Profile
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Dr Aaron Butt
Research Fellow
Not Known
Geoffrey Pope Lab 401
Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK
Research
Research projects
2013-15: Filling the target void: Identification of novel antibacterial therapeutics
Work includes:
- Constructing deletion or conditional mutants in genes predicted to be essential in either growth or virulence
- Determine the phenotype of these mutants in appropriate assays
- Collaborate with biochemists to solve the protein structure of novel targets and to design inhibitors as therapeutics.
PhD project:
2009-13: Identification and characterisation of Toxin-antitoxin systems in Burkholderia pseudomallei
The aim of this project was to identify novel Toxin-antitoxin systems in B pseudomallei, the causative agent of melioidosis and elucidate their biological role in persister cell formation and chronic persistent disease.
Grants/Funding:
- Defence Science and Technology Laboratory (DSTL)