Faculty of Health and Life Sciences

Dr Matthew Winter

Dr Matthew Winter

Associate Professor and Royal Society Industry Fellow

 M.Winter@exeter.ac.uk

 6258

 01392 726258

 Geoffrey Pope 223

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

Research interests: 

  • Pharmaceutical R&D applications of the zebrafish model. Current research activity focussed on CRISPR/Cas9 in zebrafish for drug target validation; drug-induced seizures and epilepsy; drug-induced kidney injury; and pancreatic beta cell regeneration. 
  • The effects of pharmaceuticals in the aquatic environment, particularly: sublethal markers of toxicity in fish; the use of preclincial data in ecotoxicology; and novel experimental approaches for environmental risk assessment.

Non consultancy research funding since joining Exeter:

  • BBSRC: Establishing the roles of oestrogen receptor 1 (ESR1) in olfactory development and function using novel CRISPR/Cas9-based knockouts in zebrafish, 2024-2027 - Co-I 
  • The ALS Association: Environmental toxins in ALS (amyotrophic lateral sclerosis): Validation and repurposing therapeutics. Prevention program grant, 2023-2025 - Co-I with the University of Sheffield (Andy Grierson) and the University of Surrey (Matt Parker) 
  • BBSRC: 4D imaging of the dynamic molecular, cellular and tissue organization in living systems. ALERT 21 equipment grant, 2022 - Co-I
  • CLES/AstraZeneca: Testing the translational power of zebrafish for studying human heart failure. 50:50 Industry matched Ph.D. studentship, 2023-2027 – PI
  • The Royal Society: Harnessing next generation gene editing technology in zebrafish to support novel drug target validation. Industry Fellowship, 2022-2026 - PI
  • NC3Rs: A non-protected larval zebrafish model for the investigation of novel strategies to protect against nerve agent-induced toxicity and seizures. Skills and Knowledge Transfer grant, 2021-2023 – Co-I with University of Portsmouth (Matt Parker) and Dstl.
  • BBSRC: Advancing understanding of anaesthesia and analgesia in the zebrafish. Responsive Mode research grant, 2021-2024 – Co-PI
  • BBSRC: Characterising the functional homology of drug targets in aquatic animals. Ph.D. CASE studentship award with AstraZeneca, 2021-2025 – Co-I
  • The Royal Society: Harnessing academic innovation for the industrial application of CRISPR-Cas technology in the zebrafish. Short Industry Fellowship award, 2020-2021 - PI
  • NC3Rs: An alternative approach for assessing drug-induced seizures, using non-protected larval zebrafish. Ph.D. studentship award, 2018-2022 – Co-I
  • BBSRC: Advancing mechanistic understanding of glucocorticoid effects in fish. Ph.D. CASE studentship award with AstraZeneca,  2018-2022 – Co-I
  • MERCK/UoE: Integrated health effects analysis of antidepressants inhibiting serotonin and/or norepinephrine reuptake using zebrafish models. Industry/college-funded Ph.D. studentship award, 2017-2021 – Co-I
  • AstraZeneca Science2Go/MRC (proximity to discovery): Functional live brain imaging in zebrafish for mechanism–specific detection of drug-induced seizures. Industry-MRC funded research project, 2018-2019 – Lead scientist and co-applicant
  • AstraZeneca CVMD iMed: The zebrafish as a model for kidney regeneration. Industry-funded research project, 2014-2015 – Lead applicant and scientist

Qualifications

2015: Post graduate Certificate in Academic Practice (Fellow of the Higher Education Academy)

1996–1999: Ph.D., Environmental Physiology (endocrinology). The University of Manchester

1992-1995: B.Sc. (Hons) Oceanography with Marine Biology. The University of Southampton    

Career

June 2023 - present: Associate Professor in Translational Toxicology and Pharmacology, Biosciences, University of Exeter

May 2022 - present: Royal Society Industry Fellow, University of Exeter and AstraZeneca

March 2020 - June 2021: Royal Society Short Industry Fellow, University of Exeter and AstraZeneca

June 2014 - 2023: Senior Research Fellow, Biosciences, University of Exeter 

2009-2014: Associate Principle Scientist, Safety, Health and Environment, AstraZeneca, Brixham Laboratory

2005-2009: Senior Scientist, Safety, Health and Environment, AstraZeneca, Brixham Laboratory 

2003-2005: Research Environmental Toxicologist, AstraZeneca, Brixham Laboratory

2000-2003: Post-Doctoral Research Associate, Toxicology, The University of Birmingham

1999-2000: Post-Doctoral Research Assistant, Endocrinology, The University of Manchester

Links

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Publications

Journal articles

Margiotta‐Casaluci L, Owen SF, Winter MJ (2023). Cross‐Species Extrapolation of Biological Data to Guide the Environmental Safety Assessment of Pharmaceuticals—The State of the Art and Future Priorities. Environmental Toxicology and Chemistry, 43(3), 513-525. Abstract.
Windell DL, Mourabit S, Moger J, Owen SF, Winter MJ, Tyler CR (2023). The influence of size and surface chemistry on the bioavailability, tissue distribution and toxicity of gold nanoparticles in zebrafish (Danio rerio). Ecotoxicol Environ Saf, 260 Abstract.  Author URL.
Takesono A, Dimitriadou S, Clark NJ, Handy RD, Mourabit S, Winter MJ, Kudoh T, Tyler CR (2023). Zinc oxide nanoparticles disrupt development and function of the olfactory sensory system impairing olfaction-mediated behaviour in zebrafish. Environment International, 180, 108227-108227.
Winter MJ, Ono Y, Ball JS, Walentinsson A, Michaelsson E, Tochwin A, Scholpp S, Tyler CR, Rees S, Hetheridge MJ, et al (2022). A Combined Human in Silico and CRISPR/Cas9-Mediated in Vivo Zebrafish Based Approach to Provide Phenotypic Data for Supporting Early Target Validation. Frontiers in Pharmacology, 13
Hamilton CM, Winter MJ, Margiotta-Casaluci L, Owen SF, Tyler CR (2022). Are synthetic glucocorticoids in the aquatic environment a risk to fish?. Environment International, 162 Abstract.
Pinion J, Walsh C, Goodfellow M, Randall AD, Tyler CR, Winter MJ (2022). Differential Electrographic Signatures Generated by Mechanistically-Diverse Seizurogenic Compounds in the Larval Zebrafish Brain. eNeuro, 9(2). Abstract.  Author URL.
Takesono A, Schirrmacher P, Scott A, Green JM, Lee O, Winter MJ, Kudoh T, Tyler CR (2022). Estrogens regulate early embryonic development of the olfactory sensory system via estrogen-responsive glia. Development, 149(1). Abstract.  Author URL.
Winter MJ, Pinion J, Tochwin A, Takesono A, Ball JS, Grabowski P, Metz J, Trznadel M, Tse K, Redfern WS, et al (2021). Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms. Br J Pharmacol, 178(13), 2671-2689. Abstract.  Author URL.
Gould SL, Winter MJ, Norton WHJ, Tyler CR (2021). The potential for adverse effects in fish exposed to antidepressants in the aquatic environment. Environ Sci Technol, 55(24), 16299-16312. Abstract.  Author URL.
van der Oost R, McKenzie DJ, Verweij F, Satumalay C, van der Molen N, Winter MJ, Chipman JK (2020). Identifying adverse outcome pathways (AOP) for Amsterdam city fish by integrated field monitoring. Environmental Toxicology and Pharmacology, 74, 103301-103301.
Gutiérrez HC, Vacca I, Schoenmacker G, Cleal M, Tochwin A, O'Connor B, Young AMJ, Vasquez AA, Winter MJ, Parker MO, et al (2020). Screening for drugs to reduce zebrafish aggression identifies caffeine and sildenafil. European Neuropsychopharmacology, 30, 17-29.
Reichmann F, Rimmer N, Tilley CA, Dalla Vecchia E, Pinion J, Al Oustah A, Carreño Gutiérrez H, Young AMJ, McDearmid JR, Winter MJ, et al (2020). The zebrafish histamine H3 receptor modulates aggression, neural activity and forebrain functional connectivity. Acta Physiologica, 230(4). Abstract.
Margiotta-Casaluci L, Dusza H, Moreira I, Winter MJ, Prior H (2019). Development of an adverse outcome pathway (AOP) for cardiotoxicity mediated by the blockade of L-type calcium channels. Journal of pharmacological and toxicological methods, 99
Mourabit S, Fitzgerald JA, Ellis RP, Takesono A, Porteus CS, Trznadel M, Metz J, Winter MJ, Kudoh T, Tyler CR, et al (2019). New insights into organ-specific oxidative stress mechanisms using a novel biosensor zebrafish. Environment International, 133 Abstract.
Margiotta-Casaluci L, Owen SF, Rand-Weaver M, Winter MJ (2019). Testing the translational power of the zebrafish: an inter-species analysis of responses to cardiovascular drugs. Frontiers in Pharmacology, 10(JULY). Abstract.
Winter MJ, Windell D, Metz J, Matthews P, Pinion J, Brown JT, Hetheridge MJ, Ball JS, Owen SF, Redfern WS, et al (2018). Author Correction: 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain. Sci Rep, 8(1). Abstract.  Author URL.
Brown AR, Green J, Moreman J, Gunnarsson L, Mourabit S, Ball J, Winter M, Trznadel M, Correia A, Hacker C, et al (2018). Cardiovascular Effects and Molecular Mechanisms of Bisphenol a and its Metabolite MBP in Zebrafish. Environmental Science and Technology
Moreman J, Takesono A, Trznadel M, Winter MJ, Perry A, Wood ME, Rogers NJ, Kudoh T, Tyler CR (2018). Estrogenic Mechanisms and Cardiac Responses Following Early Life Exposure to Bisphenol a (BPA) and its Metabolite 4-Methyl-2,4-bis( p-hydroxyphenyl)pent-1-ene (MBP) in Zebrafish. Environ Sci Technol, 52(11), 6656-6665. Abstract.  Author URL.
Winter MJ, Windell D, Metz J, Matthews P, Pinion J, Brown JT, Hetheridge MJ, Ball JS, Owen SF, Redfern WS, et al (2017). 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain. Sci Rep, 7(1). Abstract.  Author URL.
Lange A, Corcoran J, Miyagawa S, Iguchi T, Winter MJ, Tyler CR (2017). Development of a common carp (Cyprinus carpio) pregnane X receptor (cPXR) transactivation reporter assay and its activation by azole fungicides and pharmaceutical chemicals. Toxicol in Vitro, 41, 114-122. Abstract.  Author URL.
Huerta B, Margiotta‐Casaluci L, Rodríguez‐Mozaz S, Scholze M, Winter MJ, Barceló D, Sumpter JP (2016). Anti‐anxiety drugs and fish behavior: Establishing the link between internal concentrations of oxazepam and behavioral effects. Environmental Toxicology and Chemistry, 35(11), 2782-2790. Abstract.
Corcoran J, Winter MJ, Lange A, Cumming R, Owen SF, Tyler CR (2015). Effects of the lipid regulating drug clofibric acid on PPARα-regulated gene transcript levels in common carp (Cyprinus carpio) at pharmacological and environmental exposure levels. Aquat Toxicol, 161, 127-137. Abstract.  Author URL.
Parker T, Libourel P-A, Hetheridge MJ, Cumming RI, Sutcliffe TP, Goonesinghe AC, Ball JS, Owen SF, Chomis Y, Winter MJ, et al (2014). A multi-endpoint in vivo larval zebrafish (Danio rerio) model for the assessment of integrated cardiovascular function. J Pharmacol Toxicol Methods, 69(1), 30-38. Abstract.  Author URL.
Corcoran J, Lange A, Cumming RI, Owen SF, Ball JS, Tyler CR, Winter MJ (2014). Bioavailability of the imidazole antifungal agent clotrimazole and its effects on key biotransformation genes in the common carp (Cyprinus carpio). Aquat Toxicol, 152, 57-65. Abstract.  Author URL.
Margiotta-Casaluci L, Owen SF, Cumming RI, de Polo A, Winter MJ, Panter GH, Rand-Weaver M, Sumpter JP (2014). Quantitative Cross-Species Extrapolation between Humans and Fish: the Case of the Anti-Depressant Fluoxetine. PLoS ONE, 9(10), e110467-e110467.
Scholz S, Sela E, Blaha L, Braunbeck T, Galay-Burgos M, García-Franco M, Guinea J, Klüver N, Schirmer K, Tanneberger K, et al (2013). A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment. Regulatory Toxicology and Pharmacology, 67(3), 506-530.
Corcoran J, Lange A, Winter MJ, Tyler CR (2012). Effects of Pharmaceuticals on the Expression of Genes Involved in Detoxification in a Carp Primary Hepatocyte Model. Environmental Science and Technology, 46(11), 6306-6314. Abstract.
Bartram AE, Winter MJ, Huggett DB, McCormack P, Constantine LA, Hetheridge MJ, Hutchinson TH, Kinter LB, Ericson JF, Sumpter JP, et al (2012). In vivo and in vitro liver and gill EROD activity in rainbow trout (Oncorhynchus mykiss) exposed to the beta-blocker propranolol. Environ Toxicol, 27(10), 573-582. Abstract.  Author URL.
David RM, Jones HS, Panter GH, Winter MJ, Hutchinson TH, Kevin Chipman J (2012). Interference with xenobiotic metabolic activity by the commonly used vehicle solvents dimethylsulfoxide and methanol in zebrafish (Danio rerio) larvae but not Daphnia magna. Chemosphere, 88(8), 912-917.
Buck L, Winter M, Redfern W, Whitfield T (2012). Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish. Journal of Pharmacological and Toxicological Methods, 66(2), 163-163.
Buck LMJ, Winter MJ, Redfern WS, Whitfield TT (2012). Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish. Hearing Research, 284(1-2), 67-81.
David RM, Dakic V, Williams TD, Winter MJ, Chipman JK (2011). Transcriptional responses in neonate and adult Daphnia magna in relation to relative susceptibility to genotoxicants. Aquatic Toxicology, 104(3-4), 192-204.
David RM, Winter MJ, Chipman JK (2010). Induction of dna strand breaks by genotoxicants in the alga <i>Chlamydomonas reinhardtii</i>. Environmental Toxicology and Chemistry, 28(9), 1893-1900. Abstract.
Corcoran J, Winter MJ, Tyler CR (2010). Pharmaceuticals in the aquatic environment: a critical review of the evidence for health effects in fish. Crit Rev Toxicol, 40(4), 287-304. Abstract.  Author URL.
Redfern WS, Winter MJ, Waldron G, Butler P, Holbrook M, Wallis R, Valentin J-P (2010). Use of Zebrafish in safety pharmacology. Journal of Pharmacological and Toxicological Methods, 62(2).
Winter MJ, Owen SF, Murray-Smith R, Panter GH, Hetheridge MJ, Kinter LB (2010). Using data from drug discovery and development to aid the aquatic environmental risk assessment of human pharmaceuticals: concepts, considerations, and challenges. Integr Environ Assess Manag, 6(1), 38-51. Abstract.  Author URL.
Buck L, Winter MJ, Redfern WS, Whitfield TT (2009). 22-P006 the zebrafish as an in vivo model of drug-induced hearing and vestibular impairment. Cells and Development, 126
Easter A, Bell ME, Damewood JR, Redfern WS, Valentin J-P, Winter MJ, Fonck C, Bialecki RA (2009). Approaches to seizure risk assessment in preclinical drug discovery. Drug Discovery Today, 14(17-18), 876-884.
Hutchinson TH, Bögi C, Winter MJ, Owens JW (2009). Benefits of the maximum tolerated dose (MTD) and maximum tolerated concentration (MTC) concept in aquatic toxicology. Aquatic Toxicology, 91(3), 197-202.
Giltrow E, Eccles PD, Winter MJ, McCormack PJ, Rand-Weaver M, Hutchinson TH, Sumpter JP (2009). Chronic effects assessment and plasma concentrations of the β-blocker propranolol in fathead minnows (Pimephales promelas). Aquatic Toxicology, 95(3), 195-202.
Tyler CR, Filby AL, Bickley LK, Cumming RI, Gibson R, Labadie P, Katsu Y, Liney KE, Shears JA, Silva-Castro V, et al (2009). Environmental health impacts of equine estrogens derived from hormone replacement therapy. Environ Sci Technol, 43(10), 3897-3904. Abstract.  Author URL.
Bickley LK, Lange A, Winter MJ, Tyler CR (2009). Evaluation of a carp primary hepatocyte culture system for screening chemicals for oestrogenic activity. Aquat Toxicol, 94(3), 195-203. Abstract.  Author URL.
Winter MJ, Redfern WS (2009). Update on the use of zebrafish for early safety pharmacology assessment: Opinions and proposals. Journal of Pharmacological and Toxicological Methods, 60(2), 247-248.
Easter A, Winter M, Pollard CE, Redfern WS, Hutchinson T, Valentin JP (2008). Comparison of a hippocampal brain slice and zebra fish assay for assessment of seizure liability. Journal of Pharmacological and Toxicological Methods, 58(2).
Winter MJ, Lillicrap AD, Caunter JE, Schaffner C, Alder AC, Ramil M, Ternes TA, Giltrow E, Sumpter JP, Hutchinson TH, et al (2008). Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas). Aquatic Toxicology, 86(3), 361-369.
Valentin J-P, Waldron G, Redfern W, Butler P, Winter3 M, Holbrook M, Hutchinson3 T, Wallis R (2008). Potential value of zebrafish (Danio rerio) larvae as a front-loaded in vivo screen to assess safety pharmacology endpoin. Journal of Pharmacological and Toxicological Methods, 58(2).
Winter MJ, Redfern WS, Hayfield AJ, Owen SF, Valentin J-P, Hutchinson TH (2008). Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs. Journal of Pharmacological and Toxicological Methods, 57(3), 176-187.
Alderton WK, Kimber GM, Richards FR, Strang I, Redfern WS, Winter MJ, Hutchinson TH, Hammond TG, Valentin JP (2008). Validation of an optomotor method for assessment of visual function in zebrafish larvae. Journal of Pharmacological and Toxicological Methods, 58(2).
Richards FM, Alderton WK, Kimber GM, Liu Z, Strang I, Redfern WS, Valentin J-P, Winter MJ, Hutchinson TH (2008). Validation of the use of zebrafish larvae in visual safety assessment. Journal of Pharmacological and Toxicological Methods, 58(1), 50-58.
Redfern WS, Waldron G, Winter MJ, Butler P, Holbrook M, Wallis R, Valentin J-P (2008). Zebrafish assays as early safety pharmacology screens: Paradigm shift or red herring?. Journal of Pharmacological and Toxicological Methods, 58(2), 110-117.
Winter MJ, Redfern W, Hayfield A, Owen S, Valentin JP, Hutchinson T (2008). Zebrafish embryo-larval locomotion as a frontloaded screen for assessing seizure liability during early drug discovery. Journal of Pharmacological and Toxicological Methods, 58(2).
OWEN S, GILTROW E, HUGGETT D, HUTCHINSON T, SAYE J, WINTER M, SUMPTER J (2007). Comparative physiology, pharmacology and toxicology of β-blockers: Mammals versus fish. Aquatic Toxicology, 82(3), 145-162.
McKenzie DJ, Garofalo E, Winter MJ, Ceradini S, Verweij F, Day N, Hayes R, van der Oost R, Butler PJ, Chipman JK, et al (2007). Complex physiological traits as biomarkers of the sub-lethal toxicological effects of pollutant exposure in fishes. Philosophical Transactions of the Royal Society B: Biological Sciences, 362(1487), 2043-2059. Abstract.
Bickley L, Lange A, Tyler C, Winter M (2007). Fish hepatocyte cultures as an alternative to <i>in vivo</i> tests for screening oestrogen receptor active chemicals. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 146(4), S72-S72.  Author URL.
Winter MJ, Ellis LCJ, Hutchinson TH (2007). Formation of micronuclei in erythrocytes of the fathead minnow (Pimephales promelas) after acute treatment with mitomycin C or cyclophosphamide. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 629(2), 89-99.
Hutchinson TH, Shillabeer N, Winter MJ, Pickford DB (2006). Acute and chronic effects of carrier solvents in aquatic organisms: a critical review. Aquatic Toxicology, 76(1), 69-92.
Aniagu SO, Day N, Chipman JK, Taylor EW, Butler PJ, Winter MJ (2006). Does exhaustive exercise result in oxidative stress and associated DNA damage in the chub (<i>Leuciscus cephalus</i>)?. Environmental and Molecular Mutagenesis, 47(8), 616-623. Abstract.
Winter MJ, Verweij F, Garofalo E, Ceradini S, McKenzie DJ, Williams MA, Taylor EW, Butler PJ, van der Oost R, Kevin Chipman J, et al (2005). Tissue levels and biomarkers of organic contaminants in feral and caged chub (Leuciscus cephalus) from rivers in the West Midlands, UK. Aquatic Toxicology, 73(4), 394-405.
Hayes RA, Regondi S, Winter MJ, Butler PJ, Agradi E, Taylor EW, Kevin Chipman J (2004). Cloning of a chub metallothionein cDNA and development of competitive RT-PCR of chub metallothionein mRNA as a potential biomarker of heavy metal exposure. Marine Environmental Research, 58(2-5), 665-669.
Hayes RA, Regondi S, Winter MJ, Butler PJ, Agradi E, Taylor EW, Chipman JK (2004). Cloning of a chub metallothionein cDNA and development of competitive RT-PCR of chub metallothionein mRNA as a potential biomarker of heavy metal exposure. MARINE ENVIRONMENTAL RESEARCH, 58(2-5), 665-669.  Author URL.
Winter MJ, Day N, Hayes RA, Taylor EW, Butler PJ, Chipman JK (2004). DNA strand breaks and adducts determined in feral and caged chub (Leuciscus cephalus) exposed to rivers exhibiting variable water quality around Birmingham, UK. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 552(1-2), 163-175.
Garofalo E, Ceradini S, Winter M (2004). The use of diffusive gradients in thin-film (DGT) passive samplers for the measurement of bioavailable metals in river water. ANNALI DI CHIMICA, 94(7-8), 515-520.  Author URL.
Kirk CJ, Bottomley L, Minican N, Carpenter H, Shaw S, Kohli N, Winter M, Taylor EW, Waring RH, Michelangeli F, et al (2003). Environmental endocrine disrupters dysregulate estrogen metabolism and Ca2+ homeostasis in fish and mammals via receptor-independent mechanisms. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 135(1), 1-8.
Wilkinson I (2002). High plasma concentrations of human urotensin II do not alter local or systemic hemodynamics in man. Cardiovascular Research, 53(2), 341-347.
Affolter JT, Newby DE, Wilkinson IB, Winter MJ, Balment RJ, Webb DJ (2002). No effect on central or peripheral blood pressure of systemic urotensin II infusion in humans. British Journal of Clinical Pharmacology, 54(6), 617-621. Abstract.
Bond H, Winter MJ, Warne JM, McCrohan CR, Balment RJ (2002). Plasma concentrations of arginine vasotocin and urotensin II are reduced following transfer of the euryhaline flounder (Platichthys flesus) from seawater to fresh water. Gen Comp Endocrinol, 125, 113-120.
Winter MJ, Ashworth A, Bond H, Brierley MJ, McCrohan CR, Balment RJ (2000). The caudal neurosecretory system: control and function of a novel neuroendocrine system in fish. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 78(3), 193-203.  Author URL.
Winter MJ, Ashworth A, Bond H, Brierley MJ, McCrohan CR, Balment RJ (2000). The caudal neurosecretory system: control and function of a novel neuroendocrine system in fish. Biochemistry and Cell Biology, 78(3), 193-203. Abstract.
Winter MJ, Hubbard PC, McCrohan CR, Balment RJ (1999). A homologous radioimmunoassay for the measurement of urotensin II in the euryhaline flounder, Platichthys flesus. General and comparative endocrinology, 114, 249-256.

Conferences

Winter MJ, Ball J, Goonesinghe A, Hetheridge M (2013). The utility of the zebrafish for drug safety assessment: an industry perspective.  Author URL.
Corcoran J, Lange A, Tyler CR, Winter MJ (2010). Investigating drug-metabolising cytochrome P450 (cyp) isoforms in a fish hepatocyte model.  Author URL.
McKenzie DJ, Winter MJ, Hayes R, Garofalo E, Ceradini S, Verweij F, van der Oost R, Day N, Butler PJ, Taylor EW, et al (2005). Swimming performance in fish: a physiological biomarker of aquatic pollution?.  Author URL.

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External Engagement and Impact

Member of the editorial board for Toxics journal

Member of the SeaLife Trust Ethical Review Board 

Supporter of In2STEM, promoting Social Mobility and Diversity in Science, Technology, Engineering and Maths

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Teaching

BIO3067 - Ecotoxicology

BIO3136 - Biosciences Research Projects

BIOM549 - Advanced Laboratory Skills

BIOM555 - Bioimaging

Modules

2023/24


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Supervision / Group

Postdoctoral researchers

  • Sylvia Dimitriadou BBSRC: Advancing understanding of anaesthesia and analgesia in the zebrafish
  • Mhairi Miller BBSRC: Advancing understanding of anaesthesia and analgesia in the zebrafish

Postgraduate researchers

  • Siobhan Monaghan PhD (BBSRC Case with AstraZeneca) ~ Characterising the functional homology of drug targets in aquatic animals.

Research Technicians

  • Teigan Veale CRISPR gene editing in zebrafish

Alumni

  • Sophie Gould PhD (Merck-collaboration) ~ Integrated health effects analysis of antidepressants inhibiting serotonin and/or norepinephrine reuptake using zebrafish models.
  • Charles Hamilton PhD (BBSRC-CASE with Astrazeneca) ~ Advancing mechanistic understanding of glucocorticoid effects in fish.
  • Ali Pilehvar BBSRC: Advancing understanding of anaesthesia and analgesia in the zebrafish
  • Joseph Pinion PhD (NC3Rs) ~ Development of an alternative approach, in non-protected larval zebrafish, for assessing drug-induced seizures.
  • Victoria Turner PhD (UoE and AstraZeneca)Testing the translational power of zebrafish for studying human heart failure

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