Skip to main content

Profile

Loading content
Dr Laure Ries

Dr Laure Ries

Post-doctoral Research Associate

 Geoffrey Pope 

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

 Office hours:

Monday to Friday 09.00 - 17.00

Overview

I have been studying various aspects of fungal biology since my PhD. I started my career investigating gene regulation, epigenetics and specific transcription factors in the biotechnological-relevant fungi Trichoderma reesei and Aspergillus nidulans in order to optimise enzyme secretion for biofuel production. During my post-doctoral career I then gradually moved to the biomedical side of fungal biology and characterised virulence determinants (anti-fungal drug resistance, transcription factors, nutrient utilisation, cell signaling pathways) in the opportunistic fungal pathogen A. fumigatus; as well as in clinical isolates of A. nidulans and in clinical isolates of Aspergillus cryptic species (e.g. hybrids). My research has mainly focused on how the utilisation (signaling and metabolism) of different carbon sources affects fungal traits such as gene expression, enzyme secretion, central metabolism, secondary metabolite production and cell wall structure/composition that are important for virulence. I am currently investigating how the interaction between pathogenic gram-negative bacteria and the opportunistic fungal pathogen Candida albicans affects C. albicans cell wall structure and pathogenicity

Qualifications

B.Sc. in Biological Sciences (University of East Anglia)

PhD in Molecular Microbiology and Genetics (University of Nottingham)

Career

01/11/2017 - 30/06/2020 Young Researcher at the Faculty of Medicine of Ribeirao Preto of the University of Sao Paulo, Brazil

01/11/2016 - 30/10/2017 Postdoctoral Fellow at the Faculty of Pharmaceutical Sciences of Ribeirao Preto of the University of Sao Paulo, Brazil

 01/10/2013 - 30/09/2016 Postdoctoral Researcher at the Faculty of Pharmaceutical Sciences of Ribeirao Preto of the University of Sao Paulo, Brazil

11/2012 - 08/2013 Freelance tutor for the company cours@home, Luxembourg

09/2008 - 09/2012 PhD University of Nottingham, UK

Research group links

Research

Research interests

Fungal-bacterial interactions

Fungal cell wall

Fungal carbon source utilisation and metabolism

Mycotoxins

Research projects

Identification of Candida albicans cell wall components important for interaction with the opportunistic bacterial pathogen Serratia marcescens

Publications

Key publications | Publications by category | Publications by year

Key publications


Steenwyk JL, Lind AL, Ries LNA, dos Reis TF, Silva LP, Almeida F, Bastos RW, Fraga da Silva TFDC, Bonato VLD, Pessoni AM, et al (2020). Pathogenic Allodiploid Hybrids of Aspergillus Fungi. Current Biology, 30(13), 2495-2507.e7.
Ries LNA, Pardeshi L, Dong Z, Tan K, Steenwyk JL, Colabardini AC, Ferreira Filho JA, de Castro PA, Silva LP, Preite NW, et al (2020). The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence. PLOS Pathogens, 16(7), e1008645-e1008645. Full text.
Ries LNA, Beattie S, Cramer RA, Goldman GH (2017). Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi. Molecular Microbiology, 107(3), 277-297.

Publications by category


Journal articles

Filho APDC, Brancini GTP, de Castro PA, Valero C, Ferreira Filho JA, Silva LP, Rocha MC, Malavazi I, Pontes JGDM, Fill T, et al (2020). Aspergillus fumigatus G-Protein Coupled Receptors GprM and GprJ Are Important for the Regulation of the Cell Wall Integrity Pathway, Secondary Metabolite Production, and Virulence. mBio, 11(5). Abstract.
Drott MT, Bastos RW, Rokas A, Ries LNA, Gabaldón T, Goldman GH, Keller NP, Greco C (2020). Diversity of Secondary Metabolism in Aspergillus nidulans Clinical Isolates. mSphere, 5(2). Abstract.
Bastos RW, Valero C, Silva LP, Schoen T, Drott M, Brauer V, Silva-Rocha R, Lind A, Steenwyk JL, Rokas A, et al (2020). Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans. mSphere, 5(2). Abstract.
Steenwyk JL, Lind AL, Ries LNA, dos Reis TF, Silva LP, Almeida F, Bastos RW, Fraga da Silva TFDC, Bonato VLD, Pessoni AM, et al (2020). Pathogenic Allodiploid Hybrids of Aspergillus Fungi. Current Biology, 30(13), 2495-2507.e7.
Ries LNA, Pardeshi L, Dong Z, Tan K, Steenwyk JL, Colabardini AC, Ferreira Filho JA, de Castro PA, Silva LP, Preite NW, et al (2020). The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence. PLOS Pathogens, 16(7), e1008645-e1008645. Full text.
de Assis LJ, Silva LP, Liu L, Schmitt K, Valerius O, Braus GH, Ries LNA, Goldman GH (2020). The High Osmolarity Glycerol Mitogen-Activated Protein Kinase regulates glucose catabolite repression in filamentous fungi. PLOS Genetics, 16(8), e1008996-e1008996. Full text.
Antonieto ACC, Nogueira KMV, de Paula RG, Nora LC, Cassiano MHA, Guazzaroni M-E, Almeida F, da Silva TA, Ries LNA, de Assis LJ, et al (2019). A Novel Cys2His2 Zinc Finger Homolog of AZF1 Modulates Holocellulase Expression in Trichoderma reesei. mSystems, 4(4). Abstract.  Author URL.
de Castro PA, Colabardini AC, Manfiolli AO, Chiaratto J, Silva LP, Mattos EC, Palmisano G, Almeida F, Persinoti GF, Ries LNA, et al (2019). Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance. PLOS Genetics, 15(12), e1008551-e1008551.
Mead ME, Knowles SL, Raja HA, Beattie SR, Kowalski CH, Steenwyk JL, Silva LP, Chiaratto J, Ries LNA, Goldman GH, et al (2019). Characterizing the Pathogenic, Genomic, and Chemical Traits of Aspergillus fischeri, a Close Relative of the Major Human Fungal Pathogen Aspergillus fumigatus. mSphere, 4(1). Abstract.
Knowles SL, Raja HA, Wright AJ, Lee AML, Caesar LK, Cech NB, Mead ME, Steenwyk JL, Ries LNA, Goldman GH, et al (2019). Mapping the Fungal Battlefield: Using in situ Chemistry and Deletion Mutants to Monitor Interspecific Chemical Interactions Between Fungi. Frontiers in Microbiology, 10
Ries LNA, Steenwyk JL, de Castro PA, de Lima PBA, Almeida F, de Assis LJ, Manfiolli AO, Takahashi-Nakaguchi A, Kusuya Y, Hagiwara D, et al (2019). Nutritional Heterogeneity Among Aspergillus fumigatus Strains Has Consequences for Virulence in a Strain- and Host-Dependent Manner. Front Microbiol, 10, 854-854. Abstract.
de Assis LJ, Manfiolli A, Mattos E, Fabri JHTM, Malavazi I, Jacobsen ID, Brock M, Cramer RA, Thammahong A, Hagiwara D, et al (2018). Protein Kinase a and High-Osmolarity Glycerol Response Pathways Cooperatively Control Cell Wall Carbohydrate Mobilization in Aspergillus fumigatus. mBio, 9(6). Abstract.
de Assis LJ, Ulas M, Ries LNA, El Ramli NAM, Sarikaya-Bayram O, Braus GH, Bayram O, Goldman GH (2018). Regulation ofAspergillus nidulansCreA-Mediated Catabolite Repression by the F-Box Proteins Fbx23 and Fbx47. mBio, 9(3). Abstract.
Ries LNA, José de Assis L, Rodrigues FJS, Caldana C, Rocha MC, Malavazi I, Bayram Ö, Goldman GH (2018). TheAspergillus nidulansPyruvate Dehydrogenase Kinases Are Essential to Integrate Carbon Source Metabolism. G3: Genes|Genomes|Genetics, 8(7), 2445-2463.
Beattie SR, Mark KMK, Thammahong A, Ries LNA, Dhingra S, Caffrey-Carr AK, Cheng C, Black CC, Bowyer P, Bromley MJ, et al (2017). Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression. PLOS Pathogens, 13(4), e1006340-e1006340.
Ries LNA, Beattie S, Cramer RA, Goldman GH (2017). Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi. Molecular Microbiology, 107(3), 277-297.
Ries LNA, Rocha MC, de Castro PA, Silva-Rocha R, Silva RN, Freitas FZ, de Assis LJ, Bertolini MC, Malavazi I, Goldman GH, et al (2017). The Aspergillus fumigatus CrzA Transcription Factor Activates Chitin Synthase Gene Expression during the Caspofungin Paradoxical Effect. mBio, 8(3). Abstract.  Full text.
dos Reis TF, Nitsche BM, de Lima PBA, de Assis LJ, Mellado L, Harris SD, Meyer V, dos Santos RAC, Riaño-Pachón DM, Ries LNA, et al (2017). The low affinity glucose transporter HxtB is also involved in glucose signalling and metabolism in Aspergillus nidulans. Scientific Reports, 7(1).
Ries LNA, Beattie SR, Espeso EA, Cramer RA, Goldman GH (2016). Diverse Regulation of the CreA Carbon Catabolite Repressor in Aspergillus nidulans. Genetics, 203(1), 335-352.
Pereira Silva L, Alves de Castro P, dos Reis TF, Paziani MH, Von Zeska Kress MR, Riaño-Pachón DM, Hagiwara D, Ries LNA, Brown NA, Goldman GH, et al (2016). Genome-wide transcriptome analysis ofAspergillus fumigatusexposed to osmotic stress reveals regulators of osmotic and cell wall stresses that are SakAHOG1and MpkC dependent. Cellular Microbiology, 19(4), e12681-e12681.
dos Reis TF, de Lima PBA, Parachin NS, Mingossi FB, de Castro Oliveira JV, Ries LNA, Goldman GH (2016). Identification and characterization of putative xylose and cellobiose transporters in Aspergillus nidulans. Biotechnology for Biofuels, 9(1).
Brown NA, Ries LNA, Reis TF, Rajendran R, Corrêa dos Santos RA, Ramage G, Riaño-Pachón DM, Goldman GH (2016). RNAseq reveals hydrophobins that are involved in the adaptation of Aspergillus nidulans to lignocellulose. Biotechnology for Biofuels, 9(1).
de Assis LJ, Ries LNA, Savoldi M, dos Reis TF, Brown NA, Goldman GH (2015). Aspergillus nidulans protein kinase a plays an important role in cellulase production. Biotechnology for Biofuels, 8(1).
Brown NA, dos Reis TF, Ries LNA, Caldana C, Mah J-H, Yu J-H, Macdonald JM, Goldman GH (2015). G-protein coupled receptor-mediated nutrient sensing and developmental control inAspergillus nidulans. Molecular Microbiology, 98(3), 420-439.
de Assis LJ, Ries LNA, Savoldi M, Dinamarco TM, Goldman GH, Brown NA (2015). Multiple Phosphatases Regulate Carbon Source-Dependent Germination and Primary Metabolism inAspergillus nidulans. G3: Genes|Genomes|Genetics, 5(5), 857-872.
Colabardini A, Ries LN, Brown N, dos Reis T, Savoldi M, Goldman MHS, Menino J, Rodrigues F, Goldman G (2014). Functional characterization of a xylose transporter in Aspergillus nidulans. Biotechnology for Biofuels, 7(1), 46-46.
Brown NA, Ries LNA, Goldman GH (2014). How nutritional status signalling coordinates metabolism and lignocellulolytic enzyme secretion. Fungal Genetics and Biology, 72, 48-63.
Colabardini AC, Ries LNA, Brown NA, Savoldi M, Dinamarco TM, von Zeska MR, Goldman MHS, Goldman GH (2014). Protein Kinase C Overexpression Suppresses Calcineurin-Associated Defects in Aspergillus nidulans and is Involved in Mitochondrial Function. PLoS ONE, 9(8), e104792-e104792.
Ries L, Pullan ST, Delmas S, Malla S, Blythe MJ, Archer DB (2013). Genome-wide transcriptional response of Trichoderma reesei to lignocellulose using RNA sequencing and comparison with Aspergillus niger. BMC Genomics, 14(1), 541-541.
Ries L, Belshaw NJ, Ilmén M, Penttilä ME, Alapuranen M, Archer DB (2013). The role of CRE1 in nucleosome positioning within the cbh1 promoter and coding regions of Trichoderma reesei. Applied Microbiology and Biotechnology, 98(2), 749-762.

Publications by year


2020

Filho APDC, Brancini GTP, de Castro PA, Valero C, Ferreira Filho JA, Silva LP, Rocha MC, Malavazi I, Pontes JGDM, Fill T, et al (2020). Aspergillus fumigatus G-Protein Coupled Receptors GprM and GprJ Are Important for the Regulation of the Cell Wall Integrity Pathway, Secondary Metabolite Production, and Virulence. mBio, 11(5). Abstract.
Drott MT, Bastos RW, Rokas A, Ries LNA, Gabaldón T, Goldman GH, Keller NP, Greco C (2020). Diversity of Secondary Metabolism in Aspergillus nidulans Clinical Isolates. mSphere, 5(2). Abstract.
Bastos RW, Valero C, Silva LP, Schoen T, Drott M, Brauer V, Silva-Rocha R, Lind A, Steenwyk JL, Rokas A, et al (2020). Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans. mSphere, 5(2). Abstract.
Steenwyk JL, Lind AL, Ries LNA, dos Reis TF, Silva LP, Almeida F, Bastos RW, Fraga da Silva TFDC, Bonato VLD, Pessoni AM, et al (2020). Pathogenic Allodiploid Hybrids of Aspergillus Fungi. Current Biology, 30(13), 2495-2507.e7.
Ries LNA, Pardeshi L, Dong Z, Tan K, Steenwyk JL, Colabardini AC, Ferreira Filho JA, de Castro PA, Silva LP, Preite NW, et al (2020). The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence. PLOS Pathogens, 16(7), e1008645-e1008645. Full text.
de Assis LJ, Silva LP, Liu L, Schmitt K, Valerius O, Braus GH, Ries LNA, Goldman GH (2020). The High Osmolarity Glycerol Mitogen-Activated Protein Kinase regulates glucose catabolite repression in filamentous fungi. PLOS Genetics, 16(8), e1008996-e1008996. Full text.

2019

Antonieto ACC, Nogueira KMV, de Paula RG, Nora LC, Cassiano MHA, Guazzaroni M-E, Almeida F, da Silva TA, Ries LNA, de Assis LJ, et al (2019). A Novel Cys2His2 Zinc Finger Homolog of AZF1 Modulates Holocellulase Expression in Trichoderma reesei. mSystems, 4(4). Abstract.  Author URL.
de Castro PA, Colabardini AC, Manfiolli AO, Chiaratto J, Silva LP, Mattos EC, Palmisano G, Almeida F, Persinoti GF, Ries LNA, et al (2019). Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance. PLOS Genetics, 15(12), e1008551-e1008551.
Mead ME, Knowles SL, Raja HA, Beattie SR, Kowalski CH, Steenwyk JL, Silva LP, Chiaratto J, Ries LNA, Goldman GH, et al (2019). Characterizing the Pathogenic, Genomic, and Chemical Traits of Aspergillus fischeri, a Close Relative of the Major Human Fungal Pathogen Aspergillus fumigatus. mSphere, 4(1). Abstract.
Knowles SL, Raja HA, Wright AJ, Lee AML, Caesar LK, Cech NB, Mead ME, Steenwyk JL, Ries LNA, Goldman GH, et al (2019). Mapping the Fungal Battlefield: Using in situ Chemistry and Deletion Mutants to Monitor Interspecific Chemical Interactions Between Fungi. Frontiers in Microbiology, 10
Ries LNA, Steenwyk JL, de Castro PA, de Lima PBA, Almeida F, de Assis LJ, Manfiolli AO, Takahashi-Nakaguchi A, Kusuya Y, Hagiwara D, et al (2019). Nutritional Heterogeneity Among Aspergillus fumigatus Strains Has Consequences for Virulence in a Strain- and Host-Dependent Manner. Front Microbiol, 10, 854-854. Abstract.

2018

de Assis LJ, Manfiolli A, Mattos E, Fabri JHTM, Malavazi I, Jacobsen ID, Brock M, Cramer RA, Thammahong A, Hagiwara D, et al (2018). Protein Kinase a and High-Osmolarity Glycerol Response Pathways Cooperatively Control Cell Wall Carbohydrate Mobilization in Aspergillus fumigatus. mBio, 9(6). Abstract.
de Assis LJ, Ulas M, Ries LNA, El Ramli NAM, Sarikaya-Bayram O, Braus GH, Bayram O, Goldman GH (2018). Regulation ofAspergillus nidulansCreA-Mediated Catabolite Repression by the F-Box Proteins Fbx23 and Fbx47. mBio, 9(3). Abstract.
Ries LNA, José de Assis L, Rodrigues FJS, Caldana C, Rocha MC, Malavazi I, Bayram Ö, Goldman GH (2018). TheAspergillus nidulansPyruvate Dehydrogenase Kinases Are Essential to Integrate Carbon Source Metabolism. G3: Genes|Genomes|Genetics, 8(7), 2445-2463.

2017

Beattie SR, Mark KMK, Thammahong A, Ries LNA, Dhingra S, Caffrey-Carr AK, Cheng C, Black CC, Bowyer P, Bromley MJ, et al (2017). Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression. PLOS Pathogens, 13(4), e1006340-e1006340.
Ries LNA, Beattie S, Cramer RA, Goldman GH (2017). Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi. Molecular Microbiology, 107(3), 277-297.
Ries LNA, Rocha MC, de Castro PA, Silva-Rocha R, Silva RN, Freitas FZ, de Assis LJ, Bertolini MC, Malavazi I, Goldman GH, et al (2017). The Aspergillus fumigatus CrzA Transcription Factor Activates Chitin Synthase Gene Expression during the Caspofungin Paradoxical Effect. mBio, 8(3). Abstract.  Full text.
dos Reis TF, Nitsche BM, de Lima PBA, de Assis LJ, Mellado L, Harris SD, Meyer V, dos Santos RAC, Riaño-Pachón DM, Ries LNA, et al (2017). The low affinity glucose transporter HxtB is also involved in glucose signalling and metabolism in Aspergillus nidulans. Scientific Reports, 7(1).

2016

Ries LNA, Beattie SR, Espeso EA, Cramer RA, Goldman GH (2016). Diverse Regulation of the CreA Carbon Catabolite Repressor in Aspergillus nidulans. Genetics, 203(1), 335-352.
Pereira Silva L, Alves de Castro P, dos Reis TF, Paziani MH, Von Zeska Kress MR, Riaño-Pachón DM, Hagiwara D, Ries LNA, Brown NA, Goldman GH, et al (2016). Genome-wide transcriptome analysis ofAspergillus fumigatusexposed to osmotic stress reveals regulators of osmotic and cell wall stresses that are SakAHOG1and MpkC dependent. Cellular Microbiology, 19(4), e12681-e12681.
dos Reis TF, de Lima PBA, Parachin NS, Mingossi FB, de Castro Oliveira JV, Ries LNA, Goldman GH (2016). Identification and characterization of putative xylose and cellobiose transporters in Aspergillus nidulans. Biotechnology for Biofuels, 9(1).
Brown NA, Ries LNA, Reis TF, Rajendran R, Corrêa dos Santos RA, Ramage G, Riaño-Pachón DM, Goldman GH (2016). RNAseq reveals hydrophobins that are involved in the adaptation of Aspergillus nidulans to lignocellulose. Biotechnology for Biofuels, 9(1).

2015

de Assis LJ, Ries LNA, Savoldi M, dos Reis TF, Brown NA, Goldman GH (2015). Aspergillus nidulans protein kinase a plays an important role in cellulase production. Biotechnology for Biofuels, 8(1).
Brown NA, dos Reis TF, Ries LNA, Caldana C, Mah J-H, Yu J-H, Macdonald JM, Goldman GH (2015). G-protein coupled receptor-mediated nutrient sensing and developmental control inAspergillus nidulans. Molecular Microbiology, 98(3), 420-439.
de Assis LJ, Ries LNA, Savoldi M, Dinamarco TM, Goldman GH, Brown NA (2015). Multiple Phosphatases Regulate Carbon Source-Dependent Germination and Primary Metabolism inAspergillus nidulans. G3: Genes|Genomes|Genetics, 5(5), 857-872.

2014

Colabardini A, Ries LN, Brown N, dos Reis T, Savoldi M, Goldman MHS, Menino J, Rodrigues F, Goldman G (2014). Functional characterization of a xylose transporter in Aspergillus nidulans. Biotechnology for Biofuels, 7(1), 46-46.
Brown NA, Ries LNA, Goldman GH (2014). How nutritional status signalling coordinates metabolism and lignocellulolytic enzyme secretion. Fungal Genetics and Biology, 72, 48-63.
Colabardini AC, Ries LNA, Brown NA, Savoldi M, Dinamarco TM, von Zeska MR, Goldman MHS, Goldman GH (2014). Protein Kinase C Overexpression Suppresses Calcineurin-Associated Defects in Aspergillus nidulans and is Involved in Mitochondrial Function. PLoS ONE, 9(8), e104792-e104792.

2013

Ries L, Pullan ST, Delmas S, Malla S, Blythe MJ, Archer DB (2013). Genome-wide transcriptional response of Trichoderma reesei to lignocellulose using RNA sequencing and comparison with Aspergillus niger. BMC Genomics, 14(1), 541-541.
Ries L, Belshaw NJ, Ilmén M, Penttilä ME, Alapuranen M, Archer DB (2013). The role of CRE1 in nucleosome positioning within the cbh1 promoter and coding regions of Trichoderma reesei. Applied Microbiology and Biotechnology, 98(2), 749-762.

Laure_Ries Details from cache as at 2020-11-27 02:33:12

Refresh publications

Teaching

Supervision / Group

Back | Edit Profile