Dr Elena Roselletti
Postdoctoral Research Associate
E.Roselletti@exeter.ac.uk
Geoffrey Pope
Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK
Overview
My key career achievements to date have all centered on research on C. albicans. I have experience working with in vitro cell-based systems, in vivo rodent models as well as primary vaginal tissue samples from patients with vulvovaginal candidiasis.
Qualifications
Pharmacy degree (2008-2013), University of Perugia, Italy
PhD in Biotechnology (2014-2017), University of Perugia, Italy
Career
Postdoctoral Research (2017-2020), University of Perugia, Italy
Research group links
Research
Research interests
During these years, I have enriched my understanding of C. albicans and I was able to identify the similarities and differences between vulvovaginal candidiasis in patients and in mouse models. In particular, I am most interested in trying to clarify the profound but ambiguous role of the hyphal form in patients as well as in asymptomatic infections given that these are not always associated with inflammation. I am extremely interested to understand how the pathogenesis of vulvovaginal candidiasis is influenced by the particular C. albicans strain and how much by the patient herself. At University of Exeter I will study the influence of zinc on C. albicans inflammation.
Publications
Journal articles
Roselletti E, Pericolini E, Nore A, Takacs P, Kozma B, Sala A, De Seta F, Comar M, Usher J, Brown GD, et al (2023). Zinc prevents vaginal candidiasis by inhibiting expression of an inflammatory fungal protein. Science Translational Medicine, 15(725). Abstract.
Trevijano-Contador N, Roselletti E, García-Rodas R, Vecchiarelli A, Zaragoza Ó (2022). Role of IL-17 in Morphogenesis and Dissemination of Cryptococcus neoformans during Murine Infection. Microorganisms, 10(2), 373-373. Abstract.
Ricci E, Roselletti E, Gentili M, Sabbatini S, Perito S, Riccardi C, Migliorati G, Monari C, Ronchetti S (2021). Glucocorticoid-Induced Leucine Zipper-Mediated TLR2 Downregulation Accounts for Reduced Neutrophil Activity Following Acute DEX Treatment. Cells, 10(9), 2228-2228. Abstract.
Xiroudaki S, Ianni F, Sabbatini S, Roselletti E, Monari C, Sardella R, Vecchiarelli A, Giovagnoli S (2021). Initial in vivo evaluation of a novel amikacin-deoxycholate hydrophobic salt delivers new insights on amikacin partition in blood and tissues. Pharmaceutics, 13(1), 1-10. Abstract.
Roselletti E, Sabbatini S, Perito S, Mencacci A, Vecchiarelli A, Monari C (2020). Apoptosis of vaginal epithelial cells in clinical samples from women with diagnosed bacterial vaginosis. Scientific Reports, 10(1). Abstract.
Ardizzoni A, Sala A, Colombari B, Giva LB, Cermelli C, Peppoloni S, Vecchiarelli A, Roselletti E, Blasi E, Wheeler RT, et al (2020). Perinuclear anti-neutrophil cytoplasmic antibodies (Panca) impair neutrophil candidacidal activity and are increased in the cellular fraction of vaginal samples from women with vulvovaginal candidiasis. Journal of Fungi, 6(4), 1-14. Abstract.
Zampieri R, Brozzetti A, Pericolini E, Bartoloni E, Gabrielli E, Roselletti E, Lomonosoff G, Meshcheriakova Y, Santi L, Imperatori F, et al (2020). Prevention and treatment of autoimmune diseases with plant virus nanoparticles. Science Advances, 6(19). Abstract.
Gaziano R, Sabbatini S, Roselletti E, Perito S, Monari C (2020). Saccharomyces cerevisiae-Based Probiotics as Novel Antimicrobial Agents to Prevent and Treat Vaginal Infections. Frontiers in Microbiology, 11
Roselletti E, Monari C, Sabbatini S, Perito S, Vecchiarelli A, Sobel JD, Cassone A (2019). A Role for Yeast/Pseudohyphal Cells of Candida albicans in the Correlated Expression of NLRP3 Inflammasome Inducers in Women with Acute Vulvovaginal Candidiasis. Frontiers in Microbiology, 10
Ricci E, Ronchetti S, Gabrielli E, Pericolini E, Gentili M, Roselletti E, Vecchiarelli A, Riccardi C (2019). GILZ restrains neutrophil activation by inhibiting the MAPK pathway. Journal of Leukocyte Biology, 105(1), 187-194. Abstract.
Roselletti E, Sabbatini S, Ballet N, Perito S, Pericolini E, Blasi E, Mosci P, Cayzeele Decherf A, Monari C, Vecchiarelli A, et al (2019). Saccharomyces cerevisiae CNCM I-3856 as a new therapeutic agent against oropharyngeal candidiasis. Frontiers in Microbiology, 10(JULY). Abstract.
Roselletti E, Perito S, Sabbatini S, Monari C, Vecchiarelli A (2019). Vaginal Epithelial Cells Discriminate between Yeast and Hyphae of Candida albicans in Women Who Are Colonized or Have Vaginal Candidiasis. Journal of Infectious Diseases, 220(10), 1645-1654. Abstract.
Gabrielli E, Pericolini E, Ballet N, Roselletti E, Sabbatini S, Mosci P, Decherf AC, Pélerin F, Perito S, Jüsten P, et al (2018). Saccharomyces cerevisiae-based probiotic as novel anti-fungal and anti-inflammatory agent for therapy of vaginal candidiasis. Beneficial Microbes, 9(2), 219-230. Abstract.
Gabrielli E, Roselletti E, Pericolini E, Sabbatini S, Vecchiarelli A, Cassone A (2017). Chronic vaginal candidiasis is achievable in outbred CD-1 mice. mBio, 8(5).
Roselletti E, Perito S, Gabrielli E, Mencacci A, Pericolini E, Sabbatini S, Cassone A, Vecchiarelli A (2017). NLRP3 inflammasome is a key player in human vulvovaginal disease caused by Candida albicans. Scientific Reports, 7(1). Abstract.
Ricci E, Ronchetti S, Pericolini E, Gabrielli E, Cari L, Gentili M, Roselletti E, Migliorati G, Vecchiarelli A, Riccardi C, et al (2017). Role of the glucocorticoid-induced leucine zipper gene in dexamethasone-induced inhibition of mouse neutrophil migration via control of annexin A1 expression. FASEB Journal, 31(7), 3054-3065. Abstract.
Pericolini E, Gabrielli E, Ballet N, Sabbatini S, Roselletti E, Cayzeele Decherf A, Pélerin F, Luciano E, Perito S, Jüsten P, et al (2017). Therapeutic activity of a Saccharomyces cerevisiae-based probiotic and inactivated whole yeast on vaginal candidiasis. Virulence, 8(1), 74-90. Abstract.
Gabrielli E, Sabbatini S, Roselletti E, Kasper L, Perito S, Hube B, Cassone A, Vecchiarelli A, Pericolini E (2016). In vivo induction of neutrophil chemotaxis by secretory aspartyl proteinases of Candida albicans. Virulence, 7(7), 819-825. Abstract.
Gabrielli E, Roselletti E, Luciano E, Sabbatini S, Mosci P, Pericolini E (2015). Comparison between bioluminescence imaging technique and CFU count for the study of oropharyngeal candidiasis in mice. Cytometry Part A, 87(5), 428-436. Abstract.
Gabrielli E, Pericolini E, Luciano E, Sabbatini S, Roselletti E, Perito S, Kasper L, Hube B, Vecchiarelli A (2015). Induction of caspase-11 by aspartyl proteinases of Candida albicans and implication in promoting inflammatory response. Infection and Immunity, 83(5), 1940-1948. Abstract.
Pericolini E, Gabrielli E, Amacker M, Kasper L, Roselletti E, Luciano E, Sabbatini S, Kaeser M, Moser C, Hube B, et al (2015). Secretory aspartyl proteinases cause vaginitis and can mediate vaginitis caused by Candida albicans in mice. mBio, 6(3). Abstract.
