Fabian Salazar | Biosciences | University of Exeter

Dr Fabian Salazar

Postdoctoral Research Fellow

F.A.Salazar-Lizama@exeter.ac.uk

Geoffrey Pope 328

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

Qualifications

PhD in Immunology, University of Nottingham, UK, 2016

MSc in Biochemistry, major in Proteins and Biotechnology, University of Chile, 2010

Biochemistry (Professional Degree), University of Chile, 2010

BSc in Biochemistry, University of Chile, 2008

Career

Postdoctoral Research Fellow, University of Aberdeen, 2016-2019

Research

Research interests

The immune system utilizes sensors on immune cells named pattern recognition receptors to recognize invading pathogens and foreign substances. These receptors trigger a plethora of immune responses that confer protection against infection and could also contribute to unwanted exacerbated immune responses.

In the Brown Group, we are interested in a superfamily of receptors called C-type lectin receptors (CLRs). The prototypic member of this family, Dectin-1, identified by Prof. Gordon Brown, plays a central role in mounting a protective innate immune response against fungal infections. However, we know very little of how these receptors, in particular Dectin-1, influences adaptive immune responses to fungi.

We have recently identified a novel family of CLRs and my research is aimed at better understanding the roles and functions of these receptors and how they influence innate and adaptive immunity during fungal infection.

Research projects

Role of CLRs in innate and adaptive immunity to fungi

Role of CLRs in DC phenotype and function

Publications

Journal articles

Salazar F, Brown GD (In Press). A friendly danger. Science, 362, 292-293.

Jiménez JM, Salazar M, Arancibia S, Villar J, Salazar F, Brown GD, Lavelle EC, Martínez-Pomares L, Ortiz-Quintero J, Lavandero S, et al (In Press). TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells from Mammals. Frontiers in Immunology, 10 Abstract.

Hatinguais R, Kay M, Salazar F, Conn DP, Williams DL, Cook PC, Willment JA, Brown GD (2023). Development of Negative Controls for Fc-C-Type Lectin Receptor Probes. Microbiol Spectr, 11(3). Abstract. Author URL.

Dambuza IM, Warris A, Salazar F (2023). Unmasking a fungal fire. PLOS Pathogens, 19(5), e1011355-e1011355. Abstract.

Salazar F, Bignell E, Brown GD, Cook PC, Warris A (2022). Pathogenesis of Respiratory Viral and Fungal Coinfections. Clin Microbiol Rev, 35(1). Abstract. Author URL.

Villar J, Salazar ML, Jiménez JM, Campo MD, Manubens A, Gleisner MA, Ávalos I, Salazar-Onfray F, Salazar F, Mitchell DA, et al (2021). C-type lectin receptors MR and DC-SIGN are involved in recognition of hemocyanins, shaping their immunostimulatory effects on human dendritic cells. Eur J Immunol, 51(7), 1715-1731. Abstract. Author URL.

Speakman EA, Dambuza IM, Salazar F, Brown GD (2020). T Cell Antifungal Immunity and the Role of C-Type Lectin Receptors. Trends Immunol, 41(1), 61-76. Abstract. Author URL.

Awuah D, Alobaid M, Latif A, Salazar F, Emes RD, Ghaemmaghami AM (2019). The Cross-Talk between miR-511-3p and C-Type Lectin Receptors on Dendritic Cells Affects Dendritic Cell Function. The Journal of Immunology, 203(1), 148-157. Abstract.

Salazar F, Brown GD (2018). Antifungal innate immunity: a perspective from last 10 years. Journal of Innate Immunity, 10, 373-397. Abstract.

Riabov V, Salazar F, Htwe SS, Gudima A, Schmuttermaier C, Barthes J, Knopf-Marques H, Klüter H, Ghaemmaghami AM, Vrana NE, et al (2017). Generation of anti-inflammatory macrophages for implants and regenerative medicine using self-standing release systems with a phenotype-fixing cytokine cocktail formulation. Acta Biomaterialia, 53, 389-398.

Salazar F, Awuah D, Negm OH, Shakib F, Ghaemmaghami AM (2017). The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs. Scientific Reports, 7(1). Abstract.

Aldajani WA, Salazar F, Sewell HF, Knox A, Ghaemmaghami AM (2016). Expression and regulation of immune-modulatory enzyme indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation. Oncotarget, 7(36), 57606-57617.

Rostam HM, Singh S, Salazar F, Magennis P, Hook A, Singh T, Vrana NE, Alexander MR, Ghaemmaghami AM (2016). The impact of surface chemistry modification on macrophage polarisation. Immunobiology, 221(11), 1237-1246.

Salazar F, Hall L, Negm OH, Awuah D, Tighe PJ, Shakib F, Ghaemmaghami AM (2016). The mannose receptor negatively modulates the Toll-like receptor 4–aryl hydrocarbon receptor–indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization. Journal of Allergy and Clinical Immunology, 137(6), 1841-1851.e2.

Ebensperger LA, León C, Ramírez-Estrada J, Abades S, Hayes LD, Nova E, Salazar F, Bhattacharjee J, Becker MI (2015). Immunocompetence of breeding females is sensitive to cortisol levels but not to communal rearing in the degu (Octodon degus). Physiology & Behavior, 140, 61-70.

Arancibia S, Espinoza C, Salazar F, Del Campo M, Tampe R, Zhong T-Y, De Ioannes P, Moltedo B, Ferreira J, Lavelle EC, et al (2014). A Novel Immunomodulatory Hemocyanin from the Limpet Fissurella latimarginata Promotes Potent Anti-Tumor Activity in Melanoma. PLoS ONE, 9(1), e87240-e87240.

Harrington H, Cato P, Salazar F, Wilkinson M, Knox A, Haycock JW, Rose F, Aylott JW, Ghaemmaghami AM (2014). Immunocompetent 3D Model of Human Upper Airway for Disease Modeling and in Vitro Drug Evaluation. Molecular Pharmaceutics, 11(7), 2082-2091.

Salazar F, Ghaemmaghami AM (2013). Allergen Recognition by Innate Immune Cells: Critical Role of Dendritic and Epithelial Cells. Frontiers in Immunology, 4

Salazar F, Sewell HF, Shakib F, Ghaemmaghami AM (2013). The role of lectins in allergic sensitization and allergic disease. Journal of Allergy and Clinical Immunology, 132(1), 27-36.

Arancibia S, Campo MD, Nova E, Salazar F, Becker MI (2012). Enhanced structural stability of <i>Concholepas</i> hemocyanin increases its immunogenicity and maintains its non‐specific immunostimulatory effects. European Journal of Immunology, 42(3), 688-699. Abstract.

Del Campo M, Arancibia S, Nova E, Salazar F, González A, Moltedo B, De Ioannes P, Ferreira J, Manubens A, Becker MI, et al (2011). [Hemocyanins as immunostimulants]. Rev Med Chil, 139(2), 236-246. Abstract. Author URL.

Manubens A, Salazar F, Haussmann D, Figueroa J, Del Campo M, Pinto JM, Huaquín L, Venegas A, Becker MI (2010). Concholepas hemocyanin biosynthesis takes place in the hepatopancreas, with hemocytes being involved in its metabolism. Cell and Tissue Research, 342(3), 423-435.

Chapters

Arancibia S, Salazar F, Ins M (2012). Hemocyanins in the Immunotherapy of Superficial Bladder Cancer. In (Ed) Bladder Cancer - from Basic Science to Robotic Surgery, InTech.

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