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Dr Steven West

Dr Steven West

Associate Professor, Molecular Biology

 7458

 +44 (0)1392 727458

 Living Systems Institute T05.12

 

Living Systems Institute, University of Exeter, Stocker Road, Exeter, EX4 4QD

Overview

Following completion of my BSc at the University of Manchester, I went to Oxford University to carry out a PhD with Prof Nick Proudfoot.  There I studied mechanisms of transcription and RNA degradation - in particular the mechanism of transcriptional termination.  I had such a good time in Nick's lab that I remained there as a post-doc during which time I was also the Hayward Junior Research Fellow at Oriel College.  Following my time in Oxford, I was awarded a Wellcome Trust Research Career Development Fellowship to stary my independent lab at The University of Edinburgh.  This was also a very enjoyable time and culminated in my election into the EMBO Young Investigator Programme and my first open-ended academic post - a Senior Lectureship at the University of Sheffield.  I was then awarded both a Lister Institute Fellowship and a Wellcome Trust Investigator Award to continue pursuing my long-term interest in RNA biogenesis mechanisms.  I moved to The Living Systems Institute in Exeter as soon as it opened early in 2017.

Qualifications

2006 DPhil (PhD) University of Oxford

2002 Bsc Hons (first class) University of Manchester Institute for Science and Technology

Research

Research interests

My lab has a general interest in RNA biology and transcription by RNA polymerase II.  This is one of the most fundamental processes in life and is often disrupted in disease.  We seek to understand how the extent of transcription is controlled on a gene.  We are also interested in mechanisms that control non-coding transcription and the degradation of these poorly characterised transcripts.  We perform these studies in human cell lines that we manipulate using CRISPR-Cas9 engineering that allows us to control these processes with precision.

Research networks

Lister Institute

Wellcome Trust 

EMBO Young Investigator

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Eaton JD, Francis L, Davidson L, West S (2020). A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes. Genes Dev, 34(1-2), 132-145. Abstract.  Author URL.  Full text.
Davidson L, Francis L, Eaton JD, West S (2020). Integrator-Dependent and Allosteric/Intrinsic Mechanisms Ensure Efficient Termination of snRNA Transcription. Cell Rep, 33(4). Abstract.  Author URL.
Eaton JD, West S (2020). Termination of Transcription by RNA Polymerase II: BOOM!. Trends in Genetics, 36(9), 664-675. Abstract.
Davidson L, Francis L, Cordiner RA, Eaton JD, Estell C, Macias S, Cáceres JF, West S (2019). Rapid Depletion of DIS3, EXOSC10, or XRN2 Reveals the Immediate Impact of Exoribonucleolysis on Nuclear RNA Metabolism and Transcriptional Control. Cell Reports, 26(10), 2779-2791.e5. Abstract.  Full text.
Eaton JD, West S (2018). An end in sight? Xrn2 and transcriptional termination by RNA polymerase II. Transcription, 9(5), 321-326. Abstract.  Author URL.
Eaton JD, Davidson L, Bauer DLV, Natsume T, Kanemaki MT, West S (2018). Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity. Genes Dev, 32(2), 127-139. Abstract.  Author URL.
Muniz L, Davidson L, West S (2015). Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs. MOLECULAR AND CELLULAR BIOLOGY, 35(13), 2218-2230. Author URL.
Davidson L, Muniz L, West S (2014). 3 ' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells. GENES & DEVELOPMENT, 28(4), 342-356. Author URL.
Hett A, West S (2014). Inhibition of U4 snRNA in Human Cells Causes the Stable Retention of Polyadenylated Pre-mRNA in the Nucleus. PLOS ONE, 9(5). Author URL.
Davidson L, West S (2013). Splicing-coupled 3' end formation requires a terminal splice acceptor site, but not intron excision. NUCLEIC ACIDS RESEARCH, 41(14), 7101-7114. Author URL.
Davidson L, Kerr A, West S (2012). Co-transcriptional degradation of aberrant pre-mRNA by Xrn2. EMBO JOURNAL, 31(11), 2566-2578. Author URL.
West S (2012). The increasing functional repertoire of U1 snRNA. BIOCHEMICAL SOCIETY TRANSACTIONS, 40, 846-849. Author URL.
Schmidt M-J, West S, Norbury CJ (2011). The human cytoplasmic RNA terminal U-transferase ZCCHC11 targets histone mRNAs for degradation. RNA, 17(1), 39-44. Author URL.
West S, Proudfoot NJ (2009). Transcriptional Termination Enhances Protein Expression in Human Cells. MOLECULAR CELL, 33(3), 354-364. Author URL.
West S, Proudfoot NJ (2008). Human Pcf11 enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination. NUCLEIC ACIDS RESEARCH, 36(3), 905-914. Author URL.
West S, Proudfoot NJ, Dye MJ (2008). Molecular dissection of mammalian RNA polymerase II transcriptional termination. MOLECULAR CELL, 29(5), 600-610. Author URL.
Gromak N, West S, Proudfoot NJ (2006). Pause sites promote transcriptional termination of mammalian RNA polymerase II. MOLECULAR AND CELLULAR BIOLOGY, 26(10), 3986-3996. Author URL.
West S, Zaret K, Proudfoot NJ (2006). Transcriptional termination sequences in the mouse serum albumin gene. RNA, 12(4), 655-665. Abstract.  Author URL.
Dye MJ, Gromak N, Haussecker D, West S, Proudfoot NJ (2006). Turnover and function of noncoding RNA polymerase II transcripts. Cold Spring Harb Symp Quant Biol, 71, 275-284. Abstract.  Author URL.
Teixeira A, Tahiri-Alaoui A, West S, Thomas B, Ramadass A, Martianov I, Dye M, James W, Proudfoot NJ, Akoulitchev A, et al (2004). Autocatalytic RNA cleavage in the human beta-globin pre-mRNA promotes transcription termination. Nature, 432(7016), 526-530. Abstract.  Author URL.
West S, Gromak N, Proudfoot NJ (2004). Human 5 '-> 3 ' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites. NATURE, 432(7016), 522-525. Author URL.

Publications by year


2020

Eaton JD, Francis L, Davidson L, West S (2020). A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes. Genes Dev, 34(1-2), 132-145. Abstract.  Author URL.  Full text.
Davidson L, Francis L, Eaton JD, West S (2020). Integrator-Dependent and Allosteric/Intrinsic Mechanisms Ensure Efficient Termination of snRNA Transcription. Cell Rep, 33(4). Abstract.  Author URL.
Eaton JD, West S (2020). Termination of Transcription by RNA Polymerase II: BOOM!. Trends in Genetics, 36(9), 664-675. Abstract.

2019

Davidson L, Francis L, Cordiner RA, Eaton JD, Estell C, Macias S, Cáceres JF, West S (2019). Rapid Depletion of DIS3, EXOSC10, or XRN2 Reveals the Immediate Impact of Exoribonucleolysis on Nuclear RNA Metabolism and Transcriptional Control. Cell Reports, 26(10), 2779-2791.e5. Abstract.  Full text.

2018

Eaton JD, West S (2018). An end in sight? Xrn2 and transcriptional termination by RNA polymerase II. Transcription, 9(5), 321-326. Abstract.  Author URL.
Eaton JD, Davidson L, Bauer DLV, Natsume T, Kanemaki MT, West S (2018). Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity. Genes Dev, 32(2), 127-139. Abstract.  Author URL.

2015

Muniz L, Davidson L, West S (2015). Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs. MOLECULAR AND CELLULAR BIOLOGY, 35(13), 2218-2230. Author URL.

2014

Davidson L, Muniz L, West S (2014). 3 ' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells. GENES & DEVELOPMENT, 28(4), 342-356. Author URL.
Hett A, West S (2014). Inhibition of U4 snRNA in Human Cells Causes the Stable Retention of Polyadenylated Pre-mRNA in the Nucleus. PLOS ONE, 9(5). Author URL.

2013

Davidson L, West S (2013). Splicing-coupled 3' end formation requires a terminal splice acceptor site, but not intron excision. NUCLEIC ACIDS RESEARCH, 41(14), 7101-7114. Author URL.

2012

Davidson L, Kerr A, West S (2012). Co-transcriptional degradation of aberrant pre-mRNA by Xrn2. EMBO JOURNAL, 31(11), 2566-2578. Author URL.
West S (2012). The increasing functional repertoire of U1 snRNA. BIOCHEMICAL SOCIETY TRANSACTIONS, 40, 846-849. Author URL.

2011

Schmidt M-J, West S, Norbury CJ (2011). The human cytoplasmic RNA terminal U-transferase ZCCHC11 targets histone mRNAs for degradation. RNA, 17(1), 39-44. Author URL.

2009

West S, Proudfoot NJ (2009). Transcriptional Termination Enhances Protein Expression in Human Cells. MOLECULAR CELL, 33(3), 354-364. Author URL.

2008

West S, Proudfoot NJ (2008). Human Pcf11 enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination. NUCLEIC ACIDS RESEARCH, 36(3), 905-914. Author URL.
West S, Proudfoot NJ, Dye MJ (2008). Molecular dissection of mammalian RNA polymerase II transcriptional termination. MOLECULAR CELL, 29(5), 600-610. Author URL.

2006

Gromak N, West S, Proudfoot NJ (2006). Pause sites promote transcriptional termination of mammalian RNA polymerase II. MOLECULAR AND CELLULAR BIOLOGY, 26(10), 3986-3996. Author URL.
West S, Zaret K, Proudfoot NJ (2006). Transcriptional termination sequences in the mouse serum albumin gene. RNA, 12(4), 655-665. Abstract.  Author URL.
Dye MJ, Gromak N, Haussecker D, West S, Proudfoot NJ (2006). Turnover and function of noncoding RNA polymerase II transcripts. Cold Spring Harb Symp Quant Biol, 71, 275-284. Abstract.  Author URL.

2004

Teixeira A, Tahiri-Alaoui A, West S, Thomas B, Ramadass A, Martianov I, Dye M, James W, Proudfoot NJ, Akoulitchev A, et al (2004). Autocatalytic RNA cleavage in the human beta-globin pre-mRNA promotes transcription termination. Nature, 432(7016), 526-530. Abstract.  Author URL.
West S, Gromak N, Proudfoot NJ (2004). Human 5 '-> 3 ' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites. NATURE, 432(7016), 522-525. Author URL.

Steven_West Details from cache as at 2020-11-27 09:16:39

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Teaching

I teach undergraduates about cutting edge research in transcription.

Modules

2020/21


Supervision / Group

Postgraduate researchers

  • Francesca Carlisle
  • Lee Davidson
  • Joshua Eaton
  • Christopher Estell
  • Evelina Lucinskaite

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