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Dr Paul Boisseaux

Dr Paul Boisseaux

Postdoctoral Research Fellow in Ecotoxicology

 Geoffrey Pope 211

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

I am a Postdoctoral Research Fellow in Ecotoxicology within the EPSRC funded project EXEMPLAR: The EXEter Multidisciplinary PLAstics Research hub. Plastics and microplastics (MPs) constitute massive, highly diverse and complex contaminants of concerns into the Environment. Many MPs are detrimentals to a wide array of living organisms and they are likely altering ecosystems health. My main roles in this project are to extend the knowledge and comprehension about the toxicities of different types of microplastics as well as their levels of contamination in the environment. The toxicities of MPs to field-collected zooplankton (i.e., base of the food chain) are assessed and compared between newly formulated bioplastics, recycled products and existing plastics. In parallel, the levels of contamination at specific study sites in South-West UK are estimated as  regional demonstrator of management practices’ effectiveness. Overall, this Exemplar project aims at evaluating the feasibility and relevance of a creative circular economy system by using a holistic approach (social, economical, technical, toxicological, environmental). The main outcome is to ameliorate the environmental management of plastics and so to reduce plastic pollution and impact for a better environmental quality.

I acquired experience in standard ecotoxicity testing and the use of cell lines to study contaminant cytotoxicity and mode of action. Then, my PhD was based in Ecotoxicology with a focus on immunocompetence markers. A wide range of xenobiotics in several populations of the freshwater gastropod Lymnaea stagnalis were studied in order to understand the relevance, potentials and limits of these biomarkers. I then pursued with a Postdoctoral fellowship in Evolutionary Ecotoxicology.  The toxicity of a model toxicant was assessed as well as how it could be modulated by multigenerational toxicant selection pressure, inbreeding depression, and interactions of these factors. To that aim, a shotgun proteomic approach was used as a proxy of molecular response (and structural peculiarities).

Qualifications

2013: Master degree in Health Engineering-Environment, Montpellier (France)

2014-2017: PhD in Ecotoxicology, Lyon (France)

Career

* 2013 : Marie-Curie grant in the ITN-ECO project, Madrid (Spain)

Keywords: cell lines; graphene nanoplatelets; EROD activity; cytotoxicity biomarkers

* 2014-2017: PhD in Ecotoxicology, Lyon (France)

Keywords: Lymnaea stagnalis; freshwater; gastropod; hemocytes; immunocompetence; ecotoxicology ; life-history traits; relevance

* 2018: Postdoctoral Research Fellow in Evolutionary ecotoxicology, Rennes (France)

Keywords: Shotgun proteomics; Lymnaea stagnalis; hemocytes; digestive gland;  selection; inbreeding ; transgenerational effect

*2019- now: Postdoctoral Research Fellow in Ecotoxicology, Exeter university (UK)

Keywords: Microplastics; zooplankton; toxicity testing; alternative plastics; recycled plastics ;  environmental contamination ; circular economy ; environmental management practices

 

Research group links

Research

Research interests

1.  Disciplines, topics and concepts:

* Environmental toxicology, Ecotoxicology, Evolutionary ecotoxicology, Stress ecology

* Xenobiotics impacts and mode of action

* AOP (adverse outcome pathways)

* Change of scale: molecule → cell/tissue → organism → population

* in silico vs in vitro vs in vivo vs in situ

* multi and transgenerational effects of pollutants

* immunocompetence, immunotoxicity

* life-history traits, resource allocation, trade-offs

* toxicant tolerance vs sensitization

* biomarker variability (intraindividual, interindividual, intraspecific, interphylum)

 

2. Tools:

* Lab exposure

* Proteomics

* Bioinformatics, statistical modelling

* Spectrofluorimetric assays

* Flow cytometry

* Microscopy

 

3. Transfer:

* Regulatory (eco)toxicology / water quality

* Environmental (bio)monitoring

Publications

Key publications | Publications by category | Publications by year

Key publications


Boisseaux P, Noury P, Delorme N, Perrier L, Thomas-Guyon H, Garric J (2018). Immunocompetence analysis of the aquatic snail Lymnaea stagnalis exposed to urban wastewaters. Environmental Science and Pollution Research, 25(17), 16720-16728. Abstract.
Boisseaux P, Noury P, Thomas H, Garric J (2017). Immune responses in the aquatic gastropod Lymnaea stagnalis under short-term exposure to pharmaceuticals of concern for immune systems: Diclofenac, cyclophosphamide and cyclosporine A. Ecotoxicology and Environmental Safety, 139, 358-366. Abstract.
Boisseaux P, Delignette-Muller ML, Abbaci K, Thomas H, Garric J (2016). Analysis of hemocytes in Lymnaea stagnalis: Characterization and effects of repeated hemolymph collections. Fish and Shellfish Immunology, 57, 116-126. Abstract.
Boisseaux P, Noury P, Delignette-Muller ML, Thomas H, Garric J (2016). Recommendations for the analysis of hemocyte-related immunocompetent oxidative activity in the freshwater snail Lymnaea stagnalis. Journal of Xenobiotics, 6(2 2Special Issue), 25-27.
Lammel T, Boisseaux P, Navas JM (2015). Potentiating effect of graphene nanomaterials on aromatic environmental pollutant-induced cytochrome P450 1A expression in the topminnow fish hepatoma cell line PLHC-1. Environmental Toxicology, 30(10), 1192-1204. Abstract.
Lammel T, Boisseaux P, Fernández-Cruz ML, Navas JM (2013). Internalization and cytotoxicity of graphene oxide and carboxyl graphene nanoplatelets in the human hepatocellular carcinoma cell line Hep G2. Particle and Fibre Toxicology, 10(1). Abstract.

Publications by category


Journal articles

Boisseaux P, Noury P, Delorme N, Perrier L, Thomas-Guyon H, Garric J (2018). Immunocompetence analysis of the aquatic snail Lymnaea stagnalis exposed to urban wastewaters. Environmental Science and Pollution Research, 25(17), 16720-16728. Abstract.
Boisseaux P, Noury P, Thomas H, Garric J (2017). Immune responses in the aquatic gastropod Lymnaea stagnalis under short-term exposure to pharmaceuticals of concern for immune systems: Diclofenac, cyclophosphamide and cyclosporine A. Ecotoxicology and Environmental Safety, 139, 358-366. Abstract.
Boisseaux P, Delignette-Muller ML, Abbaci K, Thomas H, Garric J (2016). Analysis of hemocytes in Lymnaea stagnalis: Characterization and effects of repeated hemolymph collections. Fish and Shellfish Immunology, 57, 116-126. Abstract.
Boisseaux P, Noury P, Delignette-Muller ML, Thomas H, Garric J (2016). Recommendations for the analysis of hemocyte-related immunocompetent oxidative activity in the freshwater snail Lymnaea stagnalis. Journal of Xenobiotics, 6(2 2Special Issue), 25-27.
Lammel T, Boisseaux P, Navas JM (2015). Potentiating effect of graphene nanomaterials on aromatic environmental pollutant-induced cytochrome P450 1A expression in the topminnow fish hepatoma cell line PLHC-1. Environmental Toxicology, 30(10), 1192-1204. Abstract.
Lammel T, Boisseaux P, Fernández-Cruz ML, Navas JM (2013). Internalization and cytotoxicity of graphene oxide and carboxyl graphene nanoplatelets in the human hepatocellular carcinoma cell line Hep G2. Particle and Fibre Toxicology, 10(1). Abstract.

Publications by year


2018

Boisseaux P, Noury P, Delorme N, Perrier L, Thomas-Guyon H, Garric J (2018). Immunocompetence analysis of the aquatic snail Lymnaea stagnalis exposed to urban wastewaters. Environmental Science and Pollution Research, 25(17), 16720-16728. Abstract.

2017

Boisseaux P, Noury P, Thomas H, Garric J (2017). Immune responses in the aquatic gastropod Lymnaea stagnalis under short-term exposure to pharmaceuticals of concern for immune systems: Diclofenac, cyclophosphamide and cyclosporine A. Ecotoxicology and Environmental Safety, 139, 358-366. Abstract.

2016

Boisseaux P, Delignette-Muller ML, Abbaci K, Thomas H, Garric J (2016). Analysis of hemocytes in Lymnaea stagnalis: Characterization and effects of repeated hemolymph collections. Fish and Shellfish Immunology, 57, 116-126. Abstract.
Boisseaux P, Noury P, Delignette-Muller ML, Thomas H, Garric J (2016). Recommendations for the analysis of hemocyte-related immunocompetent oxidative activity in the freshwater snail Lymnaea stagnalis. Journal of Xenobiotics, 6(2 2Special Issue), 25-27.

2015

Lammel T, Boisseaux P, Navas JM (2015). Potentiating effect of graphene nanomaterials on aromatic environmental pollutant-induced cytochrome P450 1A expression in the topminnow fish hepatoma cell line PLHC-1. Environmental Toxicology, 30(10), 1192-1204. Abstract.

2013

Lammel T, Boisseaux P, Fernández-Cruz ML, Navas JM (2013). Internalization and cytotoxicity of graphene oxide and carboxyl graphene nanoplatelets in the human hepatocellular carcinoma cell line Hep G2. Particle and Fibre Toxicology, 10(1). Abstract.

Paul_Boisseaux Details from cache as at 2019-08-25 01:16:49

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