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Faculty of Health and Life Sciences

 Rebekah Boreham

Rebekah Boreham

PhD student

 Geoffrey Pope Lab 201


Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK


I am an ecotoxicology PhD researcher in the Charles Tyler lab group. My background is in animal biology, and I spent some time as an intern with a marine conservation charity in south Wales. I then returned to Exeter to start an iCASE PhD investigating the effect of pharmaceuticals in the aquatic environment, in partnership with the pharmaceutical company AstraZeneca.


PhD (University of Exeter, 2018-present)

BSc Biological sciences with Animal biology with Study abroad (University of Exeter, 2013-2017)

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Research interests

  • Ecotoxicology
  • Transgenic zebrafish
  • (Semi-) automated imaging platforms
  • Pharmaceutical-induced oxidative stress

Research projects

Project Title: Advancing transgenic zebrafish bioassays for drug analysis using imaging

Supervisors: Professor Charles Tyler, Dr Malcolm Hetheridge, Dr Jonathan Ball, Dr Stewart Owen (Industry Partner)

Funding Body: BBSRC, AstraZeneca, University of Exeter

Project Description: I use novel transgenic zebrafish in combination with different imaging platforms to investigate mixture effects of pharmaceuticals in waterways. The primary model I work with is the oxidative stress model TG(EpRE:mCherry), which I use with a semi-automated plate reader, the Acquifer, for high-throughput screening. I also apply confocal microscopy for higher-content imaging to understand the nuances of drug-induced oxidative stress and how it affects target organs. I focus particularly on the interaction of drug-induced oxidative stress with oestrogenic compounds or temperature. I am also exploring the use of mass spectrometry imaging methods for visualising the distribution of a drug and its metabolites within the body of zebrafish embryos.

Research networks

Profession memberships:

  • Society of Toxicology
  • British Toxicology Society
  • Royal Society of Biology

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