Overview
I am currently a postdoctoral research associate at the University of Exeter in Dr Hans-Wilhelm Nuetzmann’s lab studying genome organization, epigenetic gene regulation, and chromosome topology in plants. Previously I worked as a postdoctoral research assistant at the University of Bath where I optimized a Hi-C protocol in Wheat. Prior to that, I completed a PhD in Molecular Biology at Durham University where I studied plant root development under drought stress using lab-based and computational methods.
Find our lab website here.
Qualifications
PhD in Molecular Biology at Durham University (2017-2022)
MBiolSci in Biology at the University of Sheffield (2012-2016)
Career
2022-2023 – Postdoctoral Researcher at the University of Bath
2017-2022 - PhD in Molecular Biology at Durham University
Research group links
Publications
Key publications | Publications by category | Publications by year
Publications by category
Journal articles
Jacobsen AGR, Jervis G, Xu J, Topping JF, Lindsey K (2021). Root growth responses to mechanical impedance are regulated by a network of ROS, ethylene and auxin signalling in Arabidopsis.
New Phytol,
231(1), 225-242.
Abstract:
Root growth responses to mechanical impedance are regulated by a network of ROS, ethylene and auxin signalling in Arabidopsis.
The growth and development of root systems is influenced by mechanical properties of the substrate in which the plants grow. Mechanical impedance, such as by compacted soil, can reduce root elongation and limit crop productivity. To understand better the mechanisms involved in plant root responses to mechanical impedance stress, we investigated changes in the root transcriptome and hormone signalling responses of Arabidopsis to artificial root barrier systems in vitro. We demonstrate that upon encountering a barrier, reduced Arabidopsis root growth and a characteristic 'step-like' growth pattern is due to a reduction in cell elongation associated with changes in signalling gene expression. Data from RNA-sequencing combined with reporter line and mutant studies identified essential roles for reactive oxygen species, ethylene and auxin signalling during the barrier response. We propose a model in which early responses to mechanical impedance include reactive oxygen signalling integrated with ethylene and auxin responses to mediate root growth changes. Inhibition of ethylene responses allows improved growth in response to root impedance, an observation that may inform future crop breeding programmes.
Abstract.
Author URL.
Publications by year
2021
Jacobsen AGR, Jervis G, Xu J, Topping JF, Lindsey K (2021). Root growth responses to mechanical impedance are regulated by a network of ROS, ethylene and auxin signalling in Arabidopsis.
New Phytol,
231(1), 225-242.
Abstract:
Root growth responses to mechanical impedance are regulated by a network of ROS, ethylene and auxin signalling in Arabidopsis.
The growth and development of root systems is influenced by mechanical properties of the substrate in which the plants grow. Mechanical impedance, such as by compacted soil, can reduce root elongation and limit crop productivity. To understand better the mechanisms involved in plant root responses to mechanical impedance stress, we investigated changes in the root transcriptome and hormone signalling responses of Arabidopsis to artificial root barrier systems in vitro. We demonstrate that upon encountering a barrier, reduced Arabidopsis root growth and a characteristic 'step-like' growth pattern is due to a reduction in cell elongation associated with changes in signalling gene expression. Data from RNA-sequencing combined with reporter line and mutant studies identified essential roles for reactive oxygen species, ethylene and auxin signalling during the barrier response. We propose a model in which early responses to mechanical impedance include reactive oxygen signalling integrated with ethylene and auxin responses to mediate root growth changes. Inhibition of ethylene responses allows improved growth in response to root impedance, an observation that may inform future crop breeding programmes.
Abstract.
Author URL.
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