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Dr Ben Longdon

Dr Ben Longdon

Sir Henry Dale Wellcome Trust and Royal Society Research Fellow/Associate Professor

 01326259460

 Stella Turk Building Top floor

 

University of Exeter, Penryn Campus, Penryn, TR10 9FE

 Office hours:

Typically if I am in my office with the door open you are welcome to pop by and see if I am free. My virtual office hours are 13:00-14:00 Tuesdays and Wednesadays on MS teams. If I am not available on teams at this time please email me or message on teams to make an appointment. 

Overview

My research focuses on host-pathogen ecology and evolution, with a particular interest in emerging viral diseases. Current work focuses on how pathogens switch between host species, what factors affect the ability of pathogens to successfully host shift and how these may be important for the emergence of novel pathogens. Other interests include the evolution and ecology of vertically transmitted parasites and how they spread through new host species or populations.

For more information visit the lab website: https://benlongdon.com.

Qualifications

2011 PhD, Institute of Evolutionary Biology, University of Edinburgh
2006 BSc Biology, University of Bristol

Career

2022- Associate Professor

2016- Sir Henry Dale Wellcome Trust and Royal Society fellowship, Senior Research Fellow, University of Exeter
2012-2016 Postdoctoral Researcher, Department of Genetics, University of Cambridge

Links

Research group links

Research

Research interests

Evolution and ecology of host-pathogen interactions

Research projects

Research in the lab focuses on several areas related to host-pathogen evolution and ecology.

Current topics of research include:

  • The evolutionary and mechanistic basis of virus host shifts
  • Examining how genetic variation in host susceptibility differs between natural and non-natural parasites
  • Exploring the diversity of insect rhabdoviruses, how these viruses are transmitted and sweep through host populations

Grants/Funding:

  • Sir Henry Dale Fellowship extension from the Wellcome Trust and Royal Society 2022-2025: The evolutionary and mechanistic basis of virus host shifts (PI).
  • Leverhulme grant 2021-2024: A new laboratory model to test the principles of host-parasite coevolution (Co-I with Frank Jiggins, University of Cambridge))
  • Sir Henry Dale Fellowship from the Wellcome Trust and Royal Society 2016-2021: The evolutionary and mechanistic basis of virus host shifts (PI).
  • NERC grant 2014: The causes of genetic variation in susceptibility to infectious disease in natural populations (Co-I with Frank Jiggins, University of Cambridge)

Publications

Key publications | Publications by category | Publications by year

Key publications


Imrie RM, Roberts KE, Longdon B (In Press). Between virus correlations in the outcome of infection across host species: evidence of virus genotype by host species interactions.  Abstract.
Roberts KE, Longdon B, Hadfield J, Sharma MD (In Press). Changes in temperature alter the potential outcomes of virus host shifts. PLoS Pathogens
Longdon B (In Press). Host-pathogen coevolution increases genetic variation in susceptibility to infection. eLife
Longdon B, Day JP, Alves JM, Smith SCL, Houslay TM, McGonigle JE, Tagliaferri L, Jiggins FM (2018). Host shifts result in parallel genetic changes when viruses evolve in closely related species. PLoS Pathogens
Longdon B, Day JP, Schulz N, Leftwich PT, De Jong MA, Breuker CJ, Gibbs M, Obbard DJ, Wilfert L, Smith SCL, et al (2017). Vertically transmitted rhabdoviruses are found across three insect families and have dynamic interactions with their hosts. Proceedings of the Royal Society B: Biological Sciences, 284(1847). Abstract.
Longdon B, Hadfield JD, Day JP, Smith SCL, McGonigle JE, Cogni R, Cao C, Jiggins FM (2015). The causes and consequences of changes in virulence following pathogen host shifts. PLoS Pathog, 11(3). Abstract.  Author URL.

Publications by category


Journal articles

Obbard DJ, Shi M, Roberts KE, Longdon B, Dennis AB (In Press). A new lineage of segmented RNA viruses infecting animals.  Abstract.
Imrie RM, Roberts KE, Longdon B (In Press). Between virus correlations in the outcome of infection across host species: evidence of virus genotype by host species interactions.  Abstract.
Roberts KE, Hadfield JD, Sharma MD, Longdon B (In Press). Changes in temperature alter susceptibility to a virus following a host shift.  Abstract.
Roberts KE, Longdon B, Hadfield J, Sharma MD (In Press). Changes in temperature alter the potential outcomes of virus host shifts. PLoS Pathogens
Longdon B (In Press). DrosoPhyla: resources for drosophilid phylogeny and systematics. Genome Biology and Evolution
Longdon B, Day JP, Alves JM, Smith SCL, Houslay TM, McGonigle JE, Tagliaferri L, Jiggins FM (In Press). Host shifts result in parallel genetic changes when viruses evolve in closely related species.  Abstract.
Longdon B (In Press). Host-pathogen coevolution increases genetic variation in susceptibility to infection. eLife
Klümper U, Maillard A, Hesse E, Bayer F, Houte SV, Longdon B, Gaze W, Buckling A (In Press). Short-term evolution under copper stress increases probability of plasmid uptake.  Abstract.
Treagus S, Longdon B (In Press). The foodborne transmission of Hepatitis E virus. Food and Environmental Virology Abstract.
Roberts KE, Longdon B (In Press). Viral susceptibility across host species is largely independent of dietary protein to carbohydrate ratios.  Abstract.
Imrie RM, Roberts KE, Longdon B (2021). Between virus correlations in the outcome of infection across host species: Evidence of virus by host species interactions. Evolution Letters, 5(5), 472-483.
Jimenez-Guri E, Roberts KE, García FC, Tourmente M, Longdon B, Godley BJ (2021). Transgenerational effects on development following microplastic exposure in Drosophila melanogaster. PeerJ, 9 Abstract.
Roberts KE, Longdon B (2021). Viral susceptibility across host species is largely independent of dietary protein to carbohydrate ratios. Journal of Evolutionary Biology, 34(5), 746-756.
Obbard DJ, Shi M, Roberts KE, Longdon B, Dennis AB (2020). A new lineage of segmented RNA viruses infecting animals. Virus Evolution, 6(1). Abstract.
Bonneaud C, Longdon B (2020). Emerging pathogen evolution. EMBO reports, 21(9).
Martinez J, Bruner-Montero G, Arunkumar R, Smith SCL, Day JP, Longdon B, Jiggins FM (2019). Virus evolution in Wolbachia-infected Drosophila. Proc Biol Sci, 286(1914). Abstract.  Author URL.
Longdon B, Day JP, Alves JM, Smith SCL, Houslay TM, McGonigle JE, Tagliaferri L, Jiggins FM (2018). Host shifts result in parallel genetic changes when viruses evolve in closely related species. PLoS Pathogens
Walker PJ, Blasdell KR, Calisher CH, Dietzgen RG, Kondo H, Kurath G, Longdon B, Stone DM, Tesh RB, Tordo N, et al (2018). ICTV Virus Taxonomy Profile: Rhabdoviridae. J Gen Virol, 99(4), 447-448. Abstract.  Author URL.
Antonovics J, Wilson AJ, Forbes MR, Hauffe HC, Kallio ER, Leggett HC, Longdon B, Okamura B, Sait SM, Webster JP, et al (2017). The evolution of transmission mode. Philos Trans R Soc Lond B Biol Sci, 372(1719). Abstract.  Author URL.
Longdon B, Day JP, Schulz N, Leftwich PT, De Jong MA, Breuker CJ, Gibbs M, Obbard DJ, Wilfert L, Smith SCL, et al (2017). Vertically transmitted rhabdoviruses are found across three insect families and have dynamic interactions with their hosts. Proceedings of the Royal Society B: Biological Sciences, 284(1847). Abstract.
Webster CL, Longdon B, Lewis SH, Obbard DJ (2016). Twenty-five new viruses associated with the drosophilidae (Diptera). Evolutionary Bioinformatics, 12, 13-25. Abstract.
Vrancken B, Lemey P, Rambaut A, Bedford T, Longdon B, Günthard HF, Suchard MA (2015). Simultaneously estimating evolutionary history and repeated traits phylogenetic signal: applications to viral and host phenotypic evolution. Methods Ecol Evol, 6(1), 67-82. Abstract.  Author URL.
Webster CL, Waldron FM, Robertson S, Crowson D, Ferrari G, Quintana JF, Brouqui J-M, Bayne EH, Longdon B, Buck AH, et al (2015). The Discovery, Distribution, and Evolution of Viruses Associated with Drosophila melanogaster. PLoS Biol, 13(7). Abstract.  Author URL.
Longdon B, Hadfield JD, Day JP, Smith SCL, McGonigle JE, Cogni R, Cao C, Jiggins FM (2015). The causes and consequences of changes in virulence following pathogen host shifts. PLoS Pathog, 11(3). Abstract.  Author URL.
Longdon B, Murray GGR, Palmer WJ, Day JP, Parker DJ, Welch JJ, Obbard DJ, Jiggins FM (2015). The evolution, diversity, and host associations of rhabdoviruses. Virus Evolution, 1(1).
Martinez J, Longdon B, Bauer S, Chan Y-S, Miller WJ, Bourtzis K, Teixeira L, Jiggins FM (2014). Symbionts commonly provide broad spectrum resistance to viruses in insects: a comparative analysis of Wolbachia strains. PLoS Pathog, 10(9). Abstract.  Author URL.
Longdon B, Brockhurst MA, Russell CA, Welch JJ, Jiggins FM (2014). The evolution and genetics of virus host shifts. PLoS Pathog, 10(11). Abstract.  Author URL.
Longdon B, Cao C, Martinez J, Jiggins FM (2013). Previous exposure to an RNA virus does not protect against subsequent infection in Drosophila melanogaster. PLoS One, 8(9). Abstract.  Author URL.
Magwire MM, Fabian DK, Schweyen H, Cao C, Longdon B, Bayer F, Jiggins FM (2012). Genome-Wide Association Studies Reveal a Simple Genetic Basis of Resistance to Naturally Coevolving Viruses in Drosophila melanogaster. PLoS Genetics, 8(11), e1003057-e1003057.
Longdon B, Fabian DK, Hurst GDD, Jiggins FM (2012). Male-killing Wolbachia do not protect Drosophila bifasciata against viral infection. BMC Microbiol, 12 Suppl 1(Suppl 1). Abstract.  Author URL.
Longdon B, Jiggins FM (2012). Vertically transmitted viral endosymbionts of insects: do sigma viruses walk alone?. Proc Biol Sci, 279(1744), 3889-3898. Abstract.  Author URL.
Longdon B, Hadfield JD, Webster CL, Obbard DJ, Jiggins FM (2011). Host phylogeny determines viral persistence and replication in novel hosts. PLoS Pathog, 7(9). Abstract.  Author URL.
Longdon B, Wilfert L, Osei-Poku J, Cagney H, Obbard DJ, Jiggins FM (2011). Host-switching by a vertically transmitted rhabdovirus in Drosophila. Biol Lett, 7(5), 747-750. Abstract.  Author URL.
Longdon B, Wilfert L, Obbard DJ, Jiggins FM (2011). Rhabdoviruses in two species of Drosophila: vertical transmission and a recent sweep. Genetics, 188(1), 141-150. Abstract.  Author URL.
Wilfert L, Longdon B, Ferreira AGA, Bayer F, Jiggins FM (2011). Trypanosomatids are common and diverse parasites of Drosophila. Parasitology, 138(7), 858-865. Abstract.  Author URL.
Longdon B, Jiggins FM (2010). Quick guide. Paternally transmitted parasites. Curr Biol, 20(17), R695-R696. Author URL.
Longdon B, Obbard DJ, Jiggins FM (2010). Sigma viruses from three species of Drosophila form a major new clade in the rhabdovirus phylogeny. Proc Biol Sci, 277(1678), 35-44. Abstract.  Author URL.
Aleksiev AS, Longdon B, Christmas MJ, Sendova-Franks AB, Franks NR (2008). Individual and collective choice: parallel prospecting and mining in ants. Naturwissenschaften, 95(4), 301-305. Abstract.  Author URL.
Aleksiev AS, Longdon B, Christmas MJ, Sendova-Franks AB, Franks NR (2007). Individual choice of building material for nest construction by worker ants and the collective outcome for their colony. Animal Behaviour, 74(3), 559-566. Abstract.

Publications by year


In Press

Obbard DJ, Shi M, Roberts KE, Longdon B, Dennis AB (In Press). A new lineage of segmented RNA viruses infecting animals.  Abstract.
Imrie RM, Roberts KE, Longdon B (In Press). Between virus correlations in the outcome of infection across host species: evidence of virus genotype by host species interactions.  Abstract.
Roberts KE, Hadfield JD, Sharma MD, Longdon B (In Press). Changes in temperature alter susceptibility to a virus following a host shift.  Abstract.
Roberts KE, Longdon B, Hadfield J, Sharma MD (In Press). Changes in temperature alter the potential outcomes of virus host shifts. PLoS Pathogens
Longdon B (In Press). DrosoPhyla: resources for drosophilid phylogeny and systematics. Genome Biology and Evolution
Longdon B, Day JP, Alves JM, Smith SCL, Houslay TM, McGonigle JE, Tagliaferri L, Jiggins FM (In Press). Host shifts result in parallel genetic changes when viruses evolve in closely related species.  Abstract.
Longdon B (In Press). Host-pathogen coevolution increases genetic variation in susceptibility to infection. eLife
Roberts KE, Longdon B (In Press). Sex and tissue differences in virus susceptibility across species.  Abstract.
Klümper U, Maillard A, Hesse E, Bayer F, Houte SV, Longdon B, Gaze W, Buckling A (In Press). Short-term evolution under copper stress increases probability of plasmid uptake.  Abstract.
Treagus S, Longdon B (In Press). The foodborne transmission of Hepatitis E virus. Food and Environmental Virology Abstract.
Roberts KE, Longdon B (In Press). Viral susceptibility across host species is largely independent of dietary protein to carbohydrate ratios.  Abstract.

2022

Treagus S (2022). The Transmission of Enteric Viruses through the Aquatic Environment in the UK.  Abstract.
Imrie R, Imrie R (2022). Virus host shifts in Drosophila: the influences of virus genotype and coinfection on susceptibility within and across host species.  Abstract.

2021

Imrie RM, Roberts KE, Longdon B (2021). Between virus correlations in the outcome of infection across host species: Evidence of virus by host species interactions. Evolution Letters, 5(5), 472-483.
Finet C, Kassner VA, Carvalho AB, Chung H, Day JP, Day S, Delaney EK, De Ré FC, Dufour HD, Dupim E, et al (2021). DrosoPhyla: genomic resources for drosophilid phylogeny and systematics.
Jimenez-Guri E, Roberts KE, García FC, Tourmente M, Longdon B, Godley BJ (2021). Transgenerational effects on development following microplastic exposure in Drosophila melanogaster. PeerJ, 9 Abstract.
Roberts KE, Longdon B (2021). Viral susceptibility across host species is largely independent of dietary protein to carbohydrate ratios. Journal of Evolutionary Biology, 34(5), 746-756.

2020

Obbard DJ, Shi M, Roberts KE, Longdon B, Dennis AB (2020). A new lineage of segmented RNA viruses infecting animals. Virus Evolution, 6(1). Abstract.
Bonneaud C, Longdon B (2020). Emerging pathogen evolution. EMBO reports, 21(9).

2019

Martinez J, Bruner-Montero G, Arunkumar R, Smith SCL, Day JP, Longdon B, Jiggins FM (2019). Virus evolution in Wolbachia-infected Drosophila. Proc Biol Sci, 286(1914). Abstract.  Author URL.

2018

Longdon B, Day JP, Alves JM, Smith SCL, Houslay TM, McGonigle JE, Tagliaferri L, Jiggins FM (2018). Host shifts result in parallel genetic changes when viruses evolve in closely related species. PLoS Pathogens
Duxbury EM, Day JP, Vespasiani DM, Thüringer Y, Tolosana I, Smith SC, Tagliaferri L, Kamacioglu A, Lindsley I, Love L, et al (2018). Host-pathogen coevolution increases genetic variation in susceptibility to infection.
Walker PJ, Blasdell KR, Calisher CH, Dietzgen RG, Kondo H, Kurath G, Longdon B, Stone DM, Tesh RB, Tordo N, et al (2018). ICTV Virus Taxonomy Profile: Rhabdoviridae. J Gen Virol, 99(4), 447-448. Abstract.  Author URL.

2017

Antonovics J, Wilson AJ, Forbes MR, Hauffe HC, Kallio ER, Leggett HC, Longdon B, Okamura B, Sait SM, Webster JP, et al (2017). The evolution of transmission mode. Philos Trans R Soc Lond B Biol Sci, 372(1719). Abstract.  Author URL.
Longdon B, Day JP, Schulz N, Leftwich PT, De Jong MA, Breuker CJ, Gibbs M, Obbard DJ, Wilfert L, Smith SCL, et al (2017). Vertically transmitted rhabdoviruses are found across three insect families and have dynamic interactions with their hosts. Proceedings of the Royal Society B: Biological Sciences, 284(1847). Abstract.

2016

Webster CL, Longdon B, Lewis SH, Obbard DJ (2016). Twenty five new viruses associated with the Drosophilidae (Diptera).
Webster CL, Longdon B, Lewis SH, Obbard DJ (2016). Twenty-five new viruses associated with the drosophilidae (Diptera). Evolutionary Bioinformatics, 12, 13-25. Abstract.
Longdon B, Day JP, Schulz N, Leftwich PT, de Jong MA, Breuker CJ, Gibbs M, Obbard DJ, Wilfert L, Smith SC, et al (2016). Vertically transmitted rhabdoviruses are found across three insect families and have dynamic interactions with their hosts.

2015

Vrancken B, Lemey P, Rambaut A, Bedford T, Longdon B, Günthard HF, Suchard MA (2015). Simultaneously estimating evolutionary history and repeated traits phylogenetic signal: applications to viral and host phenotypic evolution. Methods Ecol Evol, 6(1), 67-82. Abstract.  Author URL.
Webster CL, Waldron FM, Robertson S, Crowson D, Ferrari G, Quintana JF, Brouqui J-M, Bayne EH, Longdon B, Buck AH, et al (2015). The Discovery, Distribution, and Evolution of Viruses Associated with Drosophila melanogaster. PLoS Biol, 13(7). Abstract.  Author URL.
Longdon B, Hadfield JD, Day JP, Smith SCL, McGonigle JE, Cogni R, Cao C, Jiggins FM (2015). The causes and consequences of changes in virulence following pathogen host shifts. PLoS Pathog, 11(3). Abstract.  Author URL.
Webster CL, Waldron FM, Robertson S, Crowson D, Ferrari G, Quintana JF, Brouqui J-M, Bayne EH, Longdon B, Buck AH, et al (2015). The discovery, distribution and evolution of viruses associated with Drosophila melanogaster.
Longdon B, Murray GG, Palmer WJ, Day JP, Parker DJ, Welch JJ, Obbard DJ, Jiggins FM (2015). The evolution, diversity and host associations of rhabdoviruses.
Longdon B, Murray GGR, Palmer WJ, Day JP, Parker DJ, Welch JJ, Obbard DJ, Jiggins FM (2015). The evolution, diversity, and host associations of rhabdoviruses. Virus Evolution, 1(1).

2014

Martinez J, Longdon B, Bauer S, Chan Y-S, Miller WJ, Bourtzis K, Teixeira L, Jiggins FM (2014). Symbionts commonly provide broad spectrum resistance to viruses in insects: a comparative analysis of Wolbachia strains. PLoS Pathog, 10(9). Abstract.  Author URL.
Longdon B, Brockhurst MA, Russell CA, Welch JJ, Jiggins FM (2014). The evolution and genetics of virus host shifts. PLoS Pathog, 10(11). Abstract.  Author URL.

2013

Longdon B, Cao C, Martinez J, Jiggins FM (2013). Previous exposure to an RNA virus does not protect against subsequent infection in Drosophila melanogaster. PLoS One, 8(9). Abstract.  Author URL.

2012

Magwire MM, Fabian DK, Schweyen H, Cao C, Longdon B, Bayer F, Jiggins FM (2012). Genome-Wide Association Studies Reveal a Simple Genetic Basis of Resistance to Naturally Coevolving Viruses in Drosophila melanogaster. PLoS Genetics, 8(11), e1003057-e1003057.
Longdon B, Fabian DK, Hurst GDD, Jiggins FM (2012). Male-killing Wolbachia do not protect Drosophila bifasciata against viral infection. BMC Microbiol, 12 Suppl 1(Suppl 1). Abstract.  Author URL.
Longdon B, Jiggins FM (2012). Vertically transmitted viral endosymbionts of insects: do sigma viruses walk alone?. Proc Biol Sci, 279(1744), 3889-3898. Abstract.  Author URL.

2011

Longdon B, Hadfield JD, Webster CL, Obbard DJ, Jiggins FM (2011). Host phylogeny determines viral persistence and replication in novel hosts. PLoS Pathog, 7(9). Abstract.  Author URL.
Longdon B, Wilfert L, Osei-Poku J, Cagney H, Obbard DJ, Jiggins FM (2011). Host-switching by a vertically transmitted rhabdovirus in Drosophila. Biol Lett, 7(5), 747-750. Abstract.  Author URL.
Longdon B, Wilfert L, Obbard DJ, Jiggins FM (2011). Rhabdoviruses in two species of Drosophila: vertical transmission and a recent sweep. Genetics, 188(1), 141-150. Abstract.  Author URL.
Wilfert L, Longdon B, Ferreira AGA, Bayer F, Jiggins FM (2011). Trypanosomatids are common and diverse parasites of Drosophila. Parasitology, 138(7), 858-865. Abstract.  Author URL.

2010

Longdon B, Jiggins FM (2010). Quick guide. Paternally transmitted parasites. Curr Biol, 20(17), R695-R696. Author URL.
Longdon B, Obbard DJ, Jiggins FM (2010). Sigma viruses from three species of Drosophila form a major new clade in the rhabdovirus phylogeny. Proc Biol Sci, 277(1678), 35-44. Abstract.  Author URL.

2008

Aleksiev AS, Longdon B, Christmas MJ, Sendova-Franks AB, Franks NR (2008). Individual and collective choice: parallel prospecting and mining in ants. Naturwissenschaften, 95(4), 301-305. Abstract.  Author URL.

2007

Aleksiev AS, Longdon B, Christmas MJ, Sendova-Franks AB, Franks NR (2007). Individual choice of building material for nest construction by worker ants and the collective outcome for their colony. Animal Behaviour, 74(3), 559-566. Abstract.

Ben_Longdon Details from cache as at 2022-11-29 05:14:03

Refresh publications

External Engagement and Impact

Media Coverage

My research has been featured on:

Virulence following host shifts
Microbiology Society BlogScience Daily

Phylogenetic determinants of host shifts
BBC TV, BBC Radio Scotland (live interview), BBC online, The Metro, The ScotsmanScience Daily, The Press Association, The Herald, Press and Journal, Edinburgh Evening News, BBSRC website, MSN news, Yahoo News, The West Australian, Rule of 6ix via Nature.com blogs and National Public Radio (USA)


Significant Impact

With collaborators at FoAM Kernow we are developing a Wellcome Trust funded citizen science project (“Viruscraft“) using visual programming, craft, tangible interfaces and games to explore virus host shifts – where a virus jumps from one host species to another.

We have also worked with TEDEd and Cabong studios to produce a video and lesson about virus host shifts – you can check it out here (has been watched more the 1.2m times!)

Teaching

I organise the departmental seminar series and teach on the evolution and behavioural ecology MSc. I also supervise undergraduate and MSc students. I am a fellow of the Higher Education Academy and sit on the University responsible metrics group.

Supervision / Group

Postdoctoral researchers

Postgraduate researchers

Alumni

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