Publications by category
Journal articles
Gardilla AC, Sanchez D, Brunt L, Scholpp S (In Press). From top to bottom: Cell polarity in Hedgehog and Wnt trafficking.
BMC Biology Full text.
Brunt L, Scholpp S (2018). The function of endocytosis in Wnt signaling.
Cellular and Molecular Life Sciences,
75(5), 785-795.
Abstract:
The function of endocytosis in Wnt signaling
© 2017, the Author(s). Wnt growth factors regulate one of the most important signaling networks during development, tissue homeostasis and disease. Despite the biological importance of Wnt signaling, the mechanism of endocytosis during this process is ill described. Wnt molecules can act as paracrine signals, which are secreted from the producing cells and transported through neighboring tissue to activate signaling in target cells. Endocytosis of the ligand is important at several stages of action: One central function of endocytic trafficking in the Wnt pathway occurs in the source cell. Furthermore, the β-catenin-dependent Wnt ligands require endocytosis for signal activation and to regulate gene transcription in the responding cells. Alternatively, Wnt/β-catenin-independent signaling regulates endocytosis of cell adherence plaques to control cell migration. In this comparative review, we elucidate these three fundamental interconnected functions, which together regulate cellular fate and cellular behavior. Based on established hypotheses and recent findings, we develop a revised picture for the complex function of endocytosis in the Wnt signaling network.
Abstract.
Full text.
Brunt LH, Begg K, Kague E, Cross S, Hammond CL (2017). Wnt signalling controls the response to mechanical loading during zebrafish joint development. Development, 144(15), 2798-2809.
Brunt LH, Roddy KA, Rayfield EJ, Hammond CL (2016). Building Finite Element Models to Investigate Zebrafish Jaw Biomechanics. Journal of Visualized Experiments(118).
Brunt LH, Skinner REH, Roddy KA, Araujo NM, Rayfield EJ, Hammond CL (2016). Differential effects of altered patterns of movement and strain on joint cell behaviour and skeletal morphogenesis. Osteoarthritis and Cartilage, 24(11), 1940-1950.
Brunt LH, Norton JL, Bright JA, Rayfield EJ, Hammond CL (2015). Finite element modelling predicts changes in joint shape and cell behaviour due to loss of muscle strain in jaw development. Journal of Biomechanics, 48(12), 3112-3122.
Mitchell RE, Huitema LFA, Skinner REH, Brunt LH, Severn C, Schulte-Merker S, Hammond CL (2013). New tools for studying osteoarthritis genetics in zebrafish. Osteoarthritis and Cartilage, 21(2), 269-278.
Publications by year
In Press
Gardilla AC, Sanchez D, Brunt L, Scholpp S (In Press). From top to bottom: Cell polarity in Hedgehog and Wnt trafficking.
BMC Biology Full text.
2018
Brunt L, Scholpp S (2018). The function of endocytosis in Wnt signaling.
Cellular and Molecular Life Sciences,
75(5), 785-795.
Abstract:
The function of endocytosis in Wnt signaling
© 2017, the Author(s). Wnt growth factors regulate one of the most important signaling networks during development, tissue homeostasis and disease. Despite the biological importance of Wnt signaling, the mechanism of endocytosis during this process is ill described. Wnt molecules can act as paracrine signals, which are secreted from the producing cells and transported through neighboring tissue to activate signaling in target cells. Endocytosis of the ligand is important at several stages of action: One central function of endocytic trafficking in the Wnt pathway occurs in the source cell. Furthermore, the β-catenin-dependent Wnt ligands require endocytosis for signal activation and to regulate gene transcription in the responding cells. Alternatively, Wnt/β-catenin-independent signaling regulates endocytosis of cell adherence plaques to control cell migration. In this comparative review, we elucidate these three fundamental interconnected functions, which together regulate cellular fate and cellular behavior. Based on established hypotheses and recent findings, we develop a revised picture for the complex function of endocytosis in the Wnt signaling network.
Abstract.
Full text.
2017
Brunt LH, Begg K, Kague E, Cross S, Hammond CL (2017). Wnt signalling controls the response to mechanical loading during zebrafish joint development. Development, 144(15), 2798-2809.
2016
Brunt LH, Roddy KA, Rayfield EJ, Hammond CL (2016). Building Finite Element Models to Investigate Zebrafish Jaw Biomechanics. Journal of Visualized Experiments(118).
Brunt LH, Skinner REH, Roddy KA, Araujo NM, Rayfield EJ, Hammond CL (2016). Differential effects of altered patterns of movement and strain on joint cell behaviour and skeletal morphogenesis. Osteoarthritis and Cartilage, 24(11), 1940-1950.
2015
Brunt LH, Norton JL, Bright JA, Rayfield EJ, Hammond CL (2015). Finite element modelling predicts changes in joint shape and cell behaviour due to loss of muscle strain in jaw development. Journal of Biomechanics, 48(12), 3112-3122.
2013
Mitchell RE, Huitema LFA, Skinner REH, Brunt LH, Severn C, Schulte-Merker S, Hammond CL (2013). New tools for studying osteoarthritis genetics in zebrafish. Osteoarthritis and Cartilage, 21(2), 269-278.