it is also the cause of common infections such as thrush, and the cause of life-threatening infections in intensive care patients.

Our aim is to understand what makes this yeast so adept at switching from a harmless component of our microbiota into an aggressive cause of infection. In part this is because Candida is able to rapidly tune its own physiology to different niches within our bodies.

We are investigating the molecular mechanisms that mediate these adaptive responses to the local nutrients and environmental stresses in these niches, and the interactions between these nutrient and stress responses. This is increasing our understanding of how Candida survives inside us.

In the longer term, this will promote the development of better diagnostics and more effective antifungal therapies.

Research Group:

  • Arnab Pradhan - Research Postdoctoral RA

  • A N Other - Research Postdoctoral RA (hiring)

  • A N Other - Research Postdoctoral RA (hiring)

  • Dan Larcombe - Research Postgraduate

  • Helen Heaney - Research Postgraduate (based in Aberdeen)

  • A N Other - Research Postgraduate (hiring)

  • A N Other - Research Technician (hiring)

Research networks

FunHoMic European ITN: https://www.funhomic.eu/en

Publications

Key publications | Publications by category | Publications by year

Publications by category


Books

Brown AJP (In Press). Microbial signaling and systems biology., BioMed Central. Abstract.
Brown AJP (2006). Fungal Genomics., Springer Berlin / Heidelberg. Abstract.

Journal articles

Brown AJP, Tuite MF (In Press). 24 Yeast Gene Analysis in the Next Millennium. Methods in Microbiology, 26, 451-461.
Brown AJP, Furness LM, Bailey D (In Press). 8 Transcript Analysis. Methods in Microbiology, 26, 119-139. Abstract.
Smith DA, Nicholls S, Morgan BA, Brown AJP, Quinn J (In Press). A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans. Molecular Biology of the Cell, 15, 4179-4190. Abstract.
Enjalbert B, Rachini A, Vediyappan G, Pietrella D, Spaccapelo R, Vecchiarelli A, Brown AJP, Enfert CD (In Press). A multifunctional, synthetic Gaussia princeps luciferase reporter for live imaging of Candida albicans infections. Infection and Immunity, 77, 4847–4858-4847–4858. Abstract.
Wicksteed BL, Collins I, Dershowitz A, Stateva LI, Green RP, Oliver SG, Brown AJP, Newlon CS (In Press). A physical comparison of chromosome III in six strains of Saccharomyces cerevisiae. Yeast, 10, 39-57. Abstract.
You T, Coghill GM, Brown AJP (In Press). A quantitative model for mRNA translation in Sacchromyces cerevisiae. Yeast, 27, 785-800. Abstract.
Hauser M, Horn P, Tournu H, Hauser NC, Hoheisel JD, Brown AJP, Dickinson JR (In Press). A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase. FEMS Yeast Research, 7, 84-92. Abstract.
Pietrella D, Rachini A, Torosantucci A, Chiani P, Brown AJP, Bistoni F, Costantino P, Mosci P, Enfert CD, Rappuoli R, et al (In Press). A β-glucan-conjugate vaccine and anti-β-glucan antibodies are effective against murine vaginal candidiasis as assessed by a novel in vivo imaging technique. Vaccine, 28, 1717-1725. Abstract.
Doedt T, Krishnamurthy S, Bockmuhl DP, Tebarth B, Stempel C, Russell CL, Brown AJP, Ernst JF (In Press). APSES proteins regulate morphogenesis and metabolism in Candida albicans. Molecular Biology of the Cell, 15, 3167-3180. Abstract.
Nicholls S, MacCallum DM, Kaffarnik FAR, Selway L, Peck SC, Brown AJP (In Press). Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicans. Fungal Genetics and Biology, 48, 297-305. Abstract.
Holyoak CD, Stratford M, Mcmullin Z, Cole MB, Crimmins K, Brown AJP, Coote PJ (In Press). Activity of the plasma membrane H+-ATPase and optimal glycolytic flux are required for rapid adaptation and growth of Saccharomyces cerevisiae in the presence of the weak-acid preservative sorbic acid. Applied and Environmental Microbiology, 62, 3158-3164. Abstract.
Brown AJP, Tuite MF (In Press). Appendix II: Yeast Growth. Methods in Microbiology, 26, 471-477.
Brown AJP (In Press). Appendix III: Useful World Wide Web Addresses for Yeast Researchers. Methods in Microbiology, 26, 479-484.
Enfert CD, Vecchiarelli A, Brown AJP (In Press). Bioluminescent fungi for real-time monitoring of fungal infections. Virulence, 1, 174-176. Abstract.
Bates S, de la Rosa JM, MacCallum DM, Brown AJP, Gow NAR, Odds FC (In Press). Candida albicans Iff11, a secreted protein required for cell wall structure and virulence. Infection and Immunity, 75, 2922-2928. Abstract.
Mota S, Alves R, Carneiro C, Silva S, Brown AJ, Istel F, Kuchler K, Sampaio P, Casal M, Henriques M, et al (In Press). Candida glabrata susceptibility to antifungals and phagocytosis is modulated by acetate. Frontiers in Microbiology, 6 Abstract.
Ene IV, Heilmann CJ, Sorgo AG, Walker LA, de Koster CG, Munro CA, Klis FM, Brown AJP (In Press). Carbon source-induced reprogramming of the cell wall proteome and secretome modulates the adherence and drug resistance of the fungal pathogen Candida albicans. Proteomics, 12, 3164-3179. Abstract.
Miramón P, Dunker C, Windecker H, Bohovych IM, Brown AJP, Kurzai O, Hube B (In Press). Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress. PloS ONE, 7 Abstract.
Hardman N, Jack PL, Brown AJP, McLachlan A (In Press). Characterisation of ribosomal satellite in total nuclear DNA from Physarum polycephalum. BBA Section Nucleic Acids and Protein Synthesis, 562, 365-376. Abstract.
Wagener J, Malireddi RKS, Lenardon MD, Koeberle M, Vautier S, MacCallum DM, Biedermann T, Schaller M, Netea MG, Kanneganti T-D, et al (In Press). Chitin recognition in fungal infections and its impact on the immune response. Mycoses, 56, 7-7.
Brown AJP, Bertram G, Feldmann PJF, Peggie MW, Swoboda RK (In Press). Codon utilisation in the pathogenic yeast, Candida albicans. Nucleic Acids Research, 19
Potrykus J, Ballou ER, Childers DS, Brown AJP (In Press). Conflicting interests in the pathogen-host tug of war: fungal micronutrient scavenging versus mammalian nutritional immunity. PLoS Pathogens, 10 Abstract.
Clark KL, Feldmann PJF, Dignard D, Larocque R, Brown AJP, Lee MG, Thomas DY, Whiteway M (In Press). Constitutive activation of the Saccharomyces cerevislae mating response pathway by a MAP kinase kinase from Candida albicans. Molecular & general genetics, 249, 609-621. Abstract.
Brown AJP (In Press). Control of metabolic flux in yeasts and fungi. Trends in Biotechnology, 15, 445-447. Abstract.
Castillo LC, Maccallum DM, Brown AJP, Gow NAR, Odds FC (In Press). Differential regulation of kidney and spleen cytokine responses in mice infected with a Candida albicans mannosylation mutant. Mycoses, 54, 114-114.
Hopke A, Brown AJP, Hall RA, Wheeler RT (In Press). Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion. Trends in Microbiology, 26, 284-295. Abstract.
Mora-Montes HM, Bates S, Netea MG, Diaz-Jimenez DF, Lopez-Romero E, Zinker S, Ponce-Norla P, Kullberg BJ, Brown AJP, Odds FC, et al (In Press). Endoplasmic reticulum alpha-glycosidases of Candida albicans are required for N glycosylation, cell wall integrity, and normal host-fungus interaction. Eukaryotic Cell, 6, 2184-2193. Abstract.
Russell CL, Brown AJP (In Press). Expression of one-hybrid fusions with Staphylococcus aureus lexA in Candida albicans confirms that Nrg1 is a transcriptional repressor and that Gcn4 is a transcriptional activator. Fungal Genetics and Biology, 42, 676-683. Abstract.
Vieira N, Casal M, Johansson BO, MacCallum DM, Brown AJP, Paiva S (In Press). Functional specialization and differential regulation of short-chain carboxylic acid transporters in the pathogen Candida albicans. Molecular Microbiology, 75, 1337-1354. Abstract.
Leach MD, Klipp E, Cowen LE, Brown AJP (In Press). Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs. Nature Reviews Microbiology, 10, 693-704. Abstract.
Potrykus J, Stead D, Maccallum DM, Urgast DS, Raab A, van Rooijen N, Feldmann JO, Brown AJP (In Press). Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events. PLoS Pathogens, 9 Abstract.
Tripathi G, Wiltshire C, MacAskill S, Tournu H, Budge S, Brown AJP (In Press). Gcn4 co-ordinates morphogenetic and metabolic responses to amino acid starvation in Candida albicans. EMBO Journal, 21, 5448-5456. Abstract.
Enjalbert B, Moran GP, Vaughan C, Yeomans T, MacCallum DM, Quinn J, Coleman DC, Brown AJP, Sullivan DJ (In Press). Genome-wide gene expression profiling and a forward genetic screen show that differential expression of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic stress. Molecular Microbiology, 72, 216-228. Abstract.
Weig M, Brown AJP (In Press). Genomics and the development of new diagnostics and anti-Candida drugs. Trends in Microbiology, 15, 310-317. Abstract.
Garcia-Sanchez S, Mavor AL, Russell CL, Argimon S, Dennison P, Enjalbert BP, Brown AJP (In Press). Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicans. Molecular Biology of the Cell, 16, 2913-2925. Abstract.
Chew SY, Ho KL, Cheah YK, Ng TS, Sandai D, Brown AJP, Lung LTT (In Press). Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and virulence of Candida glabrata. Scientific Reports, 9, 2843-2843. Abstract.
Ene IV, Cheng S-C, Netea MG, Brown AJP (In Press). Growth of Candida albicans cells on the physiologically relevant carbon source lactate affects their recognition and phagocytosis by immune cells. Infection and Immunity, 81, 238-248. Abstract.
Ene IV, Adya AK, Heilmann CJ, Sorgo AG, Klis FM, MacCallum DM, Gow NA, Brown AJP (In Press). Host carbon sources modulate cell wall architecture and virulence in Candida albicans. Mycoses, 55, 172-173.
MacKie J, Szabo EK, Urgast DS, Ballou ER, Childers DS, MacCallum DM, Feldmann J, Brown AJP (In Press). Host-Imposed Copper Poisoning Impacts Fungal Micronutrient Acquisition during Systemic Candida albicans Infections. PloS ONE, 11 Abstract.
Leach MD, Farrer RA, Tan K, Miao Z, Walker LA, Cuomo CA, Wheeler RT, Brown AJP, Wong KH, Cowen LE, et al (In Press). Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans. Nature Communications, 7 Abstract.  Full text.
Leach M, Budge S, Walker L, Munro C, Cowen LE, Brown AJP (In Press). Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast. PLoS Pathogens, 8 Abstract.
Leach MD, Stead DA, Argo E, Brown AJP (In Press). Identification of sumoylation targets, combined with inactivation of SMT3, reveals the impact of sumoylation upon growth, morphology, and stress resistance in the pathogen Candida albicans. Molecular Biology of the Cell, 22, 687-702. Abstract.
Gow NAR, Netea MG, Munro CA, Ferwerda G, Bates S, Mora-Montes HM, Walker L, Jansen T, Jacobs L, Tsoni V, et al (In Press). Immune Recognition of Candida albicans ß-glucan by Dectin-1. The journal of infectious diseases, 196, 1565-1571. Abstract.
Netea MG, Gow NAR, Munro CA, Bates S, Collins C, Ferwerda G, Hobson RP, Bertram G, Hughes HB, Jansen T, et al (In Press). Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. The Journal of Clinical Investigation, 116, 1642-1650. Abstract.
Stead DA, Paton NW, Missier P, Embury SM, Hedeler C, Jin B, Brown AJP, Preece A (In Press). Information quality in proteomics. Briefings in Bioinformatics, 9, 174-188. Abstract.
Smith RJ, Milewski S, Brown AJP, Gooday GW (In Press). Isolation and characterization of the GFA1 gene encoding the glutamine:fructose-6-phosphate amidotransferase of Candida albicans. Journal of Bacteriology, 178, 2320-2327. Abstract.
Ene IV, Brunke S, Brown AJP, Hube B (In Press). Metabolism in fungal pathogenesis. Cold Spring Harbor perspectives in medicine, 4 Abstract.
Munro CA, Bates S, Buurman ET, Hughes HB, MacCallum DM, Bertram G, Atrih A, Ferguson MA, Bain JM, Brand AC, et al (In Press). Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence. The Journal of Biological Chemistry, 280, 1051-1060. Abstract.
Munro CA, Bates S, Buurman ET, Hughes HB, MacCallum DM, Bertram G, Atrih A, Ferguson MA, Bain JM, Brand AC, et al (In Press). Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence. The Journal of Biological Chemistry, 280, 1051-1060. Abstract.
Leach MD, Tyc K, Brown AJP, Klipp E (In Press). Modelling the regulation of thermal adaptation in Candida albicans, a major fungal pathogen of humans. PloS ONE, 7 Abstract.
Leach MD, Stead DA, Argo EA, MacCallum DM, Brown AJP (In Press). Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans. Molecular Microbiology, 79, 1574-1593. Abstract.
Leach MD, Stead DA, Argo E, MacCallum DM, Brown AJP (In Press). Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans. Molecular Microbiology, 84, 594-594. Abstract.
Nicholls SM, Straffon M, Enjalbert BP, Nantel A, MacAskill S, Whiteway M, Brown AJP (In Press). Msn2- and Msn4-like transcription factors play no obvious roles in the stress responses of the fungal pathogen Candida albicans. Eukaryotic Cell, 3, 1111-1123. Abstract.
Moore PA, Bettany AJE, Brown AJP (In Press). Multiple copies of the pyruvate kinase gene affect yeast cell growth. Journal of General Microbiology, 136, 2359-2366. Abstract.
Murad AMA, Leng P, Straffon M, Wishart J, Macaskill S, MacCallum D, Schnell N, Talibi D, Marechal D, Tekaia F, et al (In Press). NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans. EMBO Journal, 20, 4742-4752. Abstract.
Enjalbert BP, MacCallum DM, Odds FC, Brown AJP (In Press). Niche-Specific Activation of the Oxidative Stress Response by the Pathogenic Fungus Candida albicans. Infection and Immunity, 75, 2143-2151. Abstract.
Bohovych I, Kastora S, Christianson S, Topil D, Kim H, Fangman T, Zhou YJ, Barrientos A, Lee J, Brown AJP, et al (In Press). Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling to Modulate Physiological Plasticity and Cellular Stress Responses. Molecular and Cellular Biology, 36, 2300-2312. Abstract.
Bates S, Hughes HB, Munro CA, Thomas WPH, MacCallum DM, Bertram G, Atrih A, Ferguson MAJ, Brown AJP, Odds FC, et al (In Press). Outer chain N-glycans are required for cell wall integrity and virulence of Candida albicans. The Journal of Biological Chemistry, 281, 90-8. Abstract.
Ikeh MAC, Kastora SL, Day AM, Herrero-de-Dios CM, Tarrant E, Waldron KJ, Banks AP, Bain JM, Lydall D, Veal EA, et al (In Press). Pho4 mediates phosphate acquisition in Candida albicans and is vital for stress resistance and metal homeostasis. Molecular Biology of the Cell, 27, 2784-2801. Abstract.
Nikolaou E, Agrafioti I, Stumpf M, Quinn J, Stansfield I, Brown AJP (In Press). Phylogenetic diversity of stress signalling pathways in fungi. BMC Evolutionary Biology, 9, 44-44. Abstract.
Chew SY, Ho KL, Cheah YK, Sandai D, Brown AJP, Lung LTT (In Press). Physiologically Relevant Alternative Carbon Sources Modulate Biofilm Formation, Cell Wall Architecture and the Stress and Antifungal Resistance of Candida glabrata. International Journal of Molecular Sciences, 20 Abstract.
Vieira N, Pereira F, Casal M, Brown AJP, Paiva S, Johansson BO (In Press). Plasmids for in vivo construction of integrative Candida albicans vectors in Saccharomyces cerevisiae. Yeast, 27, 933-939. Abstract.
Bowman SB, Zaman Z, Collinson LP, Brown AJP, Dawes IW (In Press). Positive regulation of the LPD1 gene of Saccharomyces cerevisine by the HAP2/HAP3/HAP4 activation system. Molecular & general genetics, 231, 296-303. Abstract.
Leach MD, Brown AJP (In Press). Posttranslational modifications of proteins in the pathobiology of medically relevant fungi. Eukaryotic Cell, 11, 98-108. Abstract.
Sagliocco FA, Zhu D, Vega Laso MR, McCarthy JEG, Tuite MF, Brown AJP (In Press). Rapid mRNA degradation in yeast can proceed independently of translational elongation. The Journal of Biological Chemistry, 269, 18630-18637. Abstract.
Enjalbert BP, Smith DA, Cornell MJ, Alam I, Nicholls SM, Brown AJP, Quinn J (In Press). Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans. Molecular Biology of the Cell, 17, 1018-1032. Abstract.
Nicholls S, Leach MD, Priest CL, Brown AJP (In Press). Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals. Molecular Microbiology, 74, 844-861. Abstract.
Kastora SL, Herrero De Dios C, Avelar GM, Munro CA, Brown AJP (In Press). Sfp1 and Rtg3 reciprocally modulate carbon source-conditional stress adaptation in the pathogenic yeast Candida albicans. Molecular Microbiology, 105, 620-636. Abstract.
Jacobsen MD, Beynon RJ, Gethings LA, Claydon AJ, Langridge JI, Vissers JPC, Brown AJP, Hammond DE (In Press). Specificity of the osmotic stress response in Candida albicans highlighted by quantitative proteomics. Scientific Reports, 8 Abstract.
Brown AJP, Cowen LE, Di Pietro A, Quinn J (In Press). Stress Adaptation. Microbiology spectrum, 5, 1-23. Abstract.
Kelly MT, MacCallum DM, Clancy SD, Odds FC, Brown AJP, Butler G (In Press). The Candida albicans CaACE2 gene affects morphogenesis, adherence and virulence. Molecular Microbiology, 53, 969-983. Abstract.
Crombie T, Boyle JP, Coggins JR, Brown AJP (In Press). The Folding of the Bifunctional TRP3 Protein in Yeast is Influenced by a Translational Pause which Lies in a Region of Structural Divergence with Escherichia coli Indoleglycerol‐Phosphate Synthase. European Journal of Biochemistry, 226, 657-664. Abstract.
Mercado JJ, Smith R, Sagliocco FA, Brown AJP, Gancedo JM (In Press). The Levels of Yeast Gluconeogenic mRNAs Respond to Environmental Factors. European Journal of Biochemistry, 224, 473-481. Abstract.
Leng P, Carter PE, Brown AJP (In Press). The TATA-binding protein (TBP) from the human fungal pathogen Candida albicans can complement defects in human and yeast TBPs. Journal of Bacteriology, 180, 1771-1776. Abstract.
Oliver SG, Van Der Aart QJM, Agostoni-Carbone ML, Aigle M, Alberghina L, Alexandraki D, Antoine G, Anwar R, Ballesta JPG, Benit P, et al (In Press). The complete DNA sequence of yeast chromosome III. Nature, 357, 38-46. Abstract.
Wicksteed BL, Roberts AB, Sagliocco FA, Brown AJP (In Press). The complete sequence of a 7·5 kb region of chromosome III from Saccharomyces cerevisiae that lies between CRY1 and MAT. Yeast, 7, 761-772. Abstract.
Brown AJP, Hardman N (In Press). The effect of age on the properties of poly(A)-containing messenger RNA in Physarum polycephalum. Journal of General Microbiology, 122, 143-150.
Sagliocco FA, Laso MRV, Zhu D, Tuite MF, McCarthy JEG, Brown AJP (In Press). The influence of 5’-secondary structures upon ribosome binding to mRNA during translation in yeast. The Journal of Biological Chemistry, 268, 26522-26530. Abstract.
Tillmann AT, Kaloriti D, Jacobsen M, Gow NAR, Brown AJP (In Press). The medical importance of nitrosative stress and combinatorial stresses in the human fungal pathogen Candida albicans. Mycoses, 55
Riquelme M, Aime MC, Branco S, Brand A, Brown A, Glass NL, Kahmann R, Momany M, Rokas A, Trail F, et al (In Press). The power of discussion: Support for women at the fungal Gordon Research Conference. Fungal Genetics and Biology, 121, 65-67. Abstract.
Brown AJP, Leach M, Nicholls SM (In Press). The relevance of heat shock regulation in fungal pathogens of humans. Virulence, 1, 330-332. Abstract.
Planta RJ, Brown AJP, Cadahia JL, Cerdan ME, De Jonge M, Gent ME, Hayes A, Kolen CPAM, Lombardia LJ, Sefton M, et al (In Press). Transcript analysis of 250 novel yeast genes from chromosome XIV. Yeast, 15, 329-350. Abstract.
BROWN AJP, HARDMAN N (In Press). Utilization of Polyadenylated mRNA during Growth and Starvation in Physarum polycephalum. European Journal of Biochemistry, 110, 413-420. Abstract.
Moore PA, Sagliocco FA, Wood RMC, Brown AJP (In Press). Yeast glycolytic mRNAs are differentially regulated. Molecular and Cellular Biology, 11, 5330-5337. Abstract.
Brown AJ, Sagliocco FA (In Press). mRNA abundance and half-life measurements. Methods in Molecular Biology, 53, 277-295. Abstract.
Brown AJP (In Press). mRNA translation and turnover: a cellular perspective on their relationship. Trends in Cell Biology, 3, 180-183. Abstract.
Dickson LM, Brown AJP (In Press). mRNA translation in yeast during entry into stationary phase. Molecular & general genetics, 259, 282-293. Abstract.
Brown AJP, Gow NAR, Warris A, Brown GD (2019). Memory in Fungal Pathogens Promotes Immune Evasion, Colonisation, and Infection. Trends in Microbiology, 27(3), 219-230. Abstract.
Ballard E, Zoll J, Melchers WJG, Brown AJP, Warris A, Verweij PE (2019). Raw genome sequence data for 13 isogenic Aspergillus fumigatus strains isolated over a 2 year period from a patient with chronic granulomatous disease. Data Brief, 25 Abstract.  Author URL.
Ballard E, Weber J, Melchers WJG, Tammireddy S, Whitfield PD, Brakhage AA, Brown AJP, Verweij PE, Warris A (2019). Recreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanism. Fungal Genet Biol, 130, 98-106. Abstract.  Author URL.
Beardmore RE, Cook E, Nilsson S, Smith AR, Tillmann A, Esquivel BD, Haynes K, Gow NAR, Brown AJP, White TC, et al (2018). Drug-mediated metabolic tipping between antibiotic resistant states in a mixed-species community. Nat Ecol Evol, 2(8), 1312-1320. Abstract.  Author URL.  Full text.
Pradhan A, Avelar GM, Bain JM, Childers DS, Larcombe DE, Netea MG, Shekhova E, Munro CA, Brown GD, Erwig LP, et al (2018). Hypoxia Promotes Immune Evasion by Triggering β-Glucan Masking on the Candida albicans Cell Surface via Mitochondrial and cAMP-Protein Kinase a Signaling. MBio, 9(6). Abstract.  Author URL.
Ballard E, Melchers WJG, Zoll J, Brown AJP, Verweij PE, Warris A (2018). In-host microevolution of Aspergillus fumigatus: a phenotypic and genotypic analysis. Fungal Genetics and Biology, 113, 1-13. Abstract.
Herrero de Dios C, Day AM, Tillmann AT, Kastora SL, Stead D, Salgado PS, Quinn J, Brown AJP (2018). Redox Regulation, Rather than Stress-Induced Phosphorylation, of a Hog1 Mitogen-Activated Protein Kinase Modulates its Nitrosative-Stress-Specific Outputs. mBio, 9 Abstract.
Gow NAR, Amin T, McArdle K, Brown AJP, Brown GD, Warris A, the WTSA-MMFI Consortium (2018). Strategic Research Funding: a Success Story for Medical Mycology. Trends in Microbiology, 26(10), 811-813. Abstract.
Day AM, Smith DA, Ikeh MAC, Haider M, Herrero De Dios CM, Brown AJP, Morgan BA, Erwig LP, MacCallum DM, Quinn J, et al (2017). Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation. PLoS Pathogens, 13, 1-27. Abstract.
Pradhan A, Herrero-de-Dios C, Belmonte R, Budge S, Lopez Garcia A, Kolmogorova A, Lee KK, Martin BD, Ribeiro A, Bebes A, et al (2017). Elevated catalase expression in a fungal pathogen is a double-edged sword of iron. PLoS Pathog, 13(5). Abstract.  Author URL.
Day AM, Herrero de Dios C, MacCallum DM, Brown AJP, Quinn J (2017). Stress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen. Scientific Reports, 7, 1-10. Abstract.
Ballou ER, Avelar GM, Childers DS, Mackie J, Bain JM, Wagener J, Kastora SL, Panea MD, Hardison SE, Walker LA, et al (2016). Lactate signalling regulates fungal β-glucan masking and immune evasion. Nature Microbiology, 2 Abstract.
Kos I, Patterson MJ, Znaidi S, Kaloriti D, da Silva Dantas A, Herrero-de-Dios CM, d’Enfert C, Brown AJP, Quinn J (2016). Mechanisms underlying the delayed activation of the cap1 transcription factor in Candida Albicans following combinatorial oxidative and cationic stress important for phagocytic potency. mBio, 7(2). Abstract.
Childers DS, Raziunaite I, Mol Avelar G, Mackie J, Budge S, Stead D, Gow NAR, Lenardon MD, Ballou ER, MacCallum DM, et al (2016). The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence. PLoS Pathogens, 12(4). Abstract.
Vautier S, Drummond RA, Chen K, Murray GI, Kadosh D, Brown AJP, Gow NAR, Maccallum DM, Kolls JK, Brown GD, et al (2015). Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity. Cellular Microbiology, 17(4), 445-450. Abstract.
Preechasuth K, Anderson JC, Peck SC, Brown AJP, Gow NAR, Lenardon MD (2015). Cell wall protection by the Candida albicans class I chitin synthases. Fungal Genetics and Biology, 82, 264-276. Abstract.
Ene IV, Walker LA, Schiavone M, Lee KK, Martin-Yken H, Dague E, Gow NAR, Munro CA, Brown AJP (2015). Cell wall remodeling enzymes modulate fungal cell wall elasticity and osmotic stress resistance. mBio, 6(4). Abstract.
Tillmann AT, Strijbis K, Cameron G, Radmaneshfar E, Thiel M, Munro CA, MacCallum DM, Distel B, Gow NAR, Brown AJP, et al (2015). Contribution of Fdh3 and Glr1 to glutathione redox state, stress adaptation and virulence in Candida albicans. PLoS ONE, 10(6). Abstract.
Komalapriya C, Kaloriti D, Tillmann AT, Yin Z, Herrero-de-Dios C, Jacobsen MD, Belmonte RC, Cameron G, Haynes K, Grebogi C, et al (2015). Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans. PLoS One, 10(9). Abstract.  Author URL.
Bain JM, Louw J, Lewis LE, Okai B, Walls CA, Ballou ER, Walker LA, Reid D, Munro CA, Brown AJP, et al (2014). Candida albicans hypha formation and mannan masking of β-Glucan inhibit macrophage phagosome maturation. mBio, 5(6). Abstract.
Wagener J, Malireddi RKS, Lenardon MD, Köberle M, Vautier S, MacCallum DM, Biedermann T, Schaller M, Netea MG, Kanneganti TD, et al (2014). Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation. PLoS Pathogens, 10(4). Abstract.
Kaloriti D, Jacobsen M, Yin Z, Patterson M, Tillmann A, Smith DA, Cook E, you T, Grimm MJ, Bohovych I, et al (2014). Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes. MBio, 5(4), e01334-e01314. Abstract.  Author URL.
Brown AJP, Brown GD, Netea MG, Gow NAR (2014). Metabolism impacts upon candida immunogenicity and pathogenicity at multiple levels. Trends in Microbiology, 22(11), 614-622. Abstract.
Shahana S, Childers DS, Ballou ER, Bohovych I, Odds FC, Gow NAR, Brown AJP (2014). New Clox systems for rapid and efficient gene disruption in Candida albicans. PLoS ONE, 9(6). Abstract.
Brown AJP, Budge S, Kaloriti D, Tillmann A, Jacobsen MD, Yin Z, Ene IV, Bohovych I, Sandai D, Kastora S, et al (2014). Stress adaptation in a pathogenic fungus. J Exp Biol, 217(Pt 1), 144-155. Abstract.  Author URL.
Marakalala MJ, Vautier S, Potrykus J, Walker LA, Shepardson KM, Hopke A, Mora-Montes HM, Kerrigan A, Netea MG, Murray GI, et al (2013). Differential Adaptation of Candida albicans in Vivo Modulates Immune Recognition by Dectin-1. PLoS Pathogens, 9(4). Abstract.
Radmaneshfar E, Kaloriti D, Gustin MC, Gow NAR, Brown AJP, Grebogi C, Romano MC, Thiel M (2013). From START to FINISH: the Influence of Osmotic Stress on the Cell Cycle. PLoS ONE, 8(7). Abstract.
Shahana S, Mora-Montes HM, Castillo L, Bohovych I, Sheth CC, Odds FC, Gow NAR, Brown AJP (2013). Reporters for the analysis of N-glycosylation in Candida albicans. Fungal Genetics and Biology, 56, 107-115. Abstract.
Bates S, Hall RA, Cheetham J, Netea MG, MacCallum DM, Brown AJP, Odds FC, Gow NAR (2013). Role of the Candida albicans MNN1 gene family in cell wall structure and virulence. BMC Res Notes, 6 Abstract.  Author URL.  Full text.
Hall RA, Bates S, Lenardon MD, Maccallum DM, Wagener J, Lowman DW, Kruppa MD, Williams DL, Odds FC, Brown AJP, et al (2013). The Mnn2 mannosyltransferase family modulates mannoprotein fibril length, immune recognition and virulence of Candida albicans. PLoS Pathog, 9(4). Abstract.  Author URL.  Full text.
You T, Ingram P, Jacobsen MD, Cook E, McDonagh A, Thorne T, Lenardon MD, de Moura APS, Romano MC, Thiel M, et al (2012). A systems biology analysis of long and short-term memories of osmotic stress adaptation in fungi. BMC Res Notes, 5 Abstract.  Author URL.
Gow NAR, Van De Veerdonk FL, Brown AJP, Netea MG (2012). Candida albicans morphogenesis and host defence: Discriminating invasion from colonization. Nature Reviews Microbiology, 10(2), 112-122. Abstract.
Kaloriti D, Tillmann A, Cook E, Jacobsen M, you T, Lenardon M, Ames L, Barahona M, Chandrasekaran K, Coghill G, et al (2012). Combinatorial stresses kill pathogenic Candida species. Med Mycol, 50(7), 699-709. Abstract.  Author URL.
Ene IV, Adya AK, Wehmeier S, Brand AC, Maccallum DM, Gow NAR, Brown AJP (2012). Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen. Cellular Microbiology, 14(9), 1319-1335. Abstract.
Kaloriti D, Tillmann A, Jacobsen M, Yin Z, Patterson M, Radmaneshfar E, you T, Chandrasekaran K, Pang W, Coghill G, et al (2012). Impact of combinatorial stresses upon Candida albicans. MYCOSES, 55, 15-15. Author URL.
Mayer FL, Wilson D, Jacobsen ID, Miramón P, Slesiona S, Bohovych IM, Brown AJP, Hube B (2012). Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans. PLoS One, 7(6). Abstract.  Author URL.
Sandai D, Yin Z, Selway L, Stead D, Walker J, Leach MD, Bohovych I, Ene IV, Kastora S, Budge S, et al (2012). The evolutionary rewiring of ubiquitination targets has reprogrammed the regulation of carbon assimilation in the pathogenic yeast Candida albicans. MBio, 3(6). Abstract.  Author URL.
Gow NAR, Brown GD, Brown AJP, Netea MG, McArdle KE (2012). Waging war on fungi - the unknown superbugs. Microbiology Today, 39(4), 208-211.
You T, Stansfield I, Romano MC, Brown AJP, Coghill GM (2011). Analysing GCN4 Translational Control in Yeast by Stochastic Chemical Kinetics Modelling and Simulation. BMC Systems Biology, 5, 131-131. Abstract.
Castillo L, MacCallum DM, Brown AJP, Gow NAR, Odds FC (2011). Differential regulation of kidney and spleen cytokine responses in mice challenged with pathology-standardized doses of candida albicans mannosylation mutants. Infection and Immunity, 79(1), 146-152. Abstract.
Sheth CC, Hall R, Lewis L, Brown AJP, Odds FC, Erwig LP, Gow NAR (2011). Glycosylation status of the C. albicans cell wall affects the efficiency of neutrophil phagocytosis and killing but not cytokine signaling. Medical Mycology, 49(5), 513-524. Abstract.
Mora-Montes HM, Netea MG, Ferwerda G, Lenardon MD, Brown GD, Mistry AR, Kullberg BJ, O'Callaghan CA, Sheth CC, Odds FC, et al (2011). Recognition and blocking of innate immunity cells by Candida albicans chitin. Infection and Immunity, 79(5), 1961-1970. Abstract.
Mora-Montes HM, Bates S, Netea MG, Castillo L, Brand A, Buurman ET, Díaz-Jiménez DF, Jan Kullberg B, Brown AJP, Odds FC, et al (2010). A multifunctional mannosyltransferase family in Candida albicans determines cell wall mannan structure and host-fungus interactions. J Biol Chem, 285(16), 12087-12095. Abstract.  Author URL.
Stead DA, Walker J, Holcombe L, Gibbs SRS, Yin Z, Selway L, Butler G, Brown AJP, Haynes K (2010). Impact of the transcriptional regulator, Ace2, on the Candida glabrata secretome. Proteomics, 10(2), 212-223. Abstract.  Author URL.
Walker CA, Gómez BL, Mora-Montes HM, Mackenzie KS, Munro CA, Brown AJP, Gow NAR, Kibbler CC, Odds FC (2010). Melanin externalization in candida albicans depends on cell wall chitin structures. Eukaryotic Cell, 9(9), 1329-1342. Abstract.
Lenardon MD, Milne SA, Mora-Montes HM, Kaffarnik FAR, Peck SC, Brown AJP, Munro CA, Gow NAR (2010). Phosphorylation regulates polarisation of chitin synthesis in Candida albicans. Journal of Cell Science, 123(13), 2199-2206. Abstract.
Holcombe LJ, McAlester G, Munro CA, Enjalbert B, Brown AJP, Gow NAR, Ding C, Butler G, O'Gara F, Morrissey JP, et al (2010). Pseudomonas aeruginosa secreted factors impair biofilm development in Candida albicans. Microbiology, 156(5), 1476-1485. Abstract.
Yin Z, Stead D, Walker J, Selway L, Smith DA, Brown AJP, Quinn J (2009). A proteomic analysis of the salt, cadmium and peroxide stress responses in Candida albicans and the role of the Hog1 stress-activated MAPK in regulating the stress-induced proteome. Proteomics, 9(20), 4686-4703. Abstract.  Author URL.
MacCallum DM, Castillo L, Brown AJP, Gow NAR, Odds FC (2009). Early-expressed chemokines predict kidney immunopathology in experimental disseminated Candida albicans infections. PLoS ONE, 4(7). Abstract.
Butler G, Rasmussen MD, Lin MF, Santos MAS, Sakthikumar S, Munro CA, Rheinbay E, Grabherr M, Forche A, Reedy JL, et al (2009). Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature, 459(7247), 657-662. Abstract.  Author URL.
Walker LA, MacCallum DM, Bertram G, Gow NAR, Odds FC, Brown AJP (2009). Genome-wide analysis of Candida albicans gene expression patterns during infection of the mammalian kidney. Fungal Genetics and Biology, 46(2), 210-219. Abstract.
Rodaki A, Bohovych IM, Enjalbert B, Young T, Odds FC, Gow NAR, Brown AJP (2009). Glucose promotes stress resistance in the fungal pathogen candida albicans. Molecular Biology of the Cell, 20(22), 4845-4855. Abstract.
Brown AJP, Haynes K, Quinn J (2009). Nitrosative and oxidative stress responses in fungal pathogenicity. Curr Opin Microbiol, 12(4), 384-391. Abstract.  Author URL.
MacCallum DM, Castillo L, Nather K, Munro CA, Brown AJP, Gow NAR, Odds FC (2009). Property differences among the four major Candida albicans strain clades. Eukaryotic Cell, 8(3), 373-387. Abstract.
Fisher MC, Bosch J, Yin Z, Stead DA, Walker J, Selway L, Brown AJP, Walker LA, Gow NAR, Stajich JE, et al (2009). Proteomic and phenotypic profiling of the amphibian pathogen Batrachochytrium dendrobatidis shows that genotype is linked to virulence. Mol Ecol, 18(3), 415-429. Abstract.  Author URL.
Barelle CJ, Duncan VMS, Brown AJP, Gow NAR, Odds FC (2008). Azole antifungals induce up-regulation of SAP4, SAP5 and SAP6 secreted proteinase genes in filamentous Candida albicans cells in vitro and in vivo. Journal of Antimicrobial Chemotherapy, 61(2), 315-322. Abstract.
Wimalasena TT, Enjalbert B, Guillemette T, Plumridge A, Budge S, Yin Z, Brown AJP, Archer DB (2008). Impact of the unfolded protein response upon genome-wide expression patterns, and the role of Hac1 in the polarized growth, of Candida albicans. Fungal Genet Biol, 45(9), 1235-1247. Abstract.  Author URL.
Ramsdale M, Selway L, Stead D, Walker J, Yin Z, Nicholls SM, Crowe J, Sheils EM, Brown AJP (2008). MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans. Mol Biol Cell, 19(10), 4393-4403. Abstract.  Author URL.  Full text.
Schmidt P, Walker J, Selway L, Stead D, Yin Z, Enjalbert B, Weig M, Brown AJP (2008). Proteomic analysis of the pH response in the fungal pathogen Candida glabrata. Proteomics, 8(3), 534-544. Abstract.  Author URL.
Argimón S, Wishart JA, Leng R, Macaskill S, Mavor A, Alexandris T, Nicholls S, Knight AW, Enjalbert B, Walmsley R, et al (2007). Developmental regulation of an adhesin gene during cellular morphogenesis in the fungal pathogen Candida albicans. Eukaryotic Cell, 6(4), 682-692. Abstract.
Brown AJP, Odds FC, Gow NAR (2007). Infection-related gene expression in Candida albicans. Current Opinion in Microbiology, 10(4), 307-313. Abstract.
de Souza J (2007). Letter. AMERICAN JOURNAL OF MEDICINE, 120(11), E21-E21. Author URL.
Munro CA, Selvaggini S, De Bruijn I, Walker L, Lenardon MD, Gerssen B, Milne S, Brown AJP, Gow NAR (2007). The PKC, HOG and Ca <sup>2+</sup> signalling pathways co-ordinately regulate chitin synthesis in Candida albicans. Molecular Microbiology, 63(5), 1399-1413. Abstract.
Barelle CJ, Richard ML, Gaillardin C, Gow NAR, Brown AJP (2006). Candida albicans VAC8 is required for vacuolar inheritance and normal hyphal branching. Eukaryotic Cell, 5(2), 359-367. Abstract.
Rodaki A, Young T, Brown AJP (2006). Effects of depleting the essential central metabolic enzyme, fructose-1,6-bisphosphate aldolase,upon the growth and viability of Candida albicans: implications for antifungal drug target discovery. Eukaryotic Cell, 5, 1371-1377. Abstract.
Preece AD, Jin B, Pignotti E, Missier P, Embury S, Stead DA, Brown AJP (2006). Managing Information Quality in e-Science using Semantic Web Technology. Lecture Notes in Computer Science, 4011, 472-486. Abstract.
Barelle CJ, Priest CL, MacCallum DM, Gow NAR, Odds FC, Brown AJP (2006). Niche-specific regulation of central metabolic pathways in a fungal pathogen. Cellular Microbiology, 8(6), 961-971. Abstract.
Stead DA, Preece AD, Brown AJP (2006). Universal metrics for quality assessment of protein identifications by mass spectrometry. Molecular and Cellular Proteomics, 1205-1211.
d'Enfert C, Goyard S, Rodriguez-Arnaveilhe S, Frangeul L, Jones L, Tekaia F, Bader O, Albrecht A, Castillo L, Dominguez A, et al (2005). CandidaDB: a genome database for Candida albicans pathogenomics. Nucleic Acids Res, 33(Database issue), D353-D357. Abstract.  Author URL.
Copping VMS, Barelle CJ, Hube B, Gow NAR, Brown AJP, Odds FC (2005). Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes. Journal of Antimicrobial Chemotherapy, 55(5), 645-654. Abstract.
Dennison PMJ, Ramsdale M, Manson CL, Brown AJP (2005). Gene disruption in Candida albicans using a synthetic, codon-optimised Cre-loxP system. Fungal Genet Biol, 42(9), 737-748. Abstract.  Author URL.
Tournu H, Tripathi G, Bertram G, Macaskill S, Mavor A, Walker L, Odds FC, Gow NAR, Brown AJP (2005). Global role of the protein kinase Gcn2 in the human pathogen Candida albicans. Eukaryotic Cell, 4(10), 1687-1696. Abstract.
Stead D, Findon H, Yin Z, Walker J, Selway L, Cash P, Dujon BA, Hennequin C, Brown AJP, Haynes K, et al (2005). Proteomic changes associated with inactivation of the Candida glabrata ACE2 virulence-moderating gene. Proteomics, 5(7), 1838-1848. Abstract.  Author URL.
Zhao X, Oh S-H, Cheng G, Green CB, Nuessen JA, Yeater K, Leng RP, Brown AJP, Hoyer LL (2004). ALS3 and ALS8 represent a single locus that encodes a Candida albicans adhesin; functional comparisons between Als3p and Als1p. Microbiology, 150(Pt 7), 2415-2428. Abstract.  Author URL.
Odds FC, Brown AJP, Gow NAR (2004). Candida albicans genome sequence: a platform for genomics in the absence of genetics. Genome Biology, 5(7). Abstract.
Brand A, MacCallum DM, Brown AJP, Gow NAR, Odds FC (2004). Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus. Eukaryotic Cell, 3(4), 900-909. Abstract.
Barelle CJ, Manson CL, MacCallum DM, Odds FC, Gow NAR, Brown AJP (2004). GFP as a quantitative reporter of gene regulation in Candida albicans. Yeast, 21(4), 333-340. Abstract.
Garwood K, McLaughlin T, Garwood C, Joens S, Morrison N, Taylor CF, Carroll K, Evans C, Whetton AD, Hart S, et al (2004). PEDRo: a database for storing, searching and disseminating experimental proteomics data. BMC Genomics, 5 Abstract.  Author URL.
Yin Z, Stead D, Selway L, Walker J, Riba-Garcia I, McLnerney T, Gaskell S, Oliver SG, Cash P, Brown AJP, et al (2004). Proteomic response to amino acid starvation in Candida albicans and Saccharomyces cerevisiae. Proteomics, 4(8), 2425-2436. Abstract.  Author URL.
Taylor CF, Paton NW, Garwood KL, Kirby PD, Stead DA, Yin Z, Deutsch EW, Selway L, Walker J, Riba-Garcia I, et al (2003). A systematic approach to modeling, capturing, and disseminating proteomics experimental data. Nat Biotechnol, 21(3), 247-254. Abstract.  Author URL.
Odds FC, Brown AJP, Gow NAR (2003). Antifungal agents: Mechanisms of action. Trends in Microbiology, 11(6), 272-279. Abstract.
Barelle CJ, Bohula EA, Kron SJ, Wessels D, Soll DR, Schäfer A, Brown AJP, Gow NAR (2003). Asynchronous cell cycle and asymmetric vacuolar inheritance in true hyphae of Candida albicans. Eukaryotic Cell, 2(3), 398-410. Abstract.
Yin Z, Wilson S, Hauser NC, Tournu H, Hoheisel JD, Brown AJP (2003). Glucose triggers different global responses in yeast, depending on the strength of the signal, and transiently stabilizes ribosomal protein mRNAs. Mol Microbiol, 48(3), 713-724. Abstract.  Author URL.
Blackwell C, Russell CL, Brown AJP, Brown JD, Argimon S (2003). Protein A-tagging for purification of native macromolecular complexes from Candida albicans. Yeast, 20, 1235-1241. Abstract.
Gow NAR, Brown AJP, Odds FC (2002). Fungal morphogenesis and host invasion. Current Opinion in Microbiology, 5(4), 366-371. Abstract.
Chitnis MV, Munro CA, Brown AJP, Gooday GW, Gow NAR, Deshpande MV (2002). The zygomycetous fungus, Benjaminiella poitrasii contains a large family of differentially regulated chitin synthase genes. Fungal Genetics and Biology, 36(3), 215-223. Abstract.
Munro CA, Winter K, Buchan A, Henry K, Becker JM, Brown AJP, Bulawa CE, Gow NAR (2001). Chs1 of Candida albicans is an essential chitin synthase required for synthesis of the septum and for cell integrity. Molecular Microbiology, 39(5), 1414-1426. Abstract.
Leng P, Lee PR, Wu H, Brown AJP (2001). Efg1, a morphogenetic regulator in Candida albicans, is a sequence-specific DNA binding protein. Journal of Bacteriology, 183, 4090-4093.
Odds FC, Gow NAR, Brown AJP (2001). Fungal virulence studies come of age. Genome Biology, 2(3). Abstract.
Pearce AK, Booth IR, Brown AJP (2001). Genetic manipulation of 6-phosphofructo-1-kinase and fructose 2,6-bisphosphate levels affects the extent to which benzoic acid inhibits the growth of Saccharomyces cerevisiae. Microbiology, 147, 403-410. Abstract.
Pearce AK, Crimmins K, Groussac E, Hewlins MJ, Dickinson JR, Francois J, Booth IR, Brown AJP (2001). Pyruvate kinase (Pyk1) levels influence both the rate and direction of carbon flux in yeast under fermentative conditions. Microbiology, 147, 391-401. Abstract.
Brown AJP, Planta RJ, Restuhadi F, Bailey DA, Butler PR, Cadahia JL, Cerdan ME, De Jonge M, Gardner DC (2001). Transcript analysis of 1003 novel yeast genes using high-throughput northern hybridizations. EMBO Journal, 20, 3177-3186. Abstract.
Gow NAR, Brown AJP, Odds FC (2000). Candida's arranged marriage. Science, 289(5477), 256-257.
Yin Z, Hatton L, Brown AJ (2000). Differential post-transcriptional regulation of yeast mRNAs in response to high and low glucose concentrations. Mol Microbiol, 35(3), 553-565. Abstract.  Author URL.
Brown AJ, Barelle CJ, Budge S, Duncan J, Harris S, Lee PR, Leng P, Macaskill S, Abdul Murad AM, Ramsdale M, et al (2000). Gene regulation during morphogenesis in Candida albicans. Contrib Microbiol, 5, 112-125. Author URL.
Gow NAR, Brown AJP, Odds FC (2000). Microbiology - Candida’s arranged marriage. Science, 289, 256-257.
Odds FC, Brown AJP, Gow NAR (2000). Might Candida albicans be made to mate after all?. Trends in Microbiology, 8, 46-46.
Leng P, Sudbery PE, Brown AJP (2000). Rad6p represses yeast-hypha morphogenesis in the human fungal pathogen Candida albicans. Molecular Microbiology, 35, 1264-1275. Abstract.
Gow NAR, Bates S, Brown AJP, Buurman ET, Thomson LM, Westwater C (1999). Candida cell wall mannosylation: importance in host-fungus interaction and potential as a target for the development of antifungal drugs. Biochemical Society Transactions, 27, 512-516.
Sartori G, Aldegheri L, Mazzotta G, Lanfranchi G, Tournu H, Brown AJP, Carignani G (1999). Characterization of a new hemoprotein in the yeast Saccharomyces cerevisiae. The Journal of Biological Chemistry, 274, 5032-5037. Abstract.
Milewski S, Kuszczak D, Jedrzejczak R, Smith RJ, Brown AJP, Gooday GW (1999). Oligomeric structure and regulation of Candida albicans glucosamine-6-phosphate synthase. The Journal of Biological Chemistry, 274, 4000-4008. Abstract.
Wiltshire C, Black S, Brown AJP (1999). Over-expression of Candida albicans mitochondrial ribosomal protein S9 (MrpS9p) disturbs mitochondrial function in Saccharomyces cerevisiae. Yeast, 15, 139-143. Abstract.
Brown AJP, Gow NAR (1999). Regulatory networks controlling Candida albicans morphogenesis. Trends in Microbiology, 7(8), 333-338. Abstract.
Zaman Z, Bowman SB, Kornfeld GD, Brown AJP, Dawes IW (1999). Transcription factor GCN4 for control of amino acid biosynthesis also regulates the expression of the gene for lipoamide dehydrogenase. Biochemical Journal, 340, 855-862. Abstract.
Buurman ET, Westwater C, Hube B, Brown AJP, Odds FC, Gow NAR (1998). Molecular analysis of CaMnt1p, a mannosyl transferase important for adhesion and virulence of Candida albicans. Proceedings of the National Academy of Sciences of the United States of America, 95(13), 7670-7675. Abstract.
Tait E, Simon MC, King S, Brown AJ, Gow NA, Shaw DJ (1997). A Candida albicans genome project: cosmid contigs, physical mapping, and gene isolation. Fungal Genet Biol, 21(3), 308-314. Abstract.  Author URL.
Hube B, Sanglard D, Odds FC, Hess D, Monod M, Schäfer W, Brown AJP, Gow NAR (1997). Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence. Infection and Immunity, 65(9), 3529-3538. Abstract.
Cormack BP, Bertram G, Egerton M, Gow NAR, Falkow S, Brown AJP (1997). Yeast-enhanced green fluorescent protein (yEGFP): a reporter of gene expression in Candida albicans. Microbiology, 143(2), 303-311. Abstract.
Yin Z, Smith RJ, Brown AJ (1996). Multiple signalling pathways trigger the exquisite sensitivity of yeast gluconeogenic mRNAs to glucose. Mol Microbiol, 20(4), 751-764. Abstract.  Author URL.
Leberer E, Harcus D, Broadbent ID, Clark KL, Dignard D, Ziegelbauer K, Schmidt A, Gow NAR, Brown AJP, Thomas DY, et al (1996). Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proceedings of the National Academy of Sciences of the United States of America, 93(23), 13217-13222. Abstract.
Bertram G, Swoboda RK, Gooday GW, Gow NAR, Brown AJP (1996). Structure and regulation of the Candida albicans ADH1 gene encoding an immunogenic alcohol dehydrogenase. Yeast, 12(2), 115-127. Abstract.
Bailey DA, Feldmann PJF, Bovey M, Gow NAR, Brown AJP (1996). The Candida albicans HYR1 gene, which is activated in response to hyphal development, belongs to a gene family encoding yeast cell wall proteins. Journal of Bacteriology, 178(18), 5353-5360. Abstract.
Gow NAR, Robbins PW, Lester JW, Brown AJP, Fonzi WA, Chapman T, Kinsman OS (1994). A hyphal-specific chitin synthase gene (CHS2) is not essential for growth, dimorphism, or virulence of Candida albicans. Proceedings of the National Academy of Sciences of the United States of America, 91(13), 6216-6220. Abstract.
Hube B, Monod M, Schofield DA, Brown AJP, Gow NAR (1994). Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans. Molecular Microbiology, 14(1), 87-99. Abstract.
Swoboda RK, Bertram G, Delbrück S, Ernst JF, Gow NAR, Gooday GW, Brown AJP (1994). Fluctuations in glycolytic mRNA levels during morphogenesis in Candida albicans reflect underlying changes in growth and are not a response to cellular dimorphism. Molecular Microbiology, 13(4), 663-672. Abstract.
Cannon RD, Timberlake WE, Gow NAR, Bailey D, Brown A, Gooday GW, Hube B, Monod M, Nombela C, Navarro F, et al (1994). Molecular biological and biochemical aspects of fungal dimorphism. Medical Mycology, 32(S1), 53-64.
Swoboda RK, Bertram G, Colthurst DR, Tuite MF, Gow NAR, Gooday GW, Brown AJP (1994). Regulation of the gene encoding translation elongation factor 3 during growth and morphogenesis in Candida albicans. Microbiology, 140(10), 2611-2616. Abstract.
Swoboda RK, Bertram G, Hollander H, Greenspan D, Greenspan JS, Gow NAR, Gooday GW, Brown AJP (1993). Glycolytic enzymes of Candida albicans are nonubiquitous immunogens during candidiasis. Infection and Immunity, 61(10), 4263-4271. Abstract.

Chapters

Ene IV, Brown AJP (In Press). Integration of Metabolism with Virulence in Candida albicans. In Nowrousian M (Ed) Fungal Genomics, Springer, 349-370.  Abstract.
Brown AJP (In Press). Preparation of total RNA. In Evans IH (Ed) Yeast Protocols, Springer, 269-276.  Abstract.
(In Press). Stress Responses in Candida albicans. In. In  (Ed) .
Brown AJP, Haynes K, Gow NAR, Quinn J (2012). Stress responses Candida. In Calderone RA, Clancy CJ (Eds.) Candida and Candidiasis, ASM Press, 225-242.
Odds FC, Gow NAR, Brown AJP (2010). Towards a molecular understanding of Candida albicans virulence. In Heitman J, Filler S, Mitchell A (Eds.) Molecular Principles of Fungal Pathogenesis, ASM Press.
Brown AJP, Argimon S, Gow NAR (2007). Signal transduction and morphogenesis in Candida albicans. In Howard RJ, Gow NAR (Eds.) Biology of the Fungal Cell, Springer Berlin / Heidelberg, 167-194.  Abstract.
Brown AJP (2006). Integration of Metabolism with Virulence in Candida albicans. In Brown A (Ed) Fungal Genomics, Springer Berlin / Heidelberg, 185-203.

Conferences

Shahana S, Mora-Montes H, Castillo L, Sheth CC, Odds FC, Gow NAR, Brown AJP (In Press). A tool for analysis of N-glycosylation in Candida albicans.
Shahana S, Mora-Montes H, Castillo L, Sheth CC, Odds FC, Gow NAR, Brown AJP (In Press). A tool for analysis of N-glycosylation in Candida albicans.
Shahana S, Mora-Montes HM, Castillo L, Sheth CC, Odds FC, Gow NAR, Brown AJP (In Press). A tool for analysis of N-glycosylation in Candida albicans.
Shahana S, Mora-Montes H, Castillo L, Sheth CC, Odds FC, Gow NAR, Brown AJP (In Press). A tool for analysis of N-glycosylation in Candida albicans.
Shahana S, Mora-Montes H, Castillo L, Sheth CC, Odds FC, Gow NAR, Brown AJP (In Press). A tool for analysis of N-glycosylation in Candida albicans.
Shahana S, Childers DS, Ballou ER, Bohovych I, Odds FC, Gow NAR, Brown AJP (In Press). New Clox systems for rapid and efficient gene disruption in Candida albicans.
Shahana S, Childers DS, Ballou ER, Bohovych I, Odds FC, Gow NAR, Brown AJP (In Press). New Clox systems for rapid and efficient gene disruption in Candida albicans.
Tillmann A, Gow NAR, Brown AJP (2011). Nitric oxide and nitrosative stress tolerance in yeast.  Abstract.
You T, Coghill GM, Brown AJP (2007). A quantitative model for the translational control of GCN4 in yeast.
Preece AD, Jin B, Missier P, Embury S, Stead DA, Brown AJP (2006). Towards the Management of Information Quality in Proteomics.  Abstract.

Publications by year


In Press

Brown AJP, Tuite MF (In Press). 24 Yeast Gene Analysis in the Next Millennium. Methods in Microbiology, 26, 451-461.
Brown AJP, Furness LM, Bailey D (In Press). 8 Transcript Analysis. Methods in Microbiology, 26, 119-139. Abstract.
Smith DA, Nicholls S, Morgan BA, Brown AJP, Quinn J (In Press). A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans. Molecular Biology of the Cell, 15, 4179-4190. Abstract.
Enjalbert B, Rachini A, Vediyappan G, Pietrella D, Spaccapelo R, Vecchiarelli A, Brown AJP, Enfert CD (In Press). A multifunctional, synthetic Gaussia princeps luciferase reporter for live imaging of Candida albicans infections. Infection and Immunity, 77, 4847–4858-4847–4858. Abstract.
Wicksteed BL, Collins I, Dershowitz A, Stateva LI, Green RP, Oliver SG, Brown AJP, Newlon CS (In Press). A physical comparison of chromosome III in six strains of Saccharomyces cerevisiae. Yeast, 10, 39-57. Abstract.
You T, Coghill GM, Brown AJP (In Press). A quantitative model for mRNA translation in Sacchromyces cerevisiae. Yeast, 27, 785-800. Abstract.
Shahana S, Mora-Montes H, Castillo L, Sheth CC, Odds FC, Gow NAR, Brown AJP (In Press). A tool for analysis of N-glycosylation in Candida albicans.
Shahana S, Mora-Montes H, Castillo L, Sheth CC, Odds FC, Gow NAR, Brown AJP (In Press). A tool for analysis of N-glycosylation in Candida albicans.
Shahana S, Mora-Montes HM, Castillo L, Sheth CC, Odds FC, Gow NAR, Brown AJP (In Press). A tool for analysis of N-glycosylation in Candida albicans.
Shahana S, Mora-Montes H, Castillo L, Sheth CC, Odds FC, Gow NAR, Brown AJP (In Press). A tool for analysis of N-glycosylation in Candida albicans.
Shahana S, Mora-Montes H, Castillo L, Sheth CC, Odds FC, Gow NAR, Brown AJP (In Press). A tool for analysis of N-glycosylation in Candida albicans.
Hauser M, Horn P, Tournu H, Hauser NC, Hoheisel JD, Brown AJP, Dickinson JR (In Press). A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase. FEMS Yeast Research, 7, 84-92. Abstract.
Pietrella D, Rachini A, Torosantucci A, Chiani P, Brown AJP, Bistoni F, Costantino P, Mosci P, Enfert CD, Rappuoli R, et al (In Press). A β-glucan-conjugate vaccine and anti-β-glucan antibodies are effective against murine vaginal candidiasis as assessed by a novel in vivo imaging technique. Vaccine, 28, 1717-1725. Abstract.
Doedt T, Krishnamurthy S, Bockmuhl DP, Tebarth B, Stempel C, Russell CL, Brown AJP, Ernst JF (In Press). APSES proteins regulate morphogenesis and metabolism in Candida albicans. Molecular Biology of the Cell, 15, 3167-3180. Abstract.
Nicholls S, MacCallum DM, Kaffarnik FAR, Selway L, Peck SC, Brown AJP (In Press). Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicans. Fungal Genetics and Biology, 48, 297-305. Abstract.
Holyoak CD, Stratford M, Mcmullin Z, Cole MB, Crimmins K, Brown AJP, Coote PJ (In Press). Activity of the plasma membrane H+-ATPase and optimal glycolytic flux are required for rapid adaptation and growth of Saccharomyces cerevisiae in the presence of the weak-acid preservative sorbic acid. Applied and Environmental Microbiology, 62, 3158-3164. Abstract.
Brown AJP, Tuite MF (In Press). Appendix II: Yeast Growth. Methods in Microbiology, 26, 471-477.
Brown AJP (In Press). Appendix III: Useful World Wide Web Addresses for Yeast Researchers. Methods in Microbiology, 26, 479-484.
Enfert CD, Vecchiarelli A, Brown AJP (In Press). Bioluminescent fungi for real-time monitoring of fungal infections. Virulence, 1, 174-176. Abstract.
Bates S, de la Rosa JM, MacCallum DM, Brown AJP, Gow NAR, Odds FC (In Press). Candida albicans Iff11, a secreted protein required for cell wall structure and virulence. Infection and Immunity, 75, 2922-2928. Abstract.
Mota S, Alves R, Carneiro C, Silva S, Brown AJ, Istel F, Kuchler K, Sampaio P, Casal M, Henriques M, et al (In Press). Candida glabrata susceptibility to antifungals and phagocytosis is modulated by acetate. Frontiers in Microbiology, 6 Abstract.
Ene IV, Heilmann CJ, Sorgo AG, Walker LA, de Koster CG, Munro CA, Klis FM, Brown AJP (In Press). Carbon source-induced reprogramming of the cell wall proteome and secretome modulates the adherence and drug resistance of the fungal pathogen Candida albicans. Proteomics, 12, 3164-3179. Abstract.
Miramón P, Dunker C, Windecker H, Bohovych IM, Brown AJP, Kurzai O, Hube B (In Press). Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress. PloS ONE, 7 Abstract.
Hardman N, Jack PL, Brown AJP, McLachlan A (In Press). Characterisation of ribosomal satellite in total nuclear DNA from Physarum polycephalum. BBA Section Nucleic Acids and Protein Synthesis, 562, 365-376. Abstract.
Wagener J, Malireddi RKS, Lenardon MD, Koeberle M, Vautier S, MacCallum DM, Biedermann T, Schaller M, Netea MG, Kanneganti T-D, et al (In Press). Chitin recognition in fungal infections and its impact on the immune response. Mycoses, 56, 7-7.
Brown AJP, Bertram G, Feldmann PJF, Peggie MW, Swoboda RK (In Press). Codon utilisation in the pathogenic yeast, Candida albicans. Nucleic Acids Research, 19
Potrykus J, Ballou ER, Childers DS, Brown AJP (In Press). Conflicting interests in the pathogen-host tug of war: fungal micronutrient scavenging versus mammalian nutritional immunity. PLoS Pathogens, 10 Abstract.
Clark KL, Feldmann PJF, Dignard D, Larocque R, Brown AJP, Lee MG, Thomas DY, Whiteway M (In Press). Constitutive activation of the Saccharomyces cerevislae mating response pathway by a MAP kinase kinase from Candida albicans. Molecular & general genetics, 249, 609-621. Abstract.
Brown AJP (In Press). Control of metabolic flux in yeasts and fungi. Trends in Biotechnology, 15, 445-447. Abstract.
Castillo LC, Maccallum DM, Brown AJP, Gow NAR, Odds FC (In Press). Differential regulation of kidney and spleen cytokine responses in mice infected with a Candida albicans mannosylation mutant. Mycoses, 54, 114-114.
Hopke A, Brown AJP, Hall RA, Wheeler RT (In Press). Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion. Trends in Microbiology, 26, 284-295. Abstract.
Mora-Montes HM, Bates S, Netea MG, Diaz-Jimenez DF, Lopez-Romero E, Zinker S, Ponce-Norla P, Kullberg BJ, Brown AJP, Odds FC, et al (In Press). Endoplasmic reticulum alpha-glycosidases of Candida albicans are required for N glycosylation, cell wall integrity, and normal host-fungus interaction. Eukaryotic Cell, 6, 2184-2193. Abstract.
Russell CL, Brown AJP (In Press). Expression of one-hybrid fusions with Staphylococcus aureus lexA in Candida albicans confirms that Nrg1 is a transcriptional repressor and that Gcn4 is a transcriptional activator. Fungal Genetics and Biology, 42, 676-683. Abstract.
Vieira N, Casal M, Johansson BO, MacCallum DM, Brown AJP, Paiva S (In Press). Functional specialization and differential regulation of short-chain carboxylic acid transporters in the pathogen Candida albicans. Molecular Microbiology, 75, 1337-1354. Abstract.
Leach MD, Klipp E, Cowen LE, Brown AJP (In Press). Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs. Nature Reviews Microbiology, 10, 693-704. Abstract.
Potrykus J, Stead D, Maccallum DM, Urgast DS, Raab A, van Rooijen N, Feldmann JO, Brown AJP (In Press). Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events. PLoS Pathogens, 9 Abstract.
Tripathi G, Wiltshire C, MacAskill S, Tournu H, Budge S, Brown AJP (In Press). Gcn4 co-ordinates morphogenetic and metabolic responses to amino acid starvation in Candida albicans. EMBO Journal, 21, 5448-5456. Abstract.
Enjalbert B, Moran GP, Vaughan C, Yeomans T, MacCallum DM, Quinn J, Coleman DC, Brown AJP, Sullivan DJ (In Press). Genome-wide gene expression profiling and a forward genetic screen show that differential expression of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic stress. Molecular Microbiology, 72, 216-228. Abstract.
Weig M, Brown AJP (In Press). Genomics and the development of new diagnostics and anti-Candida drugs. Trends in Microbiology, 15, 310-317. Abstract.
Garcia-Sanchez S, Mavor AL, Russell CL, Argimon S, Dennison P, Enjalbert BP, Brown AJP (In Press). Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicans. Molecular Biology of the Cell, 16, 2913-2925. Abstract.
Chew SY, Ho KL, Cheah YK, Ng TS, Sandai D, Brown AJP, Lung LTT (In Press). Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and virulence of Candida glabrata. Scientific Reports, 9, 2843-2843. Abstract.
Ene IV, Cheng S-C, Netea MG, Brown AJP (In Press). Growth of Candida albicans cells on the physiologically relevant carbon source lactate affects their recognition and phagocytosis by immune cells. Infection and Immunity, 81, 238-248. Abstract.
Ene IV, Adya AK, Heilmann CJ, Sorgo AG, Klis FM, MacCallum DM, Gow NA, Brown AJP (In Press). Host carbon sources modulate cell wall architecture and virulence in Candida albicans. Mycoses, 55, 172-173.
MacKie J, Szabo EK, Urgast DS, Ballou ER, Childers DS, MacCallum DM, Feldmann J, Brown AJP (In Press). Host-Imposed Copper Poisoning Impacts Fungal Micronutrient Acquisition during Systemic Candida albicans Infections. PloS ONE, 11 Abstract.
Leach MD, Farrer RA, Tan K, Miao Z, Walker LA, Cuomo CA, Wheeler RT, Brown AJP, Wong KH, Cowen LE, et al (In Press). Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans. Nature Communications, 7 Abstract.  Full text.
Leach M, Budge S, Walker L, Munro C, Cowen LE, Brown AJP (In Press). Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast. PLoS Pathogens, 8 Abstract.
Leach MD, Stead DA, Argo E, Brown AJP (In Press). Identification of sumoylation targets, combined with inactivation of SMT3, reveals the impact of sumoylation upon growth, morphology, and stress resistance in the pathogen Candida albicans. Molecular Biology of the Cell, 22, 687-702. Abstract.
Gow NAR, Netea MG, Munro CA, Ferwerda G, Bates S, Mora-Montes HM, Walker L, Jansen T, Jacobs L, Tsoni V, et al (In Press). Immune Recognition of Candida albicans ß-glucan by Dectin-1. The journal of infectious diseases, 196, 1565-1571. Abstract.
Netea MG, Gow NAR, Munro CA, Bates S, Collins C, Ferwerda G, Hobson RP, Bertram G, Hughes HB, Jansen T, et al (In Press). Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. The Journal of Clinical Investigation, 116, 1642-1650. Abstract.
Stead DA, Paton NW, Missier P, Embury SM, Hedeler C, Jin B, Brown AJP, Preece A (In Press). Information quality in proteomics. Briefings in Bioinformatics, 9, 174-188. Abstract.
Ene IV, Brown AJP (In Press). Integration of Metabolism with Virulence in Candida albicans. In Nowrousian M (Ed) Fungal Genomics, Springer, 349-370.  Abstract.
Smith RJ, Milewski S, Brown AJP, Gooday GW (In Press). Isolation and characterization of the GFA1 gene encoding the glutamine:fructose-6-phosphate amidotransferase of Candida albicans. Journal of Bacteriology, 178, 2320-2327. Abstract.
Ene IV, Brunke S, Brown AJP, Hube B (In Press). Metabolism in fungal pathogenesis. Cold Spring Harbor perspectives in medicine, 4 Abstract.
Brown AJP (In Press). Microbial signaling and systems biology., BioMed Central. Abstract.
Munro CA, Bates S, Buurman ET, Hughes HB, MacCallum DM, Bertram G, Atrih A, Ferguson MA, Bain JM, Brand AC, et al (In Press). Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence. The Journal of Biological Chemistry, 280, 1051-1060. Abstract.
Munro CA, Bates S, Buurman ET, Hughes HB, MacCallum DM, Bertram G, Atrih A, Ferguson MA, Bain JM, Brand AC, et al (In Press). Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence. The Journal of Biological Chemistry, 280, 1051-1060. Abstract.
Leach MD, Tyc K, Brown AJP, Klipp E (In Press). Modelling the regulation of thermal adaptation in Candida albicans, a major fungal pathogen of humans. PloS ONE, 7 Abstract.
Leach MD, Stead DA, Argo EA, MacCallum DM, Brown AJP (In Press). Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans. Molecular Microbiology, 79, 1574-1593. Abstract.
Leach MD, Stead DA, Argo E, MacCallum DM, Brown AJP (In Press). Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans. Molecular Microbiology, 84, 594-594. Abstract.
Nicholls SM, Straffon M, Enjalbert BP, Nantel A, MacAskill S, Whiteway M, Brown AJP (In Press). Msn2- and Msn4-like transcription factors play no obvious roles in the stress responses of the fungal pathogen Candida albicans. Eukaryotic Cell, 3, 1111-1123. Abstract.
Moore PA, Bettany AJE, Brown AJP (In Press). Multiple copies of the pyruvate kinase gene affect yeast cell growth. Journal of General Microbiology, 136, 2359-2366. Abstract.
Murad AMA, Leng P, Straffon M, Wishart J, Macaskill S, MacCallum D, Schnell N, Talibi D, Marechal D, Tekaia F, et al (In Press). NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans. EMBO Journal, 20, 4742-4752. Abstract.
Shahana S, Childers DS, Ballou ER, Bohovych I, Odds FC, Gow NAR, Brown AJP (In Press). New Clox systems for rapid and efficient gene disruption in Candida albicans.
Shahana S, Childers DS, Ballou ER, Bohovych I, Odds FC, Gow NAR, Brown AJP (In Press). New Clox systems for rapid and efficient gene disruption in Candida albicans.
Enjalbert BP, MacCallum DM, Odds FC, Brown AJP (In Press). Niche-Specific Activation of the Oxidative Stress Response by the Pathogenic Fungus Candida albicans. Infection and Immunity, 75, 2143-2151. Abstract.
Bohovych I, Kastora S, Christianson S, Topil D, Kim H, Fangman T, Zhou YJ, Barrientos A, Lee J, Brown AJP, et al (In Press). Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling to Modulate Physiological Plasticity and Cellular Stress Responses. Molecular and Cellular Biology, 36, 2300-2312. Abstract.
Bates S, Hughes HB, Munro CA, Thomas WPH, MacCallum DM, Bertram G, Atrih A, Ferguson MAJ, Brown AJP, Odds FC, et al (In Press). Outer chain N-glycans are required for cell wall integrity and virulence of Candida albicans. The Journal of Biological Chemistry, 281, 90-8. Abstract.
Ikeh MAC, Kastora SL, Day AM, Herrero-de-Dios CM, Tarrant E, Waldron KJ, Banks AP, Bain JM, Lydall D, Veal EA, et al (In Press). Pho4 mediates phosphate acquisition in Candida albicans and is vital for stress resistance and metal homeostasis. Molecular Biology of the Cell, 27, 2784-2801. Abstract.
Nikolaou E, Agrafioti I, Stumpf M, Quinn J, Stansfield I, Brown AJP (In Press). Phylogenetic diversity of stress signalling pathways in fungi. BMC Evolutionary Biology, 9, 44-44. Abstract.
Chew SY, Ho KL, Cheah YK, Sandai D, Brown AJP, Lung LTT (In Press). Physiologically Relevant Alternative Carbon Sources Modulate Biofilm Formation, Cell Wall Architecture and the Stress and Antifungal Resistance of Candida glabrata. International Journal of Molecular Sciences, 20 Abstract.
Vieira N, Pereira F, Casal M, Brown AJP, Paiva S, Johansson BO (In Press). Plasmids for in vivo construction of integrative Candida albicans vectors in Saccharomyces cerevisiae. Yeast, 27, 933-939. Abstract.
Bowman SB, Zaman Z, Collinson LP, Brown AJP, Dawes IW (In Press). Positive regulation of the LPD1 gene of Saccharomyces cerevisine by the HAP2/HAP3/HAP4 activation system. Molecular & general genetics, 231, 296-303. Abstract.
Leach MD, Brown AJP (In Press). Posttranslational modifications of proteins in the pathobiology of medically relevant fungi. Eukaryotic Cell, 11, 98-108. Abstract.
Brown AJP (In Press). Preparation of total RNA. In Evans IH (Ed) Yeast Protocols, Springer, 269-276.  Abstract.
Sagliocco FA, Zhu D, Vega Laso MR, McCarthy JEG, Tuite MF, Brown AJP (In Press). Rapid mRNA degradation in yeast can proceed independently of translational elongation. The Journal of Biological Chemistry, 269, 18630-18637. Abstract.
Enjalbert BP, Smith DA, Cornell MJ, Alam I, Nicholls SM, Brown AJP, Quinn J (In Press). Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans. Molecular Biology of the Cell, 17, 1018-1032. Abstract.
Nicholls S, Leach MD, Priest CL, Brown AJP (In Press). Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals. Molecular Microbiology, 74, 844-861. Abstract.
Kastora SL, Herrero De Dios C, Avelar GM, Munro CA, Brown AJP (In Press). Sfp1 and Rtg3 reciprocally modulate carbon source-conditional stress adaptation in the pathogenic yeast Candida albicans. Molecular Microbiology, 105, 620-636. Abstract.
Jacobsen MD, Beynon RJ, Gethings LA, Claydon AJ, Langridge JI, Vissers JPC, Brown AJP, Hammond DE (In Press). Specificity of the osmotic stress response in Candida albicans highlighted by quantitative proteomics. Scientific Reports, 8 Abstract.
Brown AJP, Cowen LE, Di Pietro A, Quinn J (In Press). Stress Adaptation. Microbiology spectrum, 5, 1-23. Abstract.
(In Press). Stress Responses in Candida albicans. In. In  (Ed) .
Kelly MT, MacCallum DM, Clancy SD, Odds FC, Brown AJP, Butler G (In Press). The Candida albicans CaACE2 gene affects morphogenesis, adherence and virulence. Molecular Microbiology, 53, 969-983. Abstract.
Crombie T, Boyle JP, Coggins JR, Brown AJP (In Press). The Folding of the Bifunctional TRP3 Protein in Yeast is Influenced by a Translational Pause which Lies in a Region of Structural Divergence with Escherichia coli Indoleglycerol‐Phosphate Synthase. European Journal of Biochemistry, 226, 657-664. Abstract.
Mercado JJ, Smith R, Sagliocco FA, Brown AJP, Gancedo JM (In Press). The Levels of Yeast Gluconeogenic mRNAs Respond to Environmental Factors. European Journal of Biochemistry, 224, 473-481. Abstract.
Leng P, Carter PE, Brown AJP (In Press). The TATA-binding protein (TBP) from the human fungal pathogen Candida albicans can complement defects in human and yeast TBPs. Journal of Bacteriology, 180, 1771-1776. Abstract.
Oliver SG, Van Der Aart QJM, Agostoni-Carbone ML, Aigle M, Alberghina L, Alexandraki D, Antoine G, Anwar R, Ballesta JPG, Benit P, et al (In Press). The complete DNA sequence of yeast chromosome III. Nature, 357, 38-46. Abstract.
Wicksteed BL, Roberts AB, Sagliocco FA, Brown AJP (In Press). The complete sequence of a 7·5 kb region of chromosome III from Saccharomyces cerevisiae that lies between CRY1 and MAT. Yeast, 7, 761-772. Abstract.
Brown AJP, Hardman N (In Press). The effect of age on the properties of poly(A)-containing messenger RNA in Physarum polycephalum. Journal of General Microbiology, 122, 143-150.
Sagliocco FA, Laso MRV, Zhu D, Tuite MF, McCarthy JEG, Brown AJP (In Press). The influence of 5’-secondary structures upon ribosome binding to mRNA during translation in yeast. The Journal of Biological Chemistry, 268, 26522-26530. Abstract.
Tillmann AT, Kaloriti D, Jacobsen M, Gow NAR, Brown AJP (In Press). The medical importance of nitrosative stress and combinatorial stresses in the human fungal pathogen Candida albicans. Mycoses, 55
Riquelme M, Aime MC, Branco S, Brand A, Brown A, Glass NL, Kahmann R, Momany M, Rokas A, Trail F, et al (In Press). The power of discussion: Support for women at the fungal Gordon Research Conference. Fungal Genetics and Biology, 121, 65-67. Abstract.
Brown AJP, Leach M, Nicholls SM (In Press). The relevance of heat shock regulation in fungal pathogens of humans. Virulence, 1, 330-332. Abstract.
Planta RJ, Brown AJP, Cadahia JL, Cerdan ME, De Jonge M, Gent ME, Hayes A, Kolen CPAM, Lombardia LJ, Sefton M, et al (In Press). Transcript analysis of 250 novel yeast genes from chromosome XIV. Yeast, 15, 329-350. Abstract.
BROWN AJP, HARDMAN N (In Press). Utilization of Polyadenylated mRNA during Growth and Starvation in Physarum polycephalum. European Journal of Biochemistry, 110, 413-420. Abstract.
Moore PA, Sagliocco FA, Wood RMC, Brown AJP (In Press). Yeast glycolytic mRNAs are differentially regulated. Molecular and Cellular Biology, 11, 5330-5337. Abstract.
Brown AJ, Sagliocco FA (In Press). mRNA abundance and half-life measurements. Methods in Molecular Biology, 53, 277-295. Abstract.
Brown AJP (In Press). mRNA translation and turnover: a cellular perspective on their relationship. Trends in Cell Biology, 3, 180-183. Abstract.
Dickson LM, Brown AJP (In Press). mRNA translation in yeast during entry into stationary phase. Molecular & general genetics, 259, 282-293. Abstract.

2019

Brown AJP, Gow NAR, Warris A, Brown GD (2019). Memory in Fungal Pathogens Promotes Immune Evasion, Colonisation, and Infection. Trends in Microbiology, 27(3), 219-230. Abstract.
Ballard E, Zoll J, Melchers WJG, Brown AJP, Warris A, Verweij PE (2019). Raw genome sequence data for 13 isogenic Aspergillus fumigatus strains isolated over a 2 year period from a patient with chronic granulomatous disease. Data Brief, 25 Abstract.  Author URL.
Ballard E, Weber J, Melchers WJG, Tammireddy S, Whitfield PD, Brakhage AA, Brown AJP, Verweij PE, Warris A (2019). Recreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanism. Fungal Genet Biol, 130, 98-106. Abstract.  Author URL.

2018

Beardmore RE, Cook E, Nilsson S, Smith AR, Tillmann A, Esquivel BD, Haynes K, Gow NAR, Brown AJP, White TC, et al (2018). Drug-mediated metabolic tipping between antibiotic resistant states in a mixed-species community. Nat Ecol Evol, 2(8), 1312-1320. Abstract.  Author URL.  Full text.
Pradhan A, Avelar GM, Bain JM, Childers DS, Larcombe DE, Netea MG, Shekhova E, Munro CA, Brown GD, Erwig LP, et al (2018). Hypoxia Promotes Immune Evasion by Triggering β-Glucan Masking on the Candida albicans Cell Surface via Mitochondrial and cAMP-Protein Kinase a Signaling. MBio, 9(6). Abstract.  Author URL.
Ballard E, Melchers WJG, Zoll J, Brown AJP, Verweij PE, Warris A (2018). In-host microevolution of Aspergillus fumigatus: a phenotypic and genotypic analysis. Fungal Genetics and Biology, 113, 1-13. Abstract.
Herrero de Dios C, Day AM, Tillmann AT, Kastora SL, Stead D, Salgado PS, Quinn J, Brown AJP (2018). Redox Regulation, Rather than Stress-Induced Phosphorylation, of a Hog1 Mitogen-Activated Protein Kinase Modulates its Nitrosative-Stress-Specific Outputs. mBio, 9 Abstract.
Gow NAR, Amin T, McArdle K, Brown AJP, Brown GD, Warris A, the WTSA-MMFI Consortium (2018). Strategic Research Funding: a Success Story for Medical Mycology. Trends in Microbiology, 26(10), 811-813. Abstract.

2017

Day AM, Smith DA, Ikeh MAC, Haider M, Herrero De Dios CM, Brown AJP, Morgan BA, Erwig LP, MacCallum DM, Quinn J, et al (2017). Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation. PLoS Pathogens, 13, 1-27. Abstract.
Pradhan A, Herrero-de-Dios C, Belmonte R, Budge S, Lopez Garcia A, Kolmogorova A, Lee KK, Martin BD, Ribeiro A, Bebes A, et al (2017). Elevated catalase expression in a fungal pathogen is a double-edged sword of iron. PLoS Pathog, 13(5). Abstract.  Author URL.
Day AM, Herrero de Dios C, MacCallum DM, Brown AJP, Quinn J (2017). Stress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen. Scientific Reports, 7, 1-10. Abstract.

2016

Ballou ER, Avelar GM, Childers DS, Mackie J, Bain JM, Wagener J, Kastora SL, Panea MD, Hardison SE, Walker LA, et al (2016). Lactate signalling regulates fungal β-glucan masking and immune evasion. Nature Microbiology, 2 Abstract.
Kos I, Patterson MJ, Znaidi S, Kaloriti D, da Silva Dantas A, Herrero-de-Dios CM, d’Enfert C, Brown AJP, Quinn J (2016). Mechanisms underlying the delayed activation of the cap1 transcription factor in Candida Albicans following combinatorial oxidative and cationic stress important for phagocytic potency. mBio, 7(2). Abstract.
Childers DS, Raziunaite I, Mol Avelar G, Mackie J, Budge S, Stead D, Gow NAR, Lenardon MD, Ballou ER, MacCallum DM, et al (2016). The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence. PLoS Pathogens, 12(4). Abstract.

2015

Vautier S, Drummond RA, Chen K, Murray GI, Kadosh D, Brown AJP, Gow NAR, Maccallum DM, Kolls JK, Brown GD, et al (2015). Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity. Cellular Microbiology, 17(4), 445-450. Abstract.
Preechasuth K, Anderson JC, Peck SC, Brown AJP, Gow NAR, Lenardon MD (2015). Cell wall protection by the Candida albicans class I chitin synthases. Fungal Genetics and Biology, 82, 264-276. Abstract.
Ene IV, Walker LA, Schiavone M, Lee KK, Martin-Yken H, Dague E, Gow NAR, Munro CA, Brown AJP (2015). Cell wall remodeling enzymes modulate fungal cell wall elasticity and osmotic stress resistance. mBio, 6(4). Abstract.
Tillmann AT, Strijbis K, Cameron G, Radmaneshfar E, Thiel M, Munro CA, MacCallum DM, Distel B, Gow NAR, Brown AJP, et al (2015). Contribution of Fdh3 and Glr1 to glutathione redox state, stress adaptation and virulence in Candida albicans. PLoS ONE, 10(6). Abstract.
Komalapriya C, Kaloriti D, Tillmann AT, Yin Z, Herrero-de-Dios C, Jacobsen MD, Belmonte RC, Cameron G, Haynes K, Grebogi C, et al (2015). Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans. PLoS One, 10(9). Abstract.  Author URL.

2014

Bain JM, Louw J, Lewis LE, Okai B, Walls CA, Ballou ER, Walker LA, Reid D, Munro CA, Brown AJP, et al (2014). Candida albicans hypha formation and mannan masking of β-Glucan inhibit macrophage phagosome maturation. mBio, 5(6). Abstract.
Wagener J, Malireddi RKS, Lenardon MD, Köberle M, Vautier S, MacCallum DM, Biedermann T, Schaller M, Netea MG, Kanneganti TD, et al (2014). Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation. PLoS Pathogens, 10(4). Abstract.
Kaloriti D, Jacobsen M, Yin Z, Patterson M, Tillmann A, Smith DA, Cook E, you T, Grimm MJ, Bohovych I, et al (2014). Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes. MBio, 5(4), e01334-e01314. Abstract.  Author URL.
Brown AJP, Brown GD, Netea MG, Gow NAR (2014). Metabolism impacts upon candida immunogenicity and pathogenicity at multiple levels. Trends in Microbiology, 22(11), 614-622. Abstract.
Shahana S, Childers DS, Ballou ER, Bohovych I, Odds FC, Gow NAR, Brown AJP (2014). New Clox systems for rapid and efficient gene disruption in Candida albicans. PLoS ONE, 9(6). Abstract.
Brown AJP, Budge S, Kaloriti D, Tillmann A, Jacobsen MD, Yin Z, Ene IV, Bohovych I, Sandai D, Kastora S, et al (2014). Stress adaptation in a pathogenic fungus. J Exp Biol, 217(Pt 1), 144-155. Abstract.  Author URL.

2013

Marakalala MJ, Vautier S, Potrykus J, Walker LA, Shepardson KM, Hopke A, Mora-Montes HM, Kerrigan A, Netea MG, Murray GI, et al (2013). Differential Adaptation of Candida albicans in Vivo Modulates Immune Recognition by Dectin-1. PLoS Pathogens, 9(4). Abstract.
Radmaneshfar E, Kaloriti D, Gustin MC, Gow NAR, Brown AJP, Grebogi C, Romano MC, Thiel M (2013). From START to FINISH: the Influence of Osmotic Stress on the Cell Cycle. PLoS ONE, 8(7). Abstract.
Shahana S, Mora-Montes HM, Castillo L, Bohovych I, Sheth CC, Odds FC, Gow NAR, Brown AJP (2013). Reporters for the analysis of N-glycosylation in Candida albicans. Fungal Genetics and Biology, 56, 107-115. Abstract.
Bates S, Hall RA, Cheetham J, Netea MG, MacCallum DM, Brown AJP, Odds FC, Gow NAR (2013). Role of the Candida albicans MNN1 gene family in cell wall structure and virulence. BMC Res Notes, 6 Abstract.  Author URL.  Full text.
Hall RA, Bates S, Lenardon MD, Maccallum DM, Wagener J, Lowman DW, Kruppa MD, Williams DL, Odds FC, Brown AJP, et al (2013). The Mnn2 mannosyltransferase family modulates mannoprotein fibril length, immune recognition and virulence of Candida albicans. PLoS Pathog, 9(4). Abstract.  Author URL.  Full text.

2012

You T, Ingram P, Jacobsen MD, Cook E, McDonagh A, Thorne T, Lenardon MD, de Moura APS, Romano MC, Thiel M, et al (2012). A systems biology analysis of long and short-term memories of osmotic stress adaptation in fungi. BMC Res Notes, 5 Abstract.  Author URL.
Gow NAR, Van De Veerdonk FL, Brown AJP, Netea MG (2012). Candida albicans morphogenesis and host defence: Discriminating invasion from colonization. Nature Reviews Microbiology, 10(2), 112-122. Abstract.
Kaloriti D, Tillmann A, Cook E, Jacobsen M, you T, Lenardon M, Ames L, Barahona M, Chandrasekaran K, Coghill G, et al (2012). Combinatorial stresses kill pathogenic Candida species. Med Mycol, 50(7), 699-709. Abstract.  Author URL.
Ene IV, Adya AK, Wehmeier S, Brand AC, Maccallum DM, Gow NAR, Brown AJP (2012). Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen. Cellular Microbiology, 14(9), 1319-1335. Abstract.
Kaloriti D, Tillmann A, Jacobsen M, Yin Z, Patterson M, Radmaneshfar E, you T, Chandrasekaran K, Pang W, Coghill G, et al (2012). Impact of combinatorial stresses upon Candida albicans. MYCOSES, 55, 15-15. Author URL.
Mayer FL, Wilson D, Jacobsen ID, Miramón P, Slesiona S, Bohovych IM, Brown AJP, Hube B (2012). Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans. PLoS One, 7(6). Abstract.  Author URL.
Brown AJP, Haynes K, Gow NAR, Quinn J (2012). Stress responses Candida. In Calderone RA, Clancy CJ (Eds.) Candida and Candidiasis, ASM Press, 225-242.
Sandai D, Yin Z, Selway L, Stead D, Walker J, Leach MD, Bohovych I, Ene IV, Kastora S, Budge S, et al (2012). The evolutionary rewiring of ubiquitination targets has reprogrammed the regulation of carbon assimilation in the pathogenic yeast Candida albicans. MBio, 3(6). Abstract.  Author URL.
Gow NAR, Brown GD, Brown AJP, Netea MG, McArdle KE (2012). Waging war on fungi - the unknown superbugs. Microbiology Today, 39(4), 208-211.

2011

You T, Stansfield I, Romano MC, Brown AJP, Coghill GM (2011). Analysing GCN4 Translational Control in Yeast by Stochastic Chemical Kinetics Modelling and Simulation. BMC Systems Biology, 5, 131-131. Abstract.
Castillo L, MacCallum DM, Brown AJP, Gow NAR, Odds FC (2011). Differential regulation of kidney and spleen cytokine responses in mice challenged with pathology-standardized doses of candida albicans mannosylation mutants. Infection and Immunity, 79(1), 146-152. Abstract.
Sheth CC, Hall R, Lewis L, Brown AJP, Odds FC, Erwig LP, Gow NAR (2011). Glycosylation status of the C. albicans cell wall affects the efficiency of neutrophil phagocytosis and killing but not cytokine signaling. Medical Mycology, 49(5), 513-524. Abstract.
Tillmann A, Gow NAR, Brown AJP (2011). Nitric oxide and nitrosative stress tolerance in yeast.  Abstract.
Mora-Montes HM, Netea MG, Ferwerda G, Lenardon MD, Brown GD, Mistry AR, Kullberg BJ, O'Callaghan CA, Sheth CC, Odds FC, et al (2011). Recognition and blocking of innate immunity cells by Candida albicans chitin. Infection and Immunity, 79(5), 1961-1970. Abstract.

2010

Mora-Montes HM, Bates S, Netea MG, Castillo L, Brand A, Buurman ET, Díaz-Jiménez DF, Jan Kullberg B, Brown AJP, Odds FC, et al (2010). A multifunctional mannosyltransferase family in Candida albicans determines cell wall mannan structure and host-fungus interactions. J Biol Chem, 285(16), 12087-12095. Abstract.  Author URL.
Stead DA, Walker J, Holcombe L, Gibbs SRS, Yin Z, Selway L, Butler G, Brown AJP, Haynes K (2010). Impact of the transcriptional regulator, Ace2, on the Candida glabrata secretome. Proteomics, 10(2), 212-223. Abstract.  Author URL.
Walker CA, Gómez BL, Mora-Montes HM, Mackenzie KS, Munro CA, Brown AJP, Gow NAR, Kibbler CC, Odds FC (2010). Melanin externalization in candida albicans depends on cell wall chitin structures. Eukaryotic Cell, 9(9), 1329-1342. Abstract.
Lenardon MD, Milne SA, Mora-Montes HM, Kaffarnik FAR, Peck SC, Brown AJP, Munro CA, Gow NAR (2010). Phosphorylation regulates polarisation of chitin synthesis in Candida albicans. Journal of Cell Science, 123(13), 2199-2206. Abstract.
Holcombe LJ, McAlester G, Munro CA, Enjalbert B, Brown AJP, Gow NAR, Ding C, Butler G, O'Gara F, Morrissey JP, et al (2010). Pseudomonas aeruginosa secreted factors impair biofilm development in Candida albicans. Microbiology, 156(5), 1476-1485. Abstract.
Odds FC, Gow NAR, Brown AJP (2010). Towards a molecular understanding of Candida albicans virulence. In Heitman J, Filler S, Mitchell A (Eds.) Molecular Principles of Fungal Pathogenesis, ASM Press.

2009

Yin Z, Stead D, Walker J, Selway L, Smith DA, Brown AJP, Quinn J (2009). A proteomic analysis of the salt, cadmium and peroxide stress responses in Candida albicans and the role of the Hog1 stress-activated MAPK in regulating the stress-induced proteome. Proteomics, 9(20), 4686-4703. Abstract.  Author URL.
MacCallum DM, Castillo L, Brown AJP, Gow NAR, Odds FC (2009). Early-expressed chemokines predict kidney immunopathology in experimental disseminated Candida albicans infections. PLoS ONE, 4(7). Abstract.
Butler G, Rasmussen MD, Lin MF, Santos MAS, Sakthikumar S, Munro CA, Rheinbay E, Grabherr M, Forche A, Reedy JL, et al (2009). Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature, 459(7247), 657-662. Abstract.  Author URL.
Walker LA, MacCallum DM, Bertram G, Gow NAR, Odds FC, Brown AJP (2009). Genome-wide analysis of Candida albicans gene expression patterns during infection of the mammalian kidney. Fungal Genetics and Biology, 46(2), 210-219. Abstract.
Rodaki A, Bohovych IM, Enjalbert B, Young T, Odds FC, Gow NAR, Brown AJP (2009). Glucose promotes stress resistance in the fungal pathogen candida albicans. Molecular Biology of the Cell, 20(22), 4845-4855. Abstract.
Brown AJP, Haynes K, Quinn J (2009). Nitrosative and oxidative stress responses in fungal pathogenicity. Curr Opin Microbiol, 12(4), 384-391. Abstract.  Author URL.
MacCallum DM, Castillo L, Nather K, Munro CA, Brown AJP, Gow NAR, Odds FC (2009). Property differences among the four major Candida albicans strain clades. Eukaryotic Cell, 8(3), 373-387. Abstract.
Fisher MC, Bosch J, Yin Z, Stead DA, Walker J, Selway L, Brown AJP, Walker LA, Gow NAR, Stajich JE, et al (2009). Proteomic and phenotypic profiling of the amphibian pathogen Batrachochytrium dendrobatidis shows that genotype is linked to virulence. Mol Ecol, 18(3), 415-429. Abstract.  Author URL.

2008

Barelle CJ, Duncan VMS, Brown AJP, Gow NAR, Odds FC (2008). Azole antifungals induce up-regulation of SAP4, SAP5 and SAP6 secreted proteinase genes in filamentous Candida albicans cells in vitro and in vivo. Journal of Antimicrobial Chemotherapy, 61(2), 315-322. Abstract.
Wimalasena TT, Enjalbert B, Guillemette T, Plumridge A, Budge S, Yin Z, Brown AJP, Archer DB (2008). Impact of the unfolded protein response upon genome-wide expression patterns, and the role of Hac1 in the polarized growth, of Candida albicans. Fungal Genet Biol, 45(9), 1235-1247. Abstract.  Author URL.
Ramsdale M, Selway L, Stead D, Walker J, Yin Z, Nicholls SM, Crowe J, Sheils EM, Brown AJP (2008). MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans. Mol Biol Cell, 19(10), 4393-4403. Abstract.  Author URL.  Full text.
Schmidt P, Walker J, Selway L, Stead D, Yin Z, Enjalbert B, Weig M, Brown AJP (2008). Proteomic analysis of the pH response in the fungal pathogen Candida glabrata. Proteomics, 8(3), 534-544. Abstract.  Author URL.

2007

You T, Coghill GM, Brown AJP (2007). A quantitative model for the translational control of GCN4 in yeast.
Argimón S, Wishart JA, Leng R, Macaskill S, Mavor A, Alexandris T, Nicholls S, Knight AW, Enjalbert B, Walmsley R, et al (2007). Developmental regulation of an adhesin gene during cellular morphogenesis in the fungal pathogen Candida albicans. Eukaryotic Cell, 6(4), 682-692. Abstract.
Brown AJP, Odds FC, Gow NAR (2007). Infection-related gene expression in Candida albicans. Current Opinion in Microbiology, 10(4), 307-313. Abstract.
de Souza J (2007). Letter. AMERICAN JOURNAL OF MEDICINE, 120(11), E21-E21. Author URL.
Brown AJP, Argimon S, Gow NAR (2007). Signal transduction and morphogenesis in Candida albicans. In Howard RJ, Gow NAR (Eds.) Biology of the Fungal Cell, Springer Berlin / Heidelberg, 167-194.  Abstract.
Munro CA, Selvaggini S, De Bruijn I, Walker L, Lenardon MD, Gerssen B, Milne S, Brown AJP, Gow NAR (2007). The PKC, HOG and Ca <sup>2+</sup> signalling pathways co-ordinately regulate chitin synthesis in Candida albicans. Molecular Microbiology, 63(5), 1399-1413. Abstract.

2006

Barelle CJ, Richard ML, Gaillardin C, Gow NAR, Brown AJP (2006). Candida albicans VAC8 is required for vacuolar inheritance and normal hyphal branching. Eukaryotic Cell, 5(2), 359-367. Abstract.
Rodaki A, Young T, Brown AJP (2006). Effects of depleting the essential central metabolic enzyme, fructose-1,6-bisphosphate aldolase,upon the growth and viability of Candida albicans: implications for antifungal drug target discovery. Eukaryotic Cell, 5, 1371-1377. Abstract.
Brown AJP (2006). Fungal Genomics., Springer Berlin / Heidelberg. Abstract.
Brown AJP (2006). Integration of Metabolism with Virulence in Candida albicans. In Brown A (Ed) Fungal Genomics, Springer Berlin / Heidelberg, 185-203.
Preece AD, Jin B, Pignotti E, Missier P, Embury S, Stead DA, Brown AJP (2006). Managing Information Quality in e-Science using Semantic Web Technology. Lecture Notes in Computer Science, 4011, 472-486. Abstract.
Barelle CJ, Priest CL, MacCallum DM, Gow NAR, Odds FC, Brown AJP (2006). Niche-specific regulation of central metabolic pathways in a fungal pathogen. Cellular Microbiology, 8(6), 961-971. Abstract.
Preece AD, Jin B, Missier P, Embury S, Stead DA, Brown AJP (2006). Towards the Management of Information Quality in Proteomics.  Abstract.
Stead DA, Preece AD, Brown AJP (2006). Universal metrics for quality assessment of protein identifications by mass spectrometry. Molecular and Cellular Proteomics, 1205-1211.

2005

d'Enfert C, Goyard S, Rodriguez-Arnaveilhe S, Frangeul L, Jones L, Tekaia F, Bader O, Albrecht A, Castillo L, Dominguez A, et al (2005). CandidaDB: a genome database for Candida albicans pathogenomics. Nucleic Acids Res, 33(Database issue), D353-D357. Abstract.  Author URL.
Copping VMS, Barelle CJ, Hube B, Gow NAR, Brown AJP, Odds FC (2005). Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes. Journal of Antimicrobial Chemotherapy, 55(5), 645-654. Abstract.
Dennison PMJ, Ramsdale M, Manson CL, Brown AJP (2005). Gene disruption in Candida albicans using a synthetic, codon-optimised Cre-loxP system. Fungal Genet Biol, 42(9), 737-748. Abstract.  Author URL.
Tournu H, Tripathi G, Bertram G, Macaskill S, Mavor A, Walker L, Odds FC, Gow NAR, Brown AJP (2005). Global role of the protein kinase Gcn2 in the human pathogen Candida albicans. Eukaryotic Cell, 4(10), 1687-1696. Abstract.
Stead D, Findon H, Yin Z, Walker J, Selway L, Cash P, Dujon BA, Hennequin C, Brown AJP, Haynes K, et al (2005). Proteomic changes associated with inactivation of the Candida glabrata ACE2 virulence-moderating gene. Proteomics, 5(7), 1838-1848. Abstract.  Author URL.

2004

Zhao X, Oh S-H, Cheng G, Green CB, Nuessen JA, Yeater K, Leng RP, Brown AJP, Hoyer LL (2004). ALS3 and ALS8 represent a single locus that encodes a Candida albicans adhesin; functional comparisons between Als3p and Als1p. Microbiology, 150(Pt 7), 2415-2428. Abstract.  Author URL.
Odds FC, Brown AJP, Gow NAR (2004). Candida albicans genome sequence: a platform for genomics in the absence of genetics. Genome Biology, 5(7). Abstract.
Brand A, MacCallum DM, Brown AJP, Gow NAR, Odds FC (2004). Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus. Eukaryotic Cell, 3(4), 900-909. Abstract.
Barelle CJ, Manson CL, MacCallum DM, Odds FC, Gow NAR, Brown AJP (2004). GFP as a quantitative reporter of gene regulation in Candida albicans. Yeast, 21(4), 333-340. Abstract.
Garwood K, McLaughlin T, Garwood C, Joens S, Morrison N, Taylor CF, Carroll K, Evans C, Whetton AD, Hart S, et al (2004). PEDRo: a database for storing, searching and disseminating experimental proteomics data. BMC Genomics, 5 Abstract.  Author URL.
Yin Z, Stead D, Selway L, Walker J, Riba-Garcia I, McLnerney T, Gaskell S, Oliver SG, Cash P, Brown AJP, et al (2004). Proteomic response to amino acid starvation in Candida albicans and Saccharomyces cerevisiae. Proteomics, 4(8), 2425-2436. Abstract.  Author URL.

2003

Taylor CF, Paton NW, Garwood KL, Kirby PD, Stead DA, Yin Z, Deutsch EW, Selway L, Walker J, Riba-Garcia I, et al (2003). A systematic approach to modeling, capturing, and disseminating proteomics experimental data. Nat Biotechnol, 21(3), 247-254. Abstract.  Author URL.
Odds FC, Brown AJP, Gow NAR (2003). Antifungal agents: Mechanisms of action. Trends in Microbiology, 11(6), 272-279. Abstract.
Barelle CJ, Bohula EA, Kron SJ, Wessels D, Soll DR, Schäfer A, Brown AJP, Gow NAR (2003). Asynchronous cell cycle and asymmetric vacuolar inheritance in true hyphae of Candida albicans. Eukaryotic Cell, 2(3), 398-410. Abstract.
Yin Z, Wilson S, Hauser NC, Tournu H, Hoheisel JD, Brown AJP (2003). Glucose triggers different global responses in yeast, depending on the strength of the signal, and transiently stabilizes ribosomal protein mRNAs. Mol Microbiol, 48(3), 713-724. Abstract.  Author URL.
Blackwell C, Russell CL, Brown AJP, Brown JD, Argimon S (2003). Protein A-tagging for purification of native macromolecular complexes from Candida albicans. Yeast, 20, 1235-1241. Abstract.

2002

Gow NAR, Brown AJP, Odds FC (2002). Fungal morphogenesis and host invasion. Current Opinion in Microbiology, 5(4), 366-371. Abstract.
Chitnis MV, Munro CA, Brown AJP, Gooday GW, Gow NAR, Deshpande MV (2002). The zygomycetous fungus, Benjaminiella poitrasii contains a large family of differentially regulated chitin synthase genes. Fungal Genetics and Biology, 36(3), 215-223. Abstract.

2001

Munro CA, Winter K, Buchan A, Henry K, Becker JM, Brown AJP, Bulawa CE, Gow NAR (2001). Chs1 of Candida albicans is an essential chitin synthase required for synthesis of the septum and for cell integrity. Molecular Microbiology, 39(5), 1414-1426. Abstract.
Leng P, Lee PR, Wu H, Brown AJP (2001). Efg1, a morphogenetic regulator in Candida albicans, is a sequence-specific DNA binding protein. Journal of Bacteriology, 183, 4090-4093.
Odds FC, Gow NAR, Brown AJP (2001). Fungal virulence studies come of age. Genome Biology, 2(3). Abstract.
Pearce AK, Booth IR, Brown AJP (2001). Genetic manipulation of 6-phosphofructo-1-kinase and fructose 2,6-bisphosphate levels affects the extent to which benzoic acid inhibits the growth of Saccharomyces cerevisiae. Microbiology, 147, 403-410. Abstract.
Pearce AK, Crimmins K, Groussac E, Hewlins MJ, Dickinson JR, Francois J, Booth IR, Brown AJP (2001). Pyruvate kinase (Pyk1) levels influence both the rate and direction of carbon flux in yeast under fermentative conditions. Microbiology, 147, 391-401. Abstract.
Brown AJP, Planta RJ, Restuhadi F, Bailey DA, Butler PR, Cadahia JL, Cerdan ME, De Jonge M, Gardner DC (2001). Transcript analysis of 1003 novel yeast genes using high-throughput northern hybridizations. EMBO Journal, 20, 3177-3186. Abstract.

2000

Gow NAR, Brown AJP, Odds FC (2000). Candida's arranged marriage. Science, 289(5477), 256-257.
Yin Z, Hatton L, Brown AJ (2000). Differential post-transcriptional regulation of yeast mRNAs in response to high and low glucose concentrations. Mol Microbiol, 35(3), 553-565. Abstract.  Author URL.
Brown AJ, Barelle CJ, Budge S, Duncan J, Harris S, Lee PR, Leng P, Macaskill S, Abdul Murad AM, Ramsdale M, et al (2000). Gene regulation during morphogenesis in Candida albicans. Contrib Microbiol, 5, 112-125. Author URL.
Gow NAR, Brown AJP, Odds FC (2000). Microbiology - Candida’s arranged marriage. Science, 289, 256-257.
Odds FC, Brown AJP, Gow NAR (2000). Might Candida albicans be made to mate after all?. Trends in Microbiology, 8, 46-46.
Leng P, Sudbery PE, Brown AJP (2000). Rad6p represses yeast-hypha morphogenesis in the human fungal pathogen Candida albicans. Molecular Microbiology, 35, 1264-1275. Abstract.

1999

Gow NAR, Bates S, Brown AJP, Buurman ET, Thomson LM, Westwater C (1999). Candida cell wall mannosylation: importance in host-fungus interaction and potential as a target for the development of antifungal drugs. Biochemical Society Transactions, 27, 512-516.
Sartori G, Aldegheri L, Mazzotta G, Lanfranchi G, Tournu H, Brown AJP, Carignani G (1999). Characterization of a new hemoprotein in the yeast Saccharomyces cerevisiae. The Journal of Biological Chemistry, 274, 5032-5037. Abstract.
Milewski S, Kuszczak D, Jedrzejczak R, Smith RJ, Brown AJP, Gooday GW (1999). Oligomeric structure and regulation of Candida albicans glucosamine-6-phosphate synthase. The Journal of Biological Chemistry, 274, 4000-4008. Abstract.
Wiltshire C, Black S, Brown AJP (1999). Over-expression of Candida albicans mitochondrial ribosomal protein S9 (MrpS9p) disturbs mitochondrial function in Saccharomyces cerevisiae. Yeast, 15, 139-143. Abstract.
Brown AJP, Gow NAR (1999). Regulatory networks controlling Candida albicans morphogenesis. Trends in Microbiology, 7(8), 333-338. Abstract.
Zaman Z, Bowman SB, Kornfeld GD, Brown AJP, Dawes IW (1999). Transcription factor GCN4 for control of amino acid biosynthesis also regulates the expression of the gene for lipoamide dehydrogenase. Biochemical Journal, 340, 855-862. Abstract.

1998

Buurman ET, Westwater C, Hube B, Brown AJP, Odds FC, Gow NAR (1998). Molecular analysis of CaMnt1p, a mannosyl transferase important for adhesion and virulence of Candida albicans. Proceedings of the National Academy of Sciences of the United States of America, 95(13), 7670-7675. Abstract.

1997

Tait E, Simon MC, King S, Brown AJ, Gow NA, Shaw DJ (1997). A Candida albicans genome project: cosmid contigs, physical mapping, and gene isolation. Fungal Genet Biol, 21(3), 308-314. Abstract.  Author URL.
Hube B, Sanglard D, Odds FC, Hess D, Monod M, Schäfer W, Brown AJP, Gow NAR (1997). Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence. Infection and Immunity, 65(9), 3529-3538. Abstract.
Cormack BP, Bertram G, Egerton M, Gow NAR, Falkow S, Brown AJP (1997). Yeast-enhanced green fluorescent protein (yEGFP): a reporter of gene expression in Candida albicans. Microbiology, 143(2), 303-311. Abstract.

1996

Yin Z, Smith RJ, Brown AJ (1996). Multiple signalling pathways trigger the exquisite sensitivity of yeast gluconeogenic mRNAs to glucose. Mol Microbiol, 20(4), 751-764. Abstract.  Author URL.
Leberer E, Harcus D, Broadbent ID, Clark KL, Dignard D, Ziegelbauer K, Schmidt A, Gow NAR, Brown AJP, Thomas DY, et al (1996). Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proceedings of the National Academy of Sciences of the United States of America, 93(23), 13217-13222. Abstract.
Bertram G, Swoboda RK, Gooday GW, Gow NAR, Brown AJP (1996). Structure and regulation of the Candida albicans ADH1 gene encoding an immunogenic alcohol dehydrogenase. Yeast, 12(2), 115-127. Abstract.
Bailey DA, Feldmann PJF, Bovey M, Gow NAR, Brown AJP (1996). The Candida albicans HYR1 gene, which is activated in response to hyphal development, belongs to a gene family encoding yeast cell wall proteins. Journal of Bacteriology, 178(18), 5353-5360. Abstract.

1994

Gow NAR, Robbins PW, Lester JW, Brown AJP, Fonzi WA, Chapman T, Kinsman OS (1994). A hyphal-specific chitin synthase gene (CHS2) is not essential for growth, dimorphism, or virulence of Candida albicans. Proceedings of the National Academy of Sciences of the United States of America, 91(13), 6216-6220. Abstract.
Hube B, Monod M, Schofield DA, Brown AJP, Gow NAR (1994). Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans. Molecular Microbiology, 14(1), 87-99. Abstract.
Swoboda RK, Bertram G, Delbrück S, Ernst JF, Gow NAR, Gooday GW, Brown AJP (1994). Fluctuations in glycolytic mRNA levels during morphogenesis in Candida albicans reflect underlying changes in growth and are not a response to cellular dimorphism. Molecular Microbiology, 13(4), 663-672. Abstract.
Cannon RD, Timberlake WE, Gow NAR, Bailey D, Brown A, Gooday GW, Hube B, Monod M, Nombela C, Navarro F, et al (1994). Molecular biological and biochemical aspects of fungal dimorphism. Medical Mycology, 32(S1), 53-64.
Swoboda RK, Bertram G, Colthurst DR, Tuite MF, Gow NAR, Gooday GW, Brown AJP (1994). Regulation of the gene encoding translation elongation factor 3 during growth and morphogenesis in Candida albicans. Microbiology, 140(10), 2611-2616. Abstract.

1993

Swoboda RK, Bertram G, Hollander H, Greenspan D, Greenspan JS, Gow NAR, Gooday GW, Brown AJP (1993). Glycolytic enzymes of Candida albicans are nonubiquitous immunogens during candidiasis. Infection and Immunity, 61(10), 4263-4271. Abstract.

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