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Dr Reza Shahidi

Postdoctoral Research Fellow (LSI)

 Living Systems Institute S01.07

 

Living Systems Institute, University of Exeter, Stocker Road, Exeter, EX4 4QD

Overview

I am a Postdoctoral Research Fellow in the lab of Professor Gáspár Jékely . The focus of my research is the animal nervous system. I aim to examine how nervous systems develop in an organism, and how they evolved into the diverse networks found in animals today. Understanding the structure of these networks requires precise mapping of the synaptic connections between different neurons (connectomics), and the underlying neurotransmitters used for signalling that are expressed within them. By studying these details, we can unravel the mystery of how nervous systems function and their role in modifying animal physiology and behaviour .

Synapse-level studies require high-resolution analysis, and the technique that delivers the strongest resolving power to date is electron microscopy  (EM). I use serial section electron microscopy and related approaches to create several large, high-resolution 3D image datasets from which to reconstruct the cellular complement of an organism, including its neurons and their synaptic connections. I also use immunogold labeling of EM sections with antibodies raised against specific neuropeptides to explore the molecular character of individual neurons. Understanding the role of neuropeptidergic signaling and its modulation of synaptic expression is paramount in understanding nervous system communication.

Reconstructing the complete neuronal circuitry of an entire animal, however, is challenging and labor intensive. For example, the human brain has 86 billion neurons, with trillions of different connections between them. Therefore, the choice of specimen is crucial, since imaging resolution and data volume are key factors that must be considered. I use model organisms that are complex enough in their behaviors and neurocircuits, yet small enough in size for EM studies – such as the larval stages of marine invertebrates, like the marine worm Platynereis dumerilii.

I am also passionate about teaching and strive to promote education, training, and collaboration in the field of EM . For example, I have taught the EMBO practical course in advance electron microscopy techniques, as well as trained post-graduates in EM methods here in Exeter. If you are interested in applying the power of EM to your own research, please feel free to contact me at r.shahidi@exeter.ac.uk

Qualifications

2019  ASPIRE Associate Fellow, UK

          Associate Fellow of The Higher Education Academy, UK

2018  Certificate in Learning and Teaching Higher Education Programme (LTHE) Stage 1 & 2, University of Exeter, UK

2016  PhD Biology, University of Tübingen, Germany
1995  BSc Biology, University of British Columbia, Canada

Career

2017-Present  Postdoctoral Research Fellow, University of Exeter, UK

2016-2017  Research Associate, Max Planck Institute for Developmental Biology, Tübingen, Germany.

2011-2016  Research Assistant, Max Planck Institute for Developmental Biology, Tübingen, Germany.

Links

Research

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Shahidi R, Williams E, Conzelmann M, Asadulina A, Veraszto C, Jasek S, Bezares-Calderon LA, Jekely G (In Press). A Serial Multiplex Immunogold Labeling Method for Identifying Peptidergic Neurons in Connectomes.  Abstract.
Verasztó C, Gühmann M, Jia H, Rajan VBV, Bezares-Calderón LA, Lopez CP, Randel N, Shahidi R, Michiels NK, Yokoyama S, et al (In Press). Ciliary and rhabdomeric photoreceptor-cell circuits form a spectral depth gauge in marine zooplankton.  Abstract.
Verasztó C, Ueda N, Bezares-Calderón LA, Panzera A, Williams EA, Shahidi R, Jékely G (In Press). Ciliomotor circuitry underlying whole-body coordination of ciliary activity in the Platynereis larva.  Abstract.
Jasek S, Verasztó C, Brodrick E, Shahidi R, Kazimiers T, Jékely G (In Press). Desmosomal connectomics of all somatic muscles in an annelid larva.  Abstract.
Bezares-Calderón LA, Berger J, Jasek S, Verasztó C, Mendes S, Gühmann M, Almeda R, Shahidi R, Jékely G (In Press). Neural circuitry of a polycystin-mediated hydrodynamic startle response for predator avoidance.  Abstract.
Williams EA, Verasztó C, Jasek S, Conzelmann M, Shahidi R, Bauknecht P, Jékely G (In Press). Synaptic and peptidergic connectome of a neurosecretory centre in the annelid brain.  Abstract.
Verasztó C, Jasek S, Gühmann M, Shahidi R, Ueda N, Beard JD, Mendes S, Heinz K, Bezares-Calderón LA, Williams E, et al (In Press). Whole-animal connectome and cell-type complement of the three-segmented Platynereis dumerilii larva.  Abstract.
Verasztó C, Gühmann M, Jia H, Rajan VBV, Bezares-Calderón LA, Piñeiro-Lopez C, Randel N, Shahidi R, Michiels NK, Yokoyama S, et al (2018). Ciliary and rhabdomeric photoreceptor-cell circuits form a spectral depth gauge in marine zooplankton. Elife, 7 Abstract.  Author URL.  Full text.
Bezares-Calderón LA, Berger J, Jasek S, Verasztó C, Mendes S, Gühmann M, Almeda R, Shahidi R, Jékely G (2018). Neural circuitry of a polycystin-mediated hydrodynamic startle response for predator avoidance. Elife, 7 Abstract.  Author URL.  Full text.
Verasztó C, Ueda N, Bezares-Calderón LA, Panzera A, Williams EA, Shahidi R, Jékely G (2017). Ciliomotor circuitry underlying whole-body coordination of ciliary activity in the Platynereis larva. Elife, 6 Abstract.  Author URL.  Full text.
Williams EA, Verasztó C, Jasek S, Conzelmann M, Shahidi R, Bauknecht P, Mirabeau O, Jékely G (2017). Synaptic and peptidergic connectome of a neurosecretory center in the annelid brain. Elife, 6 Abstract.  Author URL.  Full text.
Shahidi R, Williams EA, Conzelmann M, Asadulina A, Verasztó C, Jasek S, Bezares-Calderón LA, Jékely G (2015). A serial multiplex immunogold labeling method for identifying peptidergic neurons in connectomes. Elife, 4 Abstract.  Author URL.  Full text.
Randel N, Shahidi R, Verasztó C, Bezares-Calderón LA, Schmidt S, Jékely G (2015). Inter-individual stereotypy of the Platynereis larval visual connectome. Elife, 4 Abstract.  Author URL.  Full text.
Randel N, Asadulina A, Bezares-Calderón LA, Verasztó C, Williams EA, Conzelmann M, Shahidi R, Jékely G (2014). Neuronal connectome of a sensory-motor circuit for visual navigation. Elife, 3 Abstract.  Author URL.  Full text.
Conzelmann M, Williams EA, Tunaru S, Randel N, Shahidi R, Asadulina A, Berger J, Offermanns S, Jékely G (2013). Conserved MIP receptor-ligand pair regulates Platynereis larval settlement. Proc Natl Acad Sci U S A, 110(20), 8224-8229. Abstract.  Author URL.
Randel N, Bezares-Calderón LA, Gühmann M, Shahidi R, Jékely G (2013). Expression dynamics and protein localization of rhabdomeric opsins in Platynereis larvae. Integr Comp Biol, 53(1), 7-16. Abstract.  Author URL.
Noseda M, McLean G, Niessen K, Chang L, Pollet I, Montpetit R, Shahidi R, Dorovini-Zis K, Li L, Beckstead B, et al (2004). Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation. Circ Res, 94(7), 910-917. Abstract.  Author URL.
Duriez PJ, Wong F, Dorovini-Zis K, Shahidi R, Karsan A (2000). A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor. J Biol Chem, 275(24), 18099-18107. Abstract.  Author URL.

Chapters

Buchholz TO, Krull A, Shahidi R, Pigino G, Jékely G, Jug F (2019). Content-aware image restoration for electron microscopy. In  (Ed) Methods in Cell Biology, 277-289.  Abstract.

Publications by year


In Press

Shahidi R, Williams E, Conzelmann M, Asadulina A, Veraszto C, Jasek S, Bezares-Calderon LA, Jekely G (In Press). A Serial Multiplex Immunogold Labeling Method for Identifying Peptidergic Neurons in Connectomes.  Abstract.
Verasztó C, Gühmann M, Jia H, Rajan VBV, Bezares-Calderón LA, Lopez CP, Randel N, Shahidi R, Michiels NK, Yokoyama S, et al (In Press). Ciliary and rhabdomeric photoreceptor-cell circuits form a spectral depth gauge in marine zooplankton.  Abstract.
Verasztó C, Ueda N, Bezares-Calderón LA, Panzera A, Williams EA, Shahidi R, Jékely G (In Press). Ciliomotor circuitry underlying whole-body coordination of ciliary activity in the Platynereis larva.  Abstract.
Jasek S, Verasztó C, Brodrick E, Shahidi R, Kazimiers T, Jékely G (In Press). Desmosomal connectomics of all somatic muscles in an annelid larva.  Abstract.
Bezares-Calderón LA, Berger J, Jasek S, Verasztó C, Mendes S, Gühmann M, Almeda R, Shahidi R, Jékely G (In Press). Neural circuitry of a polycystin-mediated hydrodynamic startle response for predator avoidance.  Abstract.
Williams EA, Verasztó C, Jasek S, Conzelmann M, Shahidi R, Bauknecht P, Jékely G (In Press). Synaptic and peptidergic connectome of a neurosecretory centre in the annelid brain.  Abstract.
Verasztó C, Jasek S, Gühmann M, Shahidi R, Ueda N, Beard JD, Mendes S, Heinz K, Bezares-Calderón LA, Williams E, et al (In Press). Whole-animal connectome and cell-type complement of the three-segmented Platynereis dumerilii larva.  Abstract.

2019

Buchholz TO, Krull A, Shahidi R, Pigino G, Jékely G, Jug F (2019). Content-aware image restoration for electron microscopy. In  (Ed) Methods in Cell Biology, 277-289.  Abstract.

2018

Verasztó C, Gühmann M, Jia H, Rajan VBV, Bezares-Calderón LA, Piñeiro-Lopez C, Randel N, Shahidi R, Michiels NK, Yokoyama S, et al (2018). Ciliary and rhabdomeric photoreceptor-cell circuits form a spectral depth gauge in marine zooplankton. Elife, 7 Abstract.  Author URL.  Full text.
Bezares-Calderón LA, Berger J, Jasek S, Verasztó C, Mendes S, Gühmann M, Almeda R, Shahidi R, Jékely G (2018). Neural circuitry of a polycystin-mediated hydrodynamic startle response for predator avoidance. Elife, 7 Abstract.  Author URL.  Full text.

2017

Verasztó C, Ueda N, Bezares-Calderón LA, Panzera A, Williams EA, Shahidi R, Jékely G (2017). Ciliomotor circuitry underlying whole-body coordination of ciliary activity in the Platynereis larva. Elife, 6 Abstract.  Author URL.  Full text.
Williams EA, Verasztó C, Jasek S, Conzelmann M, Shahidi R, Bauknecht P, Mirabeau O, Jékely G (2017). Synaptic and peptidergic connectome of a neurosecretory center in the annelid brain. Elife, 6 Abstract.  Author URL.  Full text.

2015

Shahidi R, Williams EA, Conzelmann M, Asadulina A, Verasztó C, Jasek S, Bezares-Calderón LA, Jékely G (2015). A serial multiplex immunogold labeling method for identifying peptidergic neurons in connectomes. Elife, 4 Abstract.  Author URL.  Full text.
Randel N, Shahidi R, Verasztó C, Bezares-Calderón LA, Schmidt S, Jékely G (2015). Inter-individual stereotypy of the Platynereis larval visual connectome. Elife, 4 Abstract.  Author URL.  Full text.

2014

Randel N, Asadulina A, Bezares-Calderón LA, Verasztó C, Williams EA, Conzelmann M, Shahidi R, Jékely G (2014). Neuronal connectome of a sensory-motor circuit for visual navigation. Elife, 3 Abstract.  Author URL.  Full text.

2013

Conzelmann M, Williams EA, Tunaru S, Randel N, Shahidi R, Asadulina A, Berger J, Offermanns S, Jékely G (2013). Conserved MIP receptor-ligand pair regulates Platynereis larval settlement. Proc Natl Acad Sci U S A, 110(20), 8224-8229. Abstract.  Author URL.
Randel N, Bezares-Calderón LA, Gühmann M, Shahidi R, Jékely G (2013). Expression dynamics and protein localization of rhabdomeric opsins in Platynereis larvae. Integr Comp Biol, 53(1), 7-16. Abstract.  Author URL.

2004

Noseda M, McLean G, Niessen K, Chang L, Pollet I, Montpetit R, Shahidi R, Dorovini-Zis K, Li L, Beckstead B, et al (2004). Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation. Circ Res, 94(7), 910-917. Abstract.  Author URL.

2000

Duriez PJ, Wong F, Dorovini-Zis K, Shahidi R, Karsan A (2000). A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor. J Biol Chem, 275(24), 18099-18107. Abstract.  Author URL.

Reza_Shahidi Details from cache as at 2021-09-28 05:04:30

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Teaching

2020   BIO2088 Advanced Cell Biology, University of Exeter, UK 
Introduction to electron microscopy and high-resolution cell anatomy

2019   EMBO Advance techniques in electron microscopy practical course, Ceske Budejovice, Invited teacher

2017-   Living Systems Institute, University of Exeter, UK
Designed and mentored modules on electron microscopy and related techniques

Supervision / Group

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