Geoffrey Pope Lab 201
Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK
I am an ecotoxicology PhD researcher in the Charles Tyler lab group. My background is in animal biology, and I spent some time as an intern with a marine conservation charity in south Wales. I then returned to Exeter to start an iCASE PhD investigating the effect of pharmaceuticals in the aquatic environment, in partnership with the pharmaceutical company AstraZeneca.
PhD (University of Exeter, 2018-present)
BSc Biological sciences with Animal biology with Study abroad (University of Exeter, 2013-2017)
- Transgenic zebrafish
- (Semi-) automated imaging platforms
- Pharmaceutical-induced oxidative stress
Project Title: Advancing transgenic zebrafish bioassays for drug analysis using imaging
Supervisors: Professor Charles Tyler, Dr Malcolm Hetheridge, Dr Jonathan Ball, Dr Stewart Owen (Industry Partner)
Funding Body: BBSRC, AstraZeneca, University of Exeter
Project Description: I use novel transgenic zebrafish in combination with different imaging platforms to investigate mixture effects of pharmaceuticals in waterways. The primary model I work with is the oxidative stress model TG(EpRE:mCherry), which I use with a semi-automated plate reader, the Acquifer, for high-throughput screening. I also apply confocal microscopy for higher-content imaging to understand the nuances of drug-induced oxidative stress and how it affects target organs. I focus particularly on the interaction of drug-induced oxidative stress with oestrogenic compounds or temperature. I am also exploring the use of mass spectrometry imaging methods for visualising the distribution of a drug and its metabolites within the body of zebrafish embryos.
- Society of Toxicology
- British Toxicology Society
- Royal Society of Biology