Dr Joseph Costello
Senior Lecturer in Cell Biology
J.Costello@exeter.ac.uk
7540
Geoffrey Pope 214
Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK
Overview
I am a molecular cell biologist interested in how interaction between organelles allows coordination of cellular trafficking and signaling. I did my PhD at the University of Sheffield and then postdoctoral work at the University of Manchester where I investigated how cells can optimise mRNA selection under different stress conditions. Following this I moved to the University of Exeter where I worked on a critical stress-response organelle, the peroxisome. Here, I identified organelle-targeting signals for membrane proteins, allowing us to discover proteins which tether peroxisomes and the ER at membrane contact sites. I took up a lectureship in Exeter in 2019 and I am focusing on membrane contact sites between organelles and how this relates to ROS homeostasis and disease.
Publications
Books
Schrader M, Islinger M, Costello J (eds)(2022). 978-2-83250-838-1. Lausanne, Frontiers Media SA.
Journal articles
Costello J, Islinger M, Schrader M (In Press). Editorial: “Molecular mechanisms and physiological significance of organelle interactions and cooperation—Volume II”. Frontiers in Cell and Developmental Biology
Kors S, Schrader M, Costello J (In Press). Multiple ways to keep FFAT under control!. Contact
Schrader T, Carmichael R, Islinger M, Costello J, Hacker C, Bonekamp N, Weishaupt J, Andersen P, Schrader M (In Press). PEX11β and FIS1 cooperate in peroxisome division independent of Mitochondrial Fission Factor. Journal of Cell Science
Costello J, Castro I, Schrader TA, Islinger M, Schrader M (In Press). Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations. Cell Cycle
Schrader M, Costello J, Godinho L, Azadi A, Islinger M (In Press). Proliferation and fission of peroxisomes - an update.
Schrader M, Godinho L, Costello J, Islinger M (In Press). The different facets of organelle interplay - an overview of organelle interactions.
Costello J, Schrader M (In Press). Unloosing the Gordian knot of peroxisome formation. Current Opinion in Cell Biology
Kors S, Costello J, Schrader M (In Press). VAP proteins – from organelle tethers to pathogenic host interactors and their role in neuronal disease. Frontiers in Cell and Developmental Biology
Costello JL, Koster J, Silva BSC, Worthy HL, Schrader TA, Hacker C, Passmore J, Kuypers FA, Waterham HR, Schrader M, et al (2023). Differential roles for ACBD4 and ACBD5 in peroxisome–ER interactions and lipid metabolism. Journal of Biological Chemistry, 299(8), 105013-105013.
Pedrosa AG, Reglinski K, Lismont C, Kors S, Costello J, Rodrigues TA, Marques M, Linka N, Argyriou C, Weinhofer I, et al (2023). Peroxisomes : novel findings and future directions. Histochem Cell Biol, 159(5), 379-387. Author URL.
Kors S, Kurian SM, Costello JL, Schrader M (2022). Controlling contacts—Molecular mechanisms to regulate organelle membrane tethering. BioEssays, 44(11). Abstract.
Kors S, Hacker C, Bolton C, Maier R, Reimann L, Kitchener EJA, Warscheid B, Costello JL, Schrader M (2022). Regulating peroxisome–ER contacts via the ACBD5-VAPB tether by FFAT motif phosphorylation and GSK3β. Journal of Cell Biology, 221(3). Abstract.
Islinger M, Costello JL, Kors S, Soupene E, Levine TP, Kuypers FA, Schrader M (2020). The diversity of ACBD proteins – from lipid binding to protein modulators and organelle tethers. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1867(5), 118675-118675.
Bishop A, Kamoshita M, Passmore J, Hacker C, Schrader T, Waterham H, Costello J, Schrader M (2019). Fluorescent tools to analyse peroxisome-ER interactions in mammalian cells. Contact, 2
Costello J, Zalckvar E, Kemp S, di Cara F, Kim P, Linka N, van der KleiEmail author I (2019). Peroxisomes: new insights into protein sorting, dynamics, quality control, signalling and roles in health and disease. Histochemistry and Cell Biology
Castro IG, Richards DM, Metz J, Costello JL, Passmore JB, Schrader TA, Gouveia A, Ribeiro D, Schrader M (2018). A role for Mitochondrial Rho GTPase 1 (MIRO1) in motility and membrane dynamics of peroxisomes. Traffic, 19(3), 229-242.
Talavera D, Kershaw CJ, Costello JL, Castelli LM, Rowe W, Sims PFG, Ashe MP, Grant CM, Pavitt GD, Hubbard SJ, et al (2018). Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions. Scientific Reports, 8(1). Abstract.
Wang Y, Metz J, Costello JL, Passmore J, Schrader M, Schultz C, Islinger M (2018). Intracellular redistribution of neuronal peroxisomes in response to ACBD5 expression. PLoS One, 13(12). Abstract. Author URL.
Costello JL, Castro IG, Hacker C, Schrader TA, Metz J, Zeuschner D, Azadi AS, Godinho LF, Costina V, Findeisen P, et al (2017). ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. The Journal of Cell Biology, 216, 331-342. Abstract.
Costello JL, Castro IG, Hacker C, Schrader TA, Metz J, Zeuschner D, Azadi AS, Godinho LF, Costina V, Findeisen P, et al (2017). ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. JOURNAL OF CELL BIOLOGY, 216(2), 331-342. Author URL.
Costello JL, Kershaw CJ, Castelli LM, Talavera D, Rowe W, Sims PFG, Ashe MP, Grant CM, Hubbard SJ, Pavitt GD, et al (2017). Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses. Genome Biology, 18(1). Abstract.
Costello JL, Castro IG, Cam oes F, Schrader TA, McNeall D, Yang J, Giannopoulou EA, Gomes S, Pogenberg V, Bonekamp NA, et al (2017). Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells. Journal of Cell Science, 130, 1675-1687. Abstract.
Jennings MD, Kershaw CJ, White C, Hoyle D, Richardson JP, Costello JL, Donaldson IJ, Zhou Y, Pavitt GD (2016). eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control. Nucleic Acids Res, 44(20), 9698-9709. Abstract. Author URL.
Costello J, Castelli LM, Rowe W, Kershaw CJ, Talavera D, Mohammad-Qureshi SS, Sims PFG, Grant CM, Pavitt GD, Hubbard SJ, et al (2015). Global mRNA selection mechanisms for translation initiation. Genome Biology, 16(1). Abstract.
Kershaw CJ, Costello JL, Talavera D, Rowe W, Castelli LM, Sims PFG, Grant CM, Ashe MP, Hubbard SJ, Pavitt GD, et al (2015). Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p. Scientific Reports, 5 Abstract.
Schrader M, Costello J, Godinho LF, Islinger M (2015). Peroxisome-mitochondria interplay and disease. Journal of Inherited Metabolic Disease, 38(4), 681-702. Abstract.
Schrader M, Costello J, Godinho LF, Islinger M (2015). Peroxisome-mitochondria interplay and disease. J Inherit Metab Dis, 38(4), 681-702. Abstract. Author URL.
Castelli LM, Talavera D, Kershaw CJ, Mohammad-Qureshi SS, Costello JL, Rowe W, Sims PFG, Grant CM, Hubbard SJ, Ashe MP, et al (2015). The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation. PLoS Genetics, 11(5). Abstract.
Kershaw CJ, Costello JL, Castelli LM, Talavera D, Rowe W, Sims PFG, Ashe MP, Hubbard SJ, Pavitt GD, Grant CM, et al (2015). The Yeast La Related Protein Slf1p is a Key Activator of Translation during the Oxidative Stress Response. PLoS Genetics, 11(1). Abstract.
Williams C, Opalinski L, Landgraf C, Costello J, Schrader M, Krikken AM, Knoops K, Kram AM, Volkmer R, van der Klei IJ, et al (2015). The membrane remodeling protein Pex11p activates the GTPase Dnm1p during peroxisomal fission. Proc Natl Acad Sci U S A, 112(20), 6377-6382. Abstract. Author URL.
Rowe W, Kershaw CJ, Castelli LM, Costello JL, Ashe MP, Grant CM, Sims PFG, Pavitt GD, Hubbard SJ (2014). Puf3p induces translational repression of genes linked to oxidative stress. Nucleic Acids Res, 42(2), 1026-1041. Abstract. Author URL.
Costello JL, Stead JA, Feigenbutz M, Jones RM, Mitchell P (2011). The C-terminal region of the exosome-associated protein Rrp47 is specifically required for box C/D small nucleolar RNA 3'-maturation. J Biol Chem, 286(6), 4535-4543. Abstract. Author URL.
Stead JA, Costello JL, Livingstone MJ, Mitchell P (2007). The PMC2NT domain of the catalytic exosome subunit Rrp6p provides the interface for binding with its cofactor Rrp47p, a nucleic acid-binding protein. Nucleic Acids Res, 35(16), 5556-5567. Abstract. Author URL.
Chapters
Costello J, Passmore J, Islinger M, Schrader M (2018). Multi-localized proteins: the peroxisome-mitochondria connection. In del Rio L, Schrader M (Eds.) Proteomics of Peroxisomes. Identifying Novel Functions and Regulatory Networks, Springer.
Conferences
Camoes F, Islinger M, Costello J, Gomes S, Bonekamp N, Almeida M, Castro I, Ribeiro D, Schrader M (2014). Targeting of tail-anchored proteins to peroxisomes and mitochondria in mammalian cells. Author URL.
