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Professor Elaine Bignell

Professor Elaine Bignell

Professor of Medical Mycology

 2996

 01392 722996

 Geoffrey Pope 317

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

Elaine Bignell is an internationally recognised leader in the field of human fungal pathogen research and a Co-Director (Research) for the MRC Centre for Medical Mycology at the University of Exeter. Her work addresses the mechanistic basis of lung diseases caused by the major mould pathogen of humans, Aspergillus fumigatus. Major contributions to the field have included pioneering work on the role of Aspergillus pH sensing in pathogenicity, transcriptional regulation of host adaptation, and the mechanistic basis of tissue invasion during invasive fungal lung disease.

A molecular geneticist by training, Elaine began her independent research career as an MRC New Investigator, and by securing a fast-track to Lectureship Award at Imperial College London. She later played a major role in establishing the Manchester Fungal Infection Group (MFIG) and in securing its success as a leading International Centre of Excellence for fungal diseases research, having served as a Director of this unit for 5 years (2015 – 2020).

Elaine’s research seeks a mechanistic understanding of fungal lung disease with a view to developing novel diagnostics and antifungal therapies. Her approach integrates infection models which transcend multiple experimental scales to address disease outcomes at the molecular, cellular, tissue, organ and whole animal levels. Most recently, via iterative MRC funding awards, Elaine has applied a systems level approach to define pathogenicity in Aspergillus fumigatus, and is now developing inhibitors of fungal pH signalling as novel antifungal drugs, and studying secreted fungal proteins as novel vaccine candidates and diagnostic tools.

Qualifications

BSc (Hons) Biochemistry

PhD (Fungal Genetics)

Career

1992 – 1995 Research Technician Fungal Genetics (Prof. H. Arst) Imperial College

1995 – 1999 PhD Fungal Genetics (Prof. H. Arst) Imperial College London

2000 – 2006 Postdoctoral Researcher Molecular Mycology (Ken Haynes) Imperial College London

2005 – 2006 Imperial College Fast Track to Lecturer Fellowship, Imperial College  London

2006 – 2009 Medical Research Council New Investigator

2009 – 2013 Lecturer in Molecular Microbiology, Imperial College London

2013 – 2019 Reader in Applied Mycology, The University of Manchester

2019 – 2020 Professor of Infection Biology, The University of Manchester

2019 – 2020 Head of Division of Infection, Immunity & Respiratory Medicine, The University of Manchester

2020             Professor of Medical Mycology, University of Exeter

2020             Co-Director MRC Centre for Medical Mycology, University of Exeter

Research group links

Research

Research interests

My research seeks a better mechanistic understanding of diseases caused by Aspergillus fumigatus, the major mould pathogen of human lungs.   We take a multi-scale approach, using in vitro, in vivo, and in silico models of the fungal host-pathogen interaction, to identify regulatory foci driving initiation and resolution of disease. Our aim is to develop a molecular understanding of fungal lung disease so that better diagnostics tools and antifungal therapies can be developed.

We are currently working in 5 main areas

  1. Fungal sensing of and adaptation to extracellular pH
  2. Secreted effectors of tissue invasion in Aspergillus fumigatus
  3. A genome scale census of pathogenicity in Aspergillus fumigatus
  4. From mucin biochemistry to pulmonary immunity: How do mucins promote antifungal lung defences?
  5. In silico modelling of IFNγ mode of antifungal action

Research projects

Effectors of Tissue Invasion in Aspergillus fumigatus

 

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Alcazar-Fuoli E (In Press). A Modified Recombineering Protocol for the Genetic Manipulation of Gene Clusters in <italic>Aspergillus fumigatus</italic>. PLoS ONE, 9, e111875-e111875. Abstract.
Bertuzzi EM (In Press). The pH-Responsive PacC Transcription Factor of <italic>Aspergillus fumigatus</italic> Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis. PLoS Pathog, 10, e1004413-e1004413. Abstract.
Furukawa T, van Rhijn N, Fraczek M, Gsaller F, Davies E, Carr P, Gago S, Fortune-Grant R, Rahman S, Gilsenan JM, et al (2020). The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus. Nat Commun, 11(1). Abstract.  Author URL.
Papastamoulis P, Furukawa T, van Rhijn N, Bromley M, Bignell E, Rattray M (2019). Bayesian Detection of Piecewise Linear Trends in Replicated Time-Series with Application to Growth Data Modelling. The International Journal of Biostatistics, 16(1). Abstract.
Bertuzzi M, Hayes GE, Bignell EM (2019). Microbial uptake by the respiratory epithelium: outcomes for host and pathogen. FEMS Microbiology Reviews, 43(2), 145-161.
Scott J, Sueiro-Olivares M, Ahmed W, Heddergott C, Zhao C, Thomas R, Bromley M, Latgé J-P, Krappmann S, Fowler S, et al (2019). Pseudomonas aeruginosa-Derived Volatile Sulfur Compounds Promote Distal Aspergillus fumigatus Growth and a Synergistic Pathogen-Pathogen Interaction That Increases Pathogenicity in Co-infection. Frontiers in Microbiology, 10
Bertuzzi M, Hayes G, Icheoku U, van Rhijn N, Denning D, Osherov N, Bignell E (2018). Anti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease. Journal of Fungi, 4(1), 8-8.
Gsaller F, Furukawa T, Carr PD, Rash B, Jöchl C, Bertuzzi M, Bignell EM, Bromley MJ (2018). Mechanistic Basis of pH-Dependent 5-Flucytosine Resistance in Aspergillus fumigatus. Antimicrob Agents Chemother, 62(6). Abstract.  Author URL.
Johns A, Scharf DH, Gsaller F, Schmidt H, Heinekamp T, Straßburger M, Oliver JD, Birch M, Beckmann N, Dobb KS, et al (2017). A Nonredundant Phosphopantetheinyl Transferase, PptA, is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and is Critical for Pathogenicity. mBio, 8(4). Abstract.  Author URL.
Ketelaar ME, Van De Kant K, Dijk FN, Klaassen EMM, Grotenboer N, Nawijn MC, Dompeling E, Koppelman GH, Murray C, Foden P, et al (2017). Abstracts from the 3rd International Severe Asthma Forum (ISAF). Clinical and Translational Allergy, 7(S2).
Loss O, Bertuzzi M, Yan Y, Fedorova N, McCann BL, Armstrong-James D, Espeso EA, Read ND, Nierman WC, Bignell EM, et al (2017). Mutual independence of alkaline- and calcium-mediated signalling in Aspergillus fumigatus refutes the existence of a conserved druggable signalling nexus. Mol Microbiol, 106(6), 861-875. Abstract.  Author URL.
Oda K, Bignell E, Kang SE, Momany M (2017). Transcript levels of the Aspergillus fumigatus Cdc42 module, polarisome, and septin genes show little change from dormancy to polarity establishment. Med Mycol, 55(4), 445-452. Abstract.  Author URL.
Amich J, Bignell E (2016). Amino acid biosynthetic routes as drug targets for pulmonary fungal pathogens: what is known and why do we need to know more?. Curr Opin Microbiol, 32, 151-158. Abstract.  Author URL.
Thomma BP, Bignell E (2016). Editorial overview: the fungal infection arena in animal and plant hosts: dynamics at the interface. Curr Opin Microbiol, 32, v-vii. Author URL.
Bignell E, Cairns TC, Throckmorton K, Nierman WC, Keller NP (2016). Secondary metabolite arsenal of an opportunistic pathogenic fungus. Philos Trans R Soc Lond B Biol Sci, 371(1709). Abstract.  Author URL.
Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Muñoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, et al (2015). Correction: the pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis. PLoS Pathog, 11(6). Author URL.
Muñoz A, Bertuzzi M, Bettgenhaeuser J, Iakobachvili N, Bignell EM, Read ND (2015). Different Stress-Induced Calcium Signatures Are Reported by Aequorin-Mediated Calcium Measurements in Living Cells of Aspergillus fumigatus. PLoS One, 10(9). Abstract.  Author URL.
Tanaka RJ, Boon NJ, Vrcelj K, Nguyen A, Vinci C, Armstrong-James D, Bignell E (2015). In silico modeling of spore inhalation reveals fungal persistence following low dose exposure. Sci Rep, 5 Abstract.  Author URL.
Bussink H-J, Bignell EM, Múnera-Huertas T, Lucena-Agell D, Scazzocchio C, Espeso EA, Bertuzzi M, Rudnicka J, Negrete-Urtasun S, Peñas-Parilla MM, et al (2015). Refining the pH response in Aspergillus nidulans: a modulatory triad involving PacX, a novel zinc binuclear cluster protein. Mol Microbiol, 98(6), 1051-1072. Abstract.  Author URL.
Huber F, Bignell E (2014). Corrigendum to "Distribution, expression and expansion of Aspergillus fumigatus LINE-like retrotransposon populations in clinical and environmental isolates" [Fungal Genet. Biol. 64 (2014) 36-44]. Fungal Genetics and Biology, 70
Huber F, Bignell E (2014). Distribution, expression and expansion of Aspergillus fumigatus LINE-like retrotransposon populations in clinical and environmental isolates. Fungal Genetics and Biology, 64, 36-44. Abstract.
Herbst S, Shah A, Carby M, Chusney G, Kikkeri N, Dorling A, Bignell E, Shaunak S, Armstrong-James D (2013). A new and clinically relevant murine model of solid-organ transplant aspergillosis. DMM Disease Models and Mechanisms, 6(3), 643-651. Abstract.
Almeida RS, Loss O, Colabardini AC, Brown NA, Bignell E, Savoldi M, Pantano S, Goldman MHS, Arst HN, Goldman GH, et al (2013). Genetic bypass of Aspergillus nidulans crzA function in calcium homeostasis. G3: Genes, Genomes, Genetics, 3(7), 1129-1141. Abstract.
Cherblanc FL, Chapman KL, Reid J, Borg AJ, Sundriyal S, Alcazar-Fuoli L, Bignell E, Demetriades M, Schofield CJ, Dimaggio PA, et al (2013). On the histone lysine methyltransferase activity of fungal metabolite chaetocin. Journal of Medicinal Chemistry, 56(21), 8616-8625. Abstract.
Grice CM, Bertuzzi M, Bignell EM (2013). Receptor-mediated signaling in Aspergillus fumigatus. Frontiers in Microbiology, 4(FEB). Abstract.
Henk DA, Shahar-Golan R, Devi KR, Boyce KJ, Zhan N, Fedorova ND, Nierman WC, Hsueh PR, Yuen KY, Sieu TPM, et al (2012). Clonality Despite Sex: the Evolution of Host-Associated Sexual Neighborhoods in the Pathogenic Fungus Penicillium marneffei. PLoS Pathogens, 8(10). Abstract.
Bignell EM (2012). Conservation in Aspergillus fumigatus of pH-signaling seven transmembrane domain and arrestin proteins, and implications for drug discovery. Annals of the New York Academy of Sciences, 1273(1), 35-43. Abstract.
Bhatti MF, Jamal A, Bignell EM, Petrou MA, Coutts RHA (2012). Incidence of dsRNA Mycoviruses in a Collection of Aspergillus fumigatus Isolates. Mycopathologia, 174(4), 323-326. Abstract.
Yasmin S, Alcazar-Fuoli L, Gründlinger M, Puempel T, Cairns T, Blatzer M, Lopez JF, Grimalt JO, Bignell E, Haas H, et al (2012). Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus. PNAS, 109, E497-E504. Abstract.  Author URL.
Bhatti MF, Bignell EM, Coutts RHA (2011). Complete nucleotide sequences of two dsRNAs associated with a new partitivirus infecting Aspergillus fumigatus. Archives of Virology, 156(9), 1677-1680.
Hartmann T, Cairns TC, Olbermann P, Morschhäuser J, Bignell EM, Krappmann S (2011). Oligopeptide transport and regulation of extracellular proteolysis are required for growth of Aspergillus fumigatus on complex substrates but not for virulence. Mol. Microbiol, 82, 917-935. Author URL.
Cherblanc F, Lo YP, De Gussem E, Alcazar-Fuoli L, Bignell E, He Y, Chapman-Rothe N, Bultinck P, Herrebout WA, Brown R, et al (2011). On the determination of the stereochemistry of semisynthetic natural product analogues using chiroptical spectroscopy: Desulfurization of epidithiodioxopiperazine fungal metabolites. Chemistry - a European Journal, 17(42), 11868-11875. Abstract.
Bertuzzi M, Bignell EM (2011). Sensory perception in fungal pathogens: Applications of the split-ubiquitin Membrane Yeast Two-Hybrid (MYTH) technique. Fungal Biology Reviews, 25(4), 165-171. Abstract.
O'Hanlon KA, Cairns T, Stack D, Schrettl M, Bignell EM, Kavanagh K, Miggin SM, O'Keeffe G, Larsen TO, Doyle S, et al (2011). Targeted Disruption of Nonribosomal Peptide Synthetase pes3 Augments the Virulence of Aspergillus fumigatus. Infect Immun, 79, 3978-3992. Abstract.  Author URL.
Bhatti MF, Jamal A, Petrou MA, Cairns TC, Bignell EM, Coutts RHA (2011). The effects of dsRNA mycoviruses on growth and murine virulence of Aspergillus fumigatus. Fungal Genet Biol, 48, 1071-1075. Author URL.
Jamal A, Bignell EM, Coutts RHA (2010). Complete nucleotide sequences of four dsRNAs associated with a new chrysovirus infecting Aspergillus fumigatus. Virus Research, 153(1), 64-70. Abstract.
Han KH, Chun YH, Pimentel Figueiredo BDC, Marianetti Soriani F, Savoldi M, Almeida A, Rodrigues F, Cairns CT, Bignell E, Tobal JM, et al (2010). Erratum: the conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans (Molecular Microbiology (2010) 75 (1372-1388)). Molecular Microbiology, 76(3).
Chamilos G, Bignell EM, Schrettl M, Lewis RE, Leventakos K, May GS, Haas H, Kontoyiannis DP (2010). Exploring the concordance of aspergillus fumigatus pathogenicity in mice and Toll-deficient flies. Medical Mycology, 48(3), 506-510. Abstract.
Han KH, Chun YH, Figueiredo Bde C, Soriani FM, Savoldi M, Almeida A, Rodrigues F, Cairns CT, Bignell E, Tobal JM, et al (2010). The conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans. Mol Microbiol, 75, 1372-1388. Abstract.  Author URL.
Cairns T, Minuzzi F, Bignell E (2010). The host-infecting fungal transcriptome. FEMS Microbiol Lett
Bergmann A, Hartmann T, Cairns T, Bignell EM, Krappmann S (2009). A regulator of Aspergillus fumigatus extracellular proteolytic activity is dispensable for virulence. Infect. Immun, 77, 4041-4050. Abstract.  Author URL.
Armstrong-James DPH, Turnbull SA, Teo I, Stark J, Rogers NJ, Rogers TRF, Bignell E, Haynes K (2009). Impaired interferon-gamma responses, increased interleukin-17 expression, and a tumor necrosis factor-alpha transcriptional program in invasive aspergillosis. J Infect Dis, 200(8), 1341-1351. Abstract.  Author URL.
Peñalva MA, Tilburn J, Bignell E, Arst HN (2008). Ambient pH gene regulation in fungi: making connections. Trends in Microbiology, 16(6), 291-300. Abstract.
Sasse C, Bignell EM, Hasenberg M, Haynes K, Gunzer M, Braus GH, Krappmann S (2008). Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis. Fungal Genet Biol, 45(5), 693-704. Abstract.  Author URL.
Soriani FM, Malavazi I, Da Silva Ferreira ME, Savoldi M, Von Zeska Kress MR, De Souza Goldman MH, Loss O, Bignell E, Goldman GH (2008). Functional characterization of the Aspergillus fumigatus CRZ1 homologue, CrzA. Molecular Microbiology, 67(6), 1274-1291. Abstract.
de Gouvêa PF, Soriani FM, Malavazi I, Savoldi M, Goldman MHDS, Loss O, Bignell E, da Silva Ferreira ME, Goldman GH (2008). Functional characterization of the Aspergillus fumigatus PHO80 homologue. Fungal Genetics and Biology, 45(7), 1135-1146. Abstract.
McDonagh A, Fedorova ND, Crabtree J, Yu Y, Kim S, Chen D, Loss O, Cairns T, Goldman G, Armstrong-James D, et al (2008). Sub-telomere directed gene expression during initiation of invasive aspergillosis. PLoS Pathog, 4(9). Abstract.  Author URL.  Full text.
Schrettl M, Bignell E, Kragl C, Sabiha Y, Loss O, Eisendle M, Wallner A, Arst Jr. HN, Haynes K, Haas H, et al (2007). Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. PLoS Pathogens, 3, 1195-1207.
Schrettl M, Bignell E, Kragl C, Sabiha Y, Loss O, Eisendle M, Wallner A, Arst HN, Haynes K, Haas H, et al (2007). Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. PLoS Pathog, 3(9), 1195-1207. Abstract.  Author URL.
Calcagno A-M, Bignell E, Rogers TR, Jones MD, Mühlschlegel FA, Haynes K (2005). Candida glabrata Ste11 is involved in adaptation to hypertonic stress, maintenance of wild-type levels of filamentation and plays a role in virulence. Med Mycol, 43(4), 355-364. Abstract.  Author URL.
Bignell E, Negrete-Urtasun S, Calcagno AM, Haynes K, Arst HN, Rogers T (2005). The Aspergillus pH-responsive transcription factor PacC regulates virulence. Mol Microbiol, 55(4), 1072-1084. Abstract.  Author URL.
Bignell E, Negrete-Urtasun S, Calcagno AM, Arst HN, Rogers T, Haynes K (2005). Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice. Infect Immun, 73(8), 5204-5207. Abstract.  Author URL.
Calcagno A-M, Bignell E, Rogers TR, Canedo M, Mühlschlegel FA, Haynes K (2004). Candida glabrata Ste20 is involved in maintaining cell wall integrity and adaptation to hypertonic stress, and is required for wild-type levels of virulence. Yeast, 21(7), 557-568. Abstract.  Author URL.
Sarkar S, Caddick MX, Bignell E, Tilburn J, Arst HN (2004). Erratum: Regulation of gene expression by ambient pH in Aspergillus: Genes expressed at acidic pH (Biochemical Society Transactions (1996) 24, Part 2 (360-363)). Biochemical Society Transactions, 32(6).
Kamran M, Calcagno A-M, Findon H, Bignell E, Jones MD, Warn P, Hopkins P, Denning DW, Butler G, Rogers T, et al (2004). Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence. Eukaryot Cell, 3(2), 546-552. Abstract.  Author URL.
Schrettl M, Bignell E, Kragl C, Joechl C, Rogers T, Arst HN, Haynes K, Haas H (2004). Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence. J Exp Med, 200(9), 1213-1219. Abstract.  Author URL.
Krappmann S, Bignell EM, Reichard U, Rogers T, Haynes K, Braus GH (2004). The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen. Mol Microbiol, 52(3), 785-799. Abstract.  Author URL.
Calcagno A-M, Bignell E, Warn P, Jones MD, Denning DW, Mühlschlegel FA, Rogers TR, Haynes K (2003). Candida glabrata STE12 is required for wild-type levels of virulence and nitrogen starvation induced filamentation. Mol Microbiol, 50(4), 1309-1318. Abstract.  Author URL.
Espeso EA, Roncal T, Diez E, Rainbow L, Bignell E, Suarez JAT, Denison SH, Tilburn J, Arst J, Penalva MA, et al (2000). Corrigendum: on how a transcription factor can avoid its proteolytic activation in the absence of signal transduction (The EMBO Journal (2000) 19, 719-728)). EMBO Journal, 19(10).
Espeso EA, Roncal T, Díez E, Rainbow L, Bignell E, Álvaro J, Suárez T, Denison SH, Tilburn J, Arst HN, et al (2000). On how a transcription factor can avoid its proteolytic activation in the absence of signal transduction. EMBO Journal, 19(4), 719-728. Abstract.
Mingot JM, Tilburn J, Diez E, Bignell E, Orejas M, Widdick DA, Sarkar S, Brown CV, Caddick MX, Espeso EA, et al (1999). Specificity determinants of proteolytic processing of Aspergillus PacC transcription factor are remote from the processing site, and processing occurs in yeast if pH signalling is bypassed. Molecular and Cellular Biology, 19(2), 1390-1400. Abstract.
Arst HN, Bignell E, Tilburn J (1994). Two new genes involved in signalling ambient pH in Aspergillus nidulans. MGG Molecular & General Genetics, 245(6), 787-790. Abstract.

Chapters

Bignell EM, Darius AJ (2012). Pathosystematic studies and the rational design of antifungal interventions. In  (Ed) Antimicrobial Drug Discovery: Emerging Strategies, 265-291.
Bignell E (2012). The Molecular Basis of pH Sensing, Signaling, and Homeostasis in Fungi. In  (Ed) Advances in Applied Microbiology, 1-18.  Abstract.

Conferences

Salek-Ardakani S, Cota E, Bignell E (2012). Host-fungal interactions: Key players of antifungal immunity.  Abstract.
Bignell E (2010). Therapeutic jackpots lie within the reach of multiscale and integrated mycological research.  Abstract.
Krappmann S, Reichard U, Bignell EM, Haynes K, Braus GH (2004). The Cross-Pathway Control system contributes to pathogenicity of Aspergillus fumigatus.  Author URL.
Sartor S, Caddick MX, Bignell E, Tilburn J, Arst HN (1996). Regulation of gene expression by ambient pH in Aspergillus: Genes expressed at acid pH.

Publications by year


In Press

Alcazar-Fuoli E (In Press). A Modified Recombineering Protocol for the Genetic Manipulation of Gene Clusters in <italic>Aspergillus fumigatus</italic>. PLoS ONE, 9, e111875-e111875. Abstract.
Bertuzzi EM (In Press). The pH-Responsive PacC Transcription Factor of <italic>Aspergillus fumigatus</italic> Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis. PLoS Pathog, 10, e1004413-e1004413. Abstract.

2020

Furukawa T, van Rhijn N, Fraczek M, Gsaller F, Davies E, Carr P, Gago S, Fortune-Grant R, Rahman S, Gilsenan JM, et al (2020). The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus. Nat Commun, 11(1). Abstract.  Author URL.

2019

Papastamoulis P, Furukawa T, van Rhijn N, Bromley M, Bignell E, Rattray M (2019). Bayesian Detection of Piecewise Linear Trends in Replicated Time-Series with Application to Growth Data Modelling. The International Journal of Biostatistics, 16(1). Abstract.
Bertuzzi M, Hayes GE, Bignell EM (2019). Microbial uptake by the respiratory epithelium: outcomes for host and pathogen. FEMS Microbiology Reviews, 43(2), 145-161.
Scott J, Sueiro-Olivares M, Ahmed W, Heddergott C, Zhao C, Thomas R, Bromley M, Latgé J-P, Krappmann S, Fowler S, et al (2019). Pseudomonas aeruginosa-Derived Volatile Sulfur Compounds Promote Distal Aspergillus fumigatus Growth and a Synergistic Pathogen-Pathogen Interaction That Increases Pathogenicity in Co-infection. Frontiers in Microbiology, 10

2018

Bertuzzi M, Hayes G, Icheoku U, van Rhijn N, Denning D, Osherov N, Bignell E (2018). Anti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease. Journal of Fungi, 4(1), 8-8.
Gsaller F, Furukawa T, Carr PD, Rash B, Jöchl C, Bertuzzi M, Bignell EM, Bromley MJ (2018). Mechanistic Basis of pH-Dependent 5-Flucytosine Resistance in Aspergillus fumigatus. Antimicrob Agents Chemother, 62(6). Abstract.  Author URL.

2017

Johns A, Scharf DH, Gsaller F, Schmidt H, Heinekamp T, Straßburger M, Oliver JD, Birch M, Beckmann N, Dobb KS, et al (2017). A Nonredundant Phosphopantetheinyl Transferase, PptA, is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and is Critical for Pathogenicity. mBio, 8(4). Abstract.  Author URL.
Ketelaar ME, Van De Kant K, Dijk FN, Klaassen EMM, Grotenboer N, Nawijn MC, Dompeling E, Koppelman GH, Murray C, Foden P, et al (2017). Abstracts from the 3rd International Severe Asthma Forum (ISAF). Clinical and Translational Allergy, 7(S2).
Loss O, Bertuzzi M, Yan Y, Fedorova N, McCann BL, Armstrong-James D, Espeso EA, Read ND, Nierman WC, Bignell EM, et al (2017). Mutual independence of alkaline- and calcium-mediated signalling in Aspergillus fumigatus refutes the existence of a conserved druggable signalling nexus. Mol Microbiol, 106(6), 861-875. Abstract.  Author URL.
Oda K, Bignell E, Kang SE, Momany M (2017). Transcript levels of the Aspergillus fumigatus Cdc42 module, polarisome, and septin genes show little change from dormancy to polarity establishment. Med Mycol, 55(4), 445-452. Abstract.  Author URL.

2016

Amich J, Bignell E (2016). Amino acid biosynthetic routes as drug targets for pulmonary fungal pathogens: what is known and why do we need to know more?. Curr Opin Microbiol, 32, 151-158. Abstract.  Author URL.
Thomma BP, Bignell E (2016). Editorial overview: the fungal infection arena in animal and plant hosts: dynamics at the interface. Curr Opin Microbiol, 32, v-vii. Author URL.
Bignell E, Cairns TC, Throckmorton K, Nierman WC, Keller NP (2016). Secondary metabolite arsenal of an opportunistic pathogenic fungus. Philos Trans R Soc Lond B Biol Sci, 371(1709). Abstract.  Author URL.

2015

Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Muñoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, et al (2015). Correction: the pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis. PLoS Pathog, 11(6). Author URL.
Muñoz A, Bertuzzi M, Bettgenhaeuser J, Iakobachvili N, Bignell EM, Read ND (2015). Different Stress-Induced Calcium Signatures Are Reported by Aequorin-Mediated Calcium Measurements in Living Cells of Aspergillus fumigatus. PLoS One, 10(9). Abstract.  Author URL.
Tanaka RJ, Boon NJ, Vrcelj K, Nguyen A, Vinci C, Armstrong-James D, Bignell E (2015). In silico modeling of spore inhalation reveals fungal persistence following low dose exposure. Sci Rep, 5 Abstract.  Author URL.
Bussink H-J, Bignell EM, Múnera-Huertas T, Lucena-Agell D, Scazzocchio C, Espeso EA, Bertuzzi M, Rudnicka J, Negrete-Urtasun S, Peñas-Parilla MM, et al (2015). Refining the pH response in Aspergillus nidulans: a modulatory triad involving PacX, a novel zinc binuclear cluster protein. Mol Microbiol, 98(6), 1051-1072. Abstract.  Author URL.

2014

Huber F, Bignell E (2014). Corrigendum to "Distribution, expression and expansion of Aspergillus fumigatus LINE-like retrotransposon populations in clinical and environmental isolates" [Fungal Genet. Biol. 64 (2014) 36-44]. Fungal Genetics and Biology, 70
Huber F, Bignell E (2014). Distribution, expression and expansion of Aspergillus fumigatus LINE-like retrotransposon populations in clinical and environmental isolates. Fungal Genetics and Biology, 64, 36-44. Abstract.

2013

Herbst S, Shah A, Carby M, Chusney G, Kikkeri N, Dorling A, Bignell E, Shaunak S, Armstrong-James D (2013). A new and clinically relevant murine model of solid-organ transplant aspergillosis. DMM Disease Models and Mechanisms, 6(3), 643-651. Abstract.
Almeida RS, Loss O, Colabardini AC, Brown NA, Bignell E, Savoldi M, Pantano S, Goldman MHS, Arst HN, Goldman GH, et al (2013). Genetic bypass of Aspergillus nidulans crzA function in calcium homeostasis. G3: Genes, Genomes, Genetics, 3(7), 1129-1141. Abstract.
Cherblanc FL, Chapman KL, Reid J, Borg AJ, Sundriyal S, Alcazar-Fuoli L, Bignell E, Demetriades M, Schofield CJ, Dimaggio PA, et al (2013). On the histone lysine methyltransferase activity of fungal metabolite chaetocin. Journal of Medicinal Chemistry, 56(21), 8616-8625. Abstract.
Grice CM, Bertuzzi M, Bignell EM (2013). Receptor-mediated signaling in Aspergillus fumigatus. Frontiers in Microbiology, 4(FEB). Abstract.

2012

Henk DA, Shahar-Golan R, Devi KR, Boyce KJ, Zhan N, Fedorova ND, Nierman WC, Hsueh PR, Yuen KY, Sieu TPM, et al (2012). Clonality Despite Sex: the Evolution of Host-Associated Sexual Neighborhoods in the Pathogenic Fungus Penicillium marneffei. PLoS Pathogens, 8(10). Abstract.
Bignell EM (2012). Conservation in Aspergillus fumigatus of pH-signaling seven transmembrane domain and arrestin proteins, and implications for drug discovery. Annals of the New York Academy of Sciences, 1273(1), 35-43. Abstract.
Salek-Ardakani S, Cota E, Bignell E (2012). Host-fungal interactions: Key players of antifungal immunity.  Abstract.
Bhatti MF, Jamal A, Bignell EM, Petrou MA, Coutts RHA (2012). Incidence of dsRNA Mycoviruses in a Collection of Aspergillus fumigatus Isolates. Mycopathologia, 174(4), 323-326. Abstract.
Yasmin S, Alcazar-Fuoli L, Gründlinger M, Puempel T, Cairns T, Blatzer M, Lopez JF, Grimalt JO, Bignell E, Haas H, et al (2012). Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus. PNAS, 109, E497-E504. Abstract.  Author URL.
Bignell EM, Darius AJ (2012). Pathosystematic studies and the rational design of antifungal interventions. In  (Ed) Antimicrobial Drug Discovery: Emerging Strategies, 265-291.
Bignell E (2012). The Molecular Basis of pH Sensing, Signaling, and Homeostasis in Fungi. In  (Ed) Advances in Applied Microbiology, 1-18.  Abstract.

2011

Bhatti MF, Bignell EM, Coutts RHA (2011). Complete nucleotide sequences of two dsRNAs associated with a new partitivirus infecting Aspergillus fumigatus. Archives of Virology, 156(9), 1677-1680.
Hartmann T, Cairns TC, Olbermann P, Morschhäuser J, Bignell EM, Krappmann S (2011). Oligopeptide transport and regulation of extracellular proteolysis are required for growth of Aspergillus fumigatus on complex substrates but not for virulence. Mol. Microbiol, 82, 917-935. Author URL.
Cherblanc F, Lo YP, De Gussem E, Alcazar-Fuoli L, Bignell E, He Y, Chapman-Rothe N, Bultinck P, Herrebout WA, Brown R, et al (2011). On the determination of the stereochemistry of semisynthetic natural product analogues using chiroptical spectroscopy: Desulfurization of epidithiodioxopiperazine fungal metabolites. Chemistry - a European Journal, 17(42), 11868-11875. Abstract.
Bertuzzi M, Bignell EM (2011). Sensory perception in fungal pathogens: Applications of the split-ubiquitin Membrane Yeast Two-Hybrid (MYTH) technique. Fungal Biology Reviews, 25(4), 165-171. Abstract.
O'Hanlon KA, Cairns T, Stack D, Schrettl M, Bignell EM, Kavanagh K, Miggin SM, O'Keeffe G, Larsen TO, Doyle S, et al (2011). Targeted Disruption of Nonribosomal Peptide Synthetase pes3 Augments the Virulence of Aspergillus fumigatus. Infect Immun, 79, 3978-3992. Abstract.  Author URL.
Bhatti MF, Jamal A, Petrou MA, Cairns TC, Bignell EM, Coutts RHA (2011). The effects of dsRNA mycoviruses on growth and murine virulence of Aspergillus fumigatus. Fungal Genet Biol, 48, 1071-1075. Author URL.

2010

Jamal A, Bignell EM, Coutts RHA (2010). Complete nucleotide sequences of four dsRNAs associated with a new chrysovirus infecting Aspergillus fumigatus. Virus Research, 153(1), 64-70. Abstract.
Han KH, Chun YH, Pimentel Figueiredo BDC, Marianetti Soriani F, Savoldi M, Almeida A, Rodrigues F, Cairns CT, Bignell E, Tobal JM, et al (2010). Erratum: the conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans (Molecular Microbiology (2010) 75 (1372-1388)). Molecular Microbiology, 76(3).
Chamilos G, Bignell EM, Schrettl M, Lewis RE, Leventakos K, May GS, Haas H, Kontoyiannis DP (2010). Exploring the concordance of aspergillus fumigatus pathogenicity in mice and Toll-deficient flies. Medical Mycology, 48(3), 506-510. Abstract.
Han KH, Chun YH, Figueiredo Bde C, Soriani FM, Savoldi M, Almeida A, Rodrigues F, Cairns CT, Bignell E, Tobal JM, et al (2010). The conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans. Mol Microbiol, 75, 1372-1388. Abstract.  Author URL.
Cairns T, Minuzzi F, Bignell E (2010). The host-infecting fungal transcriptome. FEMS Microbiol Lett
Bignell E (2010). Therapeutic jackpots lie within the reach of multiscale and integrated mycological research.  Abstract.

2009

Bergmann A, Hartmann T, Cairns T, Bignell EM, Krappmann S (2009). A regulator of Aspergillus fumigatus extracellular proteolytic activity is dispensable for virulence. Infect. Immun, 77, 4041-4050. Abstract.  Author URL.
Armstrong-James DPH, Turnbull SA, Teo I, Stark J, Rogers NJ, Rogers TRF, Bignell E, Haynes K (2009). Impaired interferon-gamma responses, increased interleukin-17 expression, and a tumor necrosis factor-alpha transcriptional program in invasive aspergillosis. J Infect Dis, 200(8), 1341-1351. Abstract.  Author URL.

2008

Peñalva MA, Tilburn J, Bignell E, Arst HN (2008). Ambient pH gene regulation in fungi: making connections. Trends in Microbiology, 16(6), 291-300. Abstract.
Sasse C, Bignell EM, Hasenberg M, Haynes K, Gunzer M, Braus GH, Krappmann S (2008). Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis. Fungal Genet Biol, 45(5), 693-704. Abstract.  Author URL.
Soriani FM, Malavazi I, Da Silva Ferreira ME, Savoldi M, Von Zeska Kress MR, De Souza Goldman MH, Loss O, Bignell E, Goldman GH (2008). Functional characterization of the Aspergillus fumigatus CRZ1 homologue, CrzA. Molecular Microbiology, 67(6), 1274-1291. Abstract.
de Gouvêa PF, Soriani FM, Malavazi I, Savoldi M, Goldman MHDS, Loss O, Bignell E, da Silva Ferreira ME, Goldman GH (2008). Functional characterization of the Aspergillus fumigatus PHO80 homologue. Fungal Genetics and Biology, 45(7), 1135-1146. Abstract.
McDonagh A, Fedorova ND, Crabtree J, Yu Y, Kim S, Chen D, Loss O, Cairns T, Goldman G, Armstrong-James D, et al (2008). Sub-telomere directed gene expression during initiation of invasive aspergillosis. PLoS Pathog, 4(9). Abstract.  Author URL.  Full text.

2007

Schrettl M, Bignell E, Kragl C, Sabiha Y, Loss O, Eisendle M, Wallner A, Arst Jr. HN, Haynes K, Haas H, et al (2007). Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. PLoS Pathogens, 3, 1195-1207.
Schrettl M, Bignell E, Kragl C, Sabiha Y, Loss O, Eisendle M, Wallner A, Arst HN, Haynes K, Haas H, et al (2007). Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection. PLoS Pathog, 3(9), 1195-1207. Abstract.  Author URL.

2005

Calcagno A-M, Bignell E, Rogers TR, Jones MD, Mühlschlegel FA, Haynes K (2005). Candida glabrata Ste11 is involved in adaptation to hypertonic stress, maintenance of wild-type levels of filamentation and plays a role in virulence. Med Mycol, 43(4), 355-364. Abstract.  Author URL.
Bignell E, Negrete-Urtasun S, Calcagno AM, Haynes K, Arst HN, Rogers T (2005). The Aspergillus pH-responsive transcription factor PacC regulates virulence. Mol Microbiol, 55(4), 1072-1084. Abstract.  Author URL.
Bignell E, Negrete-Urtasun S, Calcagno AM, Arst HN, Rogers T, Haynes K (2005). Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice. Infect Immun, 73(8), 5204-5207. Abstract.  Author URL.

2004

Calcagno A-M, Bignell E, Rogers TR, Canedo M, Mühlschlegel FA, Haynes K (2004). Candida glabrata Ste20 is involved in maintaining cell wall integrity and adaptation to hypertonic stress, and is required for wild-type levels of virulence. Yeast, 21(7), 557-568. Abstract.  Author URL.
Sarkar S, Caddick MX, Bignell E, Tilburn J, Arst HN (2004). Erratum: Regulation of gene expression by ambient pH in Aspergillus: Genes expressed at acidic pH (Biochemical Society Transactions (1996) 24, Part 2 (360-363)). Biochemical Society Transactions, 32(6).
Kamran M, Calcagno A-M, Findon H, Bignell E, Jones MD, Warn P, Hopkins P, Denning DW, Butler G, Rogers T, et al (2004). Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence. Eukaryot Cell, 3(2), 546-552. Abstract.  Author URL.
Schrettl M, Bignell E, Kragl C, Joechl C, Rogers T, Arst HN, Haynes K, Haas H (2004). Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence. J Exp Med, 200(9), 1213-1219. Abstract.  Author URL.
Krappmann S, Bignell EM, Reichard U, Rogers T, Haynes K, Braus GH (2004). The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen. Mol Microbiol, 52(3), 785-799. Abstract.  Author URL.
Krappmann S, Reichard U, Bignell EM, Haynes K, Braus GH (2004). The Cross-Pathway Control system contributes to pathogenicity of Aspergillus fumigatus.  Author URL.

2003

Calcagno A-M, Bignell E, Warn P, Jones MD, Denning DW, Mühlschlegel FA, Rogers TR, Haynes K (2003). Candida glabrata STE12 is required for wild-type levels of virulence and nitrogen starvation induced filamentation. Mol Microbiol, 50(4), 1309-1318. Abstract.  Author URL.

2000

Espeso EA, Roncal T, Diez E, Rainbow L, Bignell E, Suarez JAT, Denison SH, Tilburn J, Arst J, Penalva MA, et al (2000). Corrigendum: on how a transcription factor can avoid its proteolytic activation in the absence of signal transduction (The EMBO Journal (2000) 19, 719-728)). EMBO Journal, 19(10).
Espeso EA, Roncal T, Díez E, Rainbow L, Bignell E, Álvaro J, Suárez T, Denison SH, Tilburn J, Arst HN, et al (2000). On how a transcription factor can avoid its proteolytic activation in the absence of signal transduction. EMBO Journal, 19(4), 719-728. Abstract.

1999

Mingot JM, Tilburn J, Diez E, Bignell E, Orejas M, Widdick DA, Sarkar S, Brown CV, Caddick MX, Espeso EA, et al (1999). Specificity determinants of proteolytic processing of Aspergillus PacC transcription factor are remote from the processing site, and processing occurs in yeast if pH signalling is bypassed. Molecular and Cellular Biology, 19(2), 1390-1400. Abstract.

1996

Sartor S, Caddick MX, Bignell E, Tilburn J, Arst HN (1996). Regulation of gene expression by ambient pH in Aspergillus: Genes expressed at acid pH.

1994

Arst HN, Bignell E, Tilburn J (1994). Two new genes involved in signalling ambient pH in Aspergillus nidulans. MGG Molecular & General Genetics, 245(6), 787-790. Abstract.

Elaine_Bignell Details from cache as at 2020-10-20 10:28:43

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External Engagement and Impact

2006 - 2009 Steering Committee of the European Science Foundation (ESF)-funded ‘Fuminomics’ Consortium

2006-2009   Meetings secretary, British Medical Mycology Society

2012            Invited Contributor, MRC Strategic Review of Fungal Diseases Research

2012-2014   Member of the British Mycological Society Scientific Committee

2012–2017  Steering Committee of UK Wellcome Trust Strategic Award Consortium:  Medical Mycology and Fungal Immunology

2013-2015    Member of the British Mycological Society Education and Outreach Committee

2013-2016    Steering Committee of the Federation of European Biochemical Societies (FEBS) Advanced Lecture Course: Human Fungal Pathogens

2013-2016    BBSRC Pool of Experts

2016             Scientific Committee of Advances Against Aspergillosis, Manchester, UK

2016- 2019   Chair of the British Mycological Society Scientific Committee

2021              Chair elect of the 10th FEBS Advanced Lecture Course on Human Fungal Pathogens

Teaching

Supervision / Group

Postdoctoral researchers

  • Bethany McCann Effectors of Tissue Invasion in Aspergillus fumigatus

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