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Dr Mario Recker

Dr Mario Recker

Associate Professor

 01326 259329

 Stella Turk Building 

 

University of Exeter, Penryn Campus, Penryn, TR10 9FE

Overview

I am a mathematical biologist with a research focus on the evolutionary ecology and epidemiology of infectious diseases, such as malaria, dengue and (drug resistant) Staphylococcus aureus. I am particularly interested in multi-scale host-pathogen interactions and how these affect infection pathologies, pathogen evolution and disease incidence across time and space. For this I employ a wide variety of mathematical and computational techniques, from individual-based and population-level modelling to advanced statistical methods and machine learning approaches. 

Qualifications

  • DPhil, Zoology (2000 - 2003, University of Oxford)
  • MSc, Nonlinear Dynamics & Chaos (1999 - 2000, UCL)
  • Diplom Mathematiker (1995 - 1999, TFH Berlin)

Research

Research interests

Many pathogens utilise antigenic and phenotypic diversity as a means to avoid detection and clearance by the host’s immune system. This enables them to remain within the host for prolonged periods of time, allows the pathogen to establish infections in previously exposed individuals and can lead to highly varied infection outcomes. My research focuses on the multifaceted epidemiology of antigenically and phenotypically diverse pathogens, such as Plasmodium falciparum, dengue or Staphylococcus aureus. With the help of mathematical and data analytic frameworks and in close collaboration with field and laboratory scientists I investigate the pathology and evolutionary epidemiology of these pathogens, focusing on host-pathogen interactions at multiple ecological scales that link within-host processes of gene expression and immune selection to between-host epidemiological patterns of infection and disease.

Malaria

The causative agent of severe malaria in humans, Plasmodium falciparum, employs a sophisticated immune evasion strategy, called antigenic variation, to circumvent the host's immune pressure and maintain long-lasting infections. Central to this process is the var multi-gene family, which encode the cell-surface antigens PfEMP1. Mutually exclusive switching between ~60 members of these highly polymorphic genes ensures that only a small fraction of the whole antigenic repertoire is exposed to the immune system at a time. PfEMP1 are also involved in malaria virulence. They mediate the attachment of parasitised red blood cells to host tissues, which can then lead to parasite sequestration and obstruction of blood flow in vital organs, such as the brain or placenta. Different PfEMP1 variants adhere to different host tissues, and antigenic switches between var genes can therefore also lead to a phenotypic change during the course of an infection. The involvement of var genes and var gene switching is therefore central for our understanding of the infection dynamics, pathology and epidemiology of P. falciparum malaria.

I am particularly interested in the underlying patterns of var gene switching, and how these relate to observed gene expression pattern in individuals growing up in malaria endemic regions. E.g. we have shown that antigenic switching is a highly non-random process in which different genes have different, hard-wired switch characteristics in terms of the rates at which they are activated or silenced [Noble et al. (2013), Recker et al. (2011)]. Furthermore, we could show the resulting switch hierarchy is inherently linked to gene recombination and therefore the generation of further antigenic diversity in these parasites. My work currently focuses on developing multi-scale, mathematical frameworks that integrate molecular genetic processes with the dynamics of within-host infections and between-host epidemiologies.

Selected Publications

  • Valletta JJ, & Recker M (2017). Identi cation of immune signatures predictive of clinical protection from malaria. PLoS Comput. Biol., 13(10):e1005812

  • Holding T, & Recker M (2015). Maintenance of phenotypic diversity within a set of virulence encoding genes of the malaria parasite Plasmodium falciparumJ R Soc Interface, 12(113)

  • Noble R, Christodoulou Z, Kyes S, Pinches R , Newbold CI, & Recker M (2013). The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malaria. eLife 2013;2:e01074

  • Buckee CO, & Recker M (2012). Evolution of the multi-domain structures of virulence genes in the human malaria parasite Plasmodium falciparum. PLoS Comp Biol, 8(4): e1002451

  • Portugal S, Carret C, Recker M, Armitage AE, Goncalves LA, Epiphanio S, Sullivan D, Roy C, Newbold CI, Drakesmith H, & Mota MM (2011).  Host-mediated regulation of superinfection in malaria. Nat Med, 17(6):732-737

  • Recker M, Buckee CO, Serazin A, Kyes S, Pinches R, Christodoulou Z, Springer AL, Gupta S, Newbold CI (2011). Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern. PLoS Pathog, 7(3):e1001306

  • Recker M, Nee S, Bull PC, Kinyanjui S, Marsh K, Newbold C, & Gupta S (2004). Transient cross-reactive immune responses can orchestrate anti­genic variation in malaria. Nature, 429(6991):555-8

Dengue

In less than six decades dengue has emerged from South East Asia to become the most widespread arbovirus affecting human populations. A recent dramatic increase in epidemic dengue fever has mainly been attributed to factors such as vector expansion and ongoing ecological, climate and socio-demographic changes. The lack of antivirals or vaccines and the current failure to control the pathogen in endemic regions and to prevent globalized distribution of the vector-species and viral variants underlines the urgency for reassessment of previous research methods, hypothesis and empirical observations.

Previous modelling approaches have mostly focused on the impact of immunological competition between dengue’s four serotypes (DENV1-4), which can generate a frequency-dependent mechanism that partially explains dengue's temporal epidemiological patterns. We have developed a spatially explicit, individual-based model to investigate the effects of demographic and ecological stochasticities. Our model demonstrated that amplification of natural stochastic differences in disease transmission can give rise to persistent oscillations comprising semi-regular epidemic outbreaks and sequential serotype dominance that are characteristic of dengue's epidemiological dynamics. Work is currently under way to address such questions as if and how host ecological and demographic heterogeneities are shaping the viral evolution of dengue, and how different population structures (small-world, lattice, scale-free, etc) can affect the spatial epidemiology of dengue, including persistence and synchrony? This work also extends to other arborival diseases, such as chikungunya and zika.

Selected Publications

  • Lourenco J, de Lima MM, Faria NR, Walker A, Kraemer MU, Villabona-Arenas CJ, Lambert B, Marques de Cerqueira E, Pybus OG, Alcantara LC, & Recker M (2017). Epidemiological and ecological determinants of Zika virus transmission in an urban setting. eLife, 6:e29820

  • Flasche S, Jit M, Rodríguez-Barraquer I, Coudeville L, Recker M*et al. (2016). The long term safety, public health impact, and cost effectiveness of routine vaccination with a recombinant, live-attenuated dengue vaccine (Dengvaxia): a model comparison study.  PLoS Medicine, 13(11):e1002181

  • Lourenço J, & Recker M (2016). Dengue serotype immune-interactions and their consequences for vaccine impact predictions. Epidemics, 16: 40-48

  • Lourenço J, & Recker M (2014). The 2012 Madeira dengue outbreak: epidemiological determinants and future epidemic potential. PLoS Negl Trop Dis, 8(8):e3083

  • Lourenço J, & Recker M (2013). Natural, persistent oscillations in a spatial multi-strain disease system with application to dengue. PLoS Comp Biol, 9(10): e1003308

MRSA

Antimicrobial resistance (AMR) is a major global public health issue, making first-line treatments of many bacterial infections ineffective. One of the best known examples is the methicillin-resistant Staphylococcus aureus, or MRSA. It is the most common cause of hospital-acquired infections although community-acquired MRSA (CA-MRSA) is also becoming of increasing concern. S. aureus is an opportunistic pathogen. It colonises around 30% of the human population, where its interactions with the human hosts are largely asymptomatic. Infections most commonly result from breaches in the host’s innate immunity and can result in both acute and chronic disease. The most severe form of infection occurs when S. aureus gains access to the blood stream, which is referred to as bacteraemia. This is often aided by breakages in the skin or mucosal membranes, for example due to surgery or the use of catheters, and can lead to very high fatality rate in the absence of antibiotic treatment.  

The genes expressed by S. aureus and their interaction with the human immune system facilitating such varied infections are not fully understood, and my work on MRSA focuses on understanding this bacterial virulence as a complex phenotype. In collaboration with researchers at Bath University and by using whole genome approaches, combined with functional genomics, mathematical and statistical modelling we have made important headway in seeking to map phenotype directly from genotype (Laabei et al. (2014)) and to understand how bacterial virulence evolved as a trade-off between maintaining fitness at the within-host level and at the between-host level (Laabei et al. (2015)). By analysing fully sequenced and phenotyped, clinical isolates we are currently investigating if and to what degree severe infection outcomes can be predicted using machine learning algorithms, which would be an important step towards personalised medicine and infectious disease management.

Selected Publications

  • Recker, M, Laabei M, Toleman MS, Reuter S, Saunderson RB, Blane B, Torok ME, Ouadi K, Stevens E, Yokoyama M, Steventon J, Thompson L, Milne G, Bayliss S, Bacon L, Peacock SJ, & Massey RC (2017). Clonal di erences in Staphylococcus aureus bacteraemia-associated mortality. Nat Microbiol, 2(10):1381-1388

  • Laabei M, Uhlemann AC, Lowy FD, Austin ED, Yokoyama M, Ouadi K, Feil E, Thorpe HA, Williams B, Perkins M, Peacock SJ, Clarke SR, Dordel J, Holden M, Votintseva AA, Bowden R, Crook DW, Young BC, Wilson DJ, Recker M, Massey RC (2015) Evolutionary Trade-Offs Underlie the Multi-faceted Virulence of Staphylococcus aureusPLoS Biol, 13(9):e1002229

  • Laabei M, Recker M, Rudkin J, Sloan T, Williams P, Lewis K, Scowen L, Peacock S, van den Elsen J, Priest N, Feil E, Josefsson E, & Massey RC (2014). Predicting the virulence of MRSA from its genome sequence. Genome Res, 24: 839-849

  • Priest NK, RudkinJ, Feil EJ, van den Elsen J, Cheung A, Peacock JP, Laabei M, Lucks DA, Recker M, & Massey RC (2012). From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence. Nat Rev Microbiol, 10(11):791-7

  • Collins J, Rudkin J, Recker M, Pozzi C, O'Gara JP, & Massey RC (2010). Offsetting virulence and antibiotic resistance costs by MRSA. ISME J, 4(4):577-84

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Tennant W, McKinley T, Recker M (In Press). Inferring the ecological drivers of arboviral outbreaks.  Abstract.
Silva-Filho JL, Lacerda MVG, Recker M, Wassmer SC, Marti M, Costa FTM (2020). Erratum: Plasmodium vivax in Hematopoietic Niches: Hidden and Dangerous: (Trends in Parasitology 36, 447–458, 2020) (Trends in Parasitology (2020) 36(5) (447–458), (S1471492220300611), (10.1016/j.pt.2020.03.002)). Trends in Parasitology, 36(7), 648-649. Abstract.
Andrade CM, Fleckenstein H, Thomson-Luque R, Doumbo S, Lima NF, Anderson C, Hibbert J, Hopp CS, Tran TM, Li S, et al (2020). Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season. Nature Medicine
Silva-Filho JL, Lacerda MVG, Recker M, Wassmer SC, Marti M, Costa FTM (2020). Plasmodium vivax in Hematopoietic Niches: Hidden and Dangerous. Trends in Parasitology, 36(5), 447-458. Abstract.  Full text.
Talavera-López C, Bediako Y, Lin J-W, Joseph Valletta J, Recker M, Langhorne J (2019). Comparison of whole blood and spleen transcriptional signatures over the course of an experimental malaria infection. Sci Rep, 9(1). Abstract.  Author URL.
Bediako Y, Adams R, Reid AJ, Valletta JJ, Ndungu FM, Sodenkamp J, Mwacharo J, Ngoi JM, Kimani D, Kai O, et al (2019). Repeated clinical malaria episodes are associated with modification of the immune system in children. BMC Med, 17(1). Abstract.  Author URL.
Klumper U, Recker M, Zhang L, Yin X, Zhang T, Buckling A, Gaze W (2019). Selection for antimicrobial resistance is reduced when embedded in a natural microbial community. The ISME Journal Full text.
Yokoyama M, Stevens E, Laabei M, Bacon L, Heesom K, Bayliss S, Ooi N, O'Neill AJ, Murray E, Williams P, et al (2018). Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA. Genome Biology, 19(1). Abstract.  Full text.
Archer CR, Recker M, Duffy E, Hosken DJ (2018). Intralocus sexual conflict can resolve the male-female health-survival paradox. Nature Communications, 9(1). Abstract.  Full text.
Holding T, Valletta JJ, Recker M (2018). Multiscale immune selection and the transmission-diversity feedback in antigenically diverse pathogen systems. American Naturalist, 192(6), E189-E201. Abstract.  Full text.
Gates DE, Valletta JJ, Bonneaud C, Recker M (2018). Quantitative host resistance drives the evolution of increased virulence in an emerging pathogen. J Evol Biol, 31(11), 1704-1714. Abstract.  Author URL.  Full text.
Recker M, Buckee CO, Bull P (2018). Recent advances in the molecular epidemiology of clinical malaria. F1000Research Full text.
Tennant W, Recker M (2018). Robustness of the reproductive number estimates in vector-borne disease systems. PLoS Neglected Tropical Diseases, 12(12). Abstract.  Full text.
Lourenço J, Tennant W, Faria NR, Walker A, Gupta S, Recker M (2017). Challenges in dengue research: a computational perspective. Evolutionary Applications, 11(4), 516-533. Full text.
Recker M, Laabei M, Toleman MS, Reuter S, Saunderson RB, Blane B, Török ME, Ouadi K, Stevens E, Yokoyama M, et al (2017). Clonal differences in Staphylococcus aureus bacteraemia-associated mortality. Nat Microbiol, 2(10), 1381-1388. Abstract.  Author URL.  Full text.
Lourenço J, de Lima MM, Faria NR, Walker A, Kraemer MUG, Villabona-Arenas CJ, Lambert B, de Cerqueira EM, Pybus OG, Alcantara LCJ, et al (2017). Epidemiological and ecological determinants of Zika virus transmission in an urban setting. eLife, 6 Abstract.  Full text.
Valletta JJ, Recker M (2017). Identification of immune signatures predictive of clinical protection from malaria. PLoS Comput Biol, 13(10). Abstract.  Author URL.  Full text.
Recker M, Vannice K, Hombach J, Jit M, Simmons CP (2016). Assessing dengue vaccination impact: Model challenges and future directions. Vaccine, 34(38), 4461-4465. Abstract.  Full text.
Lourenço J, Recker M (2016). Dengue serotype immune-interactions and their consequences for vaccine impact predictions. Epidemics, 16, 40-48. Abstract.  Full text.
Flasche S, Jit M, Rodríguez-Barraquer I, Coudeville L, Recker M, Koelle K, Milne G, Hladish TJ, Perkins TA, Cummings DAT, et al (2016). The Long-Term Safety, Public Health Impact, and Cost-Effectiveness of Routine Vaccination with a Recombinant, Live-Attenuated Dengue Vaccine (Dengvaxia): a Model Comparison Study. PLoS Medicine, 13(11). Abstract.  Full text.
Laabei M, Uhlemann AC, Lowy FD, Austin ED, Yokoyama M, Ouadi K, Feil E, Thorpe HA, Williams B, Perkins M, et al (2015). Evolutionary Trade-Offs Underlie the Multi-faceted Virulence of Staphylococcus aureus. PLoS Biology, 13(9). Abstract.  Full text.
Holding T, Recker M (2015). Maintenance of phenotypic diversity within a set of virulence encoding genes of the malaria parasite Plasmodium falciparum. Journal of the Royal Society Interface, 12(113). Abstract.  Full text.
Laabei M, Recker M, Rudkin JK, Aldeljawi M, Gulay Z, Sloan TJ, Williams P, Endres JL, Bayles KW, Fey PD, et al (2014). Predicting the virulence of MRSA from its genome sequence. Genome Research, 24(5), 839-849. Abstract.  Full text.
Heiny SR, Pautz S, Recker M, Przyborski JM (2014). Protein traffic to the plasmodium falciparum apicoplast: Evidence for a sorting branch point at the Golgi. Traffic, 15(12), 1290-1304. Abstract.
Lourenço J, Recker M (2014). The 2012 Madeira dengue outbreak: epidemiological determinants and future epidemic potential. PLoS Negl Trop Dis, 8(8). Abstract.  Author URL.  Full text.
Lourenço J, Recker M (2013). Natural, persistent oscillations in a spatial multi-strain disease system with application to dengue. PLoS computational biology, 9(10). Abstract.  Full text.
Warimwe GM, Recker M, Kiragu EW, Buckee CO, Wambua J, Musyoki JN, Marsh K, Bull PC (2013). Plasmodium falciparum var Gene Expression Homogeneity as a Marker of the Host-Parasite Relationship under Different Levels of Naturally Acquired Immunity to Malaria. PLoS ONE, 8(7). Abstract.  Full text.
Wikramaratna PS, Sandeman M, Recker M, Gupta S (2013). The antigenic evolution of influenza: Drift or thrift?. Philosophical Transactions of the Royal Society B: Biological Sciences, 368(1614). Abstract.
Wikramaratna PS, Sandeman M, Recker M, Gupta S (2013). The antigenic evolution of influenza: drift or thrift?. Philos Trans R Soc Lond B Biol Sci, 368(1614). Abstract.  Author URL.  Full text.
Noble R, Christodoulou Z, Kyes S, Pinches R, Newbold CI, Recker M (2013). The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malaria. Elife, 2 Abstract.  Author URL.  Full text.
Noble R, Recker M (2012). A statistically rigorous method for determining antigenic switching networks. PLoS One, 7(6). Abstract.  Author URL.  Full text.
Beatty M, Boni MF, Brown S, Buathong R, Burke D, Coudeville L, Cummings DAT, Edelman R, Farrar J, Focks DA, et al (2012). Assessing the Potential of a Candidate Dengue Vaccine with Mathematical Modeling. PLOS NEGLECTED TROPICAL DISEASES, 6(3). Author URL.
Fastman Y, Noble R, Recker M, Dzikowski R (2012). Erasing the epigenetic memory and beginning to switch-the onset of antigenic switching of var genes in plasmodium falciparum. PLoS ONE, 7(3). Abstract.  Full text.
Buckee CO, Recker M (2012). Evolution of the multi-domain structures of virulence genes in the human malaria parasite, Plasmodium falciparum. PLoS Computational Biology, 8(4). Abstract.  Full text.
Priest NK, Rudkin JK, Feil EJ, Van Den Elsen JMH, Cheung A, Peacock SJ, Laabei M, Lucks DA, Recker M, Massey RC, et al (2012). From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence. Nature Reviews Microbiology, 10(11), 791-797. Abstract.
Recker M, Buckee CO, Serazin A, Kyes S, Pinches R, Christodoulou Z, Springer AL, Gupta S, Newbold CI (2011). Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern. PLoS Pathog, 7(3). Abstract.  Author URL.  Full text.
Portugal S, Carret C, Recker M, Armitage AE, Gonçalves LA, Epiphanio S, Sullivan D, Roy C, Newbold CI, Drakesmith H, et al (2011). Host-mediated regulation of superinfection in malaria. Nature Medicine, 17(6), 732-737. Abstract.
Buckee CO, Recker M, Watkins ER, Gupta S (2011). Role of stochastic processes in maintaining discrete strain structure in antigenically diverse pathogen populations. Proc Natl Acad Sci U S A, 108(37), 15504-15509. Abstract.  Author URL.
Collins J, Rudkin J, Recker M, Pozzi C, O'Gara JP, Massey RC (2010). Offsetting virulence and antibiotic resistance costs by MRSA. ISME J, 4(4), 577-584. Abstract.  Author URL.
Wikramaratna PS, Simmons CP, Gupta S, Recker M (2010). The effects of tertiary and quaternary infections on the epidemiology of dengue. PLoS One, 5(8). Abstract.  Author URL.  Full text.
Kiss IZ, Cassell J, Recker M, Simon PL (2010). The impact of information transmission on epidemic outbreaks. Mathematical Biosciences, 225(1), 1-10. Abstract.
Lourenço J, Recker M (2010). Viral and epidemiological determinants of the invasion dynamics of novel dengue genotypes. PLoS Negl Trop Dis, 4(11). Abstract.  Author URL.  Full text.
Recker M, Bouma MJ, Bamford P, Gupta S, Dobson AP (2009). Assessing the burden of pregnancy-associated malaria under changing transmission settings. Malar J, 8 Abstract.  Author URL.  Full text.
Recker M, Blyuss KB, Simmons CP, Hien TT, Wills B, Farrar J, Gupta S (2009). Immunological serotype interactions and their effect on the epidemiological pattern of dengue. Proc Biol Sci, 276(1667), 2541-2548. Abstract.  Author URL.  Full text.
Buckee CO, Jolley KA, Recker M, Penman B, Kriz P, Gupta S, Maiden MCJ (2008). Role of selection in the emergence of lineages and the evolution of virulence in Neisseria meningitidis. Proc Natl Acad Sci U S A, 105(39), 15082-15087. Abstract.  Author URL.
Recker M, Arinaminpathy N, Buckee CO (2008). The effects of a partitioned var gene repertoire of Plasmodium falciparum on antigenic diversity and the acquisition of clinical immunity. Malar J, 7 Abstract.  Author URL.  Full text.
Recker M, Pybus OG, Nee S, Gupta S (2007). The generation of influenza outbreaks by a network of host immune responses against a limited set of antigenic types. Proc Natl Acad Sci U S A, 104(18), 7711-7716. Abstract.  Author URL.
Recker M, Gupta S (2006). Conflicting immune responses can prolong the length of infection in Plasmodium falciparum malaria. Bull Math Biol, 68(4), 821-835. Abstract.  Author URL.
Massey RC, Horsburgh MJ, Lina G, Höök M, Recker M (2006). The evolution and maintenance of virulence in Staphylococcus aureus: a role for host-to-host transmission?. Nat Rev Microbiol, 4(12), 953-958. Abstract.  Author URL.
Recker M, Al-Bader R, Gupta S (2005). A mathematical model for a new mechanism of phenotypic variation in malaria. Parasitology, 131(2), 151-159. Abstract.
Recker M, Al-Bader R, Gupta S (2005). A mathematical model for a new mechanism of phenotypic variation in malaria. Parasitology, 131(Pt 2), 151-159. Abstract.  Author URL.
Recker M, Gupta S (2005). A model for pathogen population structure with cross-protection depending on the extent of overlap in antigenic variant repertoires. J Theor Biol, 232(3), 363-373. Abstract.  Author URL.
Williams TN, Mwangi TW, Wambua S, Peto TEA, Weatherall DJ, Gupta S, Recker M, Penman BS, Uyoga S, MacHaria A, et al (2005). Negative epistasis between the malaria-protective effects of α<sup>+</sup>-thalassemia and the sickle cell trait. Nature Genetics, 37(11), 1253-1257. Abstract.
Recker M, Nee S, Bull PC, Kinyanjui S, Marsh K, Newbold C, Gupta S (2004). Transient cross-reactive immune responses can orchestrate antigenic variation in malaria. Nature, 429(6991), 555-558. Abstract.  Author URL.

Conferences

Tennant W, Lourenco J, Faria N, Junior Alcantara L, Recker M (2018). INFLUENCE OF TEMPERATURE AND RAINFALL ON THE EPIDEMIOLOGY OF ARBOVIRAL DISEASES IN ENVIRONMENTALLY DISTINCTIVE REGIONS OF BRAZIL.  Author URL.
Bediako Y, Adams R, Reid A, Valletta J, Ndungu F, Mwacharo J, Ngoi J, Kimani D, Kai O, Wambua J, et al (2018). INVESTIGATING IMMUNE SIGNATURES IN MALARIA-EXPOSED CHILDREN.  Author URL.
Valletta JJ, Lin J, Recker M, Langhorne J (2017). COMPARATIVE TRANSCRIPTOME ANALYSIS OF THE HOST RESPONSE IN BLOOD AND SPLEEN DURING THE COURSE OF a PLASMODIUM CHABAUDI CHABAUDI INFECTION.  Author URL.
Tennant WS, Recker M (2017). EFFECTS OF COMMUNITY STRUCTURES AND ENVIRONMENTAL HETEROGENEITIES ON THE SPREAD AND PERSISTENCE OF DENGUE.  Author URL.
Recker M, Valletta JJ (2017). IDENTIFICATION OF IMMUNE SIGNATURES UNDERLYING CLINICAL IMMUNITY TO PLASMODIUM FALCIPARUM MALARIA.  Author URL.
Holding T, Recker M (2017). PLASMODIUM FALCIPARUM EPIDEMIOLOGY IS GOVERNED BY MULTI-SCALE IMMUNE SELECTION AND a DIVERSITY-TRANSMISSION FEEDBACK.  Author URL.

Publications by year


In Press

Tennant W, McKinley T, Recker M (In Press). Inferring the ecological drivers of arboviral outbreaks.  Abstract.

2020

Silva-Filho JL, Lacerda MVG, Recker M, Wassmer SC, Marti M, Costa FTM (2020). Erratum: Plasmodium vivax in Hematopoietic Niches: Hidden and Dangerous: (Trends in Parasitology 36, 447–458, 2020) (Trends in Parasitology (2020) 36(5) (447–458), (S1471492220300611), (10.1016/j.pt.2020.03.002)). Trends in Parasitology, 36(7), 648-649. Abstract.
Andrade CM, Fleckenstein H, Thomson-Luque R, Doumbo S, Lima NF, Anderson C, Hibbert J, Hopp CS, Tran TM, Li S, et al (2020). Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season. Nature Medicine
Silva-Filho JL, Lacerda MVG, Recker M, Wassmer SC, Marti M, Costa FTM (2020). Plasmodium vivax in Hematopoietic Niches: Hidden and Dangerous. Trends in Parasitology, 36(5), 447-458. Abstract.  Full text.
Tennant W (2020). The Effects of Spatio-Temporal Heterogeneities on the Emergence and Spread of Dengue Virus.  Abstract.  Full text.

2019

Talavera-López C, Bediako Y, Lin J-W, Joseph Valletta J, Recker M, Langhorne J (2019). Comparison of whole blood and spleen transcriptional signatures over the course of an experimental malaria infection. Sci Rep, 9(1). Abstract.  Author URL.
Bediako Y, Adams R, Reid AJ, Valletta JJ, Ndungu FM, Sodenkamp J, Mwacharo J, Ngoi JM, Kimani D, Kai O, et al (2019). Repeated clinical malaria episodes are associated with modification of the immune system in children. BMC Med, 17(1). Abstract.  Author URL.
Klumper U, Recker M, Zhang L, Yin X, Zhang T, Buckling A, Gaze W (2019). Selection for antimicrobial resistance is reduced when embedded in a natural microbial community. The ISME Journal Full text.

2018

Yokoyama M, Stevens E, Laabei M, Bacon L, Heesom K, Bayliss S, Ooi N, O'Neill AJ, Murray E, Williams P, et al (2018). Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA. Genome Biology, 19(1). Abstract.  Full text.
Tennant W, Lourenco J, Faria N, Junior Alcantara L, Recker M (2018). INFLUENCE OF TEMPERATURE AND RAINFALL ON THE EPIDEMIOLOGY OF ARBOVIRAL DISEASES IN ENVIRONMENTALLY DISTINCTIVE REGIONS OF BRAZIL.  Author URL.
Bediako Y, Adams R, Reid A, Valletta J, Ndungu F, Mwacharo J, Ngoi J, Kimani D, Kai O, Wambua J, et al (2018). INVESTIGATING IMMUNE SIGNATURES IN MALARIA-EXPOSED CHILDREN.  Author URL.
Archer CR, Recker M, Duffy E, Hosken DJ (2018). Intralocus sexual conflict can resolve the male-female health-survival paradox. Nature Communications, 9(1). Abstract.  Full text.
Holding T, Valletta JJ, Recker M (2018). Multiscale immune selection and the transmission-diversity feedback in antigenically diverse pathogen systems. American Naturalist, 192(6), E189-E201. Abstract.  Full text.
Gates DE, Valletta JJ, Bonneaud C, Recker M (2018). Quantitative host resistance drives the evolution of increased virulence in an emerging pathogen. J Evol Biol, 31(11), 1704-1714. Abstract.  Author URL.  Full text.
Recker M, Buckee CO, Bull P (2018). Recent advances in the molecular epidemiology of clinical malaria. F1000Research Full text.
Tennant W, Recker M (2018). Robustness of the reproductive number estimates in vector-borne disease systems. PLoS Neglected Tropical Diseases, 12(12). Abstract.  Full text.

2017

Valletta JJ, Lin J, Recker M, Langhorne J (2017). COMPARATIVE TRANSCRIPTOME ANALYSIS OF THE HOST RESPONSE IN BLOOD AND SPLEEN DURING THE COURSE OF a PLASMODIUM CHABAUDI CHABAUDI INFECTION.  Author URL.
Lourenço J, Tennant W, Faria NR, Walker A, Gupta S, Recker M (2017). Challenges in dengue research: a computational perspective. Evolutionary Applications, 11(4), 516-533. Full text.
Recker M, Laabei M, Toleman MS, Reuter S, Saunderson RB, Blane B, Török ME, Ouadi K, Stevens E, Yokoyama M, et al (2017). Clonal differences in Staphylococcus aureus bacteraemia-associated mortality. Nat Microbiol, 2(10), 1381-1388. Abstract.  Author URL.  Full text.
Tennant WS, Recker M (2017). EFFECTS OF COMMUNITY STRUCTURES AND ENVIRONMENTAL HETEROGENEITIES ON THE SPREAD AND PERSISTENCE OF DENGUE.  Author URL.
Lourenço J, de Lima MM, Faria NR, Walker A, Kraemer MUG, Villabona-Arenas CJ, Lambert B, de Cerqueira EM, Pybus OG, Alcantara LCJ, et al (2017). Epidemiological and ecological determinants of Zika virus transmission in an urban setting. eLife, 6 Abstract.  Full text.
Recker M, Valletta JJ (2017). IDENTIFICATION OF IMMUNE SIGNATURES UNDERLYING CLINICAL IMMUNITY TO PLASMODIUM FALCIPARUM MALARIA.  Author URL.
Valletta JJ, Recker M (2017). Identification of immune signatures predictive of clinical protection from malaria. PLoS Comput Biol, 13(10). Abstract.  Author URL.  Full text.
Holding T, Recker M (2017). PLASMODIUM FALCIPARUM EPIDEMIOLOGY IS GOVERNED BY MULTI-SCALE IMMUNE SELECTION AND a DIVERSITY-TRANSMISSION FEEDBACK.  Author URL.

2016

Recker M, Vannice K, Hombach J, Jit M, Simmons CP (2016). Assessing dengue vaccination impact: Model challenges and future directions. Vaccine, 34(38), 4461-4465. Abstract.  Full text.
Lourenço J, Recker M (2016). Dengue serotype immune-interactions and their consequences for vaccine impact predictions. Epidemics, 16, 40-48. Abstract.  Full text.
Flasche S, Jit M, Rodríguez-Barraquer I, Coudeville L, Recker M, Koelle K, Milne G, Hladish TJ, Perkins TA, Cummings DAT, et al (2016). The Long-Term Safety, Public Health Impact, and Cost-Effectiveness of Routine Vaccination with a Recombinant, Live-Attenuated Dengue Vaccine (Dengvaxia): a Model Comparison Study. PLoS Medicine, 13(11). Abstract.  Full text.

2015

Laabei M, Uhlemann AC, Lowy FD, Austin ED, Yokoyama M, Ouadi K, Feil E, Thorpe HA, Williams B, Perkins M, et al (2015). Evolutionary Trade-Offs Underlie the Multi-faceted Virulence of Staphylococcus aureus. PLoS Biology, 13(9). Abstract.  Full text.
Holding T, Recker M (2015). Maintenance of phenotypic diversity within a set of virulence encoding genes of the malaria parasite Plasmodium falciparum. Journal of the Royal Society Interface, 12(113). Abstract.  Full text.

2014

Laabei M, Recker M, Rudkin JK, Aldeljawi M, Gulay Z, Sloan TJ, Williams P, Endres JL, Bayles KW, Fey PD, et al (2014). Predicting the virulence of MRSA from its genome sequence. Genome Research, 24(5), 839-849. Abstract.  Full text.
Heiny SR, Pautz S, Recker M, Przyborski JM (2014). Protein traffic to the plasmodium falciparum apicoplast: Evidence for a sorting branch point at the Golgi. Traffic, 15(12), 1290-1304. Abstract.
Lourenço J, Recker M (2014). The 2012 Madeira dengue outbreak: epidemiological determinants and future epidemic potential. PLoS Negl Trop Dis, 8(8). Abstract.  Author URL.  Full text.

2013

Lourenço J, Recker M (2013). Natural, persistent oscillations in a spatial multi-strain disease system with application to dengue. PLoS computational biology, 9(10). Abstract.  Full text.
Warimwe GM, Recker M, Kiragu EW, Buckee CO, Wambua J, Musyoki JN, Marsh K, Bull PC (2013). Plasmodium falciparum var Gene Expression Homogeneity as a Marker of the Host-Parasite Relationship under Different Levels of Naturally Acquired Immunity to Malaria. PLoS ONE, 8(7). Abstract.  Full text.
Wikramaratna PS, Sandeman M, Recker M, Gupta S (2013). The antigenic evolution of influenza: Drift or thrift?. Philosophical Transactions of the Royal Society B: Biological Sciences, 368(1614). Abstract.
Wikramaratna PS, Sandeman M, Recker M, Gupta S (2013). The antigenic evolution of influenza: drift or thrift?. Philos Trans R Soc Lond B Biol Sci, 368(1614). Abstract.  Author URL.  Full text.
Noble R, Christodoulou Z, Kyes S, Pinches R, Newbold CI, Recker M (2013). The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malaria. Elife, 2 Abstract.  Author URL.  Full text.

2012

Noble R, Recker M (2012). A statistically rigorous method for determining antigenic switching networks. PLoS One, 7(6). Abstract.  Author URL.  Full text.
Beatty M, Boni MF, Brown S, Buathong R, Burke D, Coudeville L, Cummings DAT, Edelman R, Farrar J, Focks DA, et al (2012). Assessing the Potential of a Candidate Dengue Vaccine with Mathematical Modeling. PLOS NEGLECTED TROPICAL DISEASES, 6(3). Author URL.
Fastman Y, Noble R, Recker M, Dzikowski R (2012). Erasing the epigenetic memory and beginning to switch-the onset of antigenic switching of var genes in plasmodium falciparum. PLoS ONE, 7(3). Abstract.  Full text.
Buckee CO, Recker M (2012). Evolution of the multi-domain structures of virulence genes in the human malaria parasite, Plasmodium falciparum. PLoS Computational Biology, 8(4). Abstract.  Full text.
Priest NK, Rudkin JK, Feil EJ, Van Den Elsen JMH, Cheung A, Peacock SJ, Laabei M, Lucks DA, Recker M, Massey RC, et al (2012). From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence. Nature Reviews Microbiology, 10(11), 791-797. Abstract.

2011

Recker M, Buckee CO, Serazin A, Kyes S, Pinches R, Christodoulou Z, Springer AL, Gupta S, Newbold CI (2011). Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern. PLoS Pathog, 7(3). Abstract.  Author URL.  Full text.
Portugal S, Carret C, Recker M, Armitage AE, Gonçalves LA, Epiphanio S, Sullivan D, Roy C, Newbold CI, Drakesmith H, et al (2011). Host-mediated regulation of superinfection in malaria. Nature Medicine, 17(6), 732-737. Abstract.
Buckee CO, Recker M, Watkins ER, Gupta S (2011). Role of stochastic processes in maintaining discrete strain structure in antigenically diverse pathogen populations. Proc Natl Acad Sci U S A, 108(37), 15504-15509. Abstract.  Author URL.

2010

Collins J, Rudkin J, Recker M, Pozzi C, O'Gara JP, Massey RC (2010). Offsetting virulence and antibiotic resistance costs by MRSA. ISME J, 4(4), 577-584. Abstract.  Author URL.
Wikramaratna PS, Simmons CP, Gupta S, Recker M (2010). The effects of tertiary and quaternary infections on the epidemiology of dengue. PLoS One, 5(8). Abstract.  Author URL.  Full text.
Kiss IZ, Cassell J, Recker M, Simon PL (2010). The impact of information transmission on epidemic outbreaks. Mathematical Biosciences, 225(1), 1-10. Abstract.
Lourenço J, Recker M (2010). Viral and epidemiological determinants of the invasion dynamics of novel dengue genotypes. PLoS Negl Trop Dis, 4(11). Abstract.  Author URL.  Full text.

2009

Recker M, Bouma MJ, Bamford P, Gupta S, Dobson AP (2009). Assessing the burden of pregnancy-associated malaria under changing transmission settings. Malar J, 8 Abstract.  Author URL.  Full text.
Recker M, Blyuss KB, Simmons CP, Hien TT, Wills B, Farrar J, Gupta S (2009). Immunological serotype interactions and their effect on the epidemiological pattern of dengue. Proc Biol Sci, 276(1667), 2541-2548. Abstract.  Author URL.  Full text.

2008

Buckee CO, Jolley KA, Recker M, Penman B, Kriz P, Gupta S, Maiden MCJ (2008). Role of selection in the emergence of lineages and the evolution of virulence in Neisseria meningitidis. Proc Natl Acad Sci U S A, 105(39), 15082-15087. Abstract.  Author URL.
Recker M, Arinaminpathy N, Buckee CO (2008). The effects of a partitioned var gene repertoire of Plasmodium falciparum on antigenic diversity and the acquisition of clinical immunity. Malar J, 7 Abstract.  Author URL.  Full text.

2007

Recker M, Pybus OG, Nee S, Gupta S (2007). The generation of influenza outbreaks by a network of host immune responses against a limited set of antigenic types. Proc Natl Acad Sci U S A, 104(18), 7711-7716. Abstract.  Author URL.

2006

Recker M, Gupta S (2006). Conflicting immune responses can prolong the length of infection in Plasmodium falciparum malaria. Bull Math Biol, 68(4), 821-835. Abstract.  Author URL.
Massey RC, Horsburgh MJ, Lina G, Höök M, Recker M (2006). The evolution and maintenance of virulence in Staphylococcus aureus: a role for host-to-host transmission?. Nat Rev Microbiol, 4(12), 953-958. Abstract.  Author URL.

2005

Recker M, Al-Bader R, Gupta S (2005). A mathematical model for a new mechanism of phenotypic variation in malaria. Parasitology, 131(2), 151-159. Abstract.
Recker M, Al-Bader R, Gupta S (2005). A mathematical model for a new mechanism of phenotypic variation in malaria. Parasitology, 131(Pt 2), 151-159. Abstract.  Author URL.
Recker M, Gupta S (2005). A model for pathogen population structure with cross-protection depending on the extent of overlap in antigenic variant repertoires. J Theor Biol, 232(3), 363-373. Abstract.  Author URL.
Williams TN, Mwangi TW, Wambua S, Peto TEA, Weatherall DJ, Gupta S, Recker M, Penman BS, Uyoga S, MacHaria A, et al (2005). Negative epistasis between the malaria-protective effects of α<sup>+</sup>-thalassemia and the sickle cell trait. Nature Genetics, 37(11), 1253-1257. Abstract.

2004

Recker M, Nee S, Bull PC, Kinyanjui S, Marsh K, Newbold C, Gupta S (2004). Transient cross-reactive immune responses can orchestrate antigenic variation in malaria. Nature, 429(6991), 555-558. Abstract.  Author URL.

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