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Dr Carolina Coelho

Lecturer in Biosciences

 

Overview

I was always interested in microbes and the diseases they cause. I completed a degree in Pharmaceutical Sciences at University of Porto, Portugal in my native Portugal. I did my graduate studies in joint-mentorship from Teresa Gonçalves at University of Coimbra and Arturo Casadevall at Albert Einstein College of Medicine, Bronx. Then I continued my research into the pathogenesis of Cryptococcus neoformans with Arturo Casadevall, now at Johns Hopkins Bloomberg School of Public Health, in Baltimore. I am looking forward to initiate my own research group at MRC Centre for Medical Mycology, studying immunity to C. neoformans infections.

Qualifications

PhD

Research group links

Research

Research interests

Cryptococcus neoformans is responsible for almost 200,000 deaths each year, more than any other fungal pathogen. Cryptococcal infection is incredibly difficult to treat, sometimes requiring lifelong therapy, and the best medical treatment cannot avoid a mortality rate as high as 30%. My primary research interest is to understand how cells from the innate immune system recognize and kill this pathogenic yeast. My focus is the recently discovered immune functions of mitochondria. By understanding what constitutes an effective fungicidal response, and why this effective response sometimes fails, we will be able to find better solutions to treat this killer disease.

Publications

Key publications | Publications by category | Publications by year

Key publications


Fu MS, Coelho C, De Leon-Rodriguez CM, Rossi DCP, Camacho E, Jung EH, Kulkarni M, Casadevall A (2018). Cryptococcus neoformans urease affects the outcome of intracellular pathogenesis by modulating phagolysosomal pH. PLoS Pathogens, 14(6). Abstract.
Casadevall A, Coelho C, Alanio A (2018). Mechanisms of Cryptococcus neoformans-mediated host damage. Frontiers in Immunology, 9(APR). Abstract.
Hommel B, Mukaremera L, Cordero RJB, Coelho C, Desjardins CA, Sturny-Leclère A, Janbon G, Perfect JR, Fraser JA, Casadevall A, et al (2018). Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators. PLoS Pathogens, 14(5). Abstract.
Coelho C, Oliveira Souza AC, Da Silveira Derengowski L, De Leon-Rodriguez C, Wang B, Leon-Rivera R, Bocca AL, Gonçalves T, Casadevall A (2015). Macrophage mitochondrial and stress response to ingestion of Cryptococcus neoformans. Journal of Immunology, 194(5), 2345-2357. Abstract.
Coelho C, Bocca AL, Casadevall A (2014). The intracellular life of Cryptococcus neoformans. Annu Rev Pathol, 9, 219-238. Abstract.  Author URL.
Coelho C, Tesfa L, Zhang J, Rivera J, Goncalves T, Casadevall A (2012). Analysis of Cell Cycle and Replication of Mouse Macrophages after in Vivo and in Vitro Cryptococcus neoformans Infection Using Laser Scanning Cytometry. INFECTION AND IMMUNITY, 80(4), 1467-1478. Author URL.

Publications by category


Journal articles

Hatanaka O, Rezende CP, Moreno P, Freitas Fernandes F, Oliveira Brito PKM, Martinez R, Coelho C, Roque-Barreira MC, Casadevall A, Almeida F, et al (In Press). Galectin-3 Inhibits Paracoccidioides brasiliensis Growth and Impacts Paracoccidioidomycosis through Multiple Mechanisms. mSphere, 4(2). Abstract.  Author URL.
Coelho C, Brown L, Maryam M, Vij R, Smith DFQ, Burnet MC, Kyle JE, Heyman HM, Ramirez J, Prados-Rosales R, et al (In Press). Listeria monocytogenes virulence factors, including listeriolysin O, are secreted in biologically active extracellular vesicles. J Biol Chem, 294(4), 1202-1217. Abstract.  Author URL.
Hawk CS, Coelho C, Lima de Oliveira DS, Paredes V, Albuquerque P, Bocca AL, Correa dos Santos A, Rusakova V, Holemon H, Silva-Pereira I, et al (2019). Integrin B1 promotes the interaction of murine IgG3 with effector cells. Journal of Immunology, 202(9), 2782-2794. Abstract.
Almeida F, Rodrigues ML, Coelho C (2019). The Still Underestimated Problem of Fungal Diseases Worldwide. FRONTIERS IN MICROBIOLOGY, 10 Author URL.
Freij JB, Fu MS, Rodriguez CMDL, Dziedzic A, Jedlicka AE, Dragotakes Q, Rossi DCP, Jung EH, Coelho C, Casadevall A, et al (2018). Conservation of Intracellular Pathogenic Strategy among Distantly Related Cryptococcal Species. INFECTION AND IMMUNITY, 86(7). Author URL.
Fu MS, Coelho C, De Leon-Rodriguez CM, Rossi DCP, Camacho E, Jung EH, Kulkarni M, Casadevall A (2018). Cryptococcus neoformans urease affects the outcome of intracellular pathogenesis by modulating phagolysosomal pH. PLoS Pathogens, 14(6). Abstract.
Casadevall A, Coelho C, Alanio A (2018). Mechanisms of Cryptococcus neoformans-mediated host damage. Frontiers in Immunology, 9(APR). Abstract.
De Leon-Rodriguez CM, Rossi DCP, Fu MS, Dragotakes Q, Coelho C, Ros IG, Caballero B, Nolan SJ, Casadevall A (2018). The Outcome of the Cryptococcus neoformans-Macrophage Interaction Depends on Phagolysosomal Membrane Integrity. JOURNAL OF IMMUNOLOGY, 201(2), 583-603. Author URL.
Casadevall A, Coelho C, Cordero RJB, Dragotakes Q, Jung E, Vij R, Wear MP (2018). The capsule of Cryptococcus neoformans. Virulence Abstract.
Hommel B, Mukaremera L, Cordero RJB, Coelho C, Desjardins CA, Sturny-Leclère A, Janbon G, Perfect JR, Fraser JA, Casadevall A, et al (2018). Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators. PLoS Pathogens, 14(5). Abstract.
Rossi DCP, Gleason JE, Sanchez H, Schatzman SS, Culbertson EM, Johnson CJ, McNees CA, Coelho C, Nett JE, Andes DR, et al (2017). Candida albicans FRE8 encodes a member of the NADPH oxidase family that produces a burst of ROS during fungal morphogenesis. PLOS PATHOGENS, 13(12). Author URL.
Coelho C, Casadevall A (2016). Cryptococcal therapies and drug targets: the old, the new and the promising. CELLULAR MICROBIOLOGY, 18(6), 792-799. Author URL.
Stamatiades EG, Tremblay M-E, Bohm M, Crozet L, Bisht K, Kao D, Coelho C, Fan X, Yewdell WT, Davidson A, et al (2016). Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages. Cell, 166(4), 991-1003.
Stukes S, Coelho C, Rivera J, Jedlicka AE, Hajjar KA, Casadevall A (2016). The Membrane Phospholipid Binding Protein Annexin A2 Promotes Phagocytosis and Nonlytic Exocytosis of Cryptococcus neoformans and Impacts Survival in Fungal Infection. JOURNAL OF IMMUNOLOGY, 197(4), 1252-1261. Author URL.
Coelho C, Oliveira Souza AC, Da Silveira Derengowski L, De Leon-Rodriguez C, Wang B, Leon-Rivera R, Bocca AL, Gonçalves T, Casadevall A (2015). Macrophage mitochondrial and stress response to ingestion of Cryptococcus neoformans. Journal of Immunology, 194(5), 2345-2357. Abstract.
Grguric-Smith LM, Lee HH, Gandhi JA, Brennan MB, DeLeon-Rodriguez CM, Coelho C, Han G, Martinez LR (2015). Neutropenia exacerbates infection by Acinetobacter baumannii clinical isolates in a murine wound model. Frontiers in Microbiology, 6(OCT). Abstract.
Gandhi JA, Ekhar VV, Asplund MB, Abdulkareem AF, Ahmadi M, Coelho C, Martinez LR (2014). Alcohol enhances Acinetobacter baumannii-Associated pneumonia and systemic dissemination by impairing neutrophil antimicrobial activity in a murine model of infection. PLoS ONE, 9(4). Abstract.
Coelho C, Bocca AL, Casadevall A (2014). The intracellular life of Cryptococcus neoformans. Annu Rev Pathol, 9, 219-238. Abstract.  Author URL.
Asplund MB, Coelho C, Cordero RJB, Martinez LR (2013). Alcohol impairs J774.16 macrophagelike cell antimicrobial functions in Acinetobacter baumannii infection. Virulence, 4(6). Abstract.
Miranda I, Silva-Dias A, Rocha R, Teixeira-Santos R, Coelho C, Gonçalves T, Santos MAS, Pina-Vaz C, Solis NV, Filler SG, et al (2013). Candida albicans CUG mistranslation is a mechanism to create cell surface variation. mBio, 4(4). Abstract.
Manepalli S, Gandhi JA, Ekhar VV, Asplund MB, Coelho C, Martinez LR (2013). Characterization of a cyclophosphamide-induced murine model of immunosuppression to study Acinetobacter baumannii pathogenesis. JOURNAL OF MEDICAL MICROBIOLOGY, 62, 1747-1754. Author URL.
Coelho C, Tesfa L, Zhang J, Rivera J, Goncalves T, Casadevall A (2012). Analysis of Cell Cycle and Replication of Mouse Macrophages after in Vivo and in Vitro Cryptococcus neoformans Infection Using Laser Scanning Cytometry. INFECTION AND IMMUNITY, 80(4), 1467-1478. Author URL.

Chapters

Coelho C, Bocca AL, Casadevall A (2014). The Tools for Virulence of Cryptococcus neoformans. In  (Ed) Advances in Applied Microbiology, 1-41.  Abstract.

Publications by year


In Press

Hatanaka O, Rezende CP, Moreno P, Freitas Fernandes F, Oliveira Brito PKM, Martinez R, Coelho C, Roque-Barreira MC, Casadevall A, Almeida F, et al (In Press). Galectin-3 Inhibits Paracoccidioides brasiliensis Growth and Impacts Paracoccidioidomycosis through Multiple Mechanisms. mSphere, 4(2). Abstract.  Author URL.
Coelho C, Brown L, Maryam M, Vij R, Smith DFQ, Burnet MC, Kyle JE, Heyman HM, Ramirez J, Prados-Rosales R, et al (In Press). Listeria monocytogenes virulence factors, including listeriolysin O, are secreted in biologically active extracellular vesicles. J Biol Chem, 294(4), 1202-1217. Abstract.  Author URL.

2019

Hawk CS, Coelho C, Lima de Oliveira DS, Paredes V, Albuquerque P, Bocca AL, Correa dos Santos A, Rusakova V, Holemon H, Silva-Pereira I, et al (2019). Integrin B1 promotes the interaction of murine IgG3 with effector cells. Journal of Immunology, 202(9), 2782-2794. Abstract.
Almeida F, Rodrigues ML, Coelho C (2019). The Still Underestimated Problem of Fungal Diseases Worldwide. FRONTIERS IN MICROBIOLOGY, 10 Author URL.

2018

Freij JB, Fu MS, Rodriguez CMDL, Dziedzic A, Jedlicka AE, Dragotakes Q, Rossi DCP, Jung EH, Coelho C, Casadevall A, et al (2018). Conservation of Intracellular Pathogenic Strategy among Distantly Related Cryptococcal Species. INFECTION AND IMMUNITY, 86(7). Author URL.
Fu MS, Coelho C, De Leon-Rodriguez CM, Rossi DCP, Camacho E, Jung EH, Kulkarni M, Casadevall A (2018). Cryptococcus neoformans urease affects the outcome of intracellular pathogenesis by modulating phagolysosomal pH. PLoS Pathogens, 14(6). Abstract.
Casadevall A, Coelho C, Alanio A (2018). Mechanisms of Cryptococcus neoformans-mediated host damage. Frontiers in Immunology, 9(APR). Abstract.
De Leon-Rodriguez CM, Rossi DCP, Fu MS, Dragotakes Q, Coelho C, Ros IG, Caballero B, Nolan SJ, Casadevall A (2018). The Outcome of the Cryptococcus neoformans-Macrophage Interaction Depends on Phagolysosomal Membrane Integrity. JOURNAL OF IMMUNOLOGY, 201(2), 583-603. Author URL.
Casadevall A, Coelho C, Cordero RJB, Dragotakes Q, Jung E, Vij R, Wear MP (2018). The capsule of Cryptococcus neoformans. Virulence Abstract.
Hommel B, Mukaremera L, Cordero RJB, Coelho C, Desjardins CA, Sturny-Leclère A, Janbon G, Perfect JR, Fraser JA, Casadevall A, et al (2018). Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators. PLoS Pathogens, 14(5). Abstract.

2017

Rossi DCP, Gleason JE, Sanchez H, Schatzman SS, Culbertson EM, Johnson CJ, McNees CA, Coelho C, Nett JE, Andes DR, et al (2017). Candida albicans FRE8 encodes a member of the NADPH oxidase family that produces a burst of ROS during fungal morphogenesis. PLOS PATHOGENS, 13(12). Author URL.

2016

Coelho C, Casadevall A (2016). Cryptococcal therapies and drug targets: the old, the new and the promising. CELLULAR MICROBIOLOGY, 18(6), 792-799. Author URL.
Stamatiades EG, Tremblay M-E, Bohm M, Crozet L, Bisht K, Kao D, Coelho C, Fan X, Yewdell WT, Davidson A, et al (2016). Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages. Cell, 166(4), 991-1003.
Stukes S, Coelho C, Rivera J, Jedlicka AE, Hajjar KA, Casadevall A (2016). The Membrane Phospholipid Binding Protein Annexin A2 Promotes Phagocytosis and Nonlytic Exocytosis of Cryptococcus neoformans and Impacts Survival in Fungal Infection. JOURNAL OF IMMUNOLOGY, 197(4), 1252-1261. Author URL.

2015

Coelho C, Oliveira Souza AC, Da Silveira Derengowski L, De Leon-Rodriguez C, Wang B, Leon-Rivera R, Bocca AL, Gonçalves T, Casadevall A (2015). Macrophage mitochondrial and stress response to ingestion of Cryptococcus neoformans. Journal of Immunology, 194(5), 2345-2357. Abstract.
Grguric-Smith LM, Lee HH, Gandhi JA, Brennan MB, DeLeon-Rodriguez CM, Coelho C, Han G, Martinez LR (2015). Neutropenia exacerbates infection by Acinetobacter baumannii clinical isolates in a murine wound model. Frontiers in Microbiology, 6(OCT). Abstract.

2014

Gandhi JA, Ekhar VV, Asplund MB, Abdulkareem AF, Ahmadi M, Coelho C, Martinez LR (2014). Alcohol enhances Acinetobacter baumannii-Associated pneumonia and systemic dissemination by impairing neutrophil antimicrobial activity in a murine model of infection. PLoS ONE, 9(4). Abstract.
Coelho C, Bocca AL, Casadevall A (2014). The Tools for Virulence of Cryptococcus neoformans. In  (Ed) Advances in Applied Microbiology, 1-41.  Abstract.
Coelho C, Bocca AL, Casadevall A (2014). The intracellular life of Cryptococcus neoformans. Annu Rev Pathol, 9, 219-238. Abstract.  Author URL.

2013

Asplund MB, Coelho C, Cordero RJB, Martinez LR (2013). Alcohol impairs J774.16 macrophagelike cell antimicrobial functions in Acinetobacter baumannii infection. Virulence, 4(6). Abstract.
Miranda I, Silva-Dias A, Rocha R, Teixeira-Santos R, Coelho C, Gonçalves T, Santos MAS, Pina-Vaz C, Solis NV, Filler SG, et al (2013). Candida albicans CUG mistranslation is a mechanism to create cell surface variation. mBio, 4(4). Abstract.
Manepalli S, Gandhi JA, Ekhar VV, Asplund MB, Coelho C, Martinez LR (2013). Characterization of a cyclophosphamide-induced murine model of immunosuppression to study Acinetobacter baumannii pathogenesis. JOURNAL OF MEDICAL MICROBIOLOGY, 62, 1747-1754. Author URL.

2012

Coelho C, Tesfa L, Zhang J, Rivera J, Goncalves T, Casadevall A (2012). Analysis of Cell Cycle and Replication of Mouse Macrophages after in Vivo and in Vitro Cryptococcus neoformans Infection Using Laser Scanning Cytometry. INFECTION AND IMMUNITY, 80(4), 1467-1478. Author URL.

Carolina_Coelho Details from cache as at 2019-06-20 23:21:57

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