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Dr Steven West

Dr Steven West

Associate Professor, Molecular Biology

 7458

 +44 (0)1392 727458

 Living Systems Institute T05.12

 

Living Systems Institute, University of Exeter, Stocker Road, Exeter, EX4 4QD

Overview

Following completion of my BSc at the University of Manchester and PhD at the University of Oxford, I was awarded a Wellcome Trust Research Career Development Fellowship at the University of Edinburgh. I then moved to the University of Sheffield where I was appointed as a Senior Lecturer in the Department of Molecular Biology and Biotechnology.

Research

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Eaton JD, Davidson L, Bauer DLV, Natsume T, Kanemaki MT, West S (In Press). Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity. Genes Dev, 32(2), 127-139. Abstract.  Author URL.
Davidson L, Francis L, Cordiner RA, Eaton JD, Estell C, Macias S, C├íceres JF, West S (2019). Rapid Depletion of DIS3, EXOSC10, or XRN2 Reveals the Immediate Impact of Exoribonucleolysis on Nuclear RNA Metabolism and Transcriptional Control. Cell Reports, 26(10), 2779-2791.e5. Abstract.  Full text.
Eaton JD, West S (2018). An end in sight? Xrn2 and transcriptional termination by RNA polymerase II. Transcription, 9(5), 321-326. Abstract.  Author URL.
Muniz L, Davidson L, West S (2015). Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs. MOLECULAR AND CELLULAR BIOLOGY, 35(13), 2218-2230. Author URL.
Davidson L, Muniz L, West S (2014). 3 ' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells. GENES & DEVELOPMENT, 28(4), 342-356. Author URL.
Hett A, West S (2014). Inhibition of U4 snRNA in Human Cells Causes the Stable Retention of Polyadenylated Pre-mRNA in the Nucleus. PLOS ONE, 9(5). Author URL.
Davidson L, West S (2013). Splicing-coupled 3' end formation requires a terminal splice acceptor site, but not intron excision. NUCLEIC ACIDS RESEARCH, 41(14), 7101-7114. Author URL.
Davidson L, Kerr A, West S (2012). Co-transcriptional degradation of aberrant pre-mRNA by Xrn2. EMBO JOURNAL, 31(11), 2566-2578. Author URL.
West S (2012). The increasing functional repertoire of U1 snRNA. BIOCHEMICAL SOCIETY TRANSACTIONS, 40, 846-849. Author URL.
Schmidt M-J, West S, Norbury CJ (2011). The human cytoplasmic RNA terminal U-transferase ZCCHC11 targets histone mRNAs for degradation. RNA, 17(1), 39-44. Author URL.
West S, Proudfoot NJ (2009). Transcriptional Termination Enhances Protein Expression in Human Cells. MOLECULAR CELL, 33(3), 354-364. Author URL.
West S, Proudfoot NJ (2008). Human Pcf11 enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination. NUCLEIC ACIDS RESEARCH, 36(3), 905-914. Author URL.
West S, Proudfoot NJ, Dye MJ (2008). Molecular dissection of mammalian RNA polymerase II transcriptional termination. MOLECULAR CELL, 29(5), 600-610. Author URL.
Gromak N, West S, Proudfoot NJ (2006). Pause sites promote transcriptional termination of mammalian RNA polymerase II. MOLECULAR AND CELLULAR BIOLOGY, 26(10), 3986-3996. Author URL.
West S, Zaret K, Proudfoot NJ (2006). Transcriptional termination sequences in the mouse serum albumin gene. RNA, 12(4), 655-665. Abstract.  Author URL.
Dye MJ, Gromak N, Haussecker D, West S, Proudfoot NJ (2006). Turnover and function of noncoding RNA polymerase II transcripts. Cold Spring Harb Symp Quant Biol, 71, 275-284. Abstract.  Author URL.
Teixeira A, Tahiri-Alaoui A, West S, Thomas B, Ramadass A, Martianov I, Dye M, James W, Proudfoot NJ, Akoulitchev A, et al (2004). Autocatalytic RNA cleavage in the human beta-globin pre-mRNA promotes transcription termination. Nature, 432(7016), 526-530. Abstract.  Author URL.
West S, Gromak N, Proudfoot NJ (2004). Human 5 '-> 3 ' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites. NATURE, 432(7016), 522-525. Author URL.

Publications by year


In Press

Eaton JD, Davidson L, Bauer DLV, Natsume T, Kanemaki MT, West S (In Press). Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity. Genes Dev, 32(2), 127-139. Abstract.  Author URL.

2019

Davidson L, Francis L, Cordiner RA, Eaton JD, Estell C, Macias S, C├íceres JF, West S (2019). Rapid Depletion of DIS3, EXOSC10, or XRN2 Reveals the Immediate Impact of Exoribonucleolysis on Nuclear RNA Metabolism and Transcriptional Control. Cell Reports, 26(10), 2779-2791.e5. Abstract.  Full text.

2018

Eaton JD, West S (2018). An end in sight? Xrn2 and transcriptional termination by RNA polymerase II. Transcription, 9(5), 321-326. Abstract.  Author URL.

2015

Muniz L, Davidson L, West S (2015). Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs. MOLECULAR AND CELLULAR BIOLOGY, 35(13), 2218-2230. Author URL.

2014

Davidson L, Muniz L, West S (2014). 3 ' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells. GENES & DEVELOPMENT, 28(4), 342-356. Author URL.
Hett A, West S (2014). Inhibition of U4 snRNA in Human Cells Causes the Stable Retention of Polyadenylated Pre-mRNA in the Nucleus. PLOS ONE, 9(5). Author URL.

2013

Davidson L, West S (2013). Splicing-coupled 3' end formation requires a terminal splice acceptor site, but not intron excision. NUCLEIC ACIDS RESEARCH, 41(14), 7101-7114. Author URL.

2012

Davidson L, Kerr A, West S (2012). Co-transcriptional degradation of aberrant pre-mRNA by Xrn2. EMBO JOURNAL, 31(11), 2566-2578. Author URL.
West S (2012). The increasing functional repertoire of U1 snRNA. BIOCHEMICAL SOCIETY TRANSACTIONS, 40, 846-849. Author URL.

2011

Schmidt M-J, West S, Norbury CJ (2011). The human cytoplasmic RNA terminal U-transferase ZCCHC11 targets histone mRNAs for degradation. RNA, 17(1), 39-44. Author URL.

2009

West S, Proudfoot NJ (2009). Transcriptional Termination Enhances Protein Expression in Human Cells. MOLECULAR CELL, 33(3), 354-364. Author URL.

2008

West S, Proudfoot NJ (2008). Human Pcf11 enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination. NUCLEIC ACIDS RESEARCH, 36(3), 905-914. Author URL.
West S, Proudfoot NJ, Dye MJ (2008). Molecular dissection of mammalian RNA polymerase II transcriptional termination. MOLECULAR CELL, 29(5), 600-610. Author URL.

2006

Gromak N, West S, Proudfoot NJ (2006). Pause sites promote transcriptional termination of mammalian RNA polymerase II. MOLECULAR AND CELLULAR BIOLOGY, 26(10), 3986-3996. Author URL.
West S, Zaret K, Proudfoot NJ (2006). Transcriptional termination sequences in the mouse serum albumin gene. RNA, 12(4), 655-665. Abstract.  Author URL.
Dye MJ, Gromak N, Haussecker D, West S, Proudfoot NJ (2006). Turnover and function of noncoding RNA polymerase II transcripts. Cold Spring Harb Symp Quant Biol, 71, 275-284. Abstract.  Author URL.

2004

Teixeira A, Tahiri-Alaoui A, West S, Thomas B, Ramadass A, Martianov I, Dye M, James W, Proudfoot NJ, Akoulitchev A, et al (2004). Autocatalytic RNA cleavage in the human beta-globin pre-mRNA promotes transcription termination. Nature, 432(7016), 526-530. Abstract.  Author URL.
West S, Gromak N, Proudfoot NJ (2004). Human 5 '-> 3 ' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites. NATURE, 432(7016), 522-525. Author URL.

Steven_West Details from cache as at 2019-06-20 20:18:02

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