Mark Stappers | Biosciences | University of Exeter

Dr Mark Stappers

Research Fellow

M.Stappers@exeter.ac.uk

7622

01392 727622

Geoffrey Pope 328

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

Qualifications

PhD, Radboud University, Nijmegen, the Netherlands

Bsc & MSc in Biomedical Sciences, Radboud University, Nijmegen, the Netherlands

Career

2015 - 2019 Research Fellow, MRC Centre for Medical Mycology at the University of Aberdeen, UK

Research group links

Microbial Evolutionary Ecology

Research

Research interests

Superficial fungal infections affect a large proportion of the population worldwide but, more seriously, fungi also kill over a million people every year.

To recognise invading fungal pathogens and mount a protective immune response, our immune cells are equipped with sensors called pattern recognition receptors.

My research utilizes a set of soluble pattern recognition receptors, which recognize conserved fungal components, to understand how the fungal cell wall is made.

This research will aid in the understanding of how fungi are recognized by the immune system, and how we might kill fungi by blocking its cell wall assembly.

Publications

Journal articles

Krylov VB, Gómez-Redondo M, Solovev AS, Yashunsky DV, Brown AJP, Stappers MHT, Gow NAR, Ardá A, Jiménez-Barbero J, Nifantiev NE, et al (2023). Identification of a new DC-SIGN binding pentamannoside epitope within the complex structure of Candida albicans mannan. The Cell Surface, 10 Abstract.

Malavia-Jones D, Farrer RA, Stappers MHT, Edmondson MB, Borman AM, Johnson EM, Lipke PN, Gow NAR (2023). Strain and temperature dependent aggregation of Candida auris is attenuated by inhibition of surface amyloid proteins. The Cell Surface, 10, 100110-100110.

Stappers MHT, Nikolakopoulou C, Wiesner DL, Yuecel R, Klein BS, Willment JA, Brown GD (2021). Characterization of antifungal C-type lectin receptor expression on murine epithelial and endothelial cells in mucosal tissues. Eur J Immunol, 51(9), 2341-2344. Abstract. Author URL.

Tone K, Stappers MHT, Hatinguais R, Dambuza IM, Salazar F, Wallace C, Yuecel R, Morvay PL, Kuwano K, Willment JA, et al (2021). MelLec Exacerbates the Pathogenesis of Aspergillus fumigatus-Induced Allergic Inflammation in Mice. Frontiers in Immunology, 12 Abstract.

Vendele I, Feizi T, Spyrou M, Stappers M, Brown G, Willment J, Silva L, Palma A, Chaie W, Liu Y, et al (2021). Spatial mapping of immunological epitopes in the Candida cell wall using C-type lectin probes. Access Microbiology, 3(12).

Peeters T, Martens S, D’Onofrio V, Stappers MHT, van der Hilst JCH, Houben B, Achten R, Joosten LAB, Gyssens IC (2020). An observational study of innate immune responses in patients with acute appendicitis. Scientific Reports, 10(1). Abstract.

D’Onofrio V, Monnier AA, Kremer C, Stappers MHT, Netea MG, Gyssens IC (2020). Lesion size is associated with genetic polymorphisms in TLR1, TLR6, and TIRAP genes in patients with major abscesses and diabetic foot infections. European Journal of Clinical Microbiology and Infectious Diseases, 39(2), 353-360. Abstract.

Vendele I, Willment JA, Silva LM, Palma AS, Chai W, Liu Y, Feizi T, Spyrou M, Stappers MHT, Brown GD, et al (2020). Mannan detecting C-type lectin receptor probes recognise immune epitopes with diverse chemical, spatial and phylogenetic heterogeneity in fungal cell walls. PLoS Pathog, 16(1). Abstract. Author URL.

Tone K, Stappers MHT, Willment JA, Brown GD (2019). C-type lectin receptors of the Dectin-1 cluster: Physiological roles and involvement in disease. European Journal of Immunology, 49(12), 2127-2133. Abstract.

Haider M, Dambuza IM, Asamaphan P, Stappers M, Reid D, Yamasaki S, Brown GD, Gow NAR, Erwig LP (2019). The pattern recognition receptors dectin-2, mincle, and FcRγ impact the dynamics of phagocytosis of Candida, Saccharomyces, Malassezia, and Mucor species. PLoS One, 14(8). Abstract. Author URL.

Stappers MHT, Clark AE, Aimanianda V, Bidula S, Reid DM, Asamaphan P, Hardison SE, Dambuza IM, Valsecchi I, Kerscher B, et al (2018). Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus. Nature, 555(7696), 382-386. Abstract.

Stappers MHT, Hagen F, Reimnitz P, Mouton JW, Meis JF, Gyssens IC (2016). Bacteroides fragilis in biopsies of patients with major abscesses and diabetic foot infections: Direct molecular versus culture-based detection. Diagnostic Microbiology and Infectious Disease, 85(2), 263-265. Abstract.

Ammerdorffer A, Stappers MHT, Oosting M, Schoffelen T, Hagenaars JCJP, Bleeker-Rovers CP, Wegdam-Blans MC, Wever PC, Roest HJ, van de Vosse E, et al (2016). Genetic variation in TLR10 is not associated with chronic Q fever, despite the inhibitory effect of TLR10 on Coxiella burnetii-induced cytokines in vitro. Cytokine, 77, 196-202. Abstract.

Stappers MHT, Hagen F, Reimnitz P, Mouton JW, Meis JF, Gyssens IC (2015). Direct molecular versus culture-based assessment of Gram-positive cocci in biopsies of patients with major abscesses and diabetic foot infections. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 34(9), 1885-1892. Author URL.

Stappers MHT, Oosting M, Ioana M, Reimnitz P, Mouton JW, Netea MG, Gyssens IC, Joosten LAB (2015). Genetic variation in TLR10, an inhibitory toll-like receptor, influences susceptibility to complicated skin and skin structure infections. Journal of Infectious Diseases, 212(9), 1491-1499. Abstract.

Jaeger M, Stappers MHT, Joosten LAB, Gyssens IC, Netea MG (2015). Genetic variation in pattern recognition receptors: Functional consequences and susceptibility to infectious disease. Future Microbiology, 10(6), 989-1008. Abstract.

Stappers MHT, Thys Y, Oosting M, Plantinga TS, Ioana M, Reimnitz P, Mouton JW, Netea MG, Joosten LAB, Gyssens IC, et al (2014). Polymorphisms in cytokine genes IL6, TNF, IL10, IL17A and IFNG influence susceptibility to complicated skin and skin structure infections. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 33(12), 2267-2274. Author URL.

Stappers MHT, Thys Y, Oosting M, Plantinga TS, Ioana M, Reimnitz P, Mouton JW, Netea MG, Joosten LAB, Gyssens IC, et al (2014). TLR1, TLR2, and TLR6 gene polymorphisms are associated with increased susceptibility to complicated skin and skin structure infections. Journal of Infectious Diseases, 210(2), 311-318. Abstract.

Stappers MHT, Janssen NAF, Oosting M, Plantinga TS, Arvis P, Mouton JW, Joosten LAB, Netea MG, Gyssens IC (2012). A role for TLR1, TLR2 and NOD2 in cytokine induction by Bacteroides fragilis. Cytokine, 60(3), 861-869. Abstract.

Ioana M, Ferwerda B, Plantinga TS, Stappers M, Oosting M, McCall M, Cimpoeru A, Burada F, Panduru N, Sauerwein R, et al (2012). Different patterns of Toll-like receptor 2 polymorphisms in populations of various ethnic and geographic origins. Infect Immun, 80(5), 1917-1922. Abstract. Author URL.

Marijnissen RJ, Koenders MI, Smeets RL, Stappers MH, Nickerson-Nutter C, Joosten LA, Boots AM, van den Berg WB (2011). Increased IL-22 expression by synovial Th17 cells during late stages of arthritis is controlled by IL-1 and enhances bone degradation. Annals of the Rheumatic Diseases, 70(Suppl 2).

Marijnissen RJ, Koenders MI, Smeets RL, Stappers MHT, Nickerson-Nutter C, Joosten LAB, Boots AMH, Van Den Berg WB (2011). Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation. Arthritis and Rheumatism, 63(10), 2939-2948. Abstract.

Bosman GJCGM, Stappers M, Novotný VMJ (2010). Changes in band 3 structure as determinants of erythrocyte integrity during storage and survival after transfusion. Blood Transfus, 8 Suppl 3(Suppl 3), s48-s52. Author URL.

Chapters

Stappers MHT, Brown GD (2017). Host immune responses during infections with Candida albicans. In (Ed) Candida albicans: Cellular and Molecular Biology: Second Edition, 145-183. Abstract.

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