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Dr Julie Fletcher

Dr Julie Fletcher

Research Fellow

 5177

 Geoffrey Pope 401

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

I am a microbiologist with an interest in polymicrobial infections such as periodontal disease and diabetic foot infections. My research has focused on profiling these complex communites with a particular emphasis on the anaerobic species present. I am keen to understand the effect of the environment on the different species within these communities and how we might manipulate the environment to eliminate certain species. I am also interested in alternative delivery routes for antibiotics such as local release carriers which could reduce exposure of the gut microfllora to antibiotics and deliver the higher concentrations needed to tackle biofilms.

I have also worked in healthcare for a number of years and time spent with patients has inspired my research interests and improving patient outcomes is at the core of my work.

I studied for my PhD at the Eastman Dental Institute (UCL) and after a career break I have returned to a STEM career with the support of a Daphne Jackson Fellowship. 

Qualifications

1991-1999 PhD Microbiology, University College London
1987-1990 BSc (Hons) Biological Science, University of Plymouth

Career

2019-present Research Fellow, University of Exeter
2017-2019 Daphne Jakson Fellow, University of Exeter
1991-1999 Research assistant, University College London

Links

Research group links

Research

Research networks

National Biofilms Innovation Centre

Exeter Clinical Laboratory (Royal Devon and Exeter NHS Healthcare Trust)

Macleod Diabetes and Endocrine Centre (Royal Devon and Exeter NHS Healthcare Trust)

Eastman Dental Institute (UCL)

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Fletcher J, Porter R, Aiken S, Delury C, Michell S (2019). The effect of local release antibiotic beads on in-vitro bacterial growth from tissue taken from infected diabetic foot ulcers. Access Microbiology, 1(1A).
Fletcher JM, Nair SP, Ward JM, Henderson B, Wilson M (2001). Analysis of the effect of changing environmental conditions on the expression patterns of exported surface-associated proteins of the oral pathogen Actinobacillus actinomycetemcomitans. Microb Pathog, 30(6), 359-368. Abstract.  Author URL.
Ward J, Fletcher J, Nair SP, Wilson M, Williams RJ, Poole S, Henderson B (2001). Identification of the exported proteins of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans by using alkaline phosphatase fusions. Infect Immun, 69(4), 2748-2752. Abstract.  Author URL.
Sharp L, Poole S, Reddi K, Fletcher J, Nair S, Wilson M, Curtis M, Henderson B, Tabona P (1998). A lipid A-associated protein of Porphyromonas gingivalis, derived from the haemagglutinating domain of the RI protease gene family, is a potent stimulator of interleukin 6 synthesis. Microbiology, 144 ( Pt 11), 3019-3026. Abstract.  Author URL.
Fletcher J, Nair S, Poole S, Henderson B, Wilson M (1998). Cytokine degradation by biofilms of Porphyromonas gingivalis. Curr Microbiol, 36(4), 216-219. Abstract.  Author URL.
Fletcher J, Reddi K, Poole S, Nair S, Henderson B, Tabona P, Wilson M (1997). Interactions between periodontopathogenic bacteria and cytokines. J Periodontal Res, 32(1 Pt 2), 200-205. Abstract.  Author URL.
Wilson M, Patel H, Fletcher J (1996). Susceptibility of biofilms of Streptococcus sanguis to chlorhexidine gluconate and cetylpyridinium chloride. Oral Microbiol Immunol, 11(3), 188-192. Abstract.  Author URL.
Gibson MT, Mangat D, Gagliano G, Wilson M, Fletcher J, Bulman J, Newman HN (1994). Evaluation of the efficacy of a redox agent in the treatment of chronic periodontitis. J Clin Periodontol, 21(10), 690-700. Abstract.  Author URL.
Barber PM, Fletcher JM, Newman HN (1993). Demonstration of the Glycocalyces Associated with Three Oral Gram-Negative Bacterial Species Using a Modern Acrylic Resin Technique. Journal of Structural Biology, 110(3), 180-187.
Fletcher JM, Wilson M (1993). Effect of a Redox Agent, Methylene Blue, on the Survival of Porphyromonas gingivalis in Vitro. Clinical Infectious Diseases, 16(Supplement_4), S409-S410.

Publications by year


2019

Fletcher J, Porter R, Aiken S, Delury C, Michell S (2019). The effect of local release antibiotic beads on in-vitro bacterial growth from tissue taken from infected diabetic foot ulcers. Access Microbiology, 1(1A).

2001

Fletcher JM, Nair SP, Ward JM, Henderson B, Wilson M (2001). Analysis of the effect of changing environmental conditions on the expression patterns of exported surface-associated proteins of the oral pathogen Actinobacillus actinomycetemcomitans. Microb Pathog, 30(6), 359-368. Abstract.  Author URL.
Ward J, Fletcher J, Nair SP, Wilson M, Williams RJ, Poole S, Henderson B (2001). Identification of the exported proteins of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans by using alkaline phosphatase fusions. Infect Immun, 69(4), 2748-2752. Abstract.  Author URL.

1998

Sharp L, Poole S, Reddi K, Fletcher J, Nair S, Wilson M, Curtis M, Henderson B, Tabona P (1998). A lipid A-associated protein of Porphyromonas gingivalis, derived from the haemagglutinating domain of the RI protease gene family, is a potent stimulator of interleukin 6 synthesis. Microbiology, 144 ( Pt 11), 3019-3026. Abstract.  Author URL.
Fletcher J, Nair S, Poole S, Henderson B, Wilson M (1998). Cytokine degradation by biofilms of Porphyromonas gingivalis. Curr Microbiol, 36(4), 216-219. Abstract.  Author URL.

1997

Fletcher J, Reddi K, Poole S, Nair S, Henderson B, Tabona P, Wilson M (1997). Interactions between periodontopathogenic bacteria and cytokines. J Periodontal Res, 32(1 Pt 2), 200-205. Abstract.  Author URL.

1996

Wilson M, Patel H, Fletcher J (1996). Susceptibility of biofilms of Streptococcus sanguis to chlorhexidine gluconate and cetylpyridinium chloride. Oral Microbiol Immunol, 11(3), 188-192. Abstract.  Author URL.

1994

Gibson MT, Mangat D, Gagliano G, Wilson M, Fletcher J, Bulman J, Newman HN (1994). Evaluation of the efficacy of a redox agent in the treatment of chronic periodontitis. J Clin Periodontol, 21(10), 690-700. Abstract.  Author URL.

1993

Barber PM, Fletcher JM, Newman HN (1993). Demonstration of the Glycocalyces Associated with Three Oral Gram-Negative Bacterial Species Using a Modern Acrylic Resin Technique. Journal of Structural Biology, 110(3), 180-187.
Fletcher JM, Wilson M (1993). Effect of a Redox Agent, Methylene Blue, on the Survival of Porphyromonas gingivalis in Vitro. Clinical Infectious Diseases, 16(Supplement_4), S409-S410.

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