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Dr Tatiana Dimitriu

Dr Tatiana Dimitriu

Research Fellow

 Environment and Sustainability Institute 1:17

 

Environment and Sustainability Institute, University of Exeter, Penryn Campus, Penryn, Cornwall, TR10 9FE, UK

Overview

I'm an evolutionary biologist, interested in bacterial evolution, particularly coevolution with mobile genetic elements. My PhD focused on understanding horizontal gene transfer from a social evolution perspective, using modelling and experiments using synthetic bacterial strains. I then moved to studying bacterial evolution in more complex and realistic systems for my postdoc in Ben Raymond’s group. I used experimental evolution approaches to improve the efficacy of Bacillus thuringiensis, a pathogen of insects which virulence is mostly based on social behaviours. I am performing experimental evolution experiments, in order to analyse the evolution of strains that overcome insect host resistance. In Edze Westra’s group, I am now investigating how antibiotics can affect bacterial coevolution with phages, and restriction-modification defences.

Qualifications

2014 PhD in Evolutionary Biology (Université Paris-Descartes, France)
2010 MSc. in Genetics and Evolution (Université Paris-Sud and ENS Cachan, France)

Research

Research interests

  • social evolution
  • mobile genetic elements
  • plasmid-host coevolution
  • second-order selection

Research projects

Experimental evolution of Bacillus thuringiensis virulence to overcome insect host resistance

Diversity of plasmid transfer rates among natural isolates

Coevolution of Pseudomonas aeruginosa with phages

Publications

Key publications | Publications by category | Publications by year

Key publications


Medaney F, Dimitriu T, Ellis RJ, Raymond B (2016). Live to cheat another day: Bacterial dormancy facilitates the social exploitation of β-lactamases. ISME Journal, 10(3), 778-787. Abstract.
Dimitriu T, Misevic D, Lindner AB, Taddei F (2015). Mobile genetic elements are involved in bacterial sociality. Mob Genet Elements, 5(1), 7-11. Abstract.  Author URL.
Dimitriu T, Lotton C, Beńard-Capelle J, Misevic D, Brown SP, Lindner AB, Taddei F (2014). Genetic information transfer promotes cooperation in bacteria. Proceedings of the National Academy of Sciences of the United States of America, 111(30), 11103-11108. Abstract.

Publications by category


Journal articles

Dimitriu T, Kurilovich E, Lapinska U, Severinov K, Pagliara S, Szczelkun MD, Westra ER (In Press). Bacteriostatic antibiotics promote the evolution of CRISPR-Cas immunity.  Abstract.
Pursey E, Dimitriu T, Paganelli FL, Westra ER, van Houte S (In Press). CRISPR-Cas is associated with fewer antibiotic resistance genes in bacterial pathogens.  Abstract.
Dimitriu T, Matthews A, Buckling A (In Press). Increased copy number couples the evolution of plasmid horizontal transmission and antibiotic resistance.  Abstract.
Dimitriu T, Andrew C. M, Buckling A (In Press). Increased copy number couples the evolution of plasmid horizontal transmission and plasmid-encoded antibiotic resistance. Proceedings of the National Academy of Sciences of USA Abstract.
Dimitriu T, Misevic D, Capelle JB, Lindner AB, Brown SP, Taddei F (In Press). Selection of horizontal gene transfer through public good production.  Abstract.
Dimitriu T, Szczelkun MD, Westra ER (2020). Evolutionary Ecology and Interplay of Prokaryotic Innate and Adaptive Immune Systems. Current Biology, 30(19), R1189-R1202. Full text.
Dimitriu T, Marchant L, Buckling A, Raymond B (2019). Bacteria from natural populations transfer plasmids mostly towards their kin. Proceedings of the Royal Society B: Biological Sciences, 286 Full text.
Dimitriu T, Medaney F, Amanatidou E, Forsyth J, Ellis RJ, Raymond B (2019). Negative frequency dependent selection on plasmid carriage and low fitness costs maintain extended spectrum β-lactamases in Escherichia coli. Scientific Reports, 9(1). Abstract.
Dimitriu T, Ashby B, Westra ER (2019). Transposition: a CRISPR Way to Get Around. Current Biology, 29(18), R886-R889. Abstract.  Full text.
Dimitriu T, Misevic D, Lotton C, Brown SP, Lindner AB, Taddei F (2016). Indirect Fitness Benefits Enable the Spread of Host Genes Promoting Costly Transfer of Beneficial Plasmids. PLoS Biol, 14(6). Abstract.  Author URL.
Medaney F, Dimitriu T, Ellis RJ, Raymond B (2016). Live to cheat another day: Bacterial dormancy facilitates the social exploitation of β-lactamases. ISME Journal, 10(3), 778-787. Abstract.
Dimitriu T, Misevic D, Lindner AB, Taddei F (2015). Mobile genetic elements are involved in bacterial sociality. Mob Genet Elements, 5(1), 7-11. Abstract.  Author URL.
Dimitriu T, Lotton C, Beńard-Capelle J, Misevic D, Brown SP, Lindner AB, Taddei F (2014). Genetic information transfer promotes cooperation in bacteria. Proceedings of the National Academy of Sciences of the United States of America, 111(30), 11103-11108. Abstract.

Publications by year


In Press

Dimitriu T, Kurilovich E, Lapinska U, Severinov K, Pagliara S, Szczelkun MD, Westra ER (In Press). Bacteriostatic antibiotics promote the evolution of CRISPR-Cas immunity.  Abstract.
Pursey E, Dimitriu T, Paganelli FL, Westra ER, van Houte S (In Press). CRISPR-Cas is associated with fewer antibiotic resistance genes in bacterial pathogens.  Abstract.
Dimitriu T, Matthews A, Buckling A (In Press). Increased copy number couples the evolution of plasmid horizontal transmission and antibiotic resistance.  Abstract.
Dimitriu T, Andrew C. M, Buckling A (In Press). Increased copy number couples the evolution of plasmid horizontal transmission and plasmid-encoded antibiotic resistance. Proceedings of the National Academy of Sciences of USA Abstract.
Dimitriu T, Misevic D, Capelle JB, Lindner AB, Brown SP, Taddei F (In Press). Selection of horizontal gene transfer through public good production.  Abstract.

2021

Dimitriu T, Matthews AC, Buckling A (2021). Increased copy number couples the evolution of plasmid horizontal transmission and plasmid-encoded antibiotic resistance.  Abstract.

2020

Dimitriu T, Szczelkun MD, Westra ER (2020). Evolutionary Ecology and Interplay of Prokaryotic Innate and Adaptive Immune Systems. Current Biology, 30(19), R1189-R1202. Full text.

2019

Dimitriu T, Marchant L, Buckling A, Raymond B (2019). Bacteria from natural populations transfer plasmids mostly towards their kin. Proceedings of the Royal Society B: Biological Sciences, 286 Full text.
Dimitriu T, Medaney F, Amanatidou E, Forsyth J, Ellis RJ, Raymond B (2019). Negative frequency dependent selection on plasmid carriage and low fitness costs maintain extended spectrum β-lactamases in Escherichia coli. Scientific Reports, 9(1). Abstract.
Raymond B, Dimitriu T (2019). Negative frequency dependent selection on plasmid carriage and low fitness costs maintain extended spectrum β-lactamases in Escherichia coli.  Abstract.  Full text.
Dimitriu T, Ashby B, Westra ER (2019). Transposition: a CRISPR Way to Get Around. Current Biology, 29(18), R886-R889. Abstract.  Full text.

2016

Dimitriu T, Misevic D, Lotton C, Brown SP, Lindner AB, Taddei F (2016). Indirect Fitness Benefits Enable the Spread of Host Genes Promoting Costly Transfer of Beneficial Plasmids. PLoS Biol, 14(6). Abstract.  Author URL.
Medaney F, Dimitriu T, Ellis RJ, Raymond B (2016). Live to cheat another day: Bacterial dormancy facilitates the social exploitation of β-lactamases. ISME Journal, 10(3), 778-787. Abstract.

2015

Dimitriu T, Misevic D, Lindner AB, Taddei F (2015). Mobile genetic elements are involved in bacterial sociality. Mob Genet Elements, 5(1), 7-11. Abstract.  Author URL.

2014

Dimitriu T, Lotton C, Beńard-Capelle J, Misevic D, Brown SP, Lindner AB, Taddei F (2014). Genetic information transfer promotes cooperation in bacteria. Proceedings of the National Academy of Sciences of the United States of America, 111(30), 11103-11108. Abstract.

Tatiana_Dimitriu Details from cache as at 2021-09-24 23:25:42

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