Dr Yosuke Ono

I'm a resercher in molecular and developmetal biology using zebrafish as a model. My current research focuses on CRISPR/Cas9-mediated genome editing technologies in vivo using zebrafish embryos. I'm also working on the regulatory mechanisms of muscle morphogenesis, growth and regeneration. I'm analysing the function of genes during development using genetically modified (transgenic and mutant) zebrafish.

Current project:

Establishing precise genome editing in zebrafish and its application to advance understanding of the Wnt/PCP signalling pathway (BBSRC Industrial Partnership Award, RCo-I)

Latest research papar:

Optimised genome editing for precise DNA insertion and substitution using Prime Editors in zebrafish (bioRxiv, https://doi.org/10.1101/2025.04.23.650248)

Qualifications:

2010 PhD Aquatic Bioscience, The University of Tokyo, Japan (supervisor: Prof. Shugo Watabe)

2007 Master, Aquatic Bioscience, The University of Tokyo, Japan

2005 Bachelor, Agriculture, The University of Tokyo, Japan

Career:

2017-present Research Fellow, Living Systems Institute, University of Exeter

2013-2017 Research Fellow, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore (Philip Ingham lab)

2010-2013 Research Fellow, A*STAR Institute of Molecular and Cell Biology, Singapore (Philip Ingham lab)