Dr Bartlomiej (Bartek) Troczka
BBSRC Discovery Fellow
B.Troczka@exeter.ac.uk
SERSF
Science and Engineering Research Support Facility (SERSF):, University of Exeter, Penryn Campus, Penryn, Cornwall, TR10 9FE, UK
Overview
Qualifications
BSc Biochemistry at Aberyswyth University 2009
PhD School of Medicine, Cardiff University/Rothamsted Research 2014
Career
BBSRC Discovery Fellow: Understanding the evolution and function of
Xenobiotic detoxification enzymes
University of Exeter 2023-present
Post-doctoral research fellow: Molecular understanding of insect host shifts
University of Exeter 2019-2023
Senior Research Scientist,
Oxitec Limited 2018
Post-doctoral researcher: Bee toxicogenomics,
Rothamsted Research 2015-2018
Post-doctoral researcher: Investigation of amplification of CYP6CY3 M. persicae
Rothamsted Research 2014
BBSRC-CASE - post-graduate studentship,
Ryanodine receptors: next generation insecticide targets
Cardiff University and Rothamsted Research 2009-2014
Links
Research group links
Publications
Journal articles
Hayward A, Hunt BJ, Haas J, Bushnell-Crowther E, Troczka BJ, Pym A, Beadle K, Field J, Nelson DR, Nauen R, et al (2024). A cytochrome P450 insecticide detoxification mechanism is not conserved across the Megachilidae family of bees. Evolutionary Applications, 17(1). Abstract.
Zeng B, Hunt BJ, Pym A, Balanza V, Bass C, Bielza P, Troczka BJ (2024). Aberrant splicing of a nicotinic acetylcholine receptor alpha 6 subunit is associated with spinosad tolerance in the thrips predator Orius laevigatus. Pesticide Biochemistry and Physiology, 200
Bass C, Hayward A, Troczka BJ, Haas J, Nauen R (2024). The molecular determinants of pesticide sensitivity in bee pollinators. The Science of the Total Environment, 915
Pym A, Troczka BJ, Hayward A, Zeng B, Gao CF, Elias J, Slater R, Zimmer CT, Bass C (2024). The role of the Bemisia tabaci and Trialeurodes vaporariorum cytochrome-P450 clade CYP6DPx in resistance to nicotine and neonicotinoids. Pesticide Biochemistry and Physiology, 198 Abstract.
Haas J, Beck E, Troczka BJ, Hayward A, Hertlein G, Zaworra M, Lueke B, Buer B, Maiwald F, Beck ME, et al (2023). A conserved hymenopteran-specific family of cytochrome P450s protects bee pollinators from toxic nectar alkaloids. Sci Adv, 9(15). Abstract. Author URL.
Pym A, Mina JGM, Troczka BJ, Hayward A, Daum E, Elias J, Slater R, Vontas J, Bass C, Zimmer CT, et al (2023). A single point mutation in the Bemisia tabaci cytochrome-P450 CYP6CM1 causes enhanced resistance to neonicotinoids. Insect Biochem Mol Biol, 156 Abstract. Author URL.
Trissi N, Troczka BJ, Ozsanlav-Harris L, Singh KS, Mallott M, Aishwarya V, O'Reilly A, Bass C, Wilding CS (2023). Differential regulation of the Tor gene homolog drives the red/green pigmentation phenotype in the aphid Myzuspersicae. Insect Biochem Mol Biol, 153 Abstract. Author URL.
Grant C, Singh KS, Hayward A, Hunt BJ, Troczka BJ, Pym A, Ahn S-J, Zeng B, Gao C-F, Leroux A, et al (2023). Overexpression of the UDP-glycosyltransferase UGT34A23 confers resistance to the diamide insecticide chlorantraniliprole in the tomato leafminer, Tuta absoluta. Insect Biochem Mol Biol, 159 Abstract. Author URL.
Richardson E, Homem RA, Troczka BJ, George CH, Ebbinghaus-Kintscher U, Williamson MS, Nauen R, Davies TE (2022). Diamide insecticide resistance in transgenic Drosophila and Sf9-cells expressing a full-length diamondback moth ryanodine receptor carrying an I4790M mutation. Pest Management Science, 78(3), 869-880. Abstract.
Pym A, Umina PA, Reidy-Crofts J, Troczka BJ, Matthews A, Gardner J, Hunt BJ, van Rooyen AR, Edwards OR, Bass C, et al (2022). Overexpression of UDP-glucuronosyltransferase and cytochrome P450 enzymes confers resistance to sulfoxaflor in field populations of the aphid, Myzus persicae. Insect Biochem Mol Biol, 143 Abstract. Author URL.
Duarte A, Pym A, Garrood WT, Troczka BJ, Zimmer CT, Davies TGE, Nauen R, O’Reilly AO, Bass C (2022). P450 gene duplication and divergence led to the evolution of dual novel functions and insecticide cross-resistance in the brown planthopper Nilaparvata lugens. PLOS Genetics, 18(6), e1010279-e1010279. Abstract.
Reavey CE, Walker AS, Joyce SP, Broom L, Willse A, Ercit K, Poletto M, Barnes ZH, Marubbi T, Troczka BJ, et al (2022). Self-limiting fall armyworm: a new approach in development for sustainable crop protection and resistance management. BMC Biotechnology, 22(1).
Singh KS, Cordeiro EMG, Troczka BJ, Pym A, Mackisack J, Mathers TC, Duarte A, Legeai F, Robin S, Bielza P, et al (2021). Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae. Commun Biol, 4(1). Abstract. Author URL.
Troczka BJ, Singh KS, Zimmer CT, Vontas J, Nauen R, Hayward A, Bass C (2021). Molecular innovations underlying resistance to nicotine and neonicotinoids in the aphid Myzus persicae. Pest Manag Sci, 77(12), 5311-5320. Abstract. Author URL.
Panini M, Chiesa O, Troczka BJ, Mallott M, Manicardi GC, Cassanelli S, Cominelli F, Hayward A, Mazzoni E, Bass C, et al (2021). Transposon-mediated insertional mutagenesis unmasks recessive insecticide resistance in the aphid Myzus persicae. Proc Natl Acad Sci U S A, 118(23). Abstract. Author URL.
Reid RJ, Troczka BJ, Kor L, Randall E, Williamson MS, Field LM, Nauen R, Bass C, Davies TGE (2020). Assessing the acute toxicity of insecticides to the buff-tailed bumblebee (Bombus terrestris audax). Pesticide Biochemistry and Physiology, 166 Abstract.
Richardson EB, Troczka BJ, Gutbrod O, Davies TGE, Nauen R (2020). Diamide resistance: 10 years of lessons from lepidopteran pests. Journal of Pest Science, 93(3), 911-928. Abstract.
McLeman A, Troczka BJ, Homem RA, Duarte A, Zimmer C, Garrood WT, Pym A, Beadle K, Reid RJ, Douris V, et al (2020). Fly-Tox: a panel of transgenic flies expressing pest and pollinator cytochrome P450s. Pesticide Biochemistry and Physiology, 169 Abstract.
Singh KS, Troczka BJ, Duarte A, Balabanidou V, Trissi N, Carabajal Paladino LZ, Nguyen P, Zimmer CT, Papapostolou KM, Randall E, et al (2020). The genetic architecture of a host shift: an adaptive walk protected an aphid and its endosymbiont from plant chemical defenses. Science Advances, 6(19). Abstract.
Mallott M, Hamm S, Troczka BJ, Randall E, Pym A, Grant C, Baxter S, Vogel H, Shelton AM, Field LM, et al (2019). A flavin-dependent monooxgenase confers resistance to chlorantraniliprole in the diamondback moth, Plutella xylostella. Insect Biochem Mol Biol, 115 Abstract. Author URL.
Singh KS, Troczka BJ, Beadle K, Field LM, Davies TGE, Williamson MS, Nauen R, Bass C (2019). Extension of Partial Gene Transcripts by Iterative Mapping of RNA-Seq Raw Reads. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 16(3), 1036-1041. Abstract.
Beadle K, Singh KS, Troczka BJ, Randall E, Zaworra M, Zimmer CT, Hayward A, Reid R, Kor L, Kohler M, et al (2019). Genomic insights into neonicotinoid sensitivity in the solitary bee Osmia bicornis. PLoS Genet, 15(2). Abstract. Author URL.
Troczka BJ, Homem RA, Reid R, Beadle K, Kohler M, Zaworra M, Field LM, Williamson MS, Nauen R, Bass C, et al (2019). Identification and functional characterisation of a novel N-cyanoamidine neonicotinoid metabolising cytochrome P450, CYP9Q6, from the buff-tailed bumblebee Bombus terrestris. Insect Biochem Mol Biol, 111 Abstract. Author URL.
Troczka BJ, Richardson E, Homem RA, Davies TGE (2018). An analysis of variability in genome organisation of intracellular calcium release channels across insect orders. Gene, 670, 70-86. Abstract.
Manjon C, Troczka B, Zaworra M, Beadle K, Randall E, Hertlein G, Singh K, Zimmer C, Homem R, Lueke B, et al (2018). Unravelling the molecular determinants of bee sensitivity to neonicotinoid insecticides. Current Biology, 28, 1-7.
Troczka BJ, Williamson MS, Field LM, Davies TGE (2017). Rapid selection for resistance to diamide insecticides in Plutella xylostella via specific amino acid polymorphisms in the ryanodine receptor. NeuroToxicology, 60, 224-233. Abstract.
Roditakis E, Steinbach D, Moritz G, Vasakis E, Stavrakaki M, Ilias A, García-Vidal L, Martínez-Aguirre MDR, Bielza P, Morou E, et al (2017). Ryanodine receptor point mutations confer diamide insecticide resistance in tomato leafminer, Tuta absoluta (Lepidoptera: Gelechiidae). Insect Biochem Mol Biol, 80, 11-20. Abstract. Author URL.
Troczka BJ, Williams AJ, Williamson MS, Field LM, Luëmmen P, Davies TGE (2015). Stable expression and functional characterisation of the diamondback moth ryanodine receptor G4946E variant conferring resistance to diamide insecticides. Scientific Reports, 5 Abstract.
