Faculty of Health and Life Sciences

Dr Sumita Roy

Dr Sumita Roy

Postdoctoral Research Fellow

 S.Roy@exeter.ac.uk

 Geoffrey Pope 328

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

Broad Research Specialisms:

Infectious diseases, Microbial Pathogenesis, Biochemistry, Structural biology

Qualifications

2002-2005: BSc in Biotechnology, Bangalore University (India).

2005-2006: MSc in Biomedical basis of diseases, Sheffield Hallam University, UK

2007-2010: PhD in Molecular microbiology, University of Sheffield, UK

Career

2021-Present: Postdoctoral Research Fellow. MRC of Medical Mycology. University of Exeter, UK

2017-2021: Postdoctoral researcher. Living System Institute. University of Exeter, UK

2011-2012: Research Associate. Imperial College London, UK

2010-2011: Wellcome Trust Fellowship. University of Sheffield, UK

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Research

Research interests

I am a mid-career scientist with a Ph.D. in molecular microbiology with extensive experience in synthetic biology and cell biology. I work on bacterial, fungal, and viral pathogenesis and how their virulence factors can be targeted for therapeutic purposes. 
I have worked with different pathogens including anaerobic Tanerella, Porphyromonas, and Campylobacter, Pseudomonas, Mycobacteria, Candida, and therefore, have amassed many different microbiology and molecular biology techniques to study these pathogens.

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Publications

Journal articles

Roy S, Vivoli Vega M, Ames JR, Britten N, Kent A, Evans K, Isupov MN, Harmer NJ (2023). The ROK kinase N-acetylglucosamine kinase uses a sequential random enzyme mechanism with successive conformational changes upon each substrate binding. Journal of Biological Chemistry, 299(4), 103033-103033.
Cross AR, Roy S, Vivoli Vega M, Rejzek M, Nepogodiev SA, Cliff M, Salmon D, Isupov MN, Field RA, Prior JL, et al (2022). Spinning sugars in antigen biosynthesis: characterization of the Coxiella burnetii and Streptomyces griseus TDP-sugar epimerases. J Biol Chem, 298(5). Abstract.  Author URL.
Cross AR, Roy S, Vega MV, Rejzek M, Nepogodiev SA, Cliff M, Salmon D, Isupov MN, Field RA, Prior JL, et al (2021). Spinning sugars in antigen biosynthesis: a direct study of the <i>Coxiella burnetii</i> and <i>Streptomyces griseus</i> TDP-sugar epimerases. Abstract.
Roy S, Vega MV, Ames JR, Britten N, Kent A, Evans K, Isupov MN, Harmer NJ (2021). Structure and function of <i>N</i>-acetylglucosamine kinase illuminates the catalytic mechanism of ROK kinases. Abstract.
Harmer NJ, Roy S, Vivoli M (2019). Carbohydrate Kinases: a Conserved Mechanism Across Differing Folds. Catalysts, 9, 29-29.
Cross AR, Baldwin VM, Roy S, Essex-Lopresti AE, Prior JL, Harmer NJ (2019). Zoonoses under our noses. Microbes Infect, 21(1), 10-19. Abstract.  Author URL.
Phansopa C, Roy S, Rafferty JB, Douglas CWI, Pandhal J, Wright PC, Kelly DJ, Stafford GP (2014). Structural and functional characterization of NanU, a novel high-affinity sialic acid-inducible binding protein of oral and gut-dwelling Bacteroidetes species. Biochemical Journal, 458(3), 499-511. Abstract.
Settem RP, Honma K, Nakajima T, Phansopa C, Roy S, Stafford GP, Sharma A (2013). A bacterial glycan core linked to surface (S)-layer proteins modulates host immunity through Th17 suppression. Mucosal Immunology, 6(2), 415-426.
Roy S, Phansopa C, Stafford P, Honma K, Douglas CWI, Sharma A, Stafford GP (2012). Beta-hexosaminidase activity of the oral pathogen<i>Tannerella forsythia</i>influences biofilm formation on glycoprotein substrates. FEMS Immunology & Medical Microbiology, 65(1), 116-120.
Roy S, Honma K, Douglas CWI, Sharma A, Stafford GP (2011). Role of sialidase in glycoprotein utilization by Tannerella forsythia. Microbiology, 157(11), 3195-3202. Abstract.
Stafford G, Roy S, Honma K, Sharma A (2011). Sialic acid, periodontal pathogens and <i>Tannerella forsythia</i>: stick around and enjoy the feast!. Molecular Oral Microbiology, 27(1), 11-22. Abstract.
Roy S, Douglas CWI, Stafford GP (2010). A Novel Sialic Acid Utilization and Uptake System in the Periodontal Pathogen. <i>Tannerella forsythia</i>. Journal of Bacteriology, 192(9), 2285-2293. Abstract.
Pham TK, Roy S, Noirel J, Douglas I, Wright PC, Stafford GP (2010). A quantitative proteomic analysis of biofilm adaptation by the periodontal pathogen <i>Tannerella forsythia</i>. PROTEOMICS, 10(17), 3130-3141. Abstract.
Pham TK, Roy S, Noirel J, Douglas I, Wright PC, Stafford GP (2010). A quantitative proteomic analysis of biofilm adaptation by the periodontal pathogen Tannerella forsythia. Proteomics Clinical Applications, 4(12), 965-965.

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