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Dr Tobias Bergmiller

Dr Tobias Bergmiller

Lecturer

 5160

 +44 01392 725160

 Living Systems Institute T04. 09

 

Living Systems Institute, University of Exeter, Stocker Road, Exeter, EX4 4QD

Overview

My lab is interested in bacterial multi-drug efflux pumps at several levels of organization, from the origins of trans-membrane protein insertion into bacterial membranes, their localization principles and dynamics over many cell cycles, to the bacterial strategies utilising multi-drug efflux pumps unfolding at the population-level. Our main tools are microscopy and microfluidics, which allow us to observe bacteria growing in highly controlled environments.

Qualifications

2005-2011     PhD (Molecular Microbial Ecology and Evolution)   ETH Zurich, Switzerland

1999 – 2005  Diploma/Masters (Microbiology)                              University of Constance, Germany

Career

2019 – present   Lecturer in Biosciences, University of Exeter

2018                   Parental leave

2011 – 2017       PostDoc, IST Austria

Research group links

Research

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Nikolic N, Bergmiller T, Vandervelde A, Albanese TG, Gelens L, Moll I (2018). Autoregulation of mazEFexpression underlies growth heterogeneity in bacterial populations. Nucleic Acids Research, 46(6), 2918-2931. Abstract.
Tomasek K, Bergmiller T, Guet CC (2018). Lack of cations in flow cytometry buffers affect fluorescence signals by reducing membrane stability and viability of Escherichia coli strains. Journal of Biotechnology, 268, 40-52. Abstract.
De Martino D, MC Andersson A, Bergmiller T, Guet CC, Tkačik G (2018). Statistical mechanics for metabolic networks during steady state growth. Nature Communications, 9(1). Abstract.
Renault TT, Abraham AO, Bergmiller T, Paradis G, Rainville S, Charpentier E, Guet CC, Tu Y, Namba K, Keener JP, et al (2017). Bacterial flagella grow through an injection-diffusion mechanism. eLife, 6 Abstract.
Bergmiller T, Andersson AMC, Tomasek K, Balleza E, Kiviet DJ, Hauschild R, Tkačik G, Guet CC (2017). Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity. Science, 356(6335), 311-315. Abstract.
Nikolic N, Schreiber F, Dal Co A, Kiviet DJ, Bergmiller T, Littmann S, Kuypers MMM, Ackermann M (2017). Cell-to-cell variation and specialization in sugar metabolism in clonal bacterial populations. PLoS Genetics, 13(12). Abstract.
Chait R, Ruess J, Bergmiller T, Tkačik G, Guet CC (2017). Shaping bacterial population behavior through computer-interfaced control of individual cells. Nature Communications, 8(1). Abstract.  Full text.
Wielgoss S, Bergmiller T, Bischofberger AM, Hall AR (2016). Adaptation to parasites and costs of parasite resistance in mutator and nonmutator bacteria. Molecular Biology and Evolution, 33(3), 770-782. Abstract.
Pleška M, Qian L, Okura R, Bergmiller T, Wakamoto Y, Kussell E, Guet CC (2016). Bacterial autoimmunity due to a restriction-modification system. Current Biology, 26(3), 404-409. Abstract.
Boehm A, Arnoldini M, Bergmiller T, Röösli T, Bigosch C, Ackermann M (2016). Genetic Manipulation of Glycogen Allocation Affects Replicative Lifespan in E. coli. PLoS Genetics, 12(4). Abstract.
Dhar R, Bergmiller T, Wagner A (2014). Increased gene dosage plays a predominant role in the initial stages of evolution of duplicate tem-1 beta lactamase genes. Evolution, 68(6), 1775-1791. Abstract.
Refardt D, Bergmiller T, Kümmerli R (2013). Altruism can evolve when relatedness is low: Evidence from bacteria committing suicide upon phage infection. Proceedings of the Royal Society B: Biological Sciences, 280(1759). Abstract.
Bergmiller T, Ackermann M, Silander OK (2012). Patterns of evolutionary conservation of essential genes correlate with their compensability. PLoS Genetics, 8(6). Abstract.
Bergmiller T, Ackermann M (2011). Pole age affects cell size and the timing of cell division in Methylobacterium extorquens AM1. Journal of Bacteriology, 193(19), 5216-5221. Abstract.
Bergmiller T, Peña-Miller R, Boehm A, Ackermann M (2011). Single-cell time-lapse analysis of depletion of the universally conserved essential protein YgjD. BMC Microbiol, 11 Abstract.  Author URL.
Dippel R, Bergmiller T, Böhm A, Boos W (2005). The maltodextrin system of Escherichia coli: Glycogen-derived endogenous induction and osmoregulation. Journal of Bacteriology, 187(24), 8332-8339. Abstract.

Publications by year


2018

Nikolic N, Bergmiller T, Vandervelde A, Albanese TG, Gelens L, Moll I (2018). Autoregulation of mazEFexpression underlies growth heterogeneity in bacterial populations. Nucleic Acids Research, 46(6), 2918-2931. Abstract.
Tomasek K, Bergmiller T, Guet CC (2018). Lack of cations in flow cytometry buffers affect fluorescence signals by reducing membrane stability and viability of Escherichia coli strains. Journal of Biotechnology, 268, 40-52. Abstract.
De Martino D, MC Andersson A, Bergmiller T, Guet CC, Tkačik G (2018). Statistical mechanics for metabolic networks during steady state growth. Nature Communications, 9(1). Abstract.

2017

Renault TT, Abraham AO, Bergmiller T, Paradis G, Rainville S, Charpentier E, Guet CC, Tu Y, Namba K, Keener JP, et al (2017). Bacterial flagella grow through an injection-diffusion mechanism. eLife, 6 Abstract.
Bergmiller T, Andersson AMC, Tomasek K, Balleza E, Kiviet DJ, Hauschild R, Tkačik G, Guet CC (2017). Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity. Science, 356(6335), 311-315. Abstract.
Nikolic N, Schreiber F, Dal Co A, Kiviet DJ, Bergmiller T, Littmann S, Kuypers MMM, Ackermann M (2017). Cell-to-cell variation and specialization in sugar metabolism in clonal bacterial populations. PLoS Genetics, 13(12). Abstract.
Chait R, Ruess J, Bergmiller T, Tkačik G, Guet CC (2017). Shaping bacterial population behavior through computer-interfaced control of individual cells. Nature Communications, 8(1). Abstract.  Full text.

2016

Wielgoss S, Bergmiller T, Bischofberger AM, Hall AR (2016). Adaptation to parasites and costs of parasite resistance in mutator and nonmutator bacteria. Molecular Biology and Evolution, 33(3), 770-782. Abstract.
Pleška M, Qian L, Okura R, Bergmiller T, Wakamoto Y, Kussell E, Guet CC (2016). Bacterial autoimmunity due to a restriction-modification system. Current Biology, 26(3), 404-409. Abstract.
Boehm A, Arnoldini M, Bergmiller T, Röösli T, Bigosch C, Ackermann M (2016). Genetic Manipulation of Glycogen Allocation Affects Replicative Lifespan in E. coli. PLoS Genetics, 12(4). Abstract.

2014

Dhar R, Bergmiller T, Wagner A (2014). Increased gene dosage plays a predominant role in the initial stages of evolution of duplicate tem-1 beta lactamase genes. Evolution, 68(6), 1775-1791. Abstract.

2013

Refardt D, Bergmiller T, Kümmerli R (2013). Altruism can evolve when relatedness is low: Evidence from bacteria committing suicide upon phage infection. Proceedings of the Royal Society B: Biological Sciences, 280(1759). Abstract.

2012

Bergmiller T, Ackermann M, Silander OK (2012). Patterns of evolutionary conservation of essential genes correlate with their compensability. PLoS Genetics, 8(6). Abstract.

2011

Bergmiller T, Ackermann M (2011). Pole age affects cell size and the timing of cell division in Methylobacterium extorquens AM1. Journal of Bacteriology, 193(19), 5216-5221. Abstract.
Bergmiller T, Peña-Miller R, Boehm A, Ackermann M (2011). Single-cell time-lapse analysis of depletion of the universally conserved essential protein YgjD. BMC Microbiol, 11 Abstract.  Author URL.

2005

Dippel R, Bergmiller T, Böhm A, Boos W (2005). The maltodextrin system of Escherichia coli: Glycogen-derived endogenous induction and osmoregulation. Journal of Bacteriology, 187(24), 8332-8339. Abstract.

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Supervision / Group

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