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Professor Gordon Brown

Professor (E & R) (Centre Director MRC CMM)

 Geoffrey Pope 315

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

Qualifications

1996                PhD Microbiology, University of Cape Town

Career

1996                PhD Microbiology, University of Cape Town

1996-1998      Post-Doctoral Research Fellow, University of Stellenbosch

1999-2003      Wellcome Trust Travelling Fellow, University of Oxford.

2004-2009      Wellcome Trust International Senior Research Fellow, University of Cape

2009-               6th Century Chair in Immunology, University of Aberdeen

2009-               Honorary Professor, University of Cape Town

2010-               Fellow of the Society of Biology

2011-               Fellow of the American Academy of Microbiology

2012-               Fellow of the Royal Society of South Africa

2013-               Fellow of the Royal Society of Edinburgh

2016-               Fellow of the Academy of Medical Sciences

Research

Research interests

To recognise infection, the immune system utilizes sensors on immune cells called “pattern recognition receptors” which detect invading pathogens. These sensors then trigger a number of responses which are aimed at providing protection against the infection.

Our group is focussed on understanding a particular group of these pathogen sensors, called the C-type lectins (CLRs), which stemmed from our discovery of the first receptor in this class, Dectin-1.

We have shown that CLRs are able to induce essential immune responses, and have determined the mechanisms that they utilize to trigger these effects. Importantly, we have shown that CLRs play a central role in protective immune responses during fungal infections and identified genetic variants of Dectin-1 in humans, which can confer susceptibility to disease.

We have also determined that defects in recognition by pathogen sensors can result in an untreatable fungal infection of the skin, called chromoblastomycosis; work which has led directly to the testing of a novel treatment in humans.

Our current research is aimed at gaining a more detailed understanding the role of CLRs in immunity during fungal infection, and exploring the roles and functions of new CLRs that we have recently identified.

Research networks

Research Group:

Dr Janet Willment                  Senior Scientist
Dr Petruta Morvay                 Staff Scientist
Dr Ivy Dumbuza                     Postdoctoral Fellow
Dr Fabian Salazar                  Postdoctoral Fellow
Remi Hatinguais                     PhD Student
Christina Nikolakopoulou        MRC PhD Student
Emily Speakman                     MRC PhD Student
 

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Salazar F, Brown GD (In Press). A friendly danger. Science, 362, 292-293.
Armstrong-James D, Bicanic T, Brown GD, Hoving JC, Meintjes G, Nielsen K, Workshop WGFTEMBO-AIDSRM (In Press). AIDS-Related Mycoses: Current Progress in the Field and Future Priorities. Trends in Microbiology, 25, 428-430. Abstract.
Hadebe S, Brombacher F, Brown GD (In Press). C-Type Lectin Receptors in Asthma. Frontiers in Immunology, 9, 1-11. Abstract.
Drummond RA, Swamydas M, Oikonomou V, Zhai B, Dambuza I, Schaefer BC, Bohrer AC, Mayer-Barber KD, Lira SA, Iwakura Y, et al (In Press). CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment. Nature Immunology, 20, 559-570. Abstract.
Drummond RA, Dambuza IM, Vautier S, Taylor JA, Reid DM, Bain CC, Underhill DM, Masopust D, Kaplan DH, Brown GD, et al (In Press). CD4+ T-cell survival in the GI tract requires dectin-1 during fungal infection. Mucosal Immunology, 9, 492-502. Abstract.
Huang J-H, Lin C-Y, Wu S-Y, Chen W-Y, Chu C-L, Brown GD, Chuu C-P, Wu-Hsieh BA (In Press). CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway. PLoS Pathogens, 11 Abstract.
Lim J, Coates CJ, Denicola PS, Garelnabi M, Smith LM, Monteith P, Macleod CL, Escaron C, Brown GD, Hall RA, et al (In Press). Characterizing the Mechanisms of Nonopsonic Uptake of Cryptococci by Macrophages. The Journal of Immunology, 200, 3539-3546. Abstract.
Wagener J, Malireddi RKS, Lenardon MD, Koeberle M, Vautier S, MacCallum DM, Biedermann T, Schaller M, Netea MG, Kanneganti T-D, et al (In Press). Chitin recognition in fungal infections and its impact on the immune response. Mycoses, 56, 7-7.
Castoldi A, Andrade-Oliveira V, Aguiar CF, Amano MT, Lee J, Miyagi MT, Latância MT, Braga TT, da Silva MB, Ignácio A, et al (In Press). Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88. Cell Reports, 19, 2272-2288. Abstract.
Rochereau N, Drocourt D, Perouzel E, Pavot V, Redelinghuys P, Brown GD, Tiraby G, Roblin X, Verrier B, Genin C, et al (In Press). Dectin-1 is Essential for Reverse Transcytosis of Glycosylated SIgA-Antigen Complexes by Intestinal M Cells. PLoS Biology, 11, 1-18. Abstract.
Zimara N, Chanyalew M, Aseffa A, van Zandbergen G, Lepenies B, Schmid M, Weiss R, Rascle A, Wege AK, Brown GD, et al (In Press). Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development. Frontiers in Immunology, 9 Abstract.
Elcombe SE, Naqvi S, Van Den Bosch MWM, Mackenzie KF, Cianfanelli F, Brown GD, Arthur JSC (In Press). Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers. PloS ONE, 8 Abstract.
Whibley N, Jaycox JR, Reid D, Garg AV, Taylor JA, Clancy CJ, Nguyen MH, Biswas PS, McGeachy MJ, Brown GD, et al (In Press). Delinking CARD9 and IL-17: Protects against Candida tropicalis Infection through a TNF-α–Dependent, IL-17–Independent Mechanism. The Journal of Immunology, 195, 3781-3792. Abstract.
Berekméri A, Latzko A, Alase A, Macleod T, Ainscough JS, Laws P, Goodfield M, Wright A, Helliwell P, Edward S, et al (In Press). Detection of IL-36γ through noninvasive tape stripping reliably discriminates psoriasis from atopic eczema. Journal of Allergy and Clinical Immunology, 142, 988-991. Abstract.
McDonald JU, Rosas M, Brown GD, Jones SA, Taylor PR (In Press). Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation. PloS ONE, 7 Abstract.
uthrich MW, Wang H, Li M, Lerksuthirat T, Hardison SE, Brown GD, Klein B (In Press). Fonsecaea pedrosoi-induced Th17-cell differentiation in mice is fostered by Dectin-2 and suppressed by Mincle recognition. European Journal of Immunology, 45, 2542-2552. Abstract.
Dambuza IM, Levitz SM, Netea MG, Brown GD (In Press). Fungal Recognition and Host Defense Mechanisms. Microbiology spectrum, 5, 1-16. Abstract.
Brown BR, Lee EJ, Snow PE, Vance EE, Iwakura Y, Ohno N, Miura N, Lin X, Brown GD, Wells CA, et al (In Press). Fungal-derived cues promote ocular autoimmunity through a Dectin-2/Card9-mediated mechanism. Clinical and Experimental Immunology, 190, 293-303. Abstract.
Brown GD, May RC (In Press). Host-Microbe Interactions: Fungi. Current Opinion in Microbiology, 40, v-vii.
Pradhan A, Avelar GM, Bain JM, Childers DS, Larcombe DE, Netea MG, Shekhova E, Munro CA, Brown GD, Erwig LP, et al (In Press). Hypoxia Promotes Immune Evasion by Triggering β-Glucan Masking on the Candida albicans Cell Surface via Mitochondrial and cAMP-Protein Kinase a Signaling. MBio, 9(6). Abstract.  Author URL.
Gow NAR, Netea MG, Munro CA, Ferwerda G, Bates S, Mora-Montes HM, Walker L, Jansen T, Jacobs L, Tsoni V, et al (In Press). Immune Recognition of Candida albicans ß-glucan by Dectin-1. The journal of infectious diseases, 196, 1565-1571. Abstract.
Hebecker B, Reid DM, Brown GD (In Press). Immunity to Trichophyton rubrum in a mouse skin infection model involves the recruitment of neutrophils. Mycoses, 61, 16-17.
Armstrong-James D, Brown GD, Netea MG, Zelante T, Gresnigt MS, van de Veerdonk FL, Levitz SM (In Press). Immunotherapeutic approaches to treatment of fungal diseases. Lancet Infectious Diseases, 17, 393-402. Abstract.
Drummond RA, Gaffen SL, Hise AG, Brown GD (In Press). Innate defense against fungal pathogens. Cold Spring Harbor perspectives in medicine, 5 Abstract.
Begun J, Lassen KG, Jijon HB, Baxt LA, Goel G, Heath RJ, Ng A, Tam JM, Kuo S-Y, Villablanca EJ, et al (In Press). Integrated Genomics of Crohn’s Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy. Cell Reports, 11, 1905-1918. Abstract.
Yang A-M, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, et al (In Press). Intestinal fungi contribute to development of alcoholic liver disease. The Journal of Clinical Investigation, 127, 2829-2841. Abstract.
Brown GD, Crocker PR (In Press). Lectin Receptors Expressed on Myeloid Cells. Microbiology spectrum, 4 Abstract.
Ozment-Skelton TR, deFluiter EA, Ha T, Li C, Graves BM, Ferguson DA, Schweitzer JB, Preizsner J, Brown GD, Gordon S, et al (In Press). Leukocyte Dectin-1 expression is differentially regulated in fungal versus polymicrobial sepsis. Critical Care Medicine, 37, 1038-1045. Abstract.
Hadebe S, Kirstein F, Fierens K, Chen K, Drummond RA, Vautier S, Sajaniemi S, Murray G, Williams DL, Redelinghuys P, et al (In Press). Microbial ligand costimulation drives neutrophilic steroid-refractory asthma. PloS ONE, 10 Abstract.
Martínez-López M, Iborra S, Conde-Garrosa R, Mastrangelo A, Danne C, Mann ER, Reid DM, Gaboriau-Routhiau V, Chaparro M, Lorenzo MP, et al (In Press). Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity. Immunity, 50, 446-461. Abstract.
Stoppelkamp S, Reid DM, Yeoh J, Taylor J, McKenzie EJ, Brown GD, Gordon S, Forrester JV, Wong SYC (In Press). Murine pattern recognition receptor dectin-1 is essential in the development of experimental autoimmune uveoretinitis. Molecular Immunology, 67, 398-406. Abstract.
Alsina-Beauchamp D, Escós A, Fajardo P, González-Romero D, Díaz-Mora E, Risco A, Martín-Serrano MA, Fresno CD, Dominguez-Andrés J, Aparicio N, et al (In Press). Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity. EMBO Molecular Medicine, 10 Abstract.
Branzk N, Lubojemska A, Hardison SE, Wang Q, Gutierrez MG, Brown GD, Papayannopoulos V (In Press). Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens. Nature Immunology, 15, 1017-1025. Abstract.
Plato A, Hardison SE, Brown GD (In Press). Pattern recognition receptors in antifungal immunity. Seminars in Immunopathology, 37, 97-106. Abstract.
Kerrigan AM, Brown GD (In Press). Phagocytes: fussy about carbs. Current Biology, 21, R500-R502. Abstract.
Dambuza IM, Brown GD (In Press). Sensing fungi at the oral epithelium. Nature Microbiology, 3, 4-5. Abstract.
Heinsbroek SEM, Taylor PR, Martinez FO, Martinez-Pomares L, Brown GD, Gordon S (In Press). Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis. PLoS Pathogens, 4 Abstract.
Jiménez JM, Salazar M, Arancibia S, Villar J, Salazar F, Brown GD, Lavelle EC, Martínez-Pomares L, Ortiz-Quintero J, Lavandero S, et al (In Press). TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells from Mammals. Frontiers in Immunology, 10 Abstract.
Xiao Y, Tang J, Guo H, Zhao Y, Tang R, Ouyang S, Zeng Q, Rappleye CA, Rajaram MVS, Schlesinger LS, et al (In Press). Targeting CBLB as a potential therapeutic approach for disseminated candidiasis. Nature Medicine, 22, 906-914. Abstract.
Toft-Petersen M, Stidsholt Roug A, Plesner T, Ebbesen L, Brown GD, Nederby L (In Press). The CLEC12A receptor marks human basophils: Potential implications for minimal residual disease detection in acute myeloid leukemia. Cytometry Part B: Clinical Cytometry, 94, 520-526. Abstract.
Dambuza IM, Drake T, Chapuis A, Zhou X, Correia J, Taylor-Smith L, Legrave N, Rasmussen T, Fisher MC, Bicanic T, et al (In Press). The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis. PLoS Pathogens, 14, 1-28. Abstract.
Schwartz IS, Boyles TH, Kenyon CR, Hoving JC, Brown GD, Denning DW (In Press). The estimated burden of fungal disease in South Africa. The South African Medical Journal Abstract.
Thompson A, Davies LC, Laio C-T, da Fonseca DM, Griffiths JS, Andrews R, Jones AV, Clement M, Brown GD, Humphreys IR, et al (In Press). The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens, 15 Abstract.
Brown GD (In Press). Trimming Surface Sugars Protects Histoplasma from Immune Attack. mBio, 7, 1-3. Abstract.
Toft-Petersen M, Nederby L, Kjeldsen E, Kerndrup GB, Brown GD, Hokland P, Stidsholt Roug A (In Press). Unravelling the relevance of CLEC12A as a cancer stem cell marker in myelodysplastic syndrome. British Journal of Haematology, 175, 393-401. Abstract.
Tsoni SV, Brown GD (In Press). beta-Glucans and Dectin-1. Annals of the New York Academy of Sciences, 1143, 45-60. Abstract.
Hadebe S, Kirstein F, Fierens K, Redelinghuys P, Murray GI, Williams DL, Lambrecht BN, Brombacher F, Brown GD (In Press). β-Glucan exacerbates allergic airway responses to house dust mite allergen. Respiratory Research, 17, 1-3. Abstract.
Brown GD, Wilson D (2019). Mammalian innate immunity to fungal infection. Semin Cell Dev Biol, 89, 1-2. Author URL.
Brown AJP, Gow NAR, Warris A, Brown GD (2019). Memory in Fungal Pathogens Promotes Immune Evasion, Colonisation, and Infection. Trends in Microbiology, 27(3), 219-230. Abstract.
Salazar F, Brown GD (2018). Antifungal innate immunity: a perspective from last 10 years. Journal of Innate Immunity, 10, 373-397. Abstract.
Brunel SF, Willment JA, Brown GD, Devereux G, Warris A (2018). Aspergillus-induced superoxide production by cystic fibrosis phagocytes is associated with disease severity. ERS Monograph, 4(2). Abstract.
Brown GD, Willment JA, Whitehead L (2018). C-type lectins in immunity and homeostasis. Nature Reviews Immunology, 18(6), 374-389. Abstract.
Stappers MHT, Clark AE, Aimanianda V, Bidula S, Reid DM, Asamaphan P, Hardison SE, Dambuza IM, Valsecchi I, Kerscher B, et al (2018). Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus. Nature, 555(7696), 382-386. Abstract.
Gow NAR, Amin T, McArdle K, Brown AJP, Brown GD, Warris A, the WTSA-MMFIC (2018). Strategic Research Funding: a Success Story for Medical Mycology. Trends in Microbiology, 26(10), 811-813. Abstract.
Wagener J, Maccallum DM, Brown GD, Gow NAR (2017). Candida albicans chitin increases arginase-1 activity in human macrophages, with an impact on macrophage antimicrobial functions. mBio, 8(1). Abstract.
Ballou ER, Avelar GM, Childers DS, Mackie J, Bain JM, Wagener J, Kastora SL, Panea MD, Hardison SE, Walker LA, et al (2016). Lactate signalling regulates fungal β-glucan masking and immune evasion. Nature Microbiology, 2 Abstract.
Redelinghuys P, Whitehead L, Augello A, Drummond RA, Levesque JM, Vautier S, Reid DM, Kerscher B, Taylor JA, Nigrovic PA, et al (2016). MICL controls inflammation in rheumatoid arthritis. Annals of the Rheumatic Diseases, 75(7), 1386-1391. Abstract.
Kerscher B, Wilson GJ, Reid DM, Mori D, Taylor JA, Besra GS, Yamasaki S, Willment JA, Brown GD (2016). Mycobacterial receptor, Clec4d (CLECSF8, MCL), is coregulated with Mincle and upregulated on mouse myeloid cells following microbial challenge. European Journal of Immunology, 46(2), 381-389. Abstract.
Kerscher B, Dambuza IM, Christofi M, Reid DM, Yamasaki S, Willment JA, Brown GD (2016). Signalling through MyD88 drives surface expression of the mycobacterial receptors MCL (Clecsf8, Clec4d) and Mincle (Clec4e) following microbial stimulation. Microbes and Infection, 18(7-8), 505-509. Abstract.
Dambuza IM, Brown GD (2015). C-type lectins in immunity: recent developments. CURRENT OPINION IN IMMUNOLOGY, 32, 21-27. Author URL.
Kashem SW, Igyarto BZ, Gerami-Nejad M, Kumamoto Y, Mohammed J, Jarrett E, Drummond RA, Zurawski SM, Zurawski G, Berman J, et al (2015). Candida albicans Morphology and Dendritic Cell Subsets Determine T Helper Cell Differentiation. IMMUNITY, 42(2), 356-366. Author URL.
Vautier S, Drummond RA, Chen K, Murray GI, Kadosh D, Brown AJP, Gow NAR, Maccallum DM, Kolls JK, Brown GD, et al (2015). Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity. Cellular Microbiology, 17(4), 445-450. Abstract.
Rieber N, Singh A, Oez H, Carevic M, Bouzani M, Amich J, Ost M, Ye Z, Ballbach M, Schaefer I, et al (2015). Pathogenic Fungi Regulate Immunity by Inducing Neutrophilic Myeloid-Derived Suppressor Cells. CELL HOST & MICROBE, 17(4), 507-514. Author URL.
Wilson GJ, Marakalala MJ, Hoving JC, Van Laarhoven A, Drummond RA, Kerscher B, Keeton R, Van De Vosse E, Ottenhoff THM, Plantinga TS, et al (2015). The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity. Cell Host and Microbe, 17(2), 252-259. Abstract.
Armstrong-James D, Meintjes G, Brown GD (2014). A neglected epidemic: fungal infections in HIV/AIDS. TRENDS IN MICROBIOLOGY, 22(3), 120-127. Author URL.
Brown GD, Meintjes G, Kolls JK, Gray C, Horsnell W, Working Group from the EMBO-AIDS Related Mycoses Workshop, Achan B, Alber G, Aloisi M, Armstrong-James D, et al (2014). AIDS-related mycoses: the way forward. Trends Microbiol, 22(3), 107-109. Abstract.  Author URL.
Bain JM, Louw J, Lewis LE, Okai B, Walls CA, Ballou ER, Walker LA, Reid D, Munro CA, Brown AJP, et al (2014). Candida albicans hypha formation and mannan masking of β-Glucan inhibit macrophage phagosome maturation. mBio, 5(6). Abstract.
Drummond RA, Wallace C, Reid DM, Way SS, Kaplan DH, Brown GD (2014). Cutting Edge: Failure of Antigen-Specific CD4(+) T Cell Recruitment to the Kidney during Systemic Candidiasis. JOURNAL OF IMMUNOLOGY, 193(11), 5381-5385. Author URL.
Loures FV, Araujo EF, Feriotti C, Bazan SB, Costa TA, Brown GD, Calich VLG (2014). Dectin-1 Induces M1 Macrophages and Prominent Expansion of CD8(+)IL-17(+) Cells in Pulmonary Paracoccidioidomycosis. JOURNAL OF INFECTIOUS DISEASES, 210(5), 762-773. Author URL.
Wagener J, Malireddi RKS, Lenardon MD, Köberle M, Vautier S, MacCallum DM, Biedermann T, Schaller M, Netea MG, Kanneganti TD, et al (2014). Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation. PLoS Pathogens, 10(4). Abstract.
Brown AJP, Brown GD, Netea MG, Gow NAR (2014). Metabolism impacts upon candida immunogenicity and pathogenicity at multiple levels. Trends in Microbiology, 22(11), 614-622. Abstract.
Ifrim DC, Bain JM, Reid DM, Oosting M, Verschueren I, Gow NAR, van Krieken JH, Brown GD, Kullberg BJ, Joosten LAB, et al (2014). Role of dectin-2 for host defense against systemic infection with Candida glabrata. Infection and Immunity, 82(3), 1064-1073. Abstract.
Hoving JC, Wilson GJ, Brown GD (2014). Signalling C-Type lectin receptors, microbial recognition and immunity. CELLULAR MICROBIOLOGY, 16(2), 185-194. Author URL.
Teixeira de Sousa MDG, Jr BW, Spina R, Lota PR, Valente NS, Brown GD, Criado PR, Benard G (2014). Topical Application of Imiquimod as a Treatment for Chromoblastomycosis. CLINICAL INFECTIOUS DISEASES, 58(12), 1734-1737. Author URL.
Roug AS, Larsen HO, Nederby L, Just T, Brown G, Nyvold CG, Ommen HB, Hokland P (2014). hMICL and CD123 in combination with a CD45/CD34/CD117 backbone - a universal marker combination for the detection of minimal residual disease in acute myeloid leukaemia. BRITISH JOURNAL OF HAEMATOLOGY, 164(2), 212-222. Author URL.
Watson CJ, Fairley CK, Grando D, Garland SM, Myers SP, Pirotta M (2013). Associations with asymptomatic colonization with candida in women reporting past vaginal candidiasis: an observational study. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 169(2), 376-379. Author URL.
Plato A, Willment JA, Brown GD (2013). C-Type lectin-like receptors of the dectin-1 cluster: Ligands and signaling pathways. International Reviews of Immunology, 32(2), 134-156. Abstract.
Suram S, Silveira LJ, Mahaffey S, Brown GD, Bonventre JV, Williams DL, Gow NAR, Bratton DL, Murphy RC, Leslie CC, et al (2013). Cytosolic Phospholipase A<inf>2</inf>α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation. PLoS ONE, 8(7). Abstract.
Marakalala MJ, Williams DL, Hoving JC, Engstad R, Netea MG, Brown GD (2013). Dectin-1 plays a redundant role in the immunomodulatory activities of beta-glucan-rich ligands in vivo. MICROBES AND INFECTION, 15(6-7), 511-515. Author URL.
Marakalala MJ, Vautier S, Potrykus J, Walker LA, Shepardson KM, Hopke A, Mora-Montes HM, Kerrigan A, Netea MG, Murray GI, et al (2013). Differential Adaptation of Candida albicans in Vivo Modulates Immune Recognition by Dectin-1. PLoS Pathogens, 9(4). Abstract.
Lim E-K, Mitchell PJ, Brown N, Drummond RA, Brown GD, Kaye PM, Bowles DJ (2013). Regiospecific Methylation of a Dietary Flavonoid Scaffold Selectively Enhances IL-1 beta Production following Toll-like Receptor 2 Stimulation in THP-1 Monocytes. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(29), 21126-21135. Author URL.
Drummond RA, Brown GD (2013). Signalling C-Type Lectins in Antimicrobial Immunity. PLOS PATHOGENS, 9(7). Author URL.
Kerscher B, Willment JA, Brown GD (2013). The Dectin-2 family of C-type lectin-like receptors: an update. International Immunology, 25(5), 271-277. Abstract.
Karsten CM, Pandey MK, Figge J, Kilchenstein R, Taylor PR, Rosas M, McDonald JU, Orr SJ, Berger M, Petzold D, et al (2012). Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of Fc gamma RIIB and dectin-1. NATURE MEDICINE, 18(9), 1401-+. Author URL.
Vautier S, MacCallum DM, Brown GD (2012). C-type lectin receptors and cytokines in fungal immunity. CYTOKINE, 58(1), 89-99. Author URL.
Hardison SE, Brown GD (2012). C-type lectin receptors orchestrate antifungal immunity. NATURE IMMUNOLOGY, 13(9), 817-822. Author URL.
Faro-Trindade I, Willment JA, Kerrigan AM, Redelinghuys P, Hadebe S, Reid DM, Srinivasan N, Wainwright H, Lang DM, Steele C, et al (2012). Characterisation of innate fungal recognition in the lung. PLoS ONE, 7(4). Abstract.
Vautier S, Drummond RA, Redelinghuys P, Murray GI, MacCallum DM, Brown GD (2012). Dectin-1 is Not Required for Controlling Candida albicans Colonization of the Gastrointestinal Tract. INFECTION AND IMMUNITY, 80(12), 4216-4222. Author URL.
Gessner MA, Werner JL, Lilly LM, Nelson MP, Metz AE, Dunaway CW, Chan YR, Ouyang W, Brown GD, Weaver CT, et al (2012). Dectin-1-Dependent Interleukin-22 Contributes to Early Innate Lung Defense against Aspergillus fumigatus. INFECTION AND IMMUNITY, 80(1), 410-417. Author URL.
Brown GD, Netea MG (2012). Exciting Developments in the Immunology of Fungal Infections. CELL HOST & MICROBE, 11(5), 422-424. Author URL.
Larsen HO, Roug AS, Just T, Brown GD, Hokland P (2012). Expression of the hMICL in acute myeloid leukemia-a highly reliable disease marker at diagnosis and during follow-up. CYTOMETRY PART B-CLINICAL CYTOMETRY, 82B(1), 3-8. Author URL.
Netea MG, Brown GD (2012). Fungal infections: the next challenge. CURRENT OPINION IN MICROBIOLOGY, 15(4), 403-405. Author URL.
Brown GD, Denning DW, Gow NAR, Levitz SM, Netea MG, White TC (2012). Hidden killers: Human fungal infections. Science Translational Medicine, 4(165). Abstract.
Brown GD (2012). IMMUNOLOGY Actin' dangerously. NATURE, 485(7400), 589-590. Author URL.
Wu KC, McDonald PR, Liu JJ, Chaguturu R, Klaassen CD (2012). Implementation of a High-Throughput Screen for Identifying Small Molecules to Activate the Keap1-Nrf2-ARE Pathway. PLOS ONE, 7(10). Author URL.
Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, Strom SP, Brown J, Becker CA, Fleshner PR, Dubinsky M, et al (2012). Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis. SCIENCE, 336(6086), 1314-1317. Author URL.
Kerrigan AM, Navarro-Nuñez L, Pyz E, Finney BA, Willment JA, Watson SP, Brown GD (2012). Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2. Journal of Thrombosis and Haemostasis, 10(3), 484-486.
Kerrigan AM, de Sousa MDGT, Brown GD (2012). Simple assays for measuring innate interactions with fungi. Methods in Molecular Biology, 845, 303-317. Abstract.
Strasser D, Neumann K, Bergmann H, Marakalala MJ, Guler R, Rojowska A, Hopfner K-P, Brombacher F, Urlaub H, Baier G, et al (2012). Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-delta to Elicit Card9 Adaptor-Mediated Innate Immunity. IMMUNITY, 36(1), 32-42. Author URL.
Brown GD, Denning DW, Levitz SM (2012). Tackling Human Fungal Infections. SCIENCE, 336(6082), 647-647. Author URL.
Schreibelt G, Klinkenberg LJJ, Cruz LJ, Tacken PJ, Tel J, Kreutz M, Adema GJ, Brown GD, Figdor CG, de Vries IJM, et al (2012). The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3(+) myeloid dendritic cells. BLOOD, 119(10), 2284-2292. Author URL.
Graham LM, Gupta V, Schafer G, Reid DM, Kimberg M, Dennehy KM, Hornsell WG, Guler R, Campanero-Rhodes MA, Palma AS, et al (2012). The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through syk kinase. Journal of Biological Chemistry, 287(31), 25964-25974. Abstract.
Lilly LM, Gessner MA, Dunaway CW, Metz AE, Schwiebert L, Weaver CT, Brown GD, Steele C (2012). The beta-Glucan Receptor Dectin-1 Promotes Lung Immunopathology during Fungal Allergy via IL-22. JOURNAL OF IMMUNOLOGY, 189(7), 3653-3660. Author URL.
Gow NAR, Brown GD, Brown AJP, Netea MG, McArdle KE (2012). Waging war on fungi - the unknown superbugs. Microbiology Today, 39(4), 208-211.
Marakalala MJ, Kerrigan AM, Brown GD (2011). Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans. MAMMALIAN GENOME, 22(1-2), 55-65. Author URL.
Gazi U, Rosas M, Singh S, Heinsbroek S, Haq I, Johnson S, Brown GD, Williams DL, Taylor PR, Martinez-Pomares L, et al (2011). Fungal Recognition Enhances Mannose Receptor Shedding through Dectin-1 Engagement. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(10), 7822-7829. Author URL.
McDonald JU, Cortini A, Rosas M, Fossati-Jimack L, Ling GS, Lewis KJ, Dewitt S, Liddiard K, Brown GD, Jones SA, et al (2011). In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils. FASEB JOURNAL, 25(6), 1972-1982. Author URL.
Redelinghuys P, Brown GD (2011). Inhibitory C-type lectin receptors in myeloid cells. IMMUNOLOGY LETTERS, 136(1), 1-12. Author URL.
Werner JL, Gessner MA, Lilly LM, Nelson MP, Metz AE, Horn D, Dunaway CW, Deshane J, Chaplin DD, Weaver CT, et al (2011). Neutrophils Produce Interleukin 17A (IL-17A) in a Dectin-1-and IL-23-Dependent Manner during Invasive Fungal Infection. INFECTION AND IMMUNITY, 79(10), 3966-3977. Author URL.
Mora-Montes HM, Netea MG, Ferwerda G, Lenardon MD, Brown GD, Mistry AR, Kullberg BJ, O'Callaghan CA, Sheth CC, Odds FC, et al (2011). Recognition and blocking of innate immunity cells by Candida albicans chitin. Infection and Immunity, 79(5), 1961-1970. Abstract.
da Gloria Sousa M, Reid DM, Schweighoffer E, Tybulewicz V, Ruland J, Langhorne J, Yamasaki S, Taylor PR, Almeida SR, Brown GD, et al (2011). Restoration of Pattern Recognition Receptor Costimulation to Treat Chromoblastomycosis, a Chronic Fungal Infection of the Skin. CELL HOST & MICROBE, 9(5), 436-443. Author URL.
Pyz E, Brown GD (2011). Screening for ligands of C-type lectin-like receptors. Methods in Molecular Biology, 748, 1-19. Abstract.
Kerrigan AM, Brown GD (2011). Syk-coupled C-type lectins in immunity. TRENDS IN IMMUNOLOGY, 32(4), 151-156. Author URL.
Marakalala MJ, Guler R, Matika L, Murray G, Jacobs M, Brombacher F, Rothfuchs AG, Sher A, Brown GD (2011). The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice. MICROBES AND INFECTION, 13(2), 198-201. Author URL.
Drummond RA, Brown GD (2011). The role of Dectin-1 in the host defence against fungal infections. CURRENT OPINION IN MICROBIOLOGY, 14(4), 392-399. Author URL.
Drummond RA, Saijo S, Iwakura Y, Brown GD (2011). The role of Syk/CARD9 coupled C-type lectins in antifungal immunity. EUROPEAN JOURNAL OF IMMUNOLOGY, 41(2), 276-281. Author URL.
Vautier S, Sousa MDG, Brown GD (2010). C-type lectins, fungi and Th17 responses. CYTOKINE & GROWTH FACTOR REVIEWS, 21(6), 405-412. Author URL.
Schoenen H, Bodendorfer B, Hitchens K, Manzanero S, Werninghaus K, Nimmerjahn F, Agger EM, Stenger S, Andersen P, Ruland J, et al (2010). Cutting Edge: Mincle is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate. JOURNAL OF IMMUNOLOGY, 184(6), 2756-2760. Author URL.
Parti RP, Loper R, Brown GD, Gordon S, Taylor PR, Bonventre JV, Murphy RC, Williams DL, Leslie CC (2010). Cytosolic Phospholipase A(2) Activation by Candida albicans in Alveolar Macrophages Role of Dectin-1. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 42(4), 415-423. Author URL.
Plantinga TS, Hamza OJM, Willment JA, Ferwerda B, Van De Geer NMD, Verweij PE, Matee MIN, Banahan K, O'Neill LAJ, Kullberg BJ, et al (2010). Genetic variation of innate immune genes in HIV-infected African patients with or without oropharyngeal candidiasis. Journal of Acquired Immune Deficiency Syndromes, 55(1), 87-94. Abstract.
Brown GD (2010). How Fungi Have Shaped Our Understanding of Mammalian Immunology. CELL HOST & MICROBE, 7(1), 9-11. Author URL.
Suram S, Gangelhoff TA, Taylor PR, Rosas M, Brown GD, Bonventre JV, Akira S, Uematsu S, Williams DL, Murphy RC, et al (2010). Pathways Regulating Cytosolic Phospholipase A(2) Activation and Eicosanoid Production in Macrophages by Candida albicans. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(40), 30676-30685. Author URL.
Kerrigan AM, Brown GD (2010). Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs. IMMUNOLOGICAL REVIEWS, 234, 335-352. Author URL.
Marakalala MJ, Graham LM, Brown GD (2010). The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections. Clinical & Developmental Immunology, 2010 Abstract.
Heinsbroek SEM, Kamen LA, Taylor PR, Brown GD, Swanson J, Gordon S (2009). Actin and Phosphoinositide Recruitment to Fully Formed Candida albicans Phagosomes in Mouse Macrophages. JOURNAL OF INNATE IMMUNITY, 1(3), 244-253. Author URL.
Werninghaus K, Babiak A, Gross O, Hoelscher C, Dietrich H, Agger EM, Mages J, Mocsai A, Schoenen H, Finger K, et al (2009). Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcR gamma-Syk-Card9-dependent innate immune activation. JOURNAL OF EXPERIMENTAL MEDICINE, 206(1), 89-97. Author URL.
Hise AG, Tomalka J, Ganesan S, Patel K, Hall BA, Brown GD, Fitzgerald KA (2009). An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans. CELL HOST & MICROBE, 5(5), 487-497. Author URL.
Kerrigan AM, Brown GD (2009). C-type lectins and phagocytosis. IMMUNOBIOLOGY, 214(7), 562-575. Author URL.
Kerrigan AM, Dennehy KM, Mourão-Sá D, Faro-Trindade I, Willment JA, Taylor PR, Eble JA, Reis E Sousa C, Brown GD (2009). CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. Journal of Immunology, 182(7), 4150-4157. Abstract.
Mora-Montes HM, Netea MG, Sheth CC, Brown GD, Bates S, Kullberg BJ, Brown AJP, Odds FC, Gow NAR (2009). Candida albicans cell wall glycobiology: biosynthesis of N-linked mannans and interaction with the host innate immune system. MYCOSES, 52, 24-24. Author URL.
Tsoni SV, Kerrigan AM, Marakalala MJ, Srinivasan N, Duffield M, Taylor PR, Botto M, Steele C, Brown GD (2009). Complement C3 Plays an Essential Role in the Control of Opportunistic Fungal Infections. INFECTION AND IMMUNITY, 77(9), 3679-3685. Author URL.
Robinson MJ, Osorio F, Rosas M, Freitas RP, Schweighoffer E, Gross O, SjefVerbeek J, Ruland J, Tybulewicz V, Brown GD, et al (2009). Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. JOURNAL OF EXPERIMENTAL MEDICINE, 206(9), 2037-2051. Author URL.
Plantinga TS, van der Velden WJFM, Ferwerda B, van Spriel AB, Adema G, Feuth T, Donnelly JP, Brown GD, Kullberg B-J, Blijlevens NMA, et al (2009). Early Stop Polymorphism in Human DECTIN-1 is Associated with Increased Candida Colonization in Hematopoietic Stem Cell Transplant Recipients. CLINICAL INFECTIOUS DISEASES, 49(5), 724-732. Author URL.
afer GS, Brown GD (2009). Generation of retroviral macrophage cDNA expression libraries and functional screening for surface receptors. Methods in Molecular Biology, 531, 1-15. Abstract.
Ferwerda B, Ferwerda G, Plantinga TS, Willment JA, Van Spriel AB, Venselaar H, Elbers CC, Johnson MD, Cambi A, Huysamen C, et al (2009). Human dectin-1 deficiency and mucocutaneous fungal infections. New England Journal of Medicine, 361(18), 1760-1767. Abstract.
Schaefer G, Jacobs M, Wilkinson RJ, Brown GD (2009). Non-Opsonic Recognition of Mycobacterium tuberculosis by Phagocytes. JOURNAL OF INNATE IMMUNITY, 1(3), 231-243. Author URL.
Reid DM, Gow NA, Brown GD (2009). Pattern recognition: recent insights from Dectin-1. Current Opinion in Immunology, 21(1), 30-37. Abstract.
Dennehy KM, Willment JA, Williams DL, Brown GD (2009). Reciprocal regulation of IL-23 and IL-12 following co-activation of dectin-1 and TLR signaling pathways. European Journal of Immunology, 39(5), 1379-1386. Abstract.
Werner JL, Metz AE, Horn D, Schoeb TR, Hewitt MM, Schwiebert LM, Faro-Trindade I, Brown GD, Steele C (2009). Requisite Role for the Dectin-1 beta-Glucan Receptor in Pulmonary Defense against Aspergillus fumigatus. JOURNAL OF IMMUNOLOGY, 182(8), 4938-4946. Author URL.
Graham LM, Brown GD (2009). The Dectin-2 family of C-type lectins in immunity and homeostasis. CYTOKINE, 48(1-2), 148-155. Author URL.
Schaefer G, Guler R, Murray G, Brombacher F, Brown GD (2009). The Role of Scavenger Receptor B1 in Infection with Mycobacterium tuberculosis in a Murine Model. PLOS ONE, 4(12). Author URL.
Huysamen C, Brown GD (2009). The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors. FEMS MICROBIOLOGY LETTERS, 290(2), 121-128. Author URL.
Netea MG, Brown GD, Kullberg BJ, Gow NAR (2008). An integrated model of the recognition of Candida albicans by the innate immune system. Nature Reviews Microbiology, 6(1), 67-78. Abstract.
Willment JA, Brown GD (2008). C-type lectin receptors in antifungal immunity. Trends in Microbiology, 16(1), 27-32. Abstract.
Huysamen C, Willment JA, Dennehy KM, Brown GD (2008). CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes. Journal of Biological Chemistry, 283(24), 16693-16701. Abstract.
Pyz E, Huysamen C, Marshall ASJ, Gordon S, Taylor PR, Brown GD (2008). Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand. EUROPEAN JOURNAL OF IMMUNOLOGY, 38(4), 1157-1163. Author URL.
Valera I, Ferandez N, Trinidad AG, Alonso S, Brown GD, Alonso A, Sanchez Crespo M (2008). Costimulation of dectin-1 and DC-SIGN triggers the arachidonic acid cascade in human monocyte-derived dendritic cells. JOURNAL OF IMMUNOLOGY, 180(8), 5727-5736.
Kimberg M, Brown GD (2008). Dectin-1 and its role in antifungal immunity. MEDICAL MYCOLOGY, 46(7), 631-636. Author URL.
Adams EL, Rice PJ, Graves B, Ensley HE, Yu H, Brown GD, Gordon S, Monteiro MA, Papp-Szabo E, Lowman DW, et al (2008). Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 325(1), 115-123. Author URL.
Brown GD (2008). Sensing necrosis with Mincle. NATURE IMMUNOLOGY, 9(10), 1099-1100. Author URL.
LeibundGut-Landmann S, Osorio F, Brown GD, Sousa CRE (2008). Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses. BLOOD, 112(13), 4971-4980. Author URL.
Jimenez-A MDP, Viriyakosol S, Walls L, Datta SK, Kirkland T, Heinsbroek SEM, Brown G, Fierer J (2008). Susceptibility to Coccidioides species in C57BL/6 mice is associated with expression of a truncated splice variant of Dectin-1 (Clec7a). GENES AND IMMUNITY, 9(4), 338-348. Author URL.
Dennehy KM, Ferwerda G, Faro-Trindade I, Pyz E, Willment JA, Taylor PR, Kerrigan A, Tsoni SV, Gordon S, Meyer-Wentrup F, et al (2008). Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. European Journal of Immunology, 38(2), 500-506. Abstract.
Rosas M, Liddiard K, Kimberg M, Faro-Trindade I, McDonald JU, Williams DL, Brown GD, Taylor PR (2008). The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis. JOURNAL OF IMMUNOLOGY, 181(5), 3549-3557. Author URL.
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A (2007). Dectin-1 interaction with mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells. JOURNAL OF IMMUNOLOGY, 179(6), 3463-3471. Author URL.
Taylor PR, Tsoni SV, Willment JA, Dennehy KM, Rosas M, Findon H, Haynes K, Steele C, Botto M, Gordon S, et al (2007). Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol, 8(1), 31-38. Abstract.  Author URL.
Kennedy AD, Willment JA, Dorward DW, Williams DL, Brown GD, DeLeo FR (2007). Dectin-1 promotes fungicidal activity of human neutrophils. European Journal of Immunology, 37(2), 467-478. Abstract.
Brown J, O'Callaghan CA, Marshall ASJ, Gilbert RJC, Siebold C, Gordon S, Brown GD, Jones EY (2007). Structure of the fungal beta-glucan-binding immune receptor dectin-1: Implications for function. PROTEIN SCIENCE, 16(6), 1042-1052. Author URL.
LeibundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, Tybulewicz V, Brown GD, Ruland J, et al (2007). Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. NATURE IMMUNOLOGY, 8(6), 630-638. Author URL.
Slack EC, Robinson MJ, Hernanz-Falcon P, Brown GD, Williams DL, Schweighoffer E, Tybulewicz VL, Reis e Sousa C (2007). Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan. EUROPEAN JOURNAL OF IMMUNOLOGY, 37(6), 1600-1612. Author URL.
Dennehy KM, Brown GD (2007). The role of the beta-glucan receptor Dectin-1 in control of fungal infection. JOURNAL OF LEUKOCYTE BIOLOGY, 82(2), 253-258. Author URL.
Pyz E, Marshall ASJ, Gordon S, Brown GD (2006). C-type lectin-like receptors on myeloid cells. ANNALS OF MEDICINE, 38(4), 242-251. Author URL.
Brown GD (2006). Dectin-1: a signalling non-TLR pattern-recognition receptor. NATURE REVIEWS IMMUNOLOGY, 6(1), 33-43. Author URL.
Heinsbroek SEM, Taylor PR, Rosas M, Willment JA, Williams DL, Gordon S, Brown GD (2006). Expression of functionally different dectin-1 isoforms by murine macrophages. Journal of Immunology, 176(9), 5513-5518. Abstract.
Marshall ASJ, Willment JA, Pyz E, Dennehy KM, Reid DM, Dri P, Gordon S, Wong SYC, Brown GD (2006). Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation. European Journal of Immunology, 36(8), 2159-2169. Abstract.
Palma AS, Feizi T, Zhang YB, Stoll MS, Lawson AM, Diaz-Rodriguez E, Campanero-Rhodes MA, Costa J, Gordon S, Brown GD, et al (2006). Ligands for the beta-glucan receptor, Dectin-1, assigned using "designer" microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(9), 5771-5779. Author URL.
Palma AS, Feizi T, Zhang Y, Stoll MS (2006). Ligands for the beta-glucan receptor, Dectin-1, assigned using "designer" microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides. (vol 281, pg 5771, 2006). JOURNAL OF BIOLOGICAL CHEMISTRY, 281(34), 24999-24999. Author URL.
Ozment-Skelton TR, Goldman MP, Gordon S, Brown GD, Williams DL (2006). Prolonged reduction of leukocyte membrane-associated Dectin-1 levels following beta-glucan administration. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 318(2), 540-546. Author URL.
Suram S, Brown GD, Ghosh M, Gordon S, Loper R, Taylor PR, Akira S, Uematsu S, Williams DL, Leslie CC, et al (2006). Regulation of cytosolic phospholipase A(2) activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptor. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(9), 5506-5514. Author URL.
Graham LM, Tsoni SV, Willment JA, Williams DL, Taylor PR, Gordon S, Dennehy K, Brown GD (2006). Soluble Dectin-1 as a tool to detect β-glucans. Journal of Immunological Methods, 314(1-2), 164-169. Abstract.
McGreal EP, Rosas M, Brown GD, Zamze S, Wong SYC, Gordon S, Martinez-Pomares L, Taylor PR (2006). The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. GLYCOBIOLOGY, 16(5), 422-430. Author URL.
Yoshitomi H, Sakaguchi N, Kobayashi K, Brown GD, Tagami T, Sakihama T, Hirota K, Tanaka S, Nomura T, Miki I, et al (2005). A role for fungal beta-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. JOURNAL OF EXPERIMENTAL MEDICINE, 201(6), 949-960. Author URL.
Heinsbroek SEM, Brown GD, Gordon S (2005). Dectin-1 escape by fungal dimorphism. TRENDS IN IMMUNOLOGY, 26(7), 352-354. Author URL.
Taylor PR, Reid DM, Heinsbroek SEM, Brown GD, Gordon S, Wong SYC (2005). Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo. EUROPEAN JOURNAL OF IMMUNOLOGY, 35(7), 2163-2174. Author URL.
Su YP, Bakker T, Harris J, Tsang C, Brown GD, Wormald MR, Gordon S, Dwek RA, Rudd PM, Martinez-Pomares L, et al (2005). Glycosylation influences the lectin activities of the macrophage mannose receptor. JOURNAL OF BIOLOGICAL CHEMISTRY, 280(38), 32811-32820. Author URL.
Brown GD, Gordon S (2005). Immune recognition of fungal beta-glucans. CELLULAR MICROBIOLOGY, 7(4), 471-479. Author URL.
Viriyakosol S, Fierer J, Brown GD, Kirkland TN (2005). Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on toll-like receptor 2 and dectin-1. INFECTION AND IMMUNITY, 73(3), 1553-1560. Author URL.
Hobson RP, Munro CA, Bates S, MacCullum DM, Cutler JE, Heinsbroek SE, Brown GD, Odds FC, Gow NA (2005). Loss of cell wall mannosylphosphate in Candida albicans does not influence macrophage recognition. Journal of Biological Chemistry, 279, 39628-39635.
Rice PJ, Adams EL, Ozment-Skelton T, Gonzalez AJ, Goldman MP, Lockhart BE, Barker LA, Breuel KF, DePonti WK, Kalbfleisch JH, et al (2005). Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 314(3), 1079-1086. Author URL.
Rogers NC, Slack EC, Edwards AD, Nolte MA, Schulz O, Schweighoffer E, Williams DL, Gordon S, Tybulewicz VL, Brown GD, et al (2005). Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. IMMUNITY, 22(4), 507-517. Author URL.
Willment JA, Marshall AS, Reid DM, Williams DL, Wong SYC, Gordon S, Brown GD (2005). The human β-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells. European Journal of Immunology, 35(5), 1539-1547. Abstract.
Herre J, Gordon S, Brown GD (2004). Dectin-1 and its role in the recognition of beta-glucans by macrophages. MOLECULAR IMMUNOLOGY, 40(12), 869-876. Author URL.
Herre J, Marshall ASJ, Caron E, Edwards AD, Williams DL, Schweighoffer E, Tybulewicz V, Sousa CRE, Gordon S, Brown GD, et al (2004). Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages. BLOOD, 104(13), 4038-4045. Author URL.
Marshall ASJ, Willment JA, Lin HH, Williams DL, Gordon S, Brown GD (2004). Identification and characterization of a novel human Myeloid inhibitory c-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(15), 14792-14802. Author URL.
Diniz SN, Nomizo R, Cisalpino PS, Teixeira MM, Brown GD, Mantovani A, Gordon S, Reis LFL, Dias AAM (2004). PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages. JOURNAL OF LEUKOCYTE BIOLOGY, 75(4), 649-656. Author URL.
Taylor PR, Brown GD, Herre J, Williams DL, Willment JA, Gordon S (2004). The Role of SIGNR1 and the β-Glucan Receptor (Dectin-1) in the Nonopsonic Recognition of Yeast by Specific Macrophages. Journal of Immunology, 172(2), 1157-1162. Abstract.
Mukhopadhyay S, Herre J, Brown GD, Gordon S (2004). The potential for Toll-like receptors to collaborate with other innate immune receptors. IMMUNOLOGY, 112(4), 521-530. Author URL.
Herre J, Willment JA, Gordon S, Brown GD (2004). The role of dectin-1 in antifungal immunity. Critical Reviews in Immunology, 24(3), 193-203. Abstract.
Steele C, Marrero L, Swain S, Harmsen AG, Zheng MQ, Brown GD, Gordon S, Shellito JE, Kolls JK (2003). Alveolar macrophage-mediated killing of Pneumocystis carinii f. sp muris involves molecular recognition by the dectin-1 beta-glucan receptor. JOURNAL OF EXPERIMENTAL MEDICINE, 198(11), 1677-1688. Author URL.
Martinez-Pomares L, Reid DM, Brown GD, Taylor PR, Stillion RJ, Linehan SA, Zamze S, Gordon S, Wong SYC (2003). Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies. JOURNAL OF LEUKOCYTE BIOLOGY, 73(5), 604-613. Author URL.
Willment JA, Lin HH, Reid DM, Taylor PR, Williams DL, Wong SYC, Gordon S, Brown GD (2003). Dectin-1 Expression and Function Are Enhanced on Alternatively Activated and GM-CSF-Treated Macrophages and Are Negatively Regulated by IL-10, Dexamethasone, and Lipopolysaccharide. Journal of Immunology, 171(9), 4569-4573. Abstract.
Brown GD, Herre J, Williams DL, Willment JA, Marshall ASJ, Gordon S (2003). Dectin-1 mediates the biological effects of β-glucans. Journal of Experimental Medicine, 197(9), 1119-1124. Abstract.
Brown GD, Gordon S (2003). Fungal beta-glucans and mammalian immunity. IMMUNITY, 19(3), 311-315. Author URL.
Taylor PR, Brown GD, Geldhof AB, Martinez-Pomares L, Gordon S (2003). Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo. EUROPEAN JOURNAL OF IMMUNOLOGY, 33(8), 2090-2097. Author URL.
Brown GD, Taylor PR, Reid DM, Willment JA, Williams DL, Martinez-Pomares L, Wong SYC, Gordon S (2002). Dectin-1 is a major β-glucan receptor on macrophages. Journal of Experimental Medicine, 196(3), 407-412. Abstract.
Dave JA, Gey van Pittius NC, Beyers AD, Ehlers MRW, Brown GD (2002). Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages. BMC MICROBIOLOGY, 2 Author URL.
Taylor PR, Brown GD, Reid DM, Willment JA, Martinez-Pomares L, Gordon S, Wong SYC (2002). The β-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. Journal of Immunology, 169(7), 3876-3882. Abstract.
Willment JA, Gordon S, Brown GD (2001). Characterization of the Human β-Glucan Receptor and its Alternatively Spliced Isoforms. Journal of Biological Chemistry, 276(47), 43818-43823. Abstract.
Brown GD, Gordon S (2001). Immune recognition - a new receptor for beta-glucans. NATURE, 413(6851), 36-37. Author URL.
Brown GD, Dave JA, Gey van Pittius N, Stevens L, Ehlers MRW, Beyers AD (2000). The mycosins of Mycobacterium tuberculosis H37Rv: a family of subtilisin-like serine proteases. GENE, 254(1-2), 147-155. Author URL.
Brown GD, Thomson JA (1998). Isolation and characterisation of an aryl-beta-D-glucoside uptake and utilisation system (abg) from the gram-positive ruminal Clostridium species C-longisporum. MOLECULAR AND GENERAL GENETICS, 257(2), 213-218. Author URL.
Meyers PR, Bourn WR, Steyn LM, Van Helden P, Beyers AD, Brown GD (1998). Novel method for rapid measurement of growth of mycobacteria in detergent-free media. JOURNAL OF CLINICAL MICROBIOLOGY, 36(9), 2752-2754. Author URL.
BROWN GD, JORGENSEN T, MORRIS EJ, THOMSON JA (1993). ANALYSIS OF a CELLODEXTRINASE CLONED FROM RUMINOCOCCUS-FLAVEFACIENS FD-1. FEMS MICROBIOLOGY LETTERS, 111(1), 57-61. Author URL.

Chapters

Bidula S, Brown GD (In Press). Immunology of Fungal Infections. In Ratcliffe M (Ed) Immunity to Pathogens and Tumors, Elsevier Inc. 75-82.  Abstract.
Dambuza IM, Wagener J, Brown GD, Gow NAR (In Press). Immunology of fungal disease. In Kibbler CC, Barton R, Gow NAR, Howell S, MacCallum DM, Manuel RJ (Eds.) Oxford Textbook of Medical Mycology, Oxford University Press. Abstract.
Hardison SE, Brown GD (In Press). Receptor-ligand interactions in fungal infections. In Kurzai O (Ed) Human Fungal Pathogens, Springer, 77-96.  Abstract.
Stappers MHT, Brown GD (2017). Host immune responses during infections with Candida albicans. In  (Ed) Candida albicans: Cellular and Molecular Biology: Second Edition, 145-183.  Abstract.
Asamaphan P, Willment JA, Brown GD (2016). Dectin-1 (CLEC7A, BGR, CLECSF12). In  (Ed) C-Type Lectin Receptors in Immunity, 51-63.  Abstract.
Brown GD (2011). Innate Antifungal Immunity: the Key Role of Phagocytes. In  (Ed) , 1-21.  Author URL.
Taylor PR, Martinez-Pomares L, Stacey M, Lin HH, Brown GD, Gordon S (2005). Macrophage receptors and immune recognition. In  (Ed) , 901-944.  Author URL.

Conferences

Brown G (2014). C-type lectins in anti-fungal immunity.  Author URL.
Rochereau N, Drocourt D, Perouzel E, Pavot V, Redelinghuys P, Brown GD, Roblin X, Verrier B, Genin C, Corthesy B, et al (2014). Essential role of Dectin-1 in intestinal M cell-mediated reverse transcytosis of SIgA-antigen complexes.  Author URL.
Rieber N, Singh A, Carevic M, Oez H-H, Bouzani M, Speckmann C, Grimbacher B, Ruland J, Brown GD, Beilhack A, et al (2014). Fungi undermine host defence by inducing CXCR4+granulocytic myeloid derived suppressor cells.  Author URL.
Hadebe S, Brown G, Redelinghuys P, Drummond R, Fierens K, Lambrecht B, Brombacher F, Kirstein F, Vautier S (2014). Microbial PAMP co-stimulation initiates neutrophilic steroid resistant asthma.  Author URL.
Branzk N, Lubojemska A, Hardison SE, Wang Q, Gutierrez MG, Brown GD, Papayannopoulos V (2014). Microbial size regulates neutrophil responses for efficient immune defence and minimal host damage.  Author URL.
Hadebe SG, Kirstein F, Fierens K, Murray G, Redelinghuys P, Lambrecht B, Kolls J, Brombacher F, Brown GD (2014). Understanding the pathogenesis of severe asthma.  Author URL.
Wagener J, Malireddi RKS, Lenardon MD, Koberle M, Vautier S, MacCallum DM, Alvarez FJ, Biedermann T, Schaller M, Netea MG, et al (2013). Chitin recognition in fungal infections and its impact on the immune response.  Author URL.
Drummond RA, Kaplan D, Reid DM, Brown GD (2013). Dectin-1 is required for normal CD4(+) T-cell function in the murine GI tract during systemic candidiasis.  Author URL.
Nederby L, Hokland P, Brown G, Hansen M, Nyvold CG, Roug AS (2013). Unraveling the Leukemic Nature of hMICL and CD123 Expressing Cells in Acute Myeloid Leukemia.  Author URL.
Kilchenstein R, Karsten CM, Figge J, Brown GD, Koehl J (2012). C5a drives the cutaneous lesions in experimental epidermolysis bullosa acquisita, which can be targeted by highly galactosylated IgG1 immune complexes.  Author URL.
Redelinghuys P, Drummond RA, Reid DM, Brown GD (2012). Characterisation of the myeloid inhibitory C-type lectin-like receptor (mMICL) knock-out mouse.  Author URL.
Vautier S, Drummond RA, Redelinghuys P, Murray GI, MacCallum D, Brown GD (2012). Dectin-1 is required for control of systemic, but not gastrointestinal, infections by Candida albicans.  Author URL.
Karsten CM, Pandey MK, Figge J, Taylor PR, Berger M, Strait R, Nimmerjahn F, Brown GD, Finkelman F, Koehl J, et al (2012). Galactosylated IgG1 ICs control C5aR-mediated inflammation via a novel interaction between FcgRIIB and Dectin-1.  Author URL.
Kilchenstein R, Figge J, Karsten CM, Brown GD, Ludwig R, Zillikens D, Koehl J (2012). Galactosylated IgG1 immune complexes diminish C5a-dependent inflammation in experimental Epidermolysis Bullosa Acquisita.  Author URL.
Hadebe S, Redelinghuys P, Brown G, Brombacher F (2012). Role of fungal beta-glucans and lipopolysaccharide in non-allergic airway inflammation.  Author URL.
Karsten CMK, Pandey MK, Figge J, Taylor PR, McDonald JU, Strait RT, Harris NL, Koehl G, Brown GD, Finkelman FD, et al (2011). Galactosylated IgG1 links FcRIIB and dectin-1 to suppress CSaR-mediated inflammation.  Author URL.
Marakalala MI, Tsoni SV, Kerrigan AM, Srinivasan N, Duffield M, Taylor PR, Botto M, Steele C, Brown GD (2009). Complement C3 plays an essential role in the control of opportunistic fungal infections.  Author URL.
Brown G (2008). Innate immunity: what have we learned from Dectin-1.  Author URL.
Dennehy KM, Willment JA, Williams DL, Brown GD (2008). Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1/Syk and Toll-like receptor/MyD88 signaling pathways.  Author URL.
Willment JA, Marshall AS, Gordon S, Brown GD (2005). Characterisation of the human beta-glucan receptor.  Author URL.
Heinsbroek SE, Taylor PR, Rosas M, Willment JA, Gordon S, Brown GD (2005). Dectin-1 isoforms in mice are functionally different.  Author URL.
Taylor PR, Reid DM, Heinsbroek SE, Brown GD, Gordon S, Wong SY (2005). Dectin-2 exhibits activation dependent expression on maturing inflammatory monocytes elicited in vivo.  Author URL.
Yunpeng Y, Bakker T, Harris J, Sang CT, Brown GD, Wormald MR, Gordon S, Dwek RA, Rudd PM, Martinez-Pomares L, et al (2005). Glycosylation influences the lectin activities of the mannose receptor.  Author URL.
Reid DM, Montoya M, Taylor PR, Borrow P, Gordon S, Brown GD, Wong SYC (2004). Expression of the beta-glucan receptor, dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions.  Author URL.
Heinsbroek SEM, Gordon S, Brown GD (2004). Role of Dectin-1 in Candida albicans phagocytosis by macrophages.  Author URL.

Publications by year


In Press

Salazar F, Brown GD (In Press). A friendly danger. Science, 362, 292-293.
Armstrong-James D, Bicanic T, Brown GD, Hoving JC, Meintjes G, Nielsen K, Workshop WGFTEMBO-AIDSRM (In Press). AIDS-Related Mycoses: Current Progress in the Field and Future Priorities. Trends in Microbiology, 25, 428-430. Abstract.
Hadebe S, Brombacher F, Brown GD (In Press). C-Type Lectin Receptors in Asthma. Frontiers in Immunology, 9, 1-11. Abstract.
Drummond RA, Swamydas M, Oikonomou V, Zhai B, Dambuza I, Schaefer BC, Bohrer AC, Mayer-Barber KD, Lira SA, Iwakura Y, et al (In Press). CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment. Nature Immunology, 20, 559-570. Abstract.
Drummond RA, Dambuza IM, Vautier S, Taylor JA, Reid DM, Bain CC, Underhill DM, Masopust D, Kaplan DH, Brown GD, et al (In Press). CD4+ T-cell survival in the GI tract requires dectin-1 during fungal infection. Mucosal Immunology, 9, 492-502. Abstract.
Huang J-H, Lin C-Y, Wu S-Y, Chen W-Y, Chu C-L, Brown GD, Chuu C-P, Wu-Hsieh BA (In Press). CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway. PLoS Pathogens, 11 Abstract.
Lim J, Coates CJ, Denicola PS, Garelnabi M, Smith LM, Monteith P, Macleod CL, Escaron C, Brown GD, Hall RA, et al (In Press). Characterizing the Mechanisms of Nonopsonic Uptake of Cryptococci by Macrophages. The Journal of Immunology, 200, 3539-3546. Abstract.
Wagener J, Malireddi RKS, Lenardon MD, Koeberle M, Vautier S, MacCallum DM, Biedermann T, Schaller M, Netea MG, Kanneganti T-D, et al (In Press). Chitin recognition in fungal infections and its impact on the immune response. Mycoses, 56, 7-7.
Castoldi A, Andrade-Oliveira V, Aguiar CF, Amano MT, Lee J, Miyagi MT, Latância MT, Braga TT, da Silva MB, Ignácio A, et al (In Press). Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88. Cell Reports, 19, 2272-2288. Abstract.
Rochereau N, Drocourt D, Perouzel E, Pavot V, Redelinghuys P, Brown GD, Tiraby G, Roblin X, Verrier B, Genin C, et al (In Press). Dectin-1 is Essential for Reverse Transcytosis of Glycosylated SIgA-Antigen Complexes by Intestinal M Cells. PLoS Biology, 11, 1-18. Abstract.
Zimara N, Chanyalew M, Aseffa A, van Zandbergen G, Lepenies B, Schmid M, Weiss R, Rascle A, Wege AK, Brown GD, et al (In Press). Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development. Frontiers in Immunology, 9 Abstract.
Elcombe SE, Naqvi S, Van Den Bosch MWM, Mackenzie KF, Cianfanelli F, Brown GD, Arthur JSC (In Press). Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers. PloS ONE, 8 Abstract.
Willment JA, Brown GD (In Press). Dectin-1: Basis Sequence - Mouse.  Abstract.
Whibley N, Jaycox JR, Reid D, Garg AV, Taylor JA, Clancy CJ, Nguyen MH, Biswas PS, McGeachy MJ, Brown GD, et al (In Press). Delinking CARD9 and IL-17: Protects against Candida tropicalis Infection through a TNF-α–Dependent, IL-17–Independent Mechanism. The Journal of Immunology, 195, 3781-3792. Abstract.
Berekméri A, Latzko A, Alase A, Macleod T, Ainscough JS, Laws P, Goodfield M, Wright A, Helliwell P, Edward S, et al (In Press). Detection of IL-36γ through noninvasive tape stripping reliably discriminates psoriasis from atopic eczema. Journal of Allergy and Clinical Immunology, 142, 988-991. Abstract.
McDonald JU, Rosas M, Brown GD, Jones SA, Taylor PR (In Press). Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation. PloS ONE, 7 Abstract.
uthrich MW, Wang H, Li M, Lerksuthirat T, Hardison SE, Brown GD, Klein B (In Press). Fonsecaea pedrosoi-induced Th17-cell differentiation in mice is fostered by Dectin-2 and suppressed by Mincle recognition. European Journal of Immunology, 45, 2542-2552. Abstract.
Dambuza IM, Levitz SM, Netea MG, Brown GD (In Press). Fungal Recognition and Host Defense Mechanisms. Microbiology spectrum, 5, 1-16. Abstract.
Brown BR, Lee EJ, Snow PE, Vance EE, Iwakura Y, Ohno N, Miura N, Lin X, Brown GD, Wells CA, et al (In Press). Fungal-derived cues promote ocular autoimmunity through a Dectin-2/Card9-mediated mechanism. Clinical and Experimental Immunology, 190, 293-303. Abstract.
Brown GD, May RC (In Press). Host-Microbe Interactions: Fungi. Current Opinion in Microbiology, 40, v-vii.
Pradhan A, Avelar GM, Bain JM, Childers DS, Larcombe DE, Netea MG, Shekhova E, Munro CA, Brown GD, Erwig LP, et al (In Press). Hypoxia Promotes Immune Evasion by Triggering β-Glucan Masking on the Candida albicans Cell Surface via Mitochondrial and cAMP-Protein Kinase a Signaling. MBio, 9(6). Abstract.  Author URL.
Gow NAR, Netea MG, Munro CA, Ferwerda G, Bates S, Mora-Montes HM, Walker L, Jansen T, Jacobs L, Tsoni V, et al (In Press). Immune Recognition of Candida albicans ß-glucan by Dectin-1. The journal of infectious diseases, 196, 1565-1571. Abstract.
Hebecker B, Reid DM, Brown GD (In Press). Immunity to Trichophyton rubrum in a mouse skin infection model involves the recruitment of neutrophils. Mycoses, 61, 16-17.
Bidula S, Brown GD (In Press). Immunology of Fungal Infections. In Ratcliffe M (Ed) Immunity to Pathogens and Tumors, Elsevier Inc. 75-82.  Abstract.
Dambuza IM, Wagener J, Brown GD, Gow NAR (In Press). Immunology of fungal disease. In Kibbler CC, Barton R, Gow NAR, Howell S, MacCallum DM, Manuel RJ (Eds.) Oxford Textbook of Medical Mycology, Oxford University Press. Abstract.
Armstrong-James D, Brown GD, Netea MG, Zelante T, Gresnigt MS, van de Veerdonk FL, Levitz SM (In Press). Immunotherapeutic approaches to treatment of fungal diseases. Lancet Infectious Diseases, 17, 393-402. Abstract.
Drummond RA, Gaffen SL, Hise AG, Brown GD (In Press). Innate defense against fungal pathogens. Cold Spring Harbor perspectives in medicine, 5 Abstract.
Begun J, Lassen KG, Jijon HB, Baxt LA, Goel G, Heath RJ, Ng A, Tam JM, Kuo S-Y, Villablanca EJ, et al (In Press). Integrated Genomics of Crohn’s Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy. Cell Reports, 11, 1905-1918. Abstract.
Yang A-M, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, Bluemel S, Hartmann P, Xu J, Koyama Y, et al (In Press). Intestinal fungi contribute to development of alcoholic liver disease. The Journal of Clinical Investigation, 127, 2829-2841. Abstract.
Brown GD, Crocker PR (In Press). Lectin Receptors Expressed on Myeloid Cells. Microbiology spectrum, 4 Abstract.
Ozment-Skelton TR, deFluiter EA, Ha T, Li C, Graves BM, Ferguson DA, Schweitzer JB, Preizsner J, Brown GD, Gordon S, et al (In Press). Leukocyte Dectin-1 expression is differentially regulated in fungal versus polymicrobial sepsis. Critical Care Medicine, 37, 1038-1045. Abstract.
Hadebe S, Kirstein F, Fierens K, Chen K, Drummond RA, Vautier S, Sajaniemi S, Murray G, Williams DL, Redelinghuys P, et al (In Press). Microbial ligand costimulation drives neutrophilic steroid-refractory asthma. PloS ONE, 10 Abstract.
Martínez-López M, Iborra S, Conde-Garrosa R, Mastrangelo A, Danne C, Mann ER, Reid DM, Gaboriau-Routhiau V, Chaparro M, Lorenzo MP, et al (In Press). Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity. Immunity, 50, 446-461. Abstract.
Stoppelkamp S, Reid DM, Yeoh J, Taylor J, McKenzie EJ, Brown GD, Gordon S, Forrester JV, Wong SYC (In Press). Murine pattern recognition receptor dectin-1 is essential in the development of experimental autoimmune uveoretinitis. Molecular Immunology, 67, 398-406. Abstract.
Alsina-Beauchamp D, Escós A, Fajardo P, González-Romero D, Díaz-Mora E, Risco A, Martín-Serrano MA, Fresno CD, Dominguez-Andrés J, Aparicio N, et al (In Press). Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity. EMBO Molecular Medicine, 10 Abstract.
Branzk N, Lubojemska A, Hardison SE, Wang Q, Gutierrez MG, Brown GD, Papayannopoulos V (In Press). Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens. Nature Immunology, 15, 1017-1025. Abstract.
Plato A, Hardison SE, Brown GD (In Press). Pattern recognition receptors in antifungal immunity. Seminars in Immunopathology, 37, 97-106. Abstract.
Kerrigan AM, Brown GD (In Press). Phagocytes: fussy about carbs. Current Biology, 21, R500-R502. Abstract.
Hardison SE, Brown GD (In Press). Receptor-ligand interactions in fungal infections. In Kurzai O (Ed) Human Fungal Pathogens, Springer, 77-96.  Abstract.
Dambuza IM, Brown GD (In Press). Sensing fungi at the oral epithelium. Nature Microbiology, 3, 4-5. Abstract.
Heinsbroek SEM, Taylor PR, Martinez FO, Martinez-Pomares L, Brown GD, Gordon S (In Press). Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis. PLoS Pathogens, 4 Abstract.
Jiménez JM, Salazar M, Arancibia S, Villar J, Salazar F, Brown GD, Lavelle EC, Martínez-Pomares L, Ortiz-Quintero J, Lavandero S, et al (In Press). TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells from Mammals. Frontiers in Immunology, 10 Abstract.
Xiao Y, Tang J, Guo H, Zhao Y, Tang R, Ouyang S, Zeng Q, Rappleye CA, Rajaram MVS, Schlesinger LS, et al (In Press). Targeting CBLB as a potential therapeutic approach for disseminated candidiasis. Nature Medicine, 22, 906-914. Abstract.
Toft-Petersen M, Stidsholt Roug A, Plesner T, Ebbesen L, Brown GD, Nederby L (In Press). The CLEC12A receptor marks human basophils: Potential implications for minimal residual disease detection in acute myeloid leukemia. Cytometry Part B: Clinical Cytometry, 94, 520-526. Abstract.
Dambuza IM, Drake T, Chapuis A, Zhou X, Correia J, Taylor-Smith L, Legrave N, Rasmussen T, Fisher MC, Bicanic T, et al (In Press). The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis. PLoS Pathogens, 14, 1-28. Abstract.
Schwartz IS, Boyles TH, Kenyon CR, Hoving JC, Brown GD, Denning DW (In Press). The estimated burden of fungal disease in South Africa. The South African Medical Journal Abstract.
Thompson A, Davies LC, Laio C-T, da Fonseca DM, Griffiths JS, Andrews R, Jones AV, Clement M, Brown GD, Humphreys IR, et al (In Press). The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens, 15 Abstract.
Brown GD (In Press). Trimming Surface Sugars Protects Histoplasma from Immune Attack. mBio, 7, 1-3. Abstract.
Toft-Petersen M, Nederby L, Kjeldsen E, Kerndrup GB, Brown GD, Hokland P, Stidsholt Roug A (In Press). Unravelling the relevance of CLEC12A as a cancer stem cell marker in myelodysplastic syndrome. British Journal of Haematology, 175, 393-401. Abstract.
Tsoni SV, Brown GD (In Press). beta-Glucans and Dectin-1. Annals of the New York Academy of Sciences, 1143, 45-60. Abstract.
Hadebe S, Kirstein F, Fierens K, Redelinghuys P, Murray GI, Williams DL, Lambrecht BN, Brombacher F, Brown GD (In Press). β-Glucan exacerbates allergic airway responses to house dust mite allergen. Respiratory Research, 17, 1-3. Abstract.

2019

Brown GD, Wilson D (2019). Mammalian innate immunity to fungal infection. Semin Cell Dev Biol, 89, 1-2. Author URL.
Brown AJP, Gow NAR, Warris A, Brown GD (2019). Memory in Fungal Pathogens Promotes Immune Evasion, Colonisation, and Infection. Trends in Microbiology, 27(3), 219-230. Abstract.

2018

Salazar F, Brown GD (2018). Antifungal innate immunity: a perspective from last 10 years. Journal of Innate Immunity, 10, 373-397. Abstract.
Brunel SF, Willment JA, Brown GD, Devereux G, Warris A (2018). Aspergillus-induced superoxide production by cystic fibrosis phagocytes is associated with disease severity. ERS Monograph, 4(2). Abstract.
Brown GD, Willment JA, Whitehead L (2018). C-type lectins in immunity and homeostasis. Nature Reviews Immunology, 18(6), 374-389. Abstract.
Stappers MHT, Clark AE, Aimanianda V, Bidula S, Reid DM, Asamaphan P, Hardison SE, Dambuza IM, Valsecchi I, Kerscher B, et al (2018). Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus. Nature, 555(7696), 382-386. Abstract.
Gow NAR, Amin T, McArdle K, Brown AJP, Brown GD, Warris A, the WTSA-MMFIC (2018). Strategic Research Funding: a Success Story for Medical Mycology. Trends in Microbiology, 26(10), 811-813. Abstract.

2017

Wagener J, Maccallum DM, Brown GD, Gow NAR (2017). Candida albicans chitin increases arginase-1 activity in human macrophages, with an impact on macrophage antimicrobial functions. mBio, 8(1). Abstract.
Stappers MHT, Brown GD (2017). Host immune responses during infections with Candida albicans. In  (Ed) Candida albicans: Cellular and Molecular Biology: Second Edition, 145-183.  Abstract.

2016

Asamaphan P, Willment JA, Brown GD (2016). Dectin-1 (CLEC7A, BGR, CLECSF12). In  (Ed) C-Type Lectin Receptors in Immunity, 51-63.  Abstract.
Ballou ER, Avelar GM, Childers DS, Mackie J, Bain JM, Wagener J, Kastora SL, Panea MD, Hardison SE, Walker LA, et al (2016). Lactate signalling regulates fungal β-glucan masking and immune evasion. Nature Microbiology, 2 Abstract.
Redelinghuys P, Whitehead L, Augello A, Drummond RA, Levesque JM, Vautier S, Reid DM, Kerscher B, Taylor JA, Nigrovic PA, et al (2016). MICL controls inflammation in rheumatoid arthritis. Annals of the Rheumatic Diseases, 75(7), 1386-1391. Abstract.
Kerscher B, Wilson GJ, Reid DM, Mori D, Taylor JA, Besra GS, Yamasaki S, Willment JA, Brown GD (2016). Mycobacterial receptor, Clec4d (CLECSF8, MCL), is coregulated with Mincle and upregulated on mouse myeloid cells following microbial challenge. European Journal of Immunology, 46(2), 381-389. Abstract.
Kerscher B, Dambuza IM, Christofi M, Reid DM, Yamasaki S, Willment JA, Brown GD (2016). Signalling through MyD88 drives surface expression of the mycobacterial receptors MCL (Clecsf8, Clec4d) and Mincle (Clec4e) following microbial stimulation. Microbes and Infection, 18(7-8), 505-509. Abstract.

2015

Dambuza IM, Brown GD (2015). C-type lectins in immunity: recent developments. CURRENT OPINION IN IMMUNOLOGY, 32, 21-27. Author URL.
Kashem SW, Igyarto BZ, Gerami-Nejad M, Kumamoto Y, Mohammed J, Jarrett E, Drummond RA, Zurawski SM, Zurawski G, Berman J, et al (2015). Candida albicans Morphology and Dendritic Cell Subsets Determine T Helper Cell Differentiation. IMMUNITY, 42(2), 356-366. Author URL.
Vautier S, Drummond RA, Chen K, Murray GI, Kadosh D, Brown AJP, Gow NAR, Maccallum DM, Kolls JK, Brown GD, et al (2015). Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity. Cellular Microbiology, 17(4), 445-450. Abstract.
Rieber N, Singh A, Oez H, Carevic M, Bouzani M, Amich J, Ost M, Ye Z, Ballbach M, Schaefer I, et al (2015). Pathogenic Fungi Regulate Immunity by Inducing Neutrophilic Myeloid-Derived Suppressor Cells. CELL HOST & MICROBE, 17(4), 507-514. Author URL.
Wilson GJ, Marakalala MJ, Hoving JC, Van Laarhoven A, Drummond RA, Kerscher B, Keeton R, Van De Vosse E, Ottenhoff THM, Plantinga TS, et al (2015). The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity. Cell Host and Microbe, 17(2), 252-259. Abstract.

2014

Armstrong-James D, Meintjes G, Brown GD (2014). A neglected epidemic: fungal infections in HIV/AIDS. TRENDS IN MICROBIOLOGY, 22(3), 120-127. Author URL.
Brown GD, Meintjes G, Kolls JK, Gray C, Horsnell W, Working Group from the EMBO-AIDS Related Mycoses Workshop, Achan B, Alber G, Aloisi M, Armstrong-James D, et al (2014). AIDS-related mycoses: the way forward. Trends Microbiol, 22(3), 107-109. Abstract.  Author URL.
Brown G (2014). C-type lectins in anti-fungal immunity.  Author URL.
Bain JM, Louw J, Lewis LE, Okai B, Walls CA, Ballou ER, Walker LA, Reid D, Munro CA, Brown AJP, et al (2014). Candida albicans hypha formation and mannan masking of β-Glucan inhibit macrophage phagosome maturation. mBio, 5(6). Abstract.
Drummond RA, Wallace C, Reid DM, Way SS, Kaplan DH, Brown GD (2014). Cutting Edge: Failure of Antigen-Specific CD4(+) T Cell Recruitment to the Kidney during Systemic Candidiasis. JOURNAL OF IMMUNOLOGY, 193(11), 5381-5385. Author URL.
Loures FV, Araujo EF, Feriotti C, Bazan SB, Costa TA, Brown GD, Calich VLG (2014). Dectin-1 Induces M1 Macrophages and Prominent Expansion of CD8(+)IL-17(+) Cells in Pulmonary Paracoccidioidomycosis. JOURNAL OF INFECTIOUS DISEASES, 210(5), 762-773. Author URL.
Rochereau N, Drocourt D, Perouzel E, Pavot V, Redelinghuys P, Brown GD, Roblin X, Verrier B, Genin C, Corthesy B, et al (2014). Essential role of Dectin-1 in intestinal M cell-mediated reverse transcytosis of SIgA-antigen complexes.  Author URL.
Wagener J, Malireddi RKS, Lenardon MD, Köberle M, Vautier S, MacCallum DM, Biedermann T, Schaller M, Netea MG, Kanneganti TD, et al (2014). Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation. PLoS Pathogens, 10(4). Abstract.
Rieber N, Singh A, Carevic M, Oez H-H, Bouzani M, Speckmann C, Grimbacher B, Ruland J, Brown GD, Beilhack A, et al (2014). Fungi undermine host defence by inducing CXCR4+granulocytic myeloid derived suppressor cells.  Author URL.
Brown AJP, Brown GD, Netea MG, Gow NAR (2014). Metabolism impacts upon candida immunogenicity and pathogenicity at multiple levels. Trends in Microbiology, 22(11), 614-622. Abstract.
Hadebe S, Brown G, Redelinghuys P, Drummond R, Fierens K, Lambrecht B, Brombacher F, Kirstein F, Vautier S (2014). Microbial PAMP co-stimulation initiates neutrophilic steroid resistant asthma.  Author URL.
Branzk N, Lubojemska A, Hardison SE, Wang Q, Gutierrez MG, Brown GD, Papayannopoulos V (2014). Microbial size regulates neutrophil responses for efficient immune defence and minimal host damage.  Author URL.
Ifrim DC, Bain JM, Reid DM, Oosting M, Verschueren I, Gow NAR, van Krieken JH, Brown GD, Kullberg BJ, Joosten LAB, et al (2014). Role of dectin-2 for host defense against systemic infection with Candida glabrata. Infection and Immunity, 82(3), 1064-1073. Abstract.
Hoving JC, Wilson GJ, Brown GD (2014). Signalling C-Type lectin receptors, microbial recognition and immunity. CELLULAR MICROBIOLOGY, 16(2), 185-194. Author URL.
Teixeira de Sousa MDG, Jr BW, Spina R, Lota PR, Valente NS, Brown GD, Criado PR, Benard G (2014). Topical Application of Imiquimod as a Treatment for Chromoblastomycosis. CLINICAL INFECTIOUS DISEASES, 58(12), 1734-1737. Author URL.
Hadebe SG, Kirstein F, Fierens K, Murray G, Redelinghuys P, Lambrecht B, Kolls J, Brombacher F, Brown GD (2014). Understanding the pathogenesis of severe asthma.  Author URL.
Roug AS, Larsen HO, Nederby L, Just T, Brown G, Nyvold CG, Ommen HB, Hokland P (2014). hMICL and CD123 in combination with a CD45/CD34/CD117 backbone - a universal marker combination for the detection of minimal residual disease in acute myeloid leukaemia. BRITISH JOURNAL OF HAEMATOLOGY, 164(2), 212-222. Author URL.

2013

Watson CJ, Fairley CK, Grando D, Garland SM, Myers SP, Pirotta M (2013). Associations with asymptomatic colonization with candida in women reporting past vaginal candidiasis: an observational study. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 169(2), 376-379. Author URL.
Plato A, Willment JA, Brown GD (2013). C-Type lectin-like receptors of the dectin-1 cluster: Ligands and signaling pathways. International Reviews of Immunology, 32(2), 134-156. Abstract.
Wagener J, Malireddi RKS, Lenardon MD, Koberle M, Vautier S, MacCallum DM, Alvarez FJ, Biedermann T, Schaller M, Netea MG, et al (2013). Chitin recognition in fungal infections and its impact on the immune response.  Author URL.
Suram S, Silveira LJ, Mahaffey S, Brown GD, Bonventre JV, Williams DL, Gow NAR, Bratton DL, Murphy RC, Leslie CC, et al (2013). Cytosolic Phospholipase A<inf>2</inf>α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation. PLoS ONE, 8(7). Abstract.
Drummond RA, Kaplan D, Reid DM, Brown GD (2013). Dectin-1 is required for normal CD4(+) T-cell function in the murine GI tract during systemic candidiasis.  Author URL.
Marakalala MJ, Williams DL, Hoving JC, Engstad R, Netea MG, Brown GD (2013). Dectin-1 plays a redundant role in the immunomodulatory activities of beta-glucan-rich ligands in vivo. MICROBES AND INFECTION, 15(6-7), 511-515. Author URL.
Marakalala MJ, Vautier S, Potrykus J, Walker LA, Shepardson KM, Hopke A, Mora-Montes HM, Kerrigan A, Netea MG, Murray GI, et al (2013). Differential Adaptation of Candida albicans in Vivo Modulates Immune Recognition by Dectin-1. PLoS Pathogens, 9(4). Abstract.
Lim E-K, Mitchell PJ, Brown N, Drummond RA, Brown GD, Kaye PM, Bowles DJ (2013). Regiospecific Methylation of a Dietary Flavonoid Scaffold Selectively Enhances IL-1 beta Production following Toll-like Receptor 2 Stimulation in THP-1 Monocytes. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(29), 21126-21135. Author URL.
Drummond RA, Brown GD (2013). Signalling C-Type Lectins in Antimicrobial Immunity. PLOS PATHOGENS, 9(7). Author URL.
Kerscher B, Willment JA, Brown GD (2013). The Dectin-2 family of C-type lectin-like receptors: an update. International Immunology, 25(5), 271-277. Abstract.
Nederby L, Hokland P, Brown G, Hansen M, Nyvold CG, Roug AS (2013). Unraveling the Leukemic Nature of hMICL and CD123 Expressing Cells in Acute Myeloid Leukemia.  Author URL.

2012

Karsten CM, Pandey MK, Figge J, Kilchenstein R, Taylor PR, Rosas M, McDonald JU, Orr SJ, Berger M, Petzold D, et al (2012). Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of Fc gamma RIIB and dectin-1. NATURE MEDICINE, 18(9), 1401-+. Author URL.
Vautier S, MacCallum DM, Brown GD (2012). C-type lectin receptors and cytokines in fungal immunity. CYTOKINE, 58(1), 89-99. Author URL.
Hardison SE, Brown GD (2012). C-type lectin receptors orchestrate antifungal immunity. NATURE IMMUNOLOGY, 13(9), 817-822. Author URL.
Kilchenstein R, Karsten CM, Figge J, Brown GD, Koehl J (2012). C5a drives the cutaneous lesions in experimental epidermolysis bullosa acquisita, which can be targeted by highly galactosylated IgG1 immune complexes.  Author URL.
Faro-Trindade I, Willment JA, Kerrigan AM, Redelinghuys P, Hadebe S, Reid DM, Srinivasan N, Wainwright H, Lang DM, Steele C, et al (2012). Characterisation of innate fungal recognition in the lung. PLoS ONE, 7(4). Abstract.
Redelinghuys P, Drummond RA, Reid DM, Brown GD (2012). Characterisation of the myeloid inhibitory C-type lectin-like receptor (mMICL) knock-out mouse.  Author URL.
Vautier S, Drummond RA, Redelinghuys P, Murray GI, MacCallum DM, Brown GD (2012). Dectin-1 is Not Required for Controlling Candida albicans Colonization of the Gastrointestinal Tract. INFECTION AND IMMUNITY, 80(12), 4216-4222. Author URL.
Vautier S, Drummond RA, Redelinghuys P, Murray GI, MacCallum D, Brown GD (2012). Dectin-1 is required for control of systemic, but not gastrointestinal, infections by Candida albicans.  Author URL.
Gessner MA, Werner JL, Lilly LM, Nelson MP, Metz AE, Dunaway CW, Chan YR, Ouyang W, Brown GD, Weaver CT, et al (2012). Dectin-1-Dependent Interleukin-22 Contributes to Early Innate Lung Defense against Aspergillus fumigatus. INFECTION AND IMMUNITY, 80(1), 410-417. Author URL.
Brown GD, Netea MG (2012). Exciting Developments in the Immunology of Fungal Infections. CELL HOST & MICROBE, 11(5), 422-424. Author URL.
Larsen HO, Roug AS, Just T, Brown GD, Hokland P (2012). Expression of the hMICL in acute myeloid leukemia-a highly reliable disease marker at diagnosis and during follow-up. CYTOMETRY PART B-CLINICAL CYTOMETRY, 82B(1), 3-8. Author URL.
Netea MG, Brown GD (2012). Fungal infections: the next challenge. CURRENT OPINION IN MICROBIOLOGY, 15(4), 403-405. Author URL.
Karsten CM, Pandey MK, Figge J, Taylor PR, Berger M, Strait R, Nimmerjahn F, Brown GD, Finkelman F, Koehl J, et al (2012). Galactosylated IgG1 ICs control C5aR-mediated inflammation via a novel interaction between FcgRIIB and Dectin-1.  Author URL.
Kilchenstein R, Figge J, Karsten CM, Brown GD, Ludwig R, Zillikens D, Koehl J (2012). Galactosylated IgG1 immune complexes diminish C5a-dependent inflammation in experimental Epidermolysis Bullosa Acquisita.  Author URL.
Brown GD, Denning DW, Gow NAR, Levitz SM, Netea MG, White TC (2012). Hidden killers: Human fungal infections. Science Translational Medicine, 4(165). Abstract.
Brown GD (2012). IMMUNOLOGY Actin' dangerously. NATURE, 485(7400), 589-590. Author URL.
Wu KC, McDonald PR, Liu JJ, Chaguturu R, Klaassen CD (2012). Implementation of a High-Throughput Screen for Identifying Small Molecules to Activate the Keap1-Nrf2-ARE Pathway. PLOS ONE, 7(10). Author URL.
Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, Strom SP, Brown J, Becker CA, Fleshner PR, Dubinsky M, et al (2012). Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis. SCIENCE, 336(6086), 1314-1317. Author URL.
Kerrigan AM, Navarro-Nuñez L, Pyz E, Finney BA, Willment JA, Watson SP, Brown GD (2012). Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2. Journal of Thrombosis and Haemostasis, 10(3), 484-486.
Hadebe S, Redelinghuys P, Brown G, Brombacher F (2012). Role of fungal beta-glucans and lipopolysaccharide in non-allergic airway inflammation.  Author URL.
Kerrigan AM, de Sousa MDGT, Brown GD (2012). Simple assays for measuring innate interactions with fungi. Methods in Molecular Biology, 845, 303-317. Abstract.
Strasser D, Neumann K, Bergmann H, Marakalala MJ, Guler R, Rojowska A, Hopfner K-P, Brombacher F, Urlaub H, Baier G, et al (2012). Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-delta to Elicit Card9 Adaptor-Mediated Innate Immunity. IMMUNITY, 36(1), 32-42. Author URL.
Brown GD, Denning DW, Levitz SM (2012). Tackling Human Fungal Infections. SCIENCE, 336(6082), 647-647. Author URL.
Schreibelt G, Klinkenberg LJJ, Cruz LJ, Tacken PJ, Tel J, Kreutz M, Adema GJ, Brown GD, Figdor CG, de Vries IJM, et al (2012). The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3(+) myeloid dendritic cells. BLOOD, 119(10), 2284-2292. Author URL.
Graham LM, Gupta V, Schafer G, Reid DM, Kimberg M, Dennehy KM, Hornsell WG, Guler R, Campanero-Rhodes MA, Palma AS, et al (2012). The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through syk kinase. Journal of Biological Chemistry, 287(31), 25964-25974. Abstract.
Lilly LM, Gessner MA, Dunaway CW, Metz AE, Schwiebert L, Weaver CT, Brown GD, Steele C (2012). The beta-Glucan Receptor Dectin-1 Promotes Lung Immunopathology during Fungal Allergy via IL-22. JOURNAL OF IMMUNOLOGY, 189(7), 3653-3660. Author URL.
Gow NAR, Brown GD, Brown AJP, Netea MG, McArdle KE (2012). Waging war on fungi - the unknown superbugs. Microbiology Today, 39(4), 208-211.

2011

Marakalala MJ, Kerrigan AM, Brown GD (2011). Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans. MAMMALIAN GENOME, 22(1-2), 55-65. Author URL.
Gazi U, Rosas M, Singh S, Heinsbroek S, Haq I, Johnson S, Brown GD, Williams DL, Taylor PR, Martinez-Pomares L, et al (2011). Fungal Recognition Enhances Mannose Receptor Shedding through Dectin-1 Engagement. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(10), 7822-7829. Author URL.
Karsten CMK, Pandey MK, Figge J, Taylor PR, McDonald JU, Strait RT, Harris NL, Koehl G, Brown GD, Finkelman FD, et al (2011). Galactosylated IgG1 links FcRIIB and dectin-1 to suppress CSaR-mediated inflammation.  Author URL.
McDonald JU, Cortini A, Rosas M, Fossati-Jimack L, Ling GS, Lewis KJ, Dewitt S, Liddiard K, Brown GD, Jones SA, et al (2011). In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils. FASEB JOURNAL, 25(6), 1972-1982. Author URL.
Redelinghuys P, Brown GD (2011). Inhibitory C-type lectin receptors in myeloid cells. IMMUNOLOGY LETTERS, 136(1), 1-12. Author URL.
Brown GD (2011). Innate Antifungal Immunity: the Key Role of Phagocytes. In  (Ed) , 1-21.  Author URL.
Werner JL, Gessner MA, Lilly LM, Nelson MP, Metz AE, Horn D, Dunaway CW, Deshane J, Chaplin DD, Weaver CT, et al (2011). Neutrophils Produce Interleukin 17A (IL-17A) in a Dectin-1-and IL-23-Dependent Manner during Invasive Fungal Infection. INFECTION AND IMMUNITY, 79(10), 3966-3977. Author URL.
Mora-Montes HM, Netea MG, Ferwerda G, Lenardon MD, Brown GD, Mistry AR, Kullberg BJ, O'Callaghan CA, Sheth CC, Odds FC, et al (2011). Recognition and blocking of innate immunity cells by Candida albicans chitin. Infection and Immunity, 79(5), 1961-1970. Abstract.
da Gloria Sousa M, Reid DM, Schweighoffer E, Tybulewicz V, Ruland J, Langhorne J, Yamasaki S, Taylor PR, Almeida SR, Brown GD, et al (2011). Restoration of Pattern Recognition Receptor Costimulation to Treat Chromoblastomycosis, a Chronic Fungal Infection of the Skin. CELL HOST & MICROBE, 9(5), 436-443. Author URL.
Pyz E, Brown GD (2011). Screening for ligands of C-type lectin-like receptors. Methods in Molecular Biology, 748, 1-19. Abstract.
Kerrigan AM, Brown GD (2011). Syk-coupled C-type lectins in immunity. TRENDS IN IMMUNOLOGY, 32(4), 151-156. Author URL.
Marakalala MJ, Guler R, Matika L, Murray G, Jacobs M, Brombacher F, Rothfuchs AG, Sher A, Brown GD (2011). The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice. MICROBES AND INFECTION, 13(2), 198-201. Author URL.
Drummond RA, Brown GD (2011). The role of Dectin-1 in the host defence against fungal infections. CURRENT OPINION IN MICROBIOLOGY, 14(4), 392-399. Author URL.
Drummond RA, Saijo S, Iwakura Y, Brown GD (2011). The role of Syk/CARD9 coupled C-type lectins in antifungal immunity. EUROPEAN JOURNAL OF IMMUNOLOGY, 41(2), 276-281. Author URL.

2010

Vautier S, Sousa MDG, Brown GD (2010). C-type lectins, fungi and Th17 responses. CYTOKINE & GROWTH FACTOR REVIEWS, 21(6), 405-412. Author URL.
Schoenen H, Bodendorfer B, Hitchens K, Manzanero S, Werninghaus K, Nimmerjahn F, Agger EM, Stenger S, Andersen P, Ruland J, et al (2010). Cutting Edge: Mincle is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate. JOURNAL OF IMMUNOLOGY, 184(6), 2756-2760. Author URL.
Parti RP, Loper R, Brown GD, Gordon S, Taylor PR, Bonventre JV, Murphy RC, Williams DL, Leslie CC (2010). Cytosolic Phospholipase A(2) Activation by Candida albicans in Alveolar Macrophages Role of Dectin-1. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 42(4), 415-423. Author URL.
Plantinga TS, Hamza OJM, Willment JA, Ferwerda B, Van De Geer NMD, Verweij PE, Matee MIN, Banahan K, O'Neill LAJ, Kullberg BJ, et al (2010). Genetic variation of innate immune genes in HIV-infected African patients with or without oropharyngeal candidiasis. Journal of Acquired Immune Deficiency Syndromes, 55(1), 87-94. Abstract.
Brown GD (2010). How Fungi Have Shaped Our Understanding of Mammalian Immunology. CELL HOST & MICROBE, 7(1), 9-11. Author URL.
Suram S, Gangelhoff TA, Taylor PR, Rosas M, Brown GD, Bonventre JV, Akira S, Uematsu S, Williams DL, Murphy RC, et al (2010). Pathways Regulating Cytosolic Phospholipase A(2) Activation and Eicosanoid Production in Macrophages by Candida albicans. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(40), 30676-30685. Author URL.
Kerrigan AM, Brown GD (2010). Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs. IMMUNOLOGICAL REVIEWS, 234, 335-352. Author URL.
Marakalala MJ, Graham LM, Brown GD (2010). The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections. Clinical & Developmental Immunology, 2010 Abstract.

2009

Heinsbroek SEM, Kamen LA, Taylor PR, Brown GD, Swanson J, Gordon S (2009). Actin and Phosphoinositide Recruitment to Fully Formed Candida albicans Phagosomes in Mouse Macrophages. JOURNAL OF INNATE IMMUNITY, 1(3), 244-253. Author URL.
Werninghaus K, Babiak A, Gross O, Hoelscher C, Dietrich H, Agger EM, Mages J, Mocsai A, Schoenen H, Finger K, et al (2009). Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcR gamma-Syk-Card9-dependent innate immune activation. JOURNAL OF EXPERIMENTAL MEDICINE, 206(1), 89-97. Author URL.
Hise AG, Tomalka J, Ganesan S, Patel K, Hall BA, Brown GD, Fitzgerald KA (2009). An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans. CELL HOST & MICROBE, 5(5), 487-497. Author URL.
Kerrigan AM, Brown GD (2009). C-type lectins and phagocytosis. IMMUNOBIOLOGY, 214(7), 562-575. Author URL.
Kerrigan AM, Dennehy KM, Mourão-Sá D, Faro-Trindade I, Willment JA, Taylor PR, Eble JA, Reis E Sousa C, Brown GD (2009). CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. Journal of Immunology, 182(7), 4150-4157. Abstract.
Mora-Montes HM, Netea MG, Sheth CC, Brown GD, Bates S, Kullberg BJ, Brown AJP, Odds FC, Gow NAR (2009). Candida albicans cell wall glycobiology: biosynthesis of N-linked mannans and interaction with the host innate immune system. MYCOSES, 52, 24-24. Author URL.
Tsoni SV, Kerrigan AM, Marakalala MJ, Srinivasan N, Duffield M, Taylor PR, Botto M, Steele C, Brown GD (2009). Complement C3 Plays an Essential Role in the Control of Opportunistic Fungal Infections. INFECTION AND IMMUNITY, 77(9), 3679-3685. Author URL.
Marakalala MI, Tsoni SV, Kerrigan AM, Srinivasan N, Duffield M, Taylor PR, Botto M, Steele C, Brown GD (2009). Complement C3 plays an essential role in the control of opportunistic fungal infections.  Author URL.
Robinson MJ, Osorio F, Rosas M, Freitas RP, Schweighoffer E, Gross O, SjefVerbeek J, Ruland J, Tybulewicz V, Brown GD, et al (2009). Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. JOURNAL OF EXPERIMENTAL MEDICINE, 206(9), 2037-2051. Author URL.
Plantinga TS, van der Velden WJFM, Ferwerda B, van Spriel AB, Adema G, Feuth T, Donnelly JP, Brown GD, Kullberg B-J, Blijlevens NMA, et al (2009). Early Stop Polymorphism in Human DECTIN-1 is Associated with Increased Candida Colonization in Hematopoietic Stem Cell Transplant Recipients. CLINICAL INFECTIOUS DISEASES, 49(5), 724-732. Author URL.
afer GS, Brown GD (2009). Generation of retroviral macrophage cDNA expression libraries and functional screening for surface receptors. Methods in Molecular Biology, 531, 1-15. Abstract.
Ferwerda B, Ferwerda G, Plantinga TS, Willment JA, Van Spriel AB, Venselaar H, Elbers CC, Johnson MD, Cambi A, Huysamen C, et al (2009). Human dectin-1 deficiency and mucocutaneous fungal infections. New England Journal of Medicine, 361(18), 1760-1767. Abstract.
Schaefer G, Jacobs M, Wilkinson RJ, Brown GD (2009). Non-Opsonic Recognition of Mycobacterium tuberculosis by Phagocytes. JOURNAL OF INNATE IMMUNITY, 1(3), 231-243. Author URL.
Reid DM, Gow NA, Brown GD (2009). Pattern recognition: recent insights from Dectin-1. Current Opinion in Immunology, 21(1), 30-37. Abstract.
Dennehy KM, Willment JA, Williams DL, Brown GD (2009). Reciprocal regulation of IL-23 and IL-12 following co-activation of dectin-1 and TLR signaling pathways. European Journal of Immunology, 39(5), 1379-1386. Abstract.
Werner JL, Metz AE, Horn D, Schoeb TR, Hewitt MM, Schwiebert LM, Faro-Trindade I, Brown GD, Steele C (2009). Requisite Role for the Dectin-1 beta-Glucan Receptor in Pulmonary Defense against Aspergillus fumigatus. JOURNAL OF IMMUNOLOGY, 182(8), 4938-4946. Author URL.
Graham LM, Brown GD (2009). The Dectin-2 family of C-type lectins in immunity and homeostasis. CYTOKINE, 48(1-2), 148-155. Author URL.
Schaefer G, Guler R, Murray G, Brombacher F, Brown GD (2009). The Role of Scavenger Receptor B1 in Infection with Mycobacterium tuberculosis in a Murine Model. PLOS ONE, 4(12). Author URL.
Huysamen C, Brown GD (2009). The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors. FEMS MICROBIOLOGY LETTERS, 290(2), 121-128. Author URL.

2008

Netea MG, Brown GD, Kullberg BJ, Gow NAR (2008). An integrated model of the recognition of Candida albicans by the innate immune system. Nature Reviews Microbiology, 6(1), 67-78. Abstract.
Willment JA, Brown GD (2008). C-type lectin receptors in antifungal immunity. Trends in Microbiology, 16(1), 27-32. Abstract.
Huysamen C, Willment JA, Dennehy KM, Brown GD (2008). CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes. Journal of Biological Chemistry, 283(24), 16693-16701. Abstract.
Pyz E, Huysamen C, Marshall ASJ, Gordon S, Taylor PR, Brown GD (2008). Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand. EUROPEAN JOURNAL OF IMMUNOLOGY, 38(4), 1157-1163. Author URL.
Valera I, Ferandez N, Trinidad AG, Alonso S, Brown GD, Alonso A, Sanchez Crespo M (2008). Costimulation of dectin-1 and DC-SIGN triggers the arachidonic acid cascade in human monocyte-derived dendritic cells. JOURNAL OF IMMUNOLOGY, 180(8), 5727-5736.
Kimberg M, Brown GD (2008). Dectin-1 and its role in antifungal immunity. MEDICAL MYCOLOGY, 46(7), 631-636. Author URL.
Adams EL, Rice PJ, Graves B, Ensley HE, Yu H, Brown GD, Gordon S, Monteiro MA, Papp-Szabo E, Lowman DW, et al (2008). Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 325(1), 115-123. Author URL.
Brown G (2008). Innate immunity: what have we learned from Dectin-1.  Author URL.
Dennehy KM, Willment JA, Williams DL, Brown GD (2008). Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1/Syk and Toll-like receptor/MyD88 signaling pathways.  Author URL.
Brown GD (2008). Sensing necrosis with Mincle. NATURE IMMUNOLOGY, 9(10), 1099-1100. Author URL.
LeibundGut-Landmann S, Osorio F, Brown GD, Sousa CRE (2008). Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses. BLOOD, 112(13), 4971-4980. Author URL.
Jimenez-A MDP, Viriyakosol S, Walls L, Datta SK, Kirkland T, Heinsbroek SEM, Brown G, Fierer J (2008). Susceptibility to Coccidioides species in C57BL/6 mice is associated with expression of a truncated splice variant of Dectin-1 (Clec7a). GENES AND IMMUNITY, 9(4), 338-348. Author URL.
Dennehy KM, Ferwerda G, Faro-Trindade I, Pyz E, Willment JA, Taylor PR, Kerrigan A, Tsoni SV, Gordon S, Meyer-Wentrup F, et al (2008). Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. European Journal of Immunology, 38(2), 500-506. Abstract.
Rosas M, Liddiard K, Kimberg M, Faro-Trindade I, McDonald JU, Williams DL, Brown GD, Taylor PR (2008). The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis. JOURNAL OF IMMUNOLOGY, 181(5), 3549-3557. Author URL.

2007

Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A (2007). Dectin-1 interaction with mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells. JOURNAL OF IMMUNOLOGY, 179(6), 3463-3471. Author URL.
Taylor PR, Tsoni SV, Willment JA, Dennehy KM, Rosas M, Findon H, Haynes K, Steele C, Botto M, Gordon S, et al (2007). Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol, 8(1), 31-38. Abstract.  Author URL.
Kennedy AD, Willment JA, Dorward DW, Williams DL, Brown GD, DeLeo FR (2007). Dectin-1 promotes fungicidal activity of human neutrophils. European Journal of Immunology, 37(2), 467-478. Abstract.
Brown J, O'Callaghan CA, Marshall ASJ, Gilbert RJC, Siebold C, Gordon S, Brown GD, Jones EY (2007). Structure of the fungal beta-glucan-binding immune receptor dectin-1: Implications for function. PROTEIN SCIENCE, 16(6), 1042-1052. Author URL.
LeibundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, Tybulewicz V, Brown GD, Ruland J, et al (2007). Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. NATURE IMMUNOLOGY, 8(6), 630-638. Author URL.
Slack EC, Robinson MJ, Hernanz-Falcon P, Brown GD, Williams DL, Schweighoffer E, Tybulewicz VL, Reis e Sousa C (2007). Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan. EUROPEAN JOURNAL OF IMMUNOLOGY, 37(6), 1600-1612. Author URL.
Dennehy KM, Brown GD (2007). The role of the beta-glucan receptor Dectin-1 in control of fungal infection. JOURNAL OF LEUKOCYTE BIOLOGY, 82(2), 253-258. Author URL.

2006

Pyz E, Marshall ASJ, Gordon S, Brown GD (2006). C-type lectin-like receptors on myeloid cells. ANNALS OF MEDICINE, 38(4), 242-251. Author URL.
Brown GD (2006). Dectin-1: a signalling non-TLR pattern-recognition receptor. NATURE REVIEWS IMMUNOLOGY, 6(1), 33-43. Author URL.
Heinsbroek SEM, Taylor PR, Rosas M, Willment JA, Williams DL, Gordon S, Brown GD (2006). Expression of functionally different dectin-1 isoforms by murine macrophages. Journal of Immunology, 176(9), 5513-5518. Abstract.
Marshall ASJ, Willment JA, Pyz E, Dennehy KM, Reid DM, Dri P, Gordon S, Wong SYC, Brown GD (2006). Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation. European Journal of Immunology, 36(8), 2159-2169. Abstract.
Palma AS, Feizi T, Zhang YB, Stoll MS, Lawson AM, Diaz-Rodriguez E, Campanero-Rhodes MA, Costa J, Gordon S, Brown GD, et al (2006). Ligands for the beta-glucan receptor, Dectin-1, assigned using "designer" microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(9), 5771-5779. Author URL.
Palma AS, Feizi T, Zhang Y, Stoll MS (2006). Ligands for the beta-glucan receptor, Dectin-1, assigned using "designer" microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides. (vol 281, pg 5771, 2006). JOURNAL OF BIOLOGICAL CHEMISTRY, 281(34), 24999-24999. Author URL.
Ozment-Skelton TR, Goldman MP, Gordon S, Brown GD, Williams DL (2006). Prolonged reduction of leukocyte membrane-associated Dectin-1 levels following beta-glucan administration. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 318(2), 540-546. Author URL.
Suram S, Brown GD, Ghosh M, Gordon S, Loper R, Taylor PR, Akira S, Uematsu S, Williams DL, Leslie CC, et al (2006). Regulation of cytosolic phospholipase A(2) activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptor. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(9), 5506-5514. Author URL.
Graham LM, Tsoni SV, Willment JA, Williams DL, Taylor PR, Gordon S, Dennehy K, Brown GD (2006). Soluble Dectin-1 as a tool to detect β-glucans. Journal of Immunological Methods, 314(1-2), 164-169. Abstract.
McGreal EP, Rosas M, Brown GD, Zamze S, Wong SYC, Gordon S, Martinez-Pomares L, Taylor PR (2006). The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. GLYCOBIOLOGY, 16(5), 422-430. Author URL.

2005

Yoshitomi H, Sakaguchi N, Kobayashi K, Brown GD, Tagami T, Sakihama T, Hirota K, Tanaka S, Nomura T, Miki I, et al (2005). A role for fungal beta-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. JOURNAL OF EXPERIMENTAL MEDICINE, 201(6), 949-960. Author URL.
Willment JA, Marshall AS, Gordon S, Brown GD (2005). Characterisation of the human beta-glucan receptor.  Author URL.
Heinsbroek SEM, Brown GD, Gordon S (2005). Dectin-1 escape by fungal dimorphism. TRENDS IN IMMUNOLOGY, 26(7), 352-354. Author URL.
Heinsbroek SE, Taylor PR, Rosas M, Willment JA, Gordon S, Brown GD (2005). Dectin-1 isoforms in mice are functionally different.  Author URL.
Taylor PR, Reid DM, Heinsbroek SE, Brown GD, Gordon S, Wong SY (2005). Dectin-2 exhibits activation dependent expression on maturing inflammatory monocytes elicited in vivo.  Author URL.
Taylor PR, Reid DM, Heinsbroek SEM, Brown GD, Gordon S, Wong SYC (2005). Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo. EUROPEAN JOURNAL OF IMMUNOLOGY, 35(7), 2163-2174. Author URL.
Su YP, Bakker T, Harris J, Tsang C, Brown GD, Wormald MR, Gordon S, Dwek RA, Rudd PM, Martinez-Pomares L, et al (2005). Glycosylation influences the lectin activities of the macrophage mannose receptor. JOURNAL OF BIOLOGICAL CHEMISTRY, 280(38), 32811-32820. Author URL.
Yunpeng Y, Bakker T, Harris J, Sang CT, Brown GD, Wormald MR, Gordon S, Dwek RA, Rudd PM, Martinez-Pomares L, et al (2005). Glycosylation influences the lectin activities of the mannose receptor.  Author URL.
Brown GD, Gordon S (2005). Immune recognition of fungal beta-glucans. CELLULAR MICROBIOLOGY, 7(4), 471-479. Author URL.
Viriyakosol S, Fierer J, Brown GD, Kirkland TN (2005). Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on toll-like receptor 2 and dectin-1. INFECTION AND IMMUNITY, 73(3), 1553-1560. Author URL.
Hobson RP, Munro CA, Bates S, MacCullum DM, Cutler JE, Heinsbroek SE, Brown GD, Odds FC, Gow NA (2005). Loss of cell wall mannosylphosphate in Candida albicans does not influence macrophage recognition. Journal of Biological Chemistry, 279, 39628-39635.
Taylor PR, Martinez-Pomares L, Stacey M, Lin HH, Brown GD, Gordon S (2005). Macrophage receptors and immune recognition. In  (Ed) , 901-944.  Author URL.
Rice PJ, Adams EL, Ozment-Skelton T, Gonzalez AJ, Goldman MP, Lockhart BE, Barker LA, Breuel KF, DePonti WK, Kalbfleisch JH, et al (2005). Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 314(3), 1079-1086. Author URL.
Rogers NC, Slack EC, Edwards AD, Nolte MA, Schulz O, Schweighoffer E, Williams DL, Gordon S, Tybulewicz VL, Brown GD, et al (2005). Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. IMMUNITY, 22(4), 507-517. Author URL.
Willment JA, Marshall AS, Reid DM, Williams DL, Wong SYC, Gordon S, Brown GD (2005). The human β-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells. European Journal of Immunology, 35(5), 1539-1547. Abstract.

2004

Herre J, Gordon S, Brown GD (2004). Dectin-1 and its role in the recognition of beta-glucans by macrophages. MOLECULAR IMMUNOLOGY, 40(12), 869-876. Author URL.
Herre J, Marshall ASJ, Caron E, Edwards AD, Williams DL, Schweighoffer E, Tybulewicz V, Sousa CRE, Gordon S, Brown GD, et al (2004). Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages. BLOOD, 104(13), 4038-4045. Author URL.
Reid DM, Montoya M, Taylor PR, Borrow P, Gordon S, Brown GD, Wong SYC (2004). Expression of the beta-glucan receptor, dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions.  Author URL.
Marshall ASJ, Willment JA, Lin HH, Williams DL, Gordon S, Brown GD (2004). Identification and characterization of a novel human Myeloid inhibitory c-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(15), 14792-14802. Author URL.
Diniz SN, Nomizo R, Cisalpino PS, Teixeira MM, Brown GD, Mantovani A, Gordon S, Reis LFL, Dias AAM (2004). PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages. JOURNAL OF LEUKOCYTE BIOLOGY, 75(4), 649-656. Author URL.
Heinsbroek SEM, Gordon S, Brown GD (2004). Role of Dectin-1 in Candida albicans phagocytosis by macrophages.  Author URL.
Taylor PR, Brown GD, Herre J, Williams DL, Willment JA, Gordon S (2004). The Role of SIGNR1 and the β-Glucan Receptor (Dectin-1) in the Nonopsonic Recognition of Yeast by Specific Macrophages. Journal of Immunology, 172(2), 1157-1162. Abstract.
Mukhopadhyay S, Herre J, Brown GD, Gordon S (2004). The potential for Toll-like receptors to collaborate with other innate immune receptors. IMMUNOLOGY, 112(4), 521-530. Author URL.
Herre J, Willment JA, Gordon S, Brown GD (2004). The role of dectin-1 in antifungal immunity. Critical Reviews in Immunology, 24(3), 193-203. Abstract.

2003

Steele C, Marrero L, Swain S, Harmsen AG, Zheng MQ, Brown GD, Gordon S, Shellito JE, Kolls JK (2003). Alveolar macrophage-mediated killing of Pneumocystis carinii f. sp muris involves molecular recognition by the dectin-1 beta-glucan receptor. JOURNAL OF EXPERIMENTAL MEDICINE, 198(11), 1677-1688. Author URL.
Martinez-Pomares L, Reid DM, Brown GD, Taylor PR, Stillion RJ, Linehan SA, Zamze S, Gordon S, Wong SYC (2003). Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies. JOURNAL OF LEUKOCYTE BIOLOGY, 73(5), 604-613. Author URL.
Willment JA, Lin HH, Reid DM, Taylor PR, Williams DL, Wong SYC, Gordon S, Brown GD (2003). Dectin-1 Expression and Function Are Enhanced on Alternatively Activated and GM-CSF-Treated Macrophages and Are Negatively Regulated by IL-10, Dexamethasone, and Lipopolysaccharide. Journal of Immunology, 171(9), 4569-4573. Abstract.
Brown GD, Herre J, Williams DL, Willment JA, Marshall ASJ, Gordon S (2003). Dectin-1 mediates the biological effects of β-glucans. Journal of Experimental Medicine, 197(9), 1119-1124. Abstract.
Brown GD, Gordon S (2003). Fungal beta-glucans and mammalian immunity. IMMUNITY, 19(3), 311-315. Author URL.
Taylor PR, Brown GD, Geldhof AB, Martinez-Pomares L, Gordon S (2003). Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo. EUROPEAN JOURNAL OF IMMUNOLOGY, 33(8), 2090-2097. Author URL.

2002

Brown GD, Taylor PR, Reid DM, Willment JA, Williams DL, Martinez-Pomares L, Wong SYC, Gordon S (2002). Dectin-1 is a major β-glucan receptor on macrophages. Journal of Experimental Medicine, 196(3), 407-412. Abstract.
Dave JA, Gey van Pittius NC, Beyers AD, Ehlers MRW, Brown GD (2002). Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages. BMC MICROBIOLOGY, 2 Author URL.
Taylor PR, Brown GD, Reid DM, Willment JA, Martinez-Pomares L, Gordon S, Wong SYC (2002). The β-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. Journal of Immunology, 169(7), 3876-3882. Abstract.

2001

Willment JA, Gordon S, Brown GD (2001). Characterization of the Human β-Glucan Receptor and its Alternatively Spliced Isoforms. Journal of Biological Chemistry, 276(47), 43818-43823. Abstract.
Brown GD, Gordon S (2001). Immune recognition - a new receptor for beta-glucans. NATURE, 413(6851), 36-37. Author URL.

2000

Brown GD, Dave JA, Gey van Pittius N, Stevens L, Ehlers MRW, Beyers AD (2000). The mycosins of Mycobacterium tuberculosis H37Rv: a family of subtilisin-like serine proteases. GENE, 254(1-2), 147-155. Author URL.

1998

Brown GD, Thomson JA (1998). Isolation and characterisation of an aryl-beta-D-glucoside uptake and utilisation system (abg) from the gram-positive ruminal Clostridium species C-longisporum. MOLECULAR AND GENERAL GENETICS, 257(2), 213-218. Author URL.
Meyers PR, Bourn WR, Steyn LM, Van Helden P, Beyers AD, Brown GD (1998). Novel method for rapid measurement of growth of mycobacteria in detergent-free media. JOURNAL OF CLINICAL MICROBIOLOGY, 36(9), 2752-2754. Author URL.

1993

BROWN GD, JORGENSEN T, MORRIS EJ, THOMSON JA (1993). ANALYSIS OF a CELLODEXTRINASE CLONED FROM RUMINOCOCCUS-FLAVEFACIENS FD-1. FEMS MICROBIOLOGY LETTERS, 111(1), 57-61. Author URL.

Gordon_Brown Details from cache as at 2019-09-18 12:26:02

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External Engagement and Impact

  • Director: AFGrica Unit at the University fo Cape Town.
  • Co-Director: The Medical Mycology and Fungal Immunology Consortium.
  • Adjunct member of the Institute of Infectious Disease and Moleular Medicine at the University of Cape Town.

Teaching

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