Loading content

Dr Mark Stappers

Research Fellow

 7622

 01392 727622

 Geoffrey Pope 328

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

Qualifications

PhD, Radboud University, Nijmegen, the Netherlands

Bsc & MSc in Biomedical Sciences, Radboud University, Nijmegen, the Netherlands

Career

2015 - 2019 Research Fellow, MRC Centre for Medical Mycology at the University of Aberdeen, UK

Research group links

Research

Research interests

Superficial fungal infections affect a large proportion of the population worldwide but, more seriously, fungi also kill over a million people every year.

To recognise invading fungal pathogens and mount a protective immune response, our immune cells are equipped with sensors called pattern recognition receptors.  

My research utilizes a set of soluble pattern recognition receptors, which recognize conserved fungal components, to understand how the fungal cell wall is made.

This research will aid in the understanding of how fungi are recognized by the immune system, and how we might kill fungi by blocking its cell wall assembly.

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Haider M, Dambuza IM, Asamaphan P, Stappers M, Reid D, Yamasaki S, Brown GD, Gow NAR, Erwig LP (2019). The pattern recognition receptors dectin-2, mincle, and FcRγ impact the dynamics of phagocytosis of Candida, Saccharomyces, Malassezia, and Mucor species. PLoS One, 14(8). Abstract.  Author URL.
Stappers MHT, Clark AE, Aimanianda V, Bidula S, Reid DM, Asamaphan P, Hardison SE, Dambuza IM, Valsecchi I, Kerscher B, et al (2018). Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus. Nature, 555(7696), 382-386. Abstract.
Stappers MHT, Hagen F, Reimnitz P, Mouton JW, Meis JF, Gyssens IC (2016). Bacteroides fragilis in biopsies of patients with major abscesses and diabetic foot infections: Direct molecular versus culture-based detection. Diagnostic Microbiology and Infectious Disease, 85(2), 263-265. Abstract.
Ammerdorffer A, Stappers MHT, Oosting M, Schoffelen T, Hagenaars JCJP, Bleeker-Rovers CP, Wegdam-Blans MC, Wever PC, Roest HJ, van de Vosse E, et al (2016). Genetic variation in TLR10 is not associated with chronic Q fever, despite the inhibitory effect of TLR10 on Coxiella burnetii-induced cytokines in vitro. Cytokine, 77, 196-202. Abstract.
Stappers MHT, Hagen F, Reimnitz P, Mouton JW, Meis JF, Gyssens IC (2015). Direct molecular versus culture-based assessment of Gram-positive cocci in biopsies of patients with major abscesses and diabetic foot infections. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 34(9), 1885-1892. Author URL.
Stappers MHT, Oosting M, Ioana M, Reimnitz P, Mouton JW, Netea MG, Gyssens IC, Joosten LAB (2015). Genetic variation in TLR10, an inhibitory toll-like receptor, influences susceptibility to complicated skin and skin structure infections. Journal of Infectious Diseases, 212(9), 1491-1499. Abstract.
Jaeger M, Stappers MHT, Joosten LAB, Gyssens IC, Netea MG (2015). Genetic variation in pattern recognition receptors: Functional consequences and susceptibility to infectious disease. Future Microbiology, 10(6), 989-1008. Abstract.
Stappers MHT, Thys Y, Oosting M, Plantinga TS, Ioana M, Reimnitz P, Mouton JW, Netea MG, Joosten LAB, Gyssens IC, et al (2014). Polymorphisms in cytokine genes IL6, TNF, IL10, IL17A and IFNG influence susceptibility to complicated skin and skin structure infections. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 33(12), 2267-2274. Author URL.
Stappers MHT, Thys Y, Oosting M, Plantinga TS, Ioana M, Reimnitz P, Mouton JW, Netea MG, Joosten LAB, Gyssens IC, et al (2014). TLR1, TLR2, and TLR6 gene polymorphisms are associated with increased susceptibility to complicated skin and skin structure infections. Journal of Infectious Diseases, 210(2), 311-318. Abstract.
Stappers MHT, Janssen NAF, Oosting M, Plantinga TS, Arvis P, Mouton JW, Joosten LAB, Netea MG, Gyssens IC (2012). A role for TLR1, TLR2 and NOD2 in cytokine induction by Bacteroides fragilis. Cytokine, 60(3), 861-869. Abstract.
Ioana M, Ferwerda B, Plantinga TS, Stappers M, Oosting M, McCall M, Cimpoeru A, Burada F, Panduru N, Sauerwein R, et al (2012). Different patterns of Toll-like receptor 2 polymorphisms in populations of various ethnic and geographic origins. Infect Immun, 80(5), 1917-1922. Abstract.  Author URL.
Marijnissen RJ, Koenders MI, Smeets RL, Stappers MHT, Nickerson-Nutter C, Joosten LAB, Boots AMH, Van Den Berg WB (2011). Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation. Arthritis and Rheumatism, 63(10), 2939-2948. Abstract.
Bosman GJCGM, Stappers M, Novotný VMJ (2010). Changes in band 3 structure as determinants of erythrocyte integrity during storage and survival after transfusion. Blood Transfus, 8 Suppl 3, s48-s52. Author URL.

Chapters

Stappers MHT, Brown GD (2017). Host immune responses during infections with Candida albicans. In  (Ed) Candida albicans: Cellular and Molecular Biology: Second Edition, 145-183.  Abstract.

Publications by year


2019

Haider M, Dambuza IM, Asamaphan P, Stappers M, Reid D, Yamasaki S, Brown GD, Gow NAR, Erwig LP (2019). The pattern recognition receptors dectin-2, mincle, and FcRγ impact the dynamics of phagocytosis of Candida, Saccharomyces, Malassezia, and Mucor species. PLoS One, 14(8). Abstract.  Author URL.

2018

Stappers MHT, Clark AE, Aimanianda V, Bidula S, Reid DM, Asamaphan P, Hardison SE, Dambuza IM, Valsecchi I, Kerscher B, et al (2018). Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus. Nature, 555(7696), 382-386. Abstract.

2017

Stappers MHT, Brown GD (2017). Host immune responses during infections with Candida albicans. In  (Ed) Candida albicans: Cellular and Molecular Biology: Second Edition, 145-183.  Abstract.

2016

Stappers MHT, Hagen F, Reimnitz P, Mouton JW, Meis JF, Gyssens IC (2016). Bacteroides fragilis in biopsies of patients with major abscesses and diabetic foot infections: Direct molecular versus culture-based detection. Diagnostic Microbiology and Infectious Disease, 85(2), 263-265. Abstract.
Ammerdorffer A, Stappers MHT, Oosting M, Schoffelen T, Hagenaars JCJP, Bleeker-Rovers CP, Wegdam-Blans MC, Wever PC, Roest HJ, van de Vosse E, et al (2016). Genetic variation in TLR10 is not associated with chronic Q fever, despite the inhibitory effect of TLR10 on Coxiella burnetii-induced cytokines in vitro. Cytokine, 77, 196-202. Abstract.

2015

Stappers MHT, Hagen F, Reimnitz P, Mouton JW, Meis JF, Gyssens IC (2015). Direct molecular versus culture-based assessment of Gram-positive cocci in biopsies of patients with major abscesses and diabetic foot infections. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 34(9), 1885-1892. Author URL.
Stappers MHT, Oosting M, Ioana M, Reimnitz P, Mouton JW, Netea MG, Gyssens IC, Joosten LAB (2015). Genetic variation in TLR10, an inhibitory toll-like receptor, influences susceptibility to complicated skin and skin structure infections. Journal of Infectious Diseases, 212(9), 1491-1499. Abstract.
Jaeger M, Stappers MHT, Joosten LAB, Gyssens IC, Netea MG (2015). Genetic variation in pattern recognition receptors: Functional consequences and susceptibility to infectious disease. Future Microbiology, 10(6), 989-1008. Abstract.

2014

Stappers MHT, Thys Y, Oosting M, Plantinga TS, Ioana M, Reimnitz P, Mouton JW, Netea MG, Joosten LAB, Gyssens IC, et al (2014). Polymorphisms in cytokine genes IL6, TNF, IL10, IL17A and IFNG influence susceptibility to complicated skin and skin structure infections. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 33(12), 2267-2274. Author URL.
Stappers MHT, Thys Y, Oosting M, Plantinga TS, Ioana M, Reimnitz P, Mouton JW, Netea MG, Joosten LAB, Gyssens IC, et al (2014). TLR1, TLR2, and TLR6 gene polymorphisms are associated with increased susceptibility to complicated skin and skin structure infections. Journal of Infectious Diseases, 210(2), 311-318. Abstract.

2012

Stappers MHT, Janssen NAF, Oosting M, Plantinga TS, Arvis P, Mouton JW, Joosten LAB, Netea MG, Gyssens IC (2012). A role for TLR1, TLR2 and NOD2 in cytokine induction by Bacteroides fragilis. Cytokine, 60(3), 861-869. Abstract.
Ioana M, Ferwerda B, Plantinga TS, Stappers M, Oosting M, McCall M, Cimpoeru A, Burada F, Panduru N, Sauerwein R, et al (2012). Different patterns of Toll-like receptor 2 polymorphisms in populations of various ethnic and geographic origins. Infect Immun, 80(5), 1917-1922. Abstract.  Author URL.

2011

Marijnissen RJ, Koenders MI, Smeets RL, Stappers MHT, Nickerson-Nutter C, Joosten LAB, Boots AMH, Van Den Berg WB (2011). Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation. Arthritis and Rheumatism, 63(10), 2939-2948. Abstract.

2010

Bosman GJCGM, Stappers M, Novotný VMJ (2010). Changes in band 3 structure as determinants of erythrocyte integrity during storage and survival after transfusion. Blood Transfus, 8 Suppl 3, s48-s52. Author URL.

Refresh publications

Teaching

Supervision / Group

Back | Edit Profile