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Dr Gregory Paull

Dr Gregory Paull

Aquatic Facilities Manager (Streatham Campus) & NACWO

 5846

 Geoffrey Pope Aquatic Resource Centre

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

Dr Gregory Paull is the founding manager and senior NACWO (Named Animal Care and Welfare Officer) of the Aquatic Resources Centre (ARC), a large interdisciplinary £12M facility on Streatham campus.  Greg led the design and implementation of the facility in 2011 and oversees a team of experienced husbandry staff to help manage this Centre as well as a number of smaller aquatic facilities on the Exeter campus. The ARC is a rapidly expanding research and teaching facility comprising over 600m2 of working area (including 27 wet and dry lab set ups) which currently supports approximately 20 academic research groups.    

In addition to his facility management and operational skills Greg has a successful research track record in reproductive biology of aquatic animals (including growth, stress, immune function and reproductive condition), as well as numerous ecotoxicology studies using zebrafish and roach contributing to over 40 publications.  

Greg is particularly keen in trying to promote improved husbandry and welfare practices for laboratory-maintained fish, most notably in zebrafish and is co supervisor of PhD work in this area.  In 2008, he was awarded a Winston Churchill Memorial Trust Travelling Fellowship to study zebrafish (Danio rerio; the most widely used fish species in scientific research) in the wild (Bangladesh).   A keen contributor to guidelines/policies developing best practice for working with a wide range of University hosted species  Greg  has links with the international research aquaria community, fish husbandry-related industries, and animal welfare organisations and speaks regularly at leading zebrafish/fish husbandry workshops.

Greg is currently a Co-I on a number of grants, including 

  • with Prof Rod Wilson (NC3R funded) invistigating the role of water chemistry in zebrafish welfare and reproducibility of research studies 
  • with Dr Matthew Witt and Dr Lucy Hawkes (NC3R funded), using highly innovative field techniques to refine the tagging of pelagic fish and sharks (most recenty to deploy bluefin tuna and basking sharks off the UK coasts with senor devices to monitor post-release welfare)
  • with Dr Eduarda Santos (Environment Agency funded) researching the effects of chemical exposure on whole genome RNA transcriptomics of aquatic invertebrates

Greg has recently returned from the Kalimantari Lestari Project Workshop in Palangka Raya, Borneo, invited by Professor Frank Van Veen and Dr Eduarda Santos to investigate drivers and impacts of drought and peatland fires in Indonesian Borneo and implications for building resilience through sustainable development including the valuable native species (snakehead) as a possible alternative livelihood/clean food source supply. 

Greg previously worked at CEFAS (fish histopath and molecular diagnostics disease labs) and studied at Queen Mary, London, Plymouth University and University of Exeter.  

When not looking after aquatic creatures and researchers in the ARC Greg can be found engaged in sport (challenging new Uni students at football, badminton and hockey) or outdoor / wildlife / social expeditions.

 

 

 

Research

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Paull GC, Lee CJ, Tyler CR (2023). Beyond compliance: harmonising research and husbandry practices to improve experimental reproducibility using fish models. Biol Rev Camb Philos Soc Abstract.  Author URL.
Lee CJ, Paull GC, Tyler CR (2022). Improving zebrafish laboratory welfare and scientific research through understanding their natural history. Biol Rev Camb Philos Soc, 97(3), 1038-1056. Abstract.  Author URL.
Viana J, Wildman N, Hannon E, Farbos A, Neill PO, Moore K, van Aerle R, Paull G, Santos E, Mill J, et al (2020). Clozapine-induced transcriptional changes in the zebrafish brain. NPJ Schizophr, 6(1). Abstract.  Author URL.
Lee CJ, Paull GC, Tyler CR (2019). Effects of environmental enrichment on survivorship, growth, sex ratio and behaviour in laboratory maintained zebrafish Danio rerio. J Fish Biol, 94(1), 86-95. Abstract.  Author URL.
Lee CJ, Tyler CR, Paull GC (2018). Can simple tank changes benefit the welfare of laboratory zebrafish Danio rerio?. J Fish Biol, 92(3), 653-659. Abstract.  Author URL.
Stevens CH, Croft DP, Paull GC, Tyler CR (2017). Stress and welfare in ornamental fishes: what can be learned from aquaculture?. J Fish Biol, 91(2), 409-428. Abstract.  Author URL.
Laing LV, Viana J, Dempster EL, Trznadel M, Trunkfield LA, Uren Webster TM, van Aerle R, Paull GC, Wilson RJ, Mill J, et al (2016). Bisphenol a causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Epigenetics, 11(7), 526-538. Abstract.  Author URL.
Brown AR, Owen SF, Peters J, Zhang Y, Soffker M, Paull GC, Hosken DJ, Wahab MA, Tyler CR (2015). Climate change and pollution speed declines in zebrafish populations. Proc Natl Acad Sci U S A, 112(11), E1237-E1246. Abstract.  Author URL.
Bickley LK, Brown AR, Hosken DJ, Hamilton PB, Le Page G, Paull GC, Owen SF, Tyler CR (2013). Interactive effects of inbreeding and endocrine disruption on reproduction in a model laboratory fish. Evolutionary Applications, 6(2), 279-289. Abstract.
Brown AR, Bickley LK, Ryan TA, Paull GC, Hamilton PB, Owen SF, Sharpe AD, Tyler CR (2012). Differences in sexual development in inbred and outbred zebrafish (Danio rerio) and implications for chemical testing. Aquat Toxicol, 112-113, 27-38. Abstract.  Author URL.
Filby AL, Paull GC, Searle F, Ortiz-Zarragoitia M, Tyler CR (2012). Environmental estrogen-induced alterations of male aggression and dominance hierarchies in fish: a mechanistic analysis. Environ Sci Technol, 46(6), 3472-3479. Abstract.  Author URL.
Brown AR, Bickley LK, Le Page G, Hosken DJ, Paull GC, Hamilton PB, Owen SF, Robinson J, Sharpe AD, Tyler CR, et al (2011). Are toxicological responses in laboratory (inbred) zebrafish representative of those in outbred (wild) populations? - a case study with an endocrine disrupting chemical. Environ Sci Technol, 45(9), 4166-4172. Abstract.  Author URL.
Lange A, Paull GC, Hamilton PB, Iguchi T, Tyler CR (2011). Implications of persistent exposure to treated wastewater effluent for breeding in wild roach (Rutilus rutilus) populations. Environ Sci Technol, 45(4), 1673-1679. Abstract.  Author URL.
Paull GC, Filby AL, Giddins HG, Coe TS, Hamilton PB, Tyler CR (2010). Dominance hierarchies in zebrafish (Danio rerio) and their relationship with reproductive success. Zebrafish, 7(1), 109-117. Abstract.  Author URL.
Uren-Webster TM, Lewis C, Filby AL, Paull GC, Santos EM (2010). Mechanisms of toxicity of di(2-ethylhexyl) phthalate on the reproductive health of male zebrafish. Aquat Toxicol, 99(3), 360-369. Abstract.  Author URL.
Filby AL, Paull GC, Bartlett EJ, Van Look KJW, Tyler CR (2010). Physiological and health consequences of social status in zebrafish (Danio rerio). Physiol Behav, 101(5), 576-587. Abstract.  Author URL.
Filby AL, Paull GC, Hickmore TF, Tyler CR (2010). Unravelling the neurophysiological basis of aggression in a fish model. BMC Genomics, 11 Abstract.  Author URL.
Oehlmann J, Schulte-Oehlmann U, Kloas W, Jagnytsch O, Lutz I, Kusk KO, Wollenberger L, Santos EM, Paull GC, VanLook KJW, et al (2009). A critical analysis of the biological impacts of plasticizers on wildlife. Philosophical Transactions of the Royal Society B: Biological Sciences, 364(1526), 2047-2062. Abstract.
Paull GC, Filby AL, Tyler CR (2009). Growth rate during early life affects sexual differentiation in roach (Rutilus rutilus). Environmental Biology of Fishes, 85(4), 277-284. Abstract.
Coe TS, Hamilton PB, Hodgson D, Paull GC, Tyler CR (2009). Parentage outcomes in response to estrogen exposure are modified by social grouping in zebrafish. Environ Sci Technol, 43(21), 8400-8405. Abstract.  Author URL.
Lange A, Paull GC, Coe TS, Katsu Y, Urushitani H, Iguchi T, Tyler CR (2009). Sexual reprogramming and estrogenic sensitization in wild fish exposed to ethinylestradiol. Environ Sci Technol, 43(4), 1219-1225. Abstract.  Author URL.
Lange A, Katsu Y, Ichikawa R, Paull GC, Chidgey LL, Coe TS, Iguchi T, Tyler CR (2008). Altered sexual development in roach (Rutilus rutilus) exposed to environmental concentrations of the pharmaceutical 17alpha-ethinylestradiol and associated expression dynamics of aromatases and estrogen receptors. Toxicol Sci, 106(1), 113-123. Abstract.  Author URL.
Coe TS, Hamilton PB, Hodgson D, Paull GC, Stevens JR, Sumner K, Tyler CR (2008). An environmental estrogen alters reproductive hierarchies, disrupting sexual selection in group-spawning fish. Environ Sci Technol, 42(13), 5020-5025. Abstract.  Author URL.
Paull GC, Lange A, Henshaw AC, Tyler CR (2008). Ontogeny of sexual development in the roach (Rutilus rutilus) and its interrelationships with growth and age. J Morphol, 269(7), 884-895. Abstract.  Author URL.
Santos EM, Kille P, Workman VL, Paull GC, Tyler CR (2008). Sexually dimorphic gene expression in the brains of mature zebrafish. Comp Biochem Physiol a Mol Integr Physiol, 149(3), 314-324. Abstract.  Author URL.
Paull GC, Van Look KJW, Santos EM, Filby AL, Gray DM, Nash JP, Tyler CR (2008). Variability in measures of reproductive success in laboratory-kept colonies of zebrafish and implications for studies addressing population-level effects of environmental chemicals. Aquat Toxicol, 87(2), 115-126. Abstract.  Author URL.
Lange, A. Ichikawa, R. Urushitani, H.G.C. (2007). Functional associations between two estrogen receptors, environmental oestrogens, and sexual disruption in the roach (<em>Rutilus rutilus</em>). Environmental Science and Technology, 41(9), 3368-3374.
Santos EM, Paull GC, Van Look KJW, Workman VL, Holt WV, van Aerle R, Kille P, Tyler CR (2007). Gonadal transcriptome responses and physiological consequences of exposure to oestrogen in breeding zebrafish (Danio rerio). Aquat Toxicol, 83(2), 134-142. Abstract.  Author URL.
Santos EM, Workman VL, Paull GC, Filby AL, Van Look KJW, Kille P, Tyler CR (2007). Molecular basis of sex and reproductive status in breeding zebrafish. Physiol Genomics, 30(2), 111-122. Abstract.  Author URL.
Tyler CR, Lange A, Paull GC, Katsu Y, Iguchi T (2007). The roach (Rutilus rutilus) as a sentinel for assessing endocrine disruption. Environ Sci, 14(5), 235-253. Abstract.  Author URL.

Chapters

Lee CJ, Tyler CR, Paull GC (2020). Chapter 4 Geographic Range and Natural Distribution. In  (Ed) The Zebrafish in Biomedical Research, Elsevier, 41-56.
Lee CJ, Tyler CR, Paull GC (2020). Chapter 5 Behavior of Wild Populations. In  (Ed) The Zebrafish in Biomedical Research, Elsevier, 57-72.
Lee C, Tyler C, Paull G (2019). Behaviour of wild populations. In Cartner S, Eisen J, Farmer S, Guillemin K, Kent M, Sanders G (Eds.) The Zebrafish in Biomedical Research, Academic Press.
Lee CJ, Tyler CR, Paull GC (2019). Geographic range and natural distribution. In Cartner S, Eisen J, Farmer S, Guillemin K, Kent M, Sanders G (Eds.) The Zebrafish in Biomedical Research, Academic Press.

Conferences

Viana J, Wildman N, Hannon E, Farbos A, O'Neill P, Moore K, Paszkiewicz K, van Aerle R, Paull G, Santos E, et al (2019). A ZEBRAFISH MODEL OF CLOZAPINE EXPOSURE: DRUG-INDUCED TRANSCRIPTOMIC CHANGES IN THE BRAIN.  Author URL.
Viana J, Hannon E, van Aerle R, Dempster E, Paull G, Santos E, Mill J (2019). A ZEBRAFISH MODEL OF CLOZAPINE EXPOSURE: DRUG-INDUCED TRANSCRIPTOMIC CHANGES IN THE BRAIN.  Author URL.
Tyler CR, Hamilton PB, Lange A, Filby AL, Soffkar M, Lee O, Takesono A, Kudoh T, Paull GC, Iguchi T, et al (2012). Health impacts of exposure to environmental oestrogens in fish.  Author URL.
Tyler C, Lange A, Santos E, Coe T, Paull G, Filby A, Hamilton P (2008). The feminization of fish in English rivers: Causation, mechanisms, and significance.  Author URL.

Publications by year


2023

Paull GC, Lee CJ, Tyler CR (2023). Beyond compliance: harmonising research and husbandry practices to improve experimental reproducibility using fish models. Biol Rev Camb Philos Soc Abstract.  Author URL.

2022

Lee CJ, Paull GC, Tyler CR (2022). Improving zebrafish laboratory welfare and scientific research through understanding their natural history. Biol Rev Camb Philos Soc, 97(3), 1038-1056. Abstract.  Author URL.

2020

Lee CJ, Tyler CR, Paull GC (2020). Chapter 4 Geographic Range and Natural Distribution. In  (Ed) The Zebrafish in Biomedical Research, Elsevier, 41-56.
Lee CJ, Tyler CR, Paull GC (2020). Chapter 5 Behavior of Wild Populations. In  (Ed) The Zebrafish in Biomedical Research, Elsevier, 57-72.
Viana J, Wildman N, Hannon E, Farbos A, Neill PO, Moore K, van Aerle R, Paull G, Santos E, Mill J, et al (2020). Clozapine-induced transcriptional changes in the zebrafish brain. NPJ Schizophr, 6(1). Abstract.  Author URL.

2019

Viana J, Wildman N, Hannon E, Farbos A, O'Neill P, Moore K, Paszkiewicz K, van Aerle R, Paull G, Santos E, et al (2019). A ZEBRAFISH MODEL OF CLOZAPINE EXPOSURE: DRUG-INDUCED TRANSCRIPTOMIC CHANGES IN THE BRAIN.  Author URL.
Viana J, Hannon E, van Aerle R, Dempster E, Paull G, Santos E, Mill J (2019). A ZEBRAFISH MODEL OF CLOZAPINE EXPOSURE: DRUG-INDUCED TRANSCRIPTOMIC CHANGES IN THE BRAIN.  Author URL.
Lee C, Tyler C, Paull G (2019). Behaviour of wild populations. In Cartner S, Eisen J, Farmer S, Guillemin K, Kent M, Sanders G (Eds.) The Zebrafish in Biomedical Research, Academic Press.
Lee CJ, Paull GC, Tyler CR (2019). Effects of environmental enrichment on survivorship, growth, sex ratio and behaviour in laboratory maintained zebrafish Danio rerio. J Fish Biol, 94(1), 86-95. Abstract.  Author URL.
Lee CJ, Tyler CR, Paull GC (2019). Geographic range and natural distribution. In Cartner S, Eisen J, Farmer S, Guillemin K, Kent M, Sanders G (Eds.) The Zebrafish in Biomedical Research, Academic Press.

2018

Lee CJ, Tyler CR, Paull GC (2018). Can simple tank changes benefit the welfare of laboratory zebrafish Danio rerio?. J Fish Biol, 92(3), 653-659. Abstract.  Author URL.
Stevens C (2018). Patterns in Stress and Mortality in Small Ornamental Aquarium Fish and Interventions for Improving Health and Well-being.  Abstract.

2017

Stevens CH, Croft DP, Paull GC, Tyler CR (2017). Stress and welfare in ornamental fishes: what can be learned from aquaculture?. J Fish Biol, 91(2), 409-428. Abstract.  Author URL.

2016

Laing LV, Viana J, Dempster EL, Trznadel M, Trunkfield LA, Uren Webster TM, van Aerle R, Paull GC, Wilson RJ, Mill J, et al (2016). Bisphenol a causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Epigenetics, 11(7), 526-538. Abstract.  Author URL.

2015

Brown AR, Owen SF, Peters J, Zhang Y, Soffker M, Paull GC, Hosken DJ, Wahab MA, Tyler CR (2015). Climate change and pollution speed declines in zebrafish populations. Proc Natl Acad Sci U S A, 112(11), E1237-E1246. Abstract.  Author URL.

2013

Bickley LK, Brown AR, Hosken DJ, Hamilton PB, Le Page G, Paull GC, Owen SF, Tyler CR (2013). Interactive effects of inbreeding and endocrine disruption on reproduction in a model laboratory fish. Evolutionary Applications, 6(2), 279-289. Abstract.

2012

Brown AR, Bickley LK, Ryan TA, Paull GC, Hamilton PB, Owen SF, Sharpe AD, Tyler CR (2012). Differences in sexual development in inbred and outbred zebrafish (Danio rerio) and implications for chemical testing. Aquat Toxicol, 112-113, 27-38. Abstract.  Author URL.
Filby AL, Paull GC, Searle F, Ortiz-Zarragoitia M, Tyler CR (2012). Environmental estrogen-induced alterations of male aggression and dominance hierarchies in fish: a mechanistic analysis. Environ Sci Technol, 46(6), 3472-3479. Abstract.  Author URL.
Tyler CR, Hamilton PB, Lange A, Filby AL, Soffkar M, Lee O, Takesono A, Kudoh T, Paull GC, Iguchi T, et al (2012). Health impacts of exposure to environmental oestrogens in fish.  Author URL.

2011

Brown AR, Bickley LK, Le Page G, Hosken DJ, Paull GC, Hamilton PB, Owen SF, Robinson J, Sharpe AD, Tyler CR, et al (2011). Are toxicological responses in laboratory (inbred) zebrafish representative of those in outbred (wild) populations? - a case study with an endocrine disrupting chemical. Environ Sci Technol, 45(9), 4166-4172. Abstract.  Author URL.
Lange A, Paull GC, Hamilton PB, Iguchi T, Tyler CR (2011). Implications of persistent exposure to treated wastewater effluent for breeding in wild roach (Rutilus rutilus) populations. Environ Sci Technol, 45(4), 1673-1679. Abstract.  Author URL.

2010

Paull GC, Filby AL, Giddins HG, Coe TS, Hamilton PB, Tyler CR (2010). Dominance hierarchies in zebrafish (Danio rerio) and their relationship with reproductive success. Zebrafish, 7(1), 109-117. Abstract.  Author URL.
Uren-Webster TM, Lewis C, Filby AL, Paull GC, Santos EM (2010). Mechanisms of toxicity of di(2-ethylhexyl) phthalate on the reproductive health of male zebrafish. Aquat Toxicol, 99(3), 360-369. Abstract.  Author URL.
Filby AL, Paull GC, Bartlett EJ, Van Look KJW, Tyler CR (2010). Physiological and health consequences of social status in zebrafish (Danio rerio). Physiol Behav, 101(5), 576-587. Abstract.  Author URL.
Filby AL, Paull GC, Hickmore TF, Tyler CR (2010). Unravelling the neurophysiological basis of aggression in a fish model. BMC Genomics, 11 Abstract.  Author URL.

2009

Oehlmann J, Schulte-Oehlmann U, Kloas W, Jagnytsch O, Lutz I, Kusk KO, Wollenberger L, Santos EM, Paull GC, VanLook KJW, et al (2009). A critical analysis of the biological impacts of plasticizers on wildlife. Philosophical Transactions of the Royal Society B: Biological Sciences, 364(1526), 2047-2062. Abstract.
Paull GC, Filby AL, Tyler CR (2009). Growth rate during early life affects sexual differentiation in roach (Rutilus rutilus). Environmental Biology of Fishes, 85(4), 277-284. Abstract.
Coe TS, Hamilton PB, Hodgson D, Paull GC, Tyler CR (2009). Parentage outcomes in response to estrogen exposure are modified by social grouping in zebrafish. Environ Sci Technol, 43(21), 8400-8405. Abstract.  Author URL.
Lange A, Paull GC, Coe TS, Katsu Y, Urushitani H, Iguchi T, Tyler CR (2009). Sexual reprogramming and estrogenic sensitization in wild fish exposed to ethinylestradiol. Environ Sci Technol, 43(4), 1219-1225. Abstract.  Author URL.

2008

Lange A, Katsu Y, Ichikawa R, Paull GC, Chidgey LL, Coe TS, Iguchi T, Tyler CR (2008). Altered sexual development in roach (Rutilus rutilus) exposed to environmental concentrations of the pharmaceutical 17alpha-ethinylestradiol and associated expression dynamics of aromatases and estrogen receptors. Toxicol Sci, 106(1), 113-123. Abstract.  Author URL.
Coe TS, Hamilton PB, Hodgson D, Paull GC, Stevens JR, Sumner K, Tyler CR (2008). An environmental estrogen alters reproductive hierarchies, disrupting sexual selection in group-spawning fish. Environ Sci Technol, 42(13), 5020-5025. Abstract.  Author URL.
Paull GC, Lange A, Henshaw AC, Tyler CR (2008). Ontogeny of sexual development in the roach (Rutilus rutilus) and its interrelationships with growth and age. J Morphol, 269(7), 884-895. Abstract.  Author URL.
Santos EM, Kille P, Workman VL, Paull GC, Tyler CR (2008). Sexually dimorphic gene expression in the brains of mature zebrafish. Comp Biochem Physiol a Mol Integr Physiol, 149(3), 314-324. Abstract.  Author URL.
Tyler C, Lange A, Santos E, Coe T, Paull G, Filby A, Hamilton P (2008). The feminization of fish in English rivers: Causation, mechanisms, and significance.  Author URL.
Paull GC, Van Look KJW, Santos EM, Filby AL, Gray DM, Nash JP, Tyler CR (2008). Variability in measures of reproductive success in laboratory-kept colonies of zebrafish and implications for studies addressing population-level effects of environmental chemicals. Aquat Toxicol, 87(2), 115-126. Abstract.  Author URL.

2007

Lange, A. Ichikawa, R. Urushitani, H.G.C. (2007). Functional associations between two estrogen receptors, environmental oestrogens, and sexual disruption in the roach (<em>Rutilus rutilus</em>). Environmental Science and Technology, 41(9), 3368-3374.
Santos EM, Paull GC, Van Look KJW, Workman VL, Holt WV, van Aerle R, Kille P, Tyler CR (2007). Gonadal transcriptome responses and physiological consequences of exposure to oestrogen in breeding zebrafish (Danio rerio). Aquat Toxicol, 83(2), 134-142. Abstract.  Author URL.
Santos EM, Workman VL, Paull GC, Filby AL, Van Look KJW, Kille P, Tyler CR (2007). Molecular basis of sex and reproductive status in breeding zebrafish. Physiol Genomics, 30(2), 111-122. Abstract.  Author URL.
Tyler CR, Lange A, Paull GC, Katsu Y, Iguchi T (2007). The roach (Rutilus rutilus) as a sentinel for assessing endocrine disruption. Environ Sci, 14(5), 235-253. Abstract.  Author URL.

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