Faculty of Health and Life Sciences

Dr Andrew Shaw

Dr Andrew Shaw

Associate Professor of Physical Chemistry

 Andrew.M.Shaw@exeter.ac.uk

 3495

 Geoffrey Pope 220

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

My research uses the principles of physical chemistry to make measurements on systems in Chemical Biology. We are currently developing a screening technology that will allow the concentrations of molecules in blood to be measured that may act as biomarkers of disease and extend the field of differential diagnosis. My research concentrates on the fundamental the quantitative description of measurements interpreted with a mathematical model. The research directions have led to the formation of a company to exploit the technology commercially with application in the petrochemical industry, production quality monitoring and Homeland Security.

Teaching interests in the School are Physical Chemistry for the Life Sciences, Astrochemistry and Astrobiology and Forensic Science. All modules explore the quantitative interpretation of physical processes. I have written a textbook Astrochemistry: From Astronomy to Astrobiology, published by Wiley in 2006. In addition to my teaching duties I am also Study Abroad Tutor for our international exchange programme. I am a member of the Molecules and cells research group.

Qualifications

1989-1992 PhD Physical Chemistry, University of Southampton
1985-1988, 1992 MA Natural Sciences, University of Cambridge

Career

2007 – Present, Associate Professor of Physical Chemistry
2007 – Present, Founder and Director of Attomarker Ltd
2009 – Present, Chairman of Arkiris, KTA
2005-2007 Senior Lecturer in Physical Chemistry, University of Exeter
2005-present Senior Lecturer in Physical Chemistry, School of Biosciences, University of Exeter
2001-2005 Lecturer in Physical Chemistry, Department of Chemistry, University of Exeter
2002-present Founder and Director of Research, EvanesCo Ltd
1999-2001 Postdoctoral Research Fellow, Stanford University
1992-1999 University Research Fellow, University of Southampton
1999 Fellow of the Royal Astronomical Society
1994 Member of the Royal Society of Chemistry
 

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Research group links

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Research

Research interests

Research in the group is underpinned by physical chemistry and the quantitative measurements of physical, chemical, biological and medical processes. We have studied complex fluids such as blood to screen them for components that may be important in allergy, diagnosis of complications following major surgical procedures, assessment of the efficacy of vaccines and diagnosis of autoimmune diseases. These measurements require the development of three new technologies: evanescent wave cavity ring-down spectroscopy; label-free biophotonic array screening and lens-less microscope screening of phenotype variability.  The development and analysis of the data quantitatively as a complex system is common to all investigations. In addition to reserach, if there is an entrepreneurial opportunity to commercialise the technology, we collabroate with industry and there are two spin-out companies, EvanesCo Ltd and Attomarker Ltd, associated with exploiting the reserach ideas.

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Publications

Books

Shaw AM (2006). Astrochemistry: from Astronomy to Astrobiology., Wiley.

Journal articles

James-Pemberton P, Shaw A, Lapinska U, Hyde C (In Press). Accuracy and Precision Analysis for a Biophotonic Assay of C-Reactive Protein. The Analyst
Shaw AM, Hyde C, Merrick B, James-Pemberton P, Squires BK, Olkhov RV, Batra R, Patel A, Bisnauthsing K, Nebbia G, et al (2020). Real-world evaluation of a novel technology for quantitative simultaneous antibody detection against multiple SARS-CoV-2 antigens in a cohort of patients presenting with COVID-19 syndrome. Analyst, 145(16), 5638-5646. Abstract.  Author URL.
Reader P, Shaw A, Hyde C, Olkhov R (2019). A rapid and quantitative technique for assessing IgG monomeric purity, calibrated with the NISTmAb reference material. Analytical and Bioanalytical Chemistry
pay J, Shaw AM (2019). Towards salivary C-reactive protein as a viable biomarker of systemic inflammation. Clinical Biochemistry
Reader PP, Shaw AM (2017). Kinetic Analysis of the Multivalent Ligand Binding Interaction between Protein A/G and IgG: a Standard System Setting. Journal of Physical Chemistry B, 121(38), 8919-8925. Abstract.
Clarke TL, White DA, Osborne ME, Shaw AM, Smart NJ, Daniels IR (2017). Predicting response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer with serum biomarkers. Ann R Coll Surg Engl, 99(5), 373-377. Abstract.  Author URL.
Gregory AE, Judy BM, Qazi O, Blumentritt CA, Brown KA, Shaw AM, Torres AG, Titball RW (2015). A gold nanoparticle-linked glycoconjugate vaccine against Burkholderia mallei. Nanomedicine, 11(2), 447-456. Abstract.  Author URL.
Marshall MJ, Smart NJ, Hyde C, Winyard PG, Shaw AM, Daniels IR (2015). Biomarkers for diagnosis of acute appendicitis in adults. COCHRANE DATABASE OF SYSTEMATIC REVIEWS(3).  Author URL.
Read T, Olkhov RV, Williamson ED, Shaw AM (2015). Kinetic epitope mapping of monoclonal antibodies raised against the Yersinia pestis virulence factor LcrV. Biosensors and Bioelectronics, 65, 47-53. Abstract.
Read T, Olkhov RV, Williamson ED, Shaw AM (2015). Label-free Fab and Fc affinity/avidity profiling of the antibody complex half-life for polyclonal and monoclonal efficacy screening. Analytical and Bioanalytical Chemistry Abstract.
Morad HOJ, Belete SC, Read T, Shaw AM (2015). Time-course analysis of C3a and C5a quantifies the coupling between the upper and terminal Complement pathways in vitro. JOURNAL OF IMMUNOLOGICAL METHODS, 427, 13-18.  Author URL.
McQuillan JS, Shaw AM (2014). Differential gene regulation in the Ag nanoparticle and Ag(+)-induced silver stress response in Escherichia coli: a full transcriptomic profile. Nanotoxicology, 8 Suppl 1, 177-184. Abstract.  Author URL.
van Vuuren BJ, Bergseth G, Mollnes TE, Shaw AM (2014). Electroluminescent TCC, C3dg and fB/Bb epitope assays for profiling complement cascade activation in vitro using an activated complement serum calibration standard. J Immunol Methods, 402(1-2), 50-56. Abstract.  Author URL.
van Vuuren BJ, Bergseth G, Mollnes TE, Shaw AM (2014). Electroluminescent TCC, C3dg and fB/Bb epitope assays for profiling complement cascade activation in vitro using an activated complement serum calibration standard. Journal of immunological methods, 402(1-2), 50-56. Abstract.
Olkhov RV, Weissenborn MJ, Flitsch SL, Shaw AM (2014). Glycosylation characterization of human and porcine fibrinogen proteins by lectin-binding biophotonic microarray imaging. Anal Chem, 86(1), 621-628. Abstract.  Author URL.
Olkhov RV, Shaw AM (2014). Growth kinetics of gold nanoparticles on silica/graphene surfaces for multiplex biological immunoassays. RSC Advances, 4(60), 31678-31684. Abstract.
Penwill LA, Batten GE, Castagnetti S, Shaw AM (2014). Growth phenotype screening of Schizosaccharomyces pombe using a Lensless microscope. Biosens Bioelectron, 54, 345-350. Abstract.  Author URL.
Mcquillan JS, Shaw AM (2014). Whole-cell Escherichia coli-based bio-sensor assay for dual zinc oxide nanoparticle toxicity mechanisms. Biosens Bioelectron, 51, 274-279. Abstract.  Author URL.
Read T, Olkhov RV, Shaw AM (2013). Measurement of the localised plasmon penetration depth for gold nanoparticles using a non-invasive bio-stacking method. Phys Chem Chem Phys, 15(16), 6122-6127. Abstract.  Author URL.
Walker NDL, Olkhov RV, Shaw AM (2013). pH-dependent electronic surface spectra of chromophore species in the charged silica-water interface. RSC ADVANCES, 3(27), 10927-10933.  Author URL.
Gregory AE, Shaw AM, Titball RW, Williamson ED, Prior JL, Butcher WA, Thompson IJ (2012). Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity. Vaccine Abstract.
Gregory AE, Williamson ED, Prior JL, Butcher WA, Thompson IJ, Shaw AM, Titball RW (2012). Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity. Vaccine, 30(48), 6777-6782. Abstract.  Author URL.
Heuts DPHM, Weissenborn MJ, Olkhov RV, Shaw AM, Gummadova J, Levy C, Scrutton NS (2012). Crystal structure of a soluble form of human CD73 with ecto-5'-nucleotidase activity. Chembiochem, 13(16), 2384-2391. Abstract.  Author URL.
Olkhov RV, Kaminski ER, Shaw AM (2012). Differential immuno-kinetic assays of allergen-specific binding for peanut allergy serum analysis. Analytical and Bioanalytical Chemistry, 404(8), 2241-2247. Abstract.
Olkhov RV, Kaminski ER, Shaw AM (2012). Differential immuno-kinetic assays of allergen-specific binding for peanut allergy serum analysis. Anal Bioanal Chem, 404(8), 2241-2247. Abstract.  Author URL.
McQuillan JS, Infante HG, Stokes E, Shaw AM (2012). Silver nanoparticle enhanced silver ion stress response in Escherichia coli K12. Nanotoxicology, 6, 857-866. Abstract.  Author URL.
Olkhov RV, Parker R, Shaw AM (2012). Whole blood screening of antibodies using label-free nanoparticle biophotonic array platform. Biosensors and Bioelectronics, 36(1), 1-5. Abstract.
Olkhov RV, Parker R, Shaw AM (2012). Whole blood screening of antibodies using label-free nanoparticle biophotonic array platform. Biosens Bioelectron, 36(1), 1-5. Abstract.  Author URL.
van Vuuren BJ, Read T, Olkhov RV, Shaw AM (2010). Human serum albumin interference on plasmon-based immunokinetic assay for antibody screening in model blood sera. Anal Biochem, 405(1), 114-120. Abstract.  Author URL.
Olkhov RV, Shaw AM (2010). Quantitative label-free screening for antibodies using scattering biophotonic microarray imaging. Anal Biochem, 396(1), 30-35. Abstract.  Author URL.
Kretzers IKJ, Parker RJ, Olkhov RV, Shaw AM (2009). Aggregation kinetics of gold nanoparticles at the silica-water interface. Journal of Physical Chemistry C, 113(14), 5514-5519. Abstract.
Shaw AM, Olkhov RV, Fowke JD (2009). Whole serum BSA antibody screening using a label-free biophotonic nanoparticle array. Analytical Biochemistry, 385, 234-241. Abstract.
Olkhov RV, Shaw AM (2008). Label-free antibody-antigen binding detection by optical sensor array based on surface-synthesized gold nanoparticles. Biosens Bioelectron, 23(8), 1298-1302. Abstract.  Author URL.
Hayes NW, Tremlett CJ, Melfi PJ, Sessler JD, Shaw AM (2008). Uranyl-specific binding at a functionalised interface: a chemophotonic fibre optic sensor platform. Analyst, 133(5), 616-620. Abstract.  Author URL.
Shaw AM, Rooth M (2007). Gold nanoparticle binding kinetics at a silica-water interface. Journal of Physical Chemistry C, 111(6), 2588-2594.
Rooth M, Shaw AM (2007). PH-controlled formation kinetics of self-assembled layers of thioctic acid on gold nanoparticles. Journal of Physical Chemistry C, 111(42), 15363-15369. Abstract.
Rooth M, Shaw AM (2006). Interfacial pH and surface p<i>K</i><sub>a</sub> of a thioctic acid self-assembled monolayer. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 8(41), 4741-4743.  Author URL.
Rooth M, Shaw AM (2006). Interfacial pH and surface pKa of a thioctic acid self-assembled monolayer. Phys Chem Chem Phys, 8(41), 4741-4743. Abstract.  Author URL.
Shaw, A.M. (2006). Interfacial pH of a Thioctic Acid Self-Assembled Monolayer formed on a Plasmon Resonance Particle Surface. Journal of Physical Chemistry B
Shaw AM, Fisk JD, O'Reilly JP, Perkins E (2006). Non-linear plasmon response to protein binding at a nanostructured gold particle plasmon resonance surface. Physical Chemistry Chemical Physics, 9(3), 344-345.
Fisk JD, O'Reilly JP, Shaw AM (2006). Reply to "comment on 'interfacial ph of an isolated silica-water interface'". Journal of Physical Chemistry B, 110(30), 15039-15040.
Fisk JD, Hayes NW, Barnett D, Farries M, Tasker KM, Shaw AM (2005). Fibre optic implementation of evanescent wave cavity ring-down spectroscopy for chemical detection. Proceedings of SPIE - the International Society for Optical Engineering, 5990 Abstract.
Mirov, S. Martyshkin, D. (2005). Hemoglobin Adsorption Isotherm at the Silica-Water Interface. Journal of Biomedical Optics, 10(2), 1-7.
Martin WB, Mirov S, Martyshkin D, Venugopalan R, Shaw AM (2005). Hemoglobin adsorption isotherm at the silica-water interface with evanescent wave cavity ring-down spectroscopy. Journal of Biomedical Optics, 10(2). Abstract.
Martin WB, Mirov S, Martyshkin D, Venugopalan R, Shaw AM (2005). Hemoglobin adsorption isotherm at the silica-water interface with evanescent wave cavity ring-down spectroscopy. Journal of Biomedical Optics, 10(2). Abstract.
Shaw AM, Butts CP, I'Anson IA, O'Reilly JP (2005). Interfacial pH at an Isolated Silica-Water Surface. Journal of the American Chemical Society, 127(6), 1632-1633.
Shaw AM, Batten R, Jones G, O'Reilly JP (2005). pH Dependence of the Crystal Violet Adsorption Isotherm at the Silica-Water Interface. The Journal of Physical Chemistry B, 109(30), 14475-14480.
Batten, R. Jones, G. O’Reilly, J.P. (2005). pH dependent Adsorption Isotherm for Crystal Violet at the Silica-Water Interface. Journal of Physical Chemistry B, 109(30), 14475-14480.
Shaw AM, Hannon TE, Li F, Zare RN (2003). Adsorption of crystal violet to the silica - Water interface monitored by evanescent wave cavity ring-down spectroscopy. Journal of Physical Chemistry B, 107(29), 7070-7075. Abstract.
Gammie DI, Page JC, Shaw AM (2002). Microwave and millimeter-wave spectrum of the He•••H<sub>2</sub>+ long-range complex. JOURNAL OF CHEMICAL PHYSICS, 116(14), 6072-6078.  Author URL.
Gammie DI, Page JC, Shaw AM (2002). Microwave and millimeter-wave spectrum of the He⋯H<inf>2</inf><sup>+</sup> long-range complex. Journal of Chemical Physics, 116(14), 6072-6078. Abstract.
Carrington A, Gammie DI, Page JC, Shaw AM, Hutson JM (2002). Microwave electronic spectrum of the Ne•••Ne<SUP>+</SUP> long-range complex:: the interaction potential. JOURNAL OF CHEMICAL PHYSICS, 116(9), 3662-3669.  Author URL.
Carrington A, Gammie DI, Page JC, Shaw AM, Hutson JM (2002). Microwave electronic spectrum of the Ne⋯Ne<sup>+</sup> long-range complex: the interaction potential. Journal of Chemical Physics, 116(9), 3662-3669. Abstract.
Shaw AM, Zare RN, Bennett CV, Kolner BH (2001). Bounce-by-bounce cavity ring-down spectroscopy: Femtosecond temporal imaging. ChemPhysChem, 2(2), 118-121.
Carrington A, Gammie DI, Page JC, Shaw AM, Taylor SM (1999). Microwave electronic spectrum of the Ne. Ne<sup>+</sup> long-range complex. Physical Chemistry Chemical Physics, 1(1), 29-36. Abstract.
Carrington A, Gammie DI, Page JC, Shaw AM, Taylor SM (1999). Microwave electronic spectrum of the Ne•••Ne<SUP>+</SUP> long-range complex. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 1(1), 29-36.  Author URL.
Dyke JM, Shaw AM (1998). A study of the BaO+H chemiionisation reaction. JOURNAL OF ELECTRON SPECTROSCOPY AND RELATED PHENOMENA, 97(1-2), 23-32.  Author URL.
Dyke JM, Shaw AM, Veszpremi T (1997). Chemiionization reactions of Mg, Ca, Sr and Ba with O-2(X-3 Sigma(-)(g)), O-2(a(1)Delta(g)) and O(P-3). JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS, 93(16), 2631-2636.  Author URL.
Carrington A, Pyne CH, Shaw AM, Taylor SM, Hutson JM, Law MM (1996). Microwave spectroscopy and interaction potential of the long-range He center dot center dot center dot Kr+ ion: an example of Hund's case (e). JOURNAL OF CHEMICAL PHYSICS, 105(19), 8602-8614.  Author URL.
Carrington A, Pyne CH, Shaw AM, Taylor SM, Hutson JM, Law MM (1996). Microwave spectroscopy and interaction potential of the long-range He⋯Kr<sup>+</sup> ion: an example of Hund's case (e). Journal of Chemical Physics, 105(19), 8602-8614. Abstract.
Carrington A, Gammie DI, Shaw AM, Taylor SM, Hutson JM (1996). Observation of a microwave spectrum of the long-range He center dot center dot center dot H-2(+) complex. CHEMICAL PHYSICS LETTERS, 260(3-4), 395-405.  Author URL.
Carrington A, Gammie DI, Shaw AM, Taylor SM (1996). Observation of a microwave spectrum of the long-range He center dot center dot center dot N+ complex. CHEMICAL PHYSICS LETTERS, 262(5), 598-602.  Author URL.
Carrington A, Gammie DI, Shaw AM, Taylor SM (1996). Observation of a microwave spectrum of the long-range He · · · N<sup>+</sup> complex. Chemical Physics Letters, 262(5), 598-602. Abstract.
Carrington A, Gammie DI, Shaw AM, Taylor SM, Hutson JM (1996). Observation of a microwave spectrum of the long-range He ⋯ H<sup>+</sup><inf>2</inf> complex. Chemical Physics Letters, 260(3-4), 395-405. Abstract.
Carrington A, Shaw AM, Taylor SM (1995). Ion-beam spectroscopy of long-range complexes. Journal of the Chemical Society, Faraday Transactions, 91(21), 3725-3740. Abstract.
Carrington A, Shaw AM, Taylor SM (1995). Microwave electronic spectra of the Ar<inf>2</inf><sup>+</sup> and Ne<inf>2</inf><sup>+</sup> ions: a combined neutral/ion molecular beam technique. Chemical Physics Letters, 241(5-6), 611-617. Abstract.
Carrington A, Leach CA, Marr AJ, Shaw AM, Viant MR, Hutson JM, Law MM (1995). Microwave spectroscopy and interaction potential of the long-range He⋯Ar<sup>+</sup> ion. The Journal of Chemical Physics, 102(6), 2379-2403. Abstract.
Carrington A, Gammie DI, Shaw AM, Taylor SM (1995). Millimetre-wave electronic spectrum of the D<inf>2</inf><sup>+</sup> ion. Journal of the Chemical Society, Faraday Transactions, 91(13), 1887-1889. Abstract.
DYKE JM, SHAW AM, WRIGHT TG (1995). STUDY OF CHEMIIONIZATION REACTIONS IN THE O+C2H2 REACTION MIXTURE - EVIDENCE FOR INVOLVEMENT OF THE CH(X(2)PI) AND CH(A(4)SIGMA(-)) STATES. JOURNAL OF PHYSICAL CHEMISTRY, 99(39), 14207-14216.  Author URL.
SHAW AM, DYKE JM, ZENGIN V, SUZER S (1994). A STUDY OF THE CHEMIIONIZATION REACTIONS OF CA, SR AND BA WITH O-2(X (3)SIGMA(G-)). CHEMICAL PHYSICS, 179(3), 455-462.  Author URL.
Dyke JM, Shaw AM, Wright TG (1994). Study of chemiionization reactions in the O + 2-butyne reaction mixture. Journal of Physical Chemistry, 98(25), 6327-6331. Abstract.
Carrington A, Leach CA, Marr AJ, Pyne CH, Shaw AM, Viant MR, West YD (1993). Near-dissociation microwave spectra of rare-gas diatomic ions. Chemical Physics Letters, 212(5), 473-479. Abstract.

Chapters

Shaw AM, Olkhov RV, Jerdev A, Barnes WL (2012). Plasmon biophotonic arrays for multi-analyte biosensing in complex media. In  (Ed) Nanoplasmonic Sensors, 127-151. Abstract.

Conferences

Marshall MJ, Shaw AM, Smart NJ, Daniels IR (2015). DIAGNOSTIC ACCURACY OF SERIAL COMPLEMENT PROTEIN ANALYSIS IN ACUTE APPENDICITIS: C3, C4, IC3B AND TCC.  Author URL.
Marshall MJ, Shaw AM, Smart NJ, Daniels IR (2015). SHOULD a MACROSCOPICALLY NORMAL APPENDIX BE LEFT <i>IN SITU</i>?.  Author URL.
Shaw AM, van Vuuren B, McGrath JS, Daniels I (2012). A pilot study of complement cascade activation as a marker for recovery following major abdominal surgery.  Author URL.
Khan D, Perry MH, McGrath JS, Daniels IR, Shaw AM (2011). Complement depletion as a marker for complications in open abdomen surgery.  Author URL.
Hayes NW, Tremlett CJ, Melfi PJ, Sessler JD, Shaw AM (2007). Fibre optic system for detection of uranyl Ions in the solution phase. Abstract.
Farries MC, Shaw AM, Fisk J, Garvey L (2004). Detection of low chemical concentrations by cavity ring down in an evanescently coupled fused optical fibre taper. Abstract.

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External Engagement and Impact

Committee/panel activities

Member of University of Exeter Council, 2013 - present

Chair of the Academic Staff Association of Senators (2011 - 2013)

Chairman and Vice Chair of the Peninsular Section of the Royal Society of Chemistry 2006-9

Industry

Founder and Director of Reseach , Attomarker Ltd 2009 - Current

Founder and Director of Research, EvanesCo Ltd. 2002 - 2009


Editorial responsibilities

Associated Editor of Chemistry Review

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Teaching

Undergraduate

Year 1

  • Physical Chemistry for the Life Sciences (20 Lectures)

Year 2

  • Intermediate Physical Chemistry (30 lectures)
  • Control of Metabolic Pathways (3 lectures)
  • Biological Spectroscopy (7 lectures)

Year 3

  • Reaction Kinetics (20 lectures)
  • Astrophysical Chemistry and the Origins of Life (20 lectures)

All years

  • Forensic Science (30 lectures)

Postgraduate

  • Biotechnology and Enterprise (3 lectures) MSc

Modules

2023/24

Information not currently available


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Supervision / Group

Postdoctoral researchers

Postgraduate researchers

Alumni

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