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Dr Remy Chait

Lecturer

 Living Systems Institute 

 

Living Systems Institute, University of Exeter, Stocker Road, Exeter, EX4 4QD

Overview

I enjoy ricocheting between disciplines, building research tools that change perspectives, and helping microbes, instruments, and theories converse.

Qualifications

2005-2011     PhD (Systems Biology)       Harvard University

1994-1998     BA   (Mathematics)              University of California – Berkeley

Career

2019-present             Lecturer in Biosciences      University of Exeter

2012-2018                 Posdoctoral Fellow             IST Austria

Research group links

Research

Research interests

My research is oriented around measuring and manipulating interactions between genes and their cellular, genomic, environmental, and community contexts giving rise to microbial population behaviors such as antibiotic resistance. We incorporate diverse approaches in experimental evolution, mathematics, systems microbiology, engineering and instrumentation to understand how interactions between cells shape bacterial community behaviors, the value of environmental sensing and phenotypic variation in fluctuating environments, and how phenotypes broadly respond to mutation.

My research spans elements of microbial systems biology, evolutionary biology cybergenetics, antimicrobial resistance, and engineering.

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Palmer AC, Chait R, Kishony R (2018). Nonoptimal gene expression creates latent potential for antibiotic resistance. Molecular Biology and Evolution, 35(11), 2669-2684. Abstract.  Full text.
Chait R, Ruess J, Bergmiller T, Tkačik G, Guet CC (2017). Shaping bacterial population behavior through computer-interfaced control of individual cells. Nature Communications, 8(1). Abstract.  Full text.
Stone LK, Baym M, Lieberman TD, Chait R, Clardy J, Kishony R (2016). Compounds that select against the tetracycline-resistance efflux pump. Nature Chemical Biology, 12(11), 902-904. Abstract.
Chait R, Palmer AC, Yelin I, Kishony R (2016). Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments. Nature Communications, 7 Abstract.
Baym M, Lieberman TD, Kelsic ED, Chait R, Gross R, Yelin I, Kishony R (2016). Spatiotemporal microbial evolution on antibiotic landscapes. Science, 353(6304), 1147-1151. Abstract.
Toprak E, Veres A, Yildiz S, Pedraza JM, Chait R, Paulsson J, Kishony R (2013). Building a morbidostat: an automated continuous-culture device for studying bacterial drug resistance under dynamically sustained drug inhibition. Nature Protocols, 8(3), 555-567. Abstract.
Toprak E, Veres A, Yildiz S, Pedraza JM, Chait R, Paulsson J, Kishony R (2013). Building a morbidostat: an automated continuous-culture device for studying bacterial drug resistance under dynamically sustained drug inhibition. Nature Protocols, 8(3), 555-567.
Wakamoto Y, Dhar N, Chait R, Schneider K, Signorino-Gelo F, Leibler S, McKinney JD (2013). Dynamic persistence of antibiotic-stressed mycobacteria. Science, 339(6115), 91-95. Abstract.
Toprak E, Veres A, Michel JB, Chait R, Hartl DL, Kishony R (2012). Evolutionary paths to antibiotic resistance under dynamically sustained drug selection. Nature Genetics, 44(1), 101-105. Abstract.
Chait R, Vetsigian K, Kishony R (2012). What counters antibiotic resistance in nature?. Nature Chemical Biology, 8(1), 2-5.
Chait R, Shrestha S, Shah AK, Michel JB, Kishony R (2010). A differential drug screen for compounds that select against antibiotic resistance. PLoS ONE, 5(12). Abstract.
Torella JP, Chait R, Kishony R (2010). Optimal drug synergy in Antimicrobial Treatments. PLoS Computational Biology, 6(6), 1-9. Abstract.
Bollenbach T, Quan S, Chait R, Kishony R (2009). Nonoptimal Microbial Response to Antibiotics Underlies Suppressive Drug Interactions. Cell, 139(4), 707-718. Abstract.
Michel JB, Yeh PJ, Chait R, Moellering RC, Kishony R (2008). Drug interactions modulate the potential for evolution of resistance. Proceedings of the National Academy of Sciences of the United States of America, 105(39), 14918-14923. Abstract.
Chait R, Craney A, Kishony R (2007). Antibiotic interactions that select against resistance. Nature, 446(7136), 668-671. Abstract.
Balaban NQ, Merrin J, Chait R, Kowalik L, Leibler S (2004). Bacterial persistence as a phenotypic switch. Science, 305(5690), 1622-1625. Abstract.

Publications by year


2018

Palmer AC, Chait R, Kishony R (2018). Nonoptimal gene expression creates latent potential for antibiotic resistance. Molecular Biology and Evolution, 35(11), 2669-2684. Abstract.  Full text.

2017

Chait R, Ruess J, Bergmiller T, Tkačik G, Guet CC (2017). Shaping bacterial population behavior through computer-interfaced control of individual cells. Nature Communications, 8(1). Abstract.  Full text.

2016

Stone LK, Baym M, Lieberman TD, Chait R, Clardy J, Kishony R (2016). Compounds that select against the tetracycline-resistance efflux pump. Nature Chemical Biology, 12(11), 902-904. Abstract.
Chait R, Palmer AC, Yelin I, Kishony R (2016). Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments. Nature Communications, 7 Abstract.
Baym M, Lieberman TD, Kelsic ED, Chait R, Gross R, Yelin I, Kishony R (2016). Spatiotemporal microbial evolution on antibiotic landscapes. Science, 353(6304), 1147-1151. Abstract.

2013

Toprak E, Veres A, Yildiz S, Pedraza JM, Chait R, Paulsson J, Kishony R (2013). Building a morbidostat: an automated continuous-culture device for studying bacterial drug resistance under dynamically sustained drug inhibition. Nature Protocols, 8(3), 555-567. Abstract.
Toprak E, Veres A, Yildiz S, Pedraza JM, Chait R, Paulsson J, Kishony R (2013). Building a morbidostat: an automated continuous-culture device for studying bacterial drug resistance under dynamically sustained drug inhibition. Nature Protocols, 8(3), 555-567.
Wakamoto Y, Dhar N, Chait R, Schneider K, Signorino-Gelo F, Leibler S, McKinney JD (2013). Dynamic persistence of antibiotic-stressed mycobacteria. Science, 339(6115), 91-95. Abstract.

2012

Toprak E, Veres A, Michel JB, Chait R, Hartl DL, Kishony R (2012). Evolutionary paths to antibiotic resistance under dynamically sustained drug selection. Nature Genetics, 44(1), 101-105. Abstract.
Chait R, Vetsigian K, Kishony R (2012). What counters antibiotic resistance in nature?. Nature Chemical Biology, 8(1), 2-5.

2010

Chait R, Shrestha S, Shah AK, Michel JB, Kishony R (2010). A differential drug screen for compounds that select against antibiotic resistance. PLoS ONE, 5(12). Abstract.
Torella JP, Chait R, Kishony R (2010). Optimal drug synergy in Antimicrobial Treatments. PLoS Computational Biology, 6(6), 1-9. Abstract.

2009

Bollenbach T, Quan S, Chait R, Kishony R (2009). Nonoptimal Microbial Response to Antibiotics Underlies Suppressive Drug Interactions. Cell, 139(4), 707-718. Abstract.

2008

Michel JB, Yeh PJ, Chait R, Moellering RC, Kishony R (2008). Drug interactions modulate the potential for evolution of resistance. Proceedings of the National Academy of Sciences of the United States of America, 105(39), 14918-14923. Abstract.

2007

Chait R, Craney A, Kishony R (2007). Antibiotic interactions that select against resistance. Nature, 446(7136), 668-671. Abstract.

2004

Balaban NQ, Merrin J, Chait R, Kowalik L, Leibler S (2004). Bacterial persistence as a phenotypic switch. Science, 305(5690), 1622-1625. Abstract.

Dr_Remy_Chait Details from cache as at 2019-10-17 16:29:32

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