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Dr Joseph Costello

Lecturer

 7540

 Geoffrey Pope 418

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

I am a molecular cell biologist interested in how interaction between organelles allows coordination of cellular trafficking and signaling. I did my PhD at the University of Sheffield and then postdoctoral work at the University of Manchester where I investigated how cells can optimise mRNA selection under different stress conditions. Following this I moved to the University of Exeter where I worked on a critical stress-response organelle, the peroxisome. Here, I identified organelle-targeting signals for membrane proteins, allowing us to discover proteins which tether peroxisomes and the ER at membrane contact sites. I took up a lectureship in Exeter in 2019 and I am focusing on membrane contact sites between organelles and how this relates to ROS homeostasis and disease.

Research

Publications

Key publications | Publications by category | Publications by year

Key publications


Costello JL, Castro, I, Hacker C, Schrader T, Metz J, Zeuschner D, Azadi A, Godinho L, Costina V, Findeisen P, et al (In Press). ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. Journal of Cell Biology Full text.
Costello J, Castro I, Schrader TA, Islinger M, Schrader M (In Press). Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations. Cell Cycle Full text.
Costello JL, Kershaw CJ, Castelli LM, Talavera D, Rowe W, Sims PFG, Ashe MP, Grant CM, Hubbard SJ, Pavitt GD, et al (2017). Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses. Genome Biology, 18(1). Abstract.  Full text.
Costello J, Castelli LM, Rowe W, Kershaw CJ, Talavera D, Mohammad-Qureshi SS, Sims PFG, Grant CM, Pavitt GD, Hubbard SJ, et al (2015). Global mRNA selection mechanisms for translation initiation. Genome Biology, 16(1). Abstract.  Full text.
Kershaw CJ, Costello JL, Talavera D, Rowe W, Castelli LM, Sims PFG, Grant CM, Ashe MP, Hubbard SJ, Pavitt GD, et al (2015). Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p. Scientific Reports, 5 Abstract.

Publications by category


Journal articles

Costello JL, Castro, I, Hacker C, Schrader T, Metz J, Zeuschner D, Azadi A, Godinho L, Costina V, Findeisen P, et al (In Press). ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. Journal of Cell Biology Full text.
Bishop A, Kamoshita M, Passmore J, Hacker C, Schrader T, Waterham H, Costello J, Schrader M (In Press). Fluorescent tools to analyse peroxisome-ER interactions in mammalian cells. Contact Full text.
Costello J, Castro I, Schrader TA, Islinger M, Schrader M (In Press). Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations. Cell Cycle Full text.
Costello J, Castro I, Camoes F, Schrader TA, McNeall D, Yang J, Giannopoulou EA, Gomes S, Pogenberg V, Bonekamp N, et al (In Press). Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells. Journal of Cell Science Full text.
Schrader M, Costello J, Godinho L, Azadi A, Islinger M (In Press). Proliferation and fission of peroxisomes - an update.  Full text.
Schrader M, Godinho L, Costello J, Islinger M (In Press). The different facets of organelle interplay - an overview of organelle interactions.  Full text.
Costello J, Schrader M (In Press). Unloosing the Gordian knot of peroxisome formation. Current Opinion in Cell Biology Full text.
Costello J, Zalckvar E, Kemp S, di Cara F, Kim P, Linka N, van der KleiEmail author I (2019). Peroxisomes: new insights into protein sorting, dynamics, quality control, signalling and roles in health and disease. Histochemistry and Cell Biology
Castro I, Richards DM, Metz J, Costello JL, Passmore JB, Schrader TA, Gouveia A, Ribeiro D, Schrader M (2018). A role for MIRO1 in motility and membrane dynamics of peroxisomes. Traffic Full text.
Talavera D, Kershaw CJ, Costello JL, Castelli LM, Rowe W, Sims PFG, Ashe MP, Grant CM, Pavitt GD, Hubbard SJ, et al (2018). Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions. Scientific Reports, 8(1). Abstract.  Full text.
Wang Y, Metz J, Costello JL, Passmore J, Schrader M, Schultz C, Islinger M (2018). Intracellular redistribution of neuronal peroxisomes in response to ACBD5 expression. PLoS One, 13(12). Abstract.  Author URL.  Full text.
Costello JL, Castro IG, Hacker C, Schrader TA, Metz J, Zeuschner D, Azadi AS, Godinho LF, Costina V, Findeisen P, et al (2017). ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. JOURNAL OF CELL BIOLOGY, 216(2), 331-342. Author URL.  Full text.
Costello JL, Kershaw CJ, Castelli LM, Talavera D, Rowe W, Sims PFG, Ashe MP, Grant CM, Hubbard SJ, Pavitt GD, et al (2017). Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses. Genome Biology, 18(1). Abstract.  Full text.
Jennings MD, Kershaw CJ, White C, Hoyle D, Richardson JP, Costello JL, Donaldson IJ, Zhou Y, Pavitt GD (2016). eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control. Nucleic Acids Res, 44(20), 9698-9709. Abstract.  Author URL.  Full text.
Costello J, Castelli LM, Rowe W, Kershaw CJ, Talavera D, Mohammad-Qureshi SS, Sims PFG, Grant CM, Pavitt GD, Hubbard SJ, et al (2015). Global mRNA selection mechanisms for translation initiation. Genome Biology, 16(1). Abstract.  Full text.
Kershaw CJ, Costello JL, Talavera D, Rowe W, Castelli LM, Sims PFG, Grant CM, Ashe MP, Hubbard SJ, Pavitt GD, et al (2015). Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p. Scientific Reports, 5 Abstract.
Schrader M, Costello J, Godinho LF, Islinger M (2015). Peroxisome-mitochondria interplay and disease. J Inherit Metab Dis, 38(4), 681-702. Abstract.  Author URL.  Full text.
Castelli LM, Talavera D, Kershaw CJ, Mohammad-Qureshi SS, Costello JL, Rowe W, Sims PFG, Grant CM, Hubbard SJ, Ashe MP, et al (2015). The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation. PLoS Genetics, 11(5). Abstract.
Kershaw CJ, Costello JL, Castelli LM, Talavera D, Rowe W, Sims PFG, Ashe MP, Hubbard SJ, Pavitt GD, Grant CM, et al (2015). The Yeast La Related Protein Slf1p is a Key Activator of Translation during the Oxidative Stress Response. PLoS Genetics, 11(1). Abstract.
Williams C, Opalinski L, Landgraf C, Costello J, Schrader M, Krikken AM, Knoops K, Kram AM, Volkmer R, van der Klei IJ, et al (2015). The membrane remodeling protein Pex11p activates the GTPase Dnm1p during peroxisomal fission. Proc Natl Acad Sci U S A, 112(20), 6377-6382. Abstract.  Author URL.  Full text.
Rowe W, Kershaw CJ, Castelli LM, Costello JL, Ashe MP, Grant CM, Sims PFG, Pavitt GD, Hubbard SJ (2014). Puf3p induces translational repression of genes linked to oxidative stress. Nucleic Acids Res, 42(2), 1026-1041. Abstract.  Author URL.
Costello JL, Stead JA, Feigenbutz M, Jones RM, Mitchell P (2011). The C-terminal region of the exosome-associated protein Rrp47 is specifically required for box C/D small nucleolar RNA 3'-maturation. J Biol Chem, 286(6), 4535-4543. Abstract.  Author URL.
Stead JA, Costello JL, Livingstone MJ, Mitchell P (2007). The PMC2NT domain of the catalytic exosome subunit Rrp6p provides the interface for binding with its cofactor Rrp47p, a nucleic acid-binding protein. Nucleic Acids Res, 35(16), 5556-5567. Abstract.  Author URL.

Chapters

Costello J, Passmore J, Islinger M, Schrader M (2018). Multi-localized proteins: the peroxisome-mitochondria connection. In del Rio L, Schrader M (Eds.) Proteomics of Peroxisomes. Identifying Novel Functions and Regulatory Networks, Springer. Full text.

Conferences

Camoes F, Islinger M, Costello J, Gomes S, Bonekamp N, Almeida M, Castro I, Ribeiro D, Schrader M (2014). Targeting of tail-anchored proteins to peroxisomes and mitochondria in mammalian cells.  Author URL.

Publications by year


In Press

Costello JL, Castro, I, Hacker C, Schrader T, Metz J, Zeuschner D, Azadi A, Godinho L, Costina V, Findeisen P, et al (In Press). ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. Journal of Cell Biology Full text.
Bishop A, Kamoshita M, Passmore J, Hacker C, Schrader T, Waterham H, Costello J, Schrader M (In Press). Fluorescent tools to analyse peroxisome-ER interactions in mammalian cells. Contact Full text.
Costello J, Castro I, Schrader TA, Islinger M, Schrader M (In Press). Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations. Cell Cycle Full text.
Costello J, Castro I, Camoes F, Schrader TA, McNeall D, Yang J, Giannopoulou EA, Gomes S, Pogenberg V, Bonekamp N, et al (In Press). Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells. Journal of Cell Science Full text.
Schrader M, Costello J, Godinho L, Azadi A, Islinger M (In Press). Proliferation and fission of peroxisomes - an update.  Full text.
Schrader M, Godinho L, Costello J, Islinger M (In Press). The different facets of organelle interplay - an overview of organelle interactions.  Full text.
Costello J, Schrader M (In Press). Unloosing the Gordian knot of peroxisome formation. Current Opinion in Cell Biology Full text.

2019

Costello J, Zalckvar E, Kemp S, di Cara F, Kim P, Linka N, van der KleiEmail author I (2019). Peroxisomes: new insights into protein sorting, dynamics, quality control, signalling and roles in health and disease. Histochemistry and Cell Biology

2018

Castro I, Richards DM, Metz J, Costello JL, Passmore JB, Schrader TA, Gouveia A, Ribeiro D, Schrader M (2018). A role for MIRO1 in motility and membrane dynamics of peroxisomes. Traffic Full text.
Talavera D, Kershaw CJ, Costello JL, Castelli LM, Rowe W, Sims PFG, Ashe MP, Grant CM, Pavitt GD, Hubbard SJ, et al (2018). Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions. Scientific Reports, 8(1). Abstract.  Full text.
Wang Y, Metz J, Costello JL, Passmore J, Schrader M, Schultz C, Islinger M (2018). Intracellular redistribution of neuronal peroxisomes in response to ACBD5 expression. PLoS One, 13(12). Abstract.  Author URL.  Full text.
Costello J, Passmore J, Islinger M, Schrader M (2018). Multi-localized proteins: the peroxisome-mitochondria connection. In del Rio L, Schrader M (Eds.) Proteomics of Peroxisomes. Identifying Novel Functions and Regulatory Networks, Springer. Full text.

2017

Costello JL, Castro IG, Hacker C, Schrader TA, Metz J, Zeuschner D, Azadi AS, Godinho LF, Costina V, Findeisen P, et al (2017). ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. JOURNAL OF CELL BIOLOGY, 216(2), 331-342. Author URL.  Full text.
Costello JL, Kershaw CJ, Castelli LM, Talavera D, Rowe W, Sims PFG, Ashe MP, Grant CM, Hubbard SJ, Pavitt GD, et al (2017). Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses. Genome Biology, 18(1). Abstract.  Full text.

2016

Jennings MD, Kershaw CJ, White C, Hoyle D, Richardson JP, Costello JL, Donaldson IJ, Zhou Y, Pavitt GD (2016). eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control. Nucleic Acids Res, 44(20), 9698-9709. Abstract.  Author URL.  Full text.

2015

Costello J, Castelli LM, Rowe W, Kershaw CJ, Talavera D, Mohammad-Qureshi SS, Sims PFG, Grant CM, Pavitt GD, Hubbard SJ, et al (2015). Global mRNA selection mechanisms for translation initiation. Genome Biology, 16(1). Abstract.  Full text.
Kershaw CJ, Costello JL, Talavera D, Rowe W, Castelli LM, Sims PFG, Grant CM, Ashe MP, Hubbard SJ, Pavitt GD, et al (2015). Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p. Scientific Reports, 5 Abstract.
Schrader M, Costello J, Godinho LF, Islinger M (2015). Peroxisome-mitochondria interplay and disease. J Inherit Metab Dis, 38(4), 681-702. Abstract.  Author URL.  Full text.
Castelli LM, Talavera D, Kershaw CJ, Mohammad-Qureshi SS, Costello JL, Rowe W, Sims PFG, Grant CM, Hubbard SJ, Ashe MP, et al (2015). The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation. PLoS Genetics, 11(5). Abstract.
Kershaw CJ, Costello JL, Castelli LM, Talavera D, Rowe W, Sims PFG, Ashe MP, Hubbard SJ, Pavitt GD, Grant CM, et al (2015). The Yeast La Related Protein Slf1p is a Key Activator of Translation during the Oxidative Stress Response. PLoS Genetics, 11(1). Abstract.
Williams C, Opalinski L, Landgraf C, Costello J, Schrader M, Krikken AM, Knoops K, Kram AM, Volkmer R, van der Klei IJ, et al (2015). The membrane remodeling protein Pex11p activates the GTPase Dnm1p during peroxisomal fission. Proc Natl Acad Sci U S A, 112(20), 6377-6382. Abstract.  Author URL.  Full text.

2014

Rowe W, Kershaw CJ, Castelli LM, Costello JL, Ashe MP, Grant CM, Sims PFG, Pavitt GD, Hubbard SJ (2014). Puf3p induces translational repression of genes linked to oxidative stress. Nucleic Acids Res, 42(2), 1026-1041. Abstract.  Author URL.
Camoes F, Islinger M, Costello J, Gomes S, Bonekamp N, Almeida M, Castro I, Ribeiro D, Schrader M (2014). Targeting of tail-anchored proteins to peroxisomes and mitochondria in mammalian cells.  Author URL.

2011

Costello JL, Stead JA, Feigenbutz M, Jones RM, Mitchell P (2011). The C-terminal region of the exosome-associated protein Rrp47 is specifically required for box C/D small nucleolar RNA 3'-maturation. J Biol Chem, 286(6), 4535-4543. Abstract.  Author URL.

2007

Stead JA, Costello JL, Livingstone MJ, Mitchell P (2007). The PMC2NT domain of the catalytic exosome subunit Rrp6p provides the interface for binding with its cofactor Rrp47p, a nucleic acid-binding protein. Nucleic Acids Res, 35(16), 5556-5567. Abstract.  Author URL.

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