Mr Joseph Pinion
MPH student
jp422@exeter.ac.uk
Geoffrey Pope 201
Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK
Overview
I am PhD student working on alternative approaches to seizure liability testing in larval zebrafish.
Qualifications
Medical Sciences BSc, MRes
Career
2018 - Present: PhD Researcher, University of Exeter
Research
Research interests
Broad research specialisms:
- Neuropharmacology
- Brain Functional Imaging
- Calcium Imaging
- Light-sheet Microscopy
- Brain Network Connectomics
- Zebrafish Brain Electrophysiology
Research projects
Project Title: An alternative approach for assessing drug-induced seizures, using non-protected larval zebrafish.
Supervisors: Charles Tyler, Matthew Winter, Andy Randall, Marc Goodfellow
Funding Body: NC3Rs
Project Description: We are using non-protected life-stage larval zebrafish for the detection of drugs with the potential to trigger seizures. .
Links
Publications
Journal articles
Pinion J, Walsh C, Goodfellow M, Randall AD, Tyler CR, Winter MJ (2022). Differential Electrographic Signatures Generated by Mechanistically-Diverse Seizurogenic Compounds in the Larval Zebrafish Brain. eNeuro, 9(2). Abstract. Author URL.
Winter MJ, Pinion J, Tochwin A, Takesono A, Ball JS, Grabowski P, Metz J, Trznadel M, Tse K, Redfern WS, et al (2021). Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms. Br J Pharmacol, 178(13), 2671-2689. Abstract. Author URL.
Reichmann F, Rimmer N, Tilley CA, Dalla Vecchia E, Pinion J, Al Oustah A, Carreño Gutiérrez H, Young AMJ, McDearmid JR, Winter MJ, et al (2020). The zebrafish histamine H3 receptor modulates aggression, neural activity and forebrain functional connectivity. Acta Physiologica, 230(4). Abstract.
Winter MJ, Windell D, Metz J, Matthews P, Pinion J, Brown JT, Hetheridge MJ, Ball JS, Owen SF, Redfern WS, et al (2018). Author Correction: 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain. Sci Rep, 8(1). Abstract. Author URL.
Winter MJ, Windell D, Metz J, Matthews P, Pinion J, Brown JT, Hetheridge MJ, Ball JS, Owen SF, Redfern WS, et al (2017). 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain. Sci Rep, 7(1). Abstract. Author URL.
