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Dr Elena Roselletti

Dr Elena Roselletti

Postdoctoral Research Associate

 Geoffrey Pope 

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

My key career achievements to date have all centered on research on C. albicans. I have experience working with in vitro cell-based systems, in vivo rodent models as well as primary vaginal tissue samples from patients with vulvovaginal candidiasis.

Qualifications

Pharmacy degree (2008-2013), University of Perugia, Italy

PhD in Biotechnology (2014-2017), University of Perugia, Italy

Career

Postdoctoral Research (2017-2020), University of Perugia, Italy

Research group links

Research

Research interests

During these years, I have enriched my understanding of C. albicans and I was able to identify the similarities and differences between vulvovaginal candidiasis in patients and in mouse models. In particular, I am most interested in trying to clarify the profound but ambiguous role of the hyphal form in patients as well as in asymptomatic infections given that these are not always associated with inflammation. I am extremely interested to understand how the pathogenesis of vulvovaginal candidiasis is influenced by the particular C. albicans strain and how much by the patient herself. At University of Exeter I will study the influence of zinc on C. albicans inflammation.

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Roselletti E, Sabbatini S, Perito S, Mencacci A, Vecchiarelli A, Monari C (2020). Apoptosis of vaginal epithelial cells in clinical samples from women with diagnosed bacterial vaginosis. Scientific Reports, 10(1).
Zampieri R, Brozzetti A, Pericolini E, Bartoloni E, Gabrielli E, Roselletti E, Lomonosoff G, Meshcheriakova Y, Santi L, Imperatori F, et al (2020). Prevention and treatment of autoimmune diseases with plant virus nanoparticles. Science Advances, 6(19), eaaz0295-eaaz0295. Abstract.
Gaziano R, Sabbatini S, Roselletti E, Perito S, Monari C (2020). Saccharomyces cerevisiae-Based Probiotics as Novel Antimicrobial Agents to Prevent and Treat Vaginal Infections. Frontiers in Microbiology, 11
Roselletti E, Monari C, Sabbatini S, Perito S, Vecchiarelli A, Sobel JD, Cassone A (2019). A Role for Yeast/Pseudohyphal Cells of Candida albicans in the Correlated Expression of NLRP3 Inflammasome Inducers in Women with Acute Vulvovaginal Candidiasis. Frontiers in Microbiology, 10
Ricci E, Ronchetti S, Gabrielli E, Pericolini E, Gentili M, Roselletti E, Vecchiarelli A, Riccardi C (2019). GILZ restrains neutrophil activation by inhibiting the MAPK pathway. Journal of Leukocyte Biology, 105(1), 187-194. Abstract.
Roselletti E, Sabbatini S, Ballet N, Perito S, Pericolini E, Blasi E, Mosci P, Cayzeele Decherf A, Monari C, Vecchiarelli A, et al (2019). Saccharomyces cerevisiae CNCM I-3856 as a new therapeutic agent against oropharyngeal candidiasis. Frontiers in Microbiology, 10(JULY). Abstract.
Roselletti E, Perito S, Sabbatini S, Monari C, Vecchiarelli A (2019). Vaginal Epithelial Cells Discriminate between Yeast and Hyphae of Candida albicans in Women Who Are Colonized or Have Vaginal Candidiasis. Journal of Infectious Diseases, 220(10), 1645-1654. Abstract.
Gabrielli E, Pericolini E, Ballet N, Roselletti E, Sabbatini S, Mosci P, Decherf AC, Pélerin F, Perito S, Jüsten P, et al (2018). Saccharomyces cerevisiae-based probiotic as novel anti-fungal and anti-inflammatory agent for therapy of vaginal candidiasis. Beneficial Microbes, 9(2), 219-230. Abstract.
Gabrielli E, Roselletti E, Pericolini E, Sabbatini S, Vecchiarelli A, Cassone A (2017). Chronic vaginal candidiasis is achievable in outbred CD-1 mice. mBio, 8(5).
Roselletti E, Perito S, Gabrielli E, Mencacci A, Pericolini E, Sabbatini S, Cassone A, Vecchiarelli A (2017). NLRP3 inflammasome is a key player in human vulvovaginal disease caused by Candida albicans. Scientific Reports, 7(1). Abstract.
Ricci E, Ronchetti S, Pericolini E, Gabrielli E, Cari L, Gentili M, Roselletti E, Migliorati G, Vecchiarelli A, Riccardi C, et al (2017). Role of the glucocorticoid-induced leucine zipper gene in dexamethasone-induced inhibition of mouse neutrophil migration via control of annexin A1 expression. FASEB Journal, 31(7), 3054-3065. Abstract.
Pericolini E, Gabrielli E, Ballet N, Sabbatini S, Roselletti E, Cayzeele Decherf A, Pélerin F, Luciano E, Perito S, Jüsten P, et al (2017). Therapeutic activity of a Saccharomyces cerevisiae-based probiotic and inactivated whole yeast on vaginal candidiasis. Virulence, 8(1), 74-90. Abstract.
Gabrielli E, Sabbatini S, Roselletti E, Kasper L, Perito S, Hube B, Cassone A, Vecchiarelli A, Pericolini E (2016). In vivo induction of neutrophil chemotaxis by secretory aspartyl proteinases of Candida albicans. Virulence, 7(7), 819-825. Abstract.
Gabrielli E, Roselletti E, Luciano E, Sabbatini S, Mosci P, Pericolini E (2015). Comparison between bioluminescence imaging technique and CFU count for the study of oropharyngeal candidiasis in mice. Cytometry Part A, 87(5), 428-436. Abstract.
Gabrielli E, Pericolini E, Luciano E, Sabbatini S, Roselletti E, Perito S, Kasper L, Hube B, Vecchiarelli A (2015). Induction of caspase-11 by aspartyl proteinases of Candida albicans and implication in promoting inflammatory response. Infection and Immunity, 83(5), 1940-1948. Abstract.
Pericolini E, Gabrielli E, Amacker M, Kasper L, Roselletti E, Luciano E, Sabbatini S, Kaeser M, Moser C, Hube B, et al (2015). Secretory aspartyl proteinases cause vaginitis and can mediate vaginitis caused by Candida albicans in mice. mBio, 6(3). Abstract.

Publications by year


2020

Roselletti E, Sabbatini S, Perito S, Mencacci A, Vecchiarelli A, Monari C (2020). Apoptosis of vaginal epithelial cells in clinical samples from women with diagnosed bacterial vaginosis. Scientific Reports, 10(1).
Zampieri R, Brozzetti A, Pericolini E, Bartoloni E, Gabrielli E, Roselletti E, Lomonosoff G, Meshcheriakova Y, Santi L, Imperatori F, et al (2020). Prevention and treatment of autoimmune diseases with plant virus nanoparticles. Science Advances, 6(19), eaaz0295-eaaz0295. Abstract.
Gaziano R, Sabbatini S, Roselletti E, Perito S, Monari C (2020). Saccharomyces cerevisiae-Based Probiotics as Novel Antimicrobial Agents to Prevent and Treat Vaginal Infections. Frontiers in Microbiology, 11

2019

Roselletti E, Monari C, Sabbatini S, Perito S, Vecchiarelli A, Sobel JD, Cassone A (2019). A Role for Yeast/Pseudohyphal Cells of Candida albicans in the Correlated Expression of NLRP3 Inflammasome Inducers in Women with Acute Vulvovaginal Candidiasis. Frontiers in Microbiology, 10
Ricci E, Ronchetti S, Gabrielli E, Pericolini E, Gentili M, Roselletti E, Vecchiarelli A, Riccardi C (2019). GILZ restrains neutrophil activation by inhibiting the MAPK pathway. Journal of Leukocyte Biology, 105(1), 187-194. Abstract.
Roselletti E, Sabbatini S, Ballet N, Perito S, Pericolini E, Blasi E, Mosci P, Cayzeele Decherf A, Monari C, Vecchiarelli A, et al (2019). Saccharomyces cerevisiae CNCM I-3856 as a new therapeutic agent against oropharyngeal candidiasis. Frontiers in Microbiology, 10(JULY). Abstract.
Roselletti E, Perito S, Sabbatini S, Monari C, Vecchiarelli A (2019). Vaginal Epithelial Cells Discriminate between Yeast and Hyphae of Candida albicans in Women Who Are Colonized or Have Vaginal Candidiasis. Journal of Infectious Diseases, 220(10), 1645-1654. Abstract.

2018

Gabrielli E, Pericolini E, Ballet N, Roselletti E, Sabbatini S, Mosci P, Decherf AC, Pélerin F, Perito S, Jüsten P, et al (2018). Saccharomyces cerevisiae-based probiotic as novel anti-fungal and anti-inflammatory agent for therapy of vaginal candidiasis. Beneficial Microbes, 9(2), 219-230. Abstract.

2017

Gabrielli E, Roselletti E, Pericolini E, Sabbatini S, Vecchiarelli A, Cassone A (2017). Chronic vaginal candidiasis is achievable in outbred CD-1 mice. mBio, 8(5).
Roselletti E, Perito S, Gabrielli E, Mencacci A, Pericolini E, Sabbatini S, Cassone A, Vecchiarelli A (2017). NLRP3 inflammasome is a key player in human vulvovaginal disease caused by Candida albicans. Scientific Reports, 7(1). Abstract.
Ricci E, Ronchetti S, Pericolini E, Gabrielli E, Cari L, Gentili M, Roselletti E, Migliorati G, Vecchiarelli A, Riccardi C, et al (2017). Role of the glucocorticoid-induced leucine zipper gene in dexamethasone-induced inhibition of mouse neutrophil migration via control of annexin A1 expression. FASEB Journal, 31(7), 3054-3065. Abstract.
Pericolini E, Gabrielli E, Ballet N, Sabbatini S, Roselletti E, Cayzeele Decherf A, Pélerin F, Luciano E, Perito S, Jüsten P, et al (2017). Therapeutic activity of a Saccharomyces cerevisiae-based probiotic and inactivated whole yeast on vaginal candidiasis. Virulence, 8(1), 74-90. Abstract.

2016

Gabrielli E, Sabbatini S, Roselletti E, Kasper L, Perito S, Hube B, Cassone A, Vecchiarelli A, Pericolini E (2016). In vivo induction of neutrophil chemotaxis by secretory aspartyl proteinases of Candida albicans. Virulence, 7(7), 819-825. Abstract.

2015

Gabrielli E, Roselletti E, Luciano E, Sabbatini S, Mosci P, Pericolini E (2015). Comparison between bioluminescence imaging technique and CFU count for the study of oropharyngeal candidiasis in mice. Cytometry Part A, 87(5), 428-436. Abstract.
Gabrielli E, Pericolini E, Luciano E, Sabbatini S, Roselletti E, Perito S, Kasper L, Hube B, Vecchiarelli A (2015). Induction of caspase-11 by aspartyl proteinases of Candida albicans and implication in promoting inflammatory response. Infection and Immunity, 83(5), 1940-1948. Abstract.
Pericolini E, Gabrielli E, Amacker M, Kasper L, Roselletti E, Luciano E, Sabbatini S, Kaeser M, Moser C, Hube B, et al (2015). Secretory aspartyl proteinases cause vaginitis and can mediate vaginitis caused by Candida albicans in mice. mBio, 6(3). Abstract.

Elena_Roselletti Details from cache as at 2020-06-04 17:01:58

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