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Dr Duncan Wilson

Dr Duncan Wilson

Senior Lecturer E&R (PI)

 Geoffrey Pope 316

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

Qualifications

Sir Henry Dale fellow. University of Aberdeen (2014-present)

Postdoctoral researcher. Hans Knoell Institute, Jena, Germany (2007-2014)

Doctor of Philosophy. University of Manchester (2003-2006). The role of phosphodiesterases in Candida albicans physiology

Bachelor of Science with Honours in Microbiology. University of Glasgow (1999-2003)

Career

Wellcome Trust Senior Research Fellow. University of Exeter (2019-present)

Sir Henry Dale fellow. University of Aberdeen (2014-2019)

Postdoctoral researcher. Hans Knoell Institute, Jena, Germany (2007-2014)

Doctor of Philosophy. University of Manchester (2003-2006). The role of phosphodiesterases in Candida albicans physiology

Bachelor of Science with Honours in Microbiology. University of Glasgow (1999-2003)

Research

Research interests

Our immune systems effectively prevent the vast majority of microbes from causing disease. One of the fundamental mechanisms underpinning this defence is called "nutritional immunity".

This is a system in which the human body withholds access to certain essential trace minerals that microbes require for growth. Pathogenic microbes therefore must have evolved strategies to circumvent nutritional immunity in order to grow within their host and cause disease.

Zinc is absolutely essential for the growth of all microbes and my group is trying to understand how the major human fungal pathogen, Candida albicans, adapts to zinc restriction during infection.

This is important because fungal pathogens are a huge threat to human health, and are responsible for more deaths per year than malaria, and understanding how pathogens feed during infection may pave the way to novel therapeutics.

Publications

Key publications | Publications by category | Publications by year

Key publications


Crawford AC, Lehtovirta-Morley LE, Alamir O, Niemiec MJ, Alawfi B, Alsarraf M, Skrahina V, Costa ACBP, Anderson A, Yellagunda S, et al (2018). Biphasic zinc compartmentalisation in a human fungal pathogen. PLOS Pathogens, 14(5), e1007013-e1007013.
Kjellerup L, Winther A-ML, Wilson D, Fuglsang AT (2018). Cyclic AMP Pathway Activation and Extracellular Zinc Induce Rapid Intracellular Zinc Mobilization in Candida albicans. Frontiers in Microbiology, 9
Richardson JP, Mogavero S, Moyes DL, Blagojevic M, Krüger T, Verma AH, Coleman BM, De La Cruz Diaz J, Schulz D, Ponde NO, et al (2018). Processing of Candida albicans Ece1p is Critical for Candidalysin Maturation and Fungal Virulence. mBio, 9(1). Abstract.
Malavia D, Lehtovirta-Morley LE, Alamir O, Weiß E, Gow NAR, Hube B, Wilson D (2017). Zinc Limitation Induces a Hyper-Adherent Goliath Phenotype in Candida albicans. Front Microbiol, 8 Abstract.  Author URL.
Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, et al (2016). Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature, 532(7597), 64-68.

Publications by category


Journal articles

Canteri de Souza P, Custódio Caloni C, Wilson D, Sergio Almeida R (In Press). An Invertebrate Host to Study Fungal Infections, Mycotoxins and Antifungal Drugs: Tenebrio molitor. Journal of Fungi, 4 Abstract.
Wilson D (In Press). Candida albicans: Microbe of the month. Trends in Microbiology, 27, 188-189.
Wilson D (In Press). Cellular Microbiology Interview - Dr Duncan Wilson. Cellular Microbiology, 20
Wilson D, Deepe GS (In Press). The intersection of host and fungus through the zinc lens. Current Opinion in Microbiology, 52, 35-40. Abstract.
Brown GD, Wilson D (2019). Mammalian innate immunity to fungal infection. Semin Cell Dev Biol, 89, 1-2. Author URL.
Crawford AC, Lehtovirta-Morley LE, Alamir O, Niemiec MJ, Alawfi B, Alsarraf M, Skrahina V, Costa ACBP, Anderson A, Yellagunda S, et al (2018). Biphasic zinc compartmentalisation in a human fungal pathogen. PLOS Pathogens, 14(5), e1007013-e1007013.
Kjellerup L, Winther A-ML, Wilson D, Fuglsang AT (2018). Cyclic AMP Pathway Activation and Extracellular Zinc Induce Rapid Intracellular Zinc Mobilization in Candida albicans. Frontiers in Microbiology, 9
Richardson JP, Mogavero S, Moyes DL, Blagojevic M, Krüger T, Verma AH, Coleman BM, De La Cruz Diaz J, Schulz D, Ponde NO, et al (2018). Processing of Candida albicans Ece1p is Critical for Candidalysin Maturation and Fungal Virulence. mBio, 9(1). Abstract.
Wilson D (2017). A tale of two yeasts: Saccharomyces cerevisiae as a therapeutic against candidiasis. VIRULENCE, 8(1), 15-17. Author URL.
Malavia D, Crawford A, Wilson D (2017). Nutritional Immunity and Fungal Pathogenesis: the Struggle for Micronutrients at the Host-Pathogen Interface. Adv Microb Physiol, 70, 85-103. Abstract.  Author URL.
Lehtovirta-Morley LE, Alsarraf M, Wilson D (2017). Pan-Domain Analysis of ZIP Zinc Transporters. Int J Mol Sci, 18(12). Abstract.  Author URL.
Malavia D, Lehtovirta-Morley LE, Alamir O, Weiß E, Gow NAR, Hube B, Wilson D (2017). Zinc Limitation Induces a Hyper-Adherent Goliath Phenotype in Candida albicans. Front Microbiol, 8 Abstract.  Author URL.
Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, et al (2016). Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature, 532(7597), 64-68.
Wilson D, Naglik JR, Hube B (2016). The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage. PLOS PATHOGENS, 12(10). Author URL.
Ballou ER, Wilson D (2016). The roles of zinc and copper sensing in fungal pathogenesis. Curr Opin Microbiol, 32, 128-134. Abstract.  Author URL.
Wilson D (2015). An evolutionary perspective on zinc uptake by human fungal pathogens. METALLOMICS, 7(6), 979-985. Author URL.
Kasper L, Miramon P, Jablonowski N, Wisgott S, Wilson D, Brunke S, Hube B (2015). Antifungal activity of clotrimazole against Candida albicans depends on carbon sources, growth phase and morphology. JOURNAL OF MEDICAL MICROBIOLOGY, 64, 714-723. Author URL.
Crawford A, Wilson D (2015). Essential metals at the host-pathogen interface: nutritional immunity and micronutrient assimilation by human fungal pathogens. FEMS YEAST RESEARCH, 15(7). Author URL.
Tyc KM, Kühn C, Wilson D, Klipp E (2014). Assessing the advantage of morphological changes in Candida albicans: a game theoretical study. Front Microbiol, 5 Abstract.  Author URL.
Wilson D, Mayer FL, Miramón P, Citiulo F, Slesiona S, Jacobsen ID, Hube B (2014). Distinct roles of Candida albicans-specific genes in host-pathogen interactions. Eukaryot Cell, 13(8), 977-989. Abstract.  Author URL.
Mech F, Wilson D, Lehnert T, Hube B, Thilo Figge M (2014). Epithelial invasion outcompetes hypha development during Candida albicans infection as revealed by an image-based systems biology approach. Cytometry A, 85(2), 126-139. Abstract.  Author URL.
Mayer FL, Wilson D, Hube B (2013). Candida albicans pathogenicity mechanisms. Virulence, 4(2), 119-128. Abstract.  Author URL.
Wilson D, Hebecker B, Moyes DL, Miramón P, Jablonowski N, Wisgott S, Allert S, Naglik JR, Hube B (2013). Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection. Antimicrob Agents Chemother, 57(10), 5178-5180. Abstract.  Author URL.
Mayer FL, Wilson D, Hube B (2013). Hsp21 potentiates antifungal drug tolerance in Candida albicans. PLoS One, 8(3). Abstract.  Author URL.
Jacobsen ID, Wilson D, Wächtler B, Brunke S, Naglik JR, Hube B (2012). Candida albicans dimorphism as a therapeutic target. Expert Rev Anti Infect Ther, 10(1), 85-93. Abstract.  Author URL.
Citiulo F, Jacobsen ID, Miramón P, Schild L, Brunke S, Zipfel P, Brock M, Hube B, Wilson D (2012). Candida albicans scavenges host zinc via Pra1 during endothelial invasion. PLoS Pathog, 8(6). Abstract.  Author URL.
Wächtler B, Citiulo F, Jablonowski N, Förster S, Dalle F, Schaller M, Wilson D, Hube B (2012). Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process. PLoS One, 7(5). Abstract.  Author URL.
Mayer FL, Wilson D, Jacobsen ID, Miramón P, Slesiona S, Bohovych IM, Brown AJP, Hube B (2012). Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans. PLoS One, 7(6). Abstract.  Author URL.
Mayer FL, Wilson D, Jacobsen ID, Miramón P, Große K, Hube B (2012). The novel Candida albicans transporter Dur31 is a multi-stage pathogenicity factor. PLoS Pathog, 8(3). Abstract.  Author URL.
Wächtler B, Wilson D, Hube B (2011). Candida albicans adhesion to and invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole. Antimicrob Agents Chemother, 55(9), 4436-4439. Abstract.  Author URL.
Wächtler B, Wilson D, Haedicke K, Dalle F, Hube B (2011). From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells. PLoS One, 6(2). Abstract.  Author URL.
Martin R, Wächtler B, Schaller M, Wilson D, Hube B (2011). Host-pathogen interactions and virulence-associated genes during Candida albicans oral infections. Int J Med Microbiol, 301(5), 417-422. Abstract.  Author URL.
Seider K, Brunke S, Schild L, Jablonowski N, Wilson D, Majer O, Barz D, Haas A, Kuchler K, Schaller M, et al (2011). The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation. J Immunol, 187(6), 3072-3086. Abstract.  Author URL.
Wilson D, Fiori A, Brucker KD, Dijck PV, Stateva L (2010). Candida albicans Pde1p and Gpa2p comprise a regulatory module mediating agonist-induced cAMP signalling and environmental adaptation. Fungal Genet Biol, 47(9), 742-752. Abstract.  Author URL.
Dalle F, Wächtler B, L'Ollivier C, Holland G, Bannert N, Wilson D, Labruère C, Bonnin A, Hube B (2010). Cellular interactions of Candida albicans with human oral epithelial cells and enterocytes. Cell Microbiol, 12(2), 248-271. Abstract.  Author URL.
Wilson D, Hube B (2010). Hgc1 mediates dynamic Candida albicans-endothelium adhesion events during circulation. Eukaryot Cell, 9(2), 278-287. Abstract.  Author URL.
Linde J, Wilson D, Hube B, Guthke R (2010). Regulatory network modelling of iron acquisition by a fungal pathogen in contact with epithelial cells. BMC Syst Biol, 4 Abstract.  Author URL.
Almeida RS, Wilson D, Hube B (2009). Candida albicans iron acquisition within the host. FEMS Yeast Res, 9(7), 1000-1012. Abstract.  Author URL.
Wilson D, Thewes S, Zakikhany K, Fradin C, Albrecht A, Almeida R, Brunke S, Grosse K, Martin R, Mayer F, et al (2009). Identifying infection-associated genes of Candida albicans in the postgenomic era. FEMS Yeast Res, 9(5), 688-700. Abstract.  Author URL.
Wilson D, Tutulan-Cunita A, Jung W, Hauser NC, Hernandez R, Williamson T, Piekarska K, Rupp S, Young T, Stateva L, et al (2007). Deletion of the high-affinity cAMP phosphodiesterase encoded by PDE2 affects stress responses and virulence in Candida albicans. Mol Microbiol, 65(4), 841-856. Abstract.  Author URL.

Conferences

Wilson D (In Press). Intracellular Zinc Mobilisation Fuels Candida albicans Pathogenicity.

Publications by year


In Press

Canteri de Souza P, Custódio Caloni C, Wilson D, Sergio Almeida R (In Press). An Invertebrate Host to Study Fungal Infections, Mycotoxins and Antifungal Drugs: Tenebrio molitor. Journal of Fungi, 4 Abstract.
Wilson D (In Press). Candida albicans: Microbe of the month. Trends in Microbiology, 27, 188-189.
Wilson D (In Press). Cellular Microbiology Interview - Dr Duncan Wilson. Cellular Microbiology, 20
Wilson D (In Press). Intracellular Zinc Mobilisation Fuels Candida albicans Pathogenicity.
Wilson D, Deepe GS (In Press). The intersection of host and fungus through the zinc lens. Current Opinion in Microbiology, 52, 35-40. Abstract.

2019

Brown GD, Wilson D (2019). Mammalian innate immunity to fungal infection. Semin Cell Dev Biol, 89, 1-2. Author URL.

2018

Crawford AC, Lehtovirta-Morley LE, Alamir O, Niemiec MJ, Alawfi B, Alsarraf M, Skrahina V, Costa ACBP, Anderson A, Yellagunda S, et al (2018). Biphasic zinc compartmentalisation in a human fungal pathogen. PLOS Pathogens, 14(5), e1007013-e1007013.
Kjellerup L, Winther A-ML, Wilson D, Fuglsang AT (2018). Cyclic AMP Pathway Activation and Extracellular Zinc Induce Rapid Intracellular Zinc Mobilization in Candida albicans. Frontiers in Microbiology, 9
Richardson JP, Mogavero S, Moyes DL, Blagojevic M, Krüger T, Verma AH, Coleman BM, De La Cruz Diaz J, Schulz D, Ponde NO, et al (2018). Processing of Candida albicans Ece1p is Critical for Candidalysin Maturation and Fungal Virulence. mBio, 9(1). Abstract.

2017

Wilson D (2017). A tale of two yeasts: Saccharomyces cerevisiae as a therapeutic against candidiasis. VIRULENCE, 8(1), 15-17. Author URL.
Malavia D, Crawford A, Wilson D (2017). Nutritional Immunity and Fungal Pathogenesis: the Struggle for Micronutrients at the Host-Pathogen Interface. Adv Microb Physiol, 70, 85-103. Abstract.  Author URL.
Lehtovirta-Morley LE, Alsarraf M, Wilson D (2017). Pan-Domain Analysis of ZIP Zinc Transporters. Int J Mol Sci, 18(12). Abstract.  Author URL.
Malavia D, Lehtovirta-Morley LE, Alamir O, Weiß E, Gow NAR, Hube B, Wilson D (2017). Zinc Limitation Induces a Hyper-Adherent Goliath Phenotype in Candida albicans. Front Microbiol, 8 Abstract.  Author URL.

2016

Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, et al (2016). Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature, 532(7597), 64-68.
Wilson D, Naglik JR, Hube B (2016). The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage. PLOS PATHOGENS, 12(10). Author URL.
Ballou ER, Wilson D (2016). The roles of zinc and copper sensing in fungal pathogenesis. Curr Opin Microbiol, 32, 128-134. Abstract.  Author URL.

2015

Wilson D (2015). An evolutionary perspective on zinc uptake by human fungal pathogens. METALLOMICS, 7(6), 979-985. Author URL.
Kasper L, Miramon P, Jablonowski N, Wisgott S, Wilson D, Brunke S, Hube B (2015). Antifungal activity of clotrimazole against Candida albicans depends on carbon sources, growth phase and morphology. JOURNAL OF MEDICAL MICROBIOLOGY, 64, 714-723. Author URL.
Crawford A, Wilson D (2015). Essential metals at the host-pathogen interface: nutritional immunity and micronutrient assimilation by human fungal pathogens. FEMS YEAST RESEARCH, 15(7). Author URL.

2014

Tyc KM, Kühn C, Wilson D, Klipp E (2014). Assessing the advantage of morphological changes in Candida albicans: a game theoretical study. Front Microbiol, 5 Abstract.  Author URL.
Wilson D, Mayer FL, Miramón P, Citiulo F, Slesiona S, Jacobsen ID, Hube B (2014). Distinct roles of Candida albicans-specific genes in host-pathogen interactions. Eukaryot Cell, 13(8), 977-989. Abstract.  Author URL.
Mech F, Wilson D, Lehnert T, Hube B, Thilo Figge M (2014). Epithelial invasion outcompetes hypha development during Candida albicans infection as revealed by an image-based systems biology approach. Cytometry A, 85(2), 126-139. Abstract.  Author URL.

2013

Mayer FL, Wilson D, Hube B (2013). Candida albicans pathogenicity mechanisms. Virulence, 4(2), 119-128. Abstract.  Author URL.
Wilson D, Hebecker B, Moyes DL, Miramón P, Jablonowski N, Wisgott S, Allert S, Naglik JR, Hube B (2013). Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection. Antimicrob Agents Chemother, 57(10), 5178-5180. Abstract.  Author URL.
Mayer FL, Wilson D, Hube B (2013). Hsp21 potentiates antifungal drug tolerance in Candida albicans. PLoS One, 8(3). Abstract.  Author URL.

2012

Jacobsen ID, Wilson D, Wächtler B, Brunke S, Naglik JR, Hube B (2012). Candida albicans dimorphism as a therapeutic target. Expert Rev Anti Infect Ther, 10(1), 85-93. Abstract.  Author URL.
Citiulo F, Jacobsen ID, Miramón P, Schild L, Brunke S, Zipfel P, Brock M, Hube B, Wilson D (2012). Candida albicans scavenges host zinc via Pra1 during endothelial invasion. PLoS Pathog, 8(6). Abstract.  Author URL.
Wächtler B, Citiulo F, Jablonowski N, Förster S, Dalle F, Schaller M, Wilson D, Hube B (2012). Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process. PLoS One, 7(5). Abstract.  Author URL.
Mayer FL, Wilson D, Jacobsen ID, Miramón P, Slesiona S, Bohovych IM, Brown AJP, Hube B (2012). Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans. PLoS One, 7(6). Abstract.  Author URL.
Mayer FL, Wilson D, Jacobsen ID, Miramón P, Große K, Hube B (2012). The novel Candida albicans transporter Dur31 is a multi-stage pathogenicity factor. PLoS Pathog, 8(3). Abstract.  Author URL.

2011

Wächtler B, Wilson D, Hube B (2011). Candida albicans adhesion to and invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole. Antimicrob Agents Chemother, 55(9), 4436-4439. Abstract.  Author URL.
Wächtler B, Wilson D, Haedicke K, Dalle F, Hube B (2011). From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells. PLoS One, 6(2). Abstract.  Author URL.
Martin R, Wächtler B, Schaller M, Wilson D, Hube B (2011). Host-pathogen interactions and virulence-associated genes during Candida albicans oral infections. Int J Med Microbiol, 301(5), 417-422. Abstract.  Author URL.
Seider K, Brunke S, Schild L, Jablonowski N, Wilson D, Majer O, Barz D, Haas A, Kuchler K, Schaller M, et al (2011). The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation. J Immunol, 187(6), 3072-3086. Abstract.  Author URL.

2010

Wilson D, Fiori A, Brucker KD, Dijck PV, Stateva L (2010). Candida albicans Pde1p and Gpa2p comprise a regulatory module mediating agonist-induced cAMP signalling and environmental adaptation. Fungal Genet Biol, 47(9), 742-752. Abstract.  Author URL.
Dalle F, Wächtler B, L'Ollivier C, Holland G, Bannert N, Wilson D, Labruère C, Bonnin A, Hube B (2010). Cellular interactions of Candida albicans with human oral epithelial cells and enterocytes. Cell Microbiol, 12(2), 248-271. Abstract.  Author URL.
Wilson D, Hube B (2010). Hgc1 mediates dynamic Candida albicans-endothelium adhesion events during circulation. Eukaryot Cell, 9(2), 278-287. Abstract.  Author URL.
Linde J, Wilson D, Hube B, Guthke R (2010). Regulatory network modelling of iron acquisition by a fungal pathogen in contact with epithelial cells. BMC Syst Biol, 4 Abstract.  Author URL.

2009

Almeida RS, Wilson D, Hube B (2009). Candida albicans iron acquisition within the host. FEMS Yeast Res, 9(7), 1000-1012. Abstract.  Author URL.
Wilson D, Thewes S, Zakikhany K, Fradin C, Albrecht A, Almeida R, Brunke S, Grosse K, Martin R, Mayer F, et al (2009). Identifying infection-associated genes of Candida albicans in the postgenomic era. FEMS Yeast Res, 9(5), 688-700. Abstract.  Author URL.

2007

Wilson D, Tutulan-Cunita A, Jung W, Hauser NC, Hernandez R, Williamson T, Piekarska K, Rupp S, Young T, Stateva L, et al (2007). Deletion of the high-affinity cAMP phosphodiesterase encoded by PDE2 affects stress responses and virulence in Candida albicans. Mol Microbiol, 65(4), 841-856. Abstract.  Author URL.

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